Bioanalytical Services
Validated Assays
Your Trusted Bioanalytical Partner
With over 30 years of expertise in bioanalytical services, IQVIA Laboratories is your go-to resource for robust methods that support every stage of drug discovery and development. Our team has meticulously developed and validated assays for a wide range of applications, including:
- ADME Screening and Testing: Assessing drug absorption, distribution, metabolism, and excretion.
- Metabolite Identification: Uncovering critical metabolites during discovery and development.
- Pharmacokinetics and Drug Metabolism: Understanding how drugs behave in the body.
- Immunogenicity Testing: Evaluating immune responses to biologics.
- Biomarker Analysis and Characterization: Identifying key markers for precision medicine.
- Biosimilars Testing: Ensuring safety and efficacy of biosimilar products.
Our methodologies cover the spectrum, including LC-MS bioanalysis, LC-MS/MS analysis, hybrid LC-MS assays, and immunoassay and MS-based biomarker assays. Before validation, each assay undergoes a rigorous pre-qualification process, where our scientists review preliminary data and make necessary modifications to ensure accuracy and reliability.
We are leading with science, and as one of the world’s largest and most respected bioanalytical laboratory networks, we’re equipped to tailor customized methods specifically for your unique challenges. Trust IQVIA to deliver the vital data you need to advance your research and improve patient outcomes.
Explore our available bioanalytical assays below and let’s embark on a successful scientific journey together.
Assays to Support COVID-19 Trials
COVID-19 Assays |
|
| Azithromycin | Ritonavir |
| Chloroquine, hydroxychloroquine, and desethylhydroxychloroquine | Tocaticinib |
| Remdesivir | Tenofovir |
LC-MS/MS Methods
Compound/Metabolite |
Matrix/Anticoagulant |
|---|---|
| Acyclovir; Valaciclovir | Human plasma/K3EDTA |
| Amlodipine | Human plasma/K2EDTA |
| D-Amphetamine; L-Amphetamine (chiral) | Human plasma/sodium EDTA |
| Amphetamine (achiral) | Human plasma/sodium EDTA |
| Aprepitant | Human plasma/K2EDTA |
| Asenapine and Desmethylasenapine | Human plasma/K2EDTA |
| Atorvastatin; o-Hydroxyatorvastatin; p-Hydroxyatorvastatin | Human plasma/sodium heparin and K3EDTA |
| Bortezomib | Human plasma/K2EDTA, K3EDTA, and sodium heparin |
| Bupropion; Hydroxybupropion | Human plasma/K2EDTA |
| Caffeine; Paraxanthine | Human plasma/K2EDTA (surrogate matrix Bovine Serum Albumin (BSA) Phosphate Buffered Saline (PBS)) |
| Capecitabine; 5'-DFCR/ 5'-DFUR/ 5-FU/ FBAL |
Human plasma/sodium EDTA and K3EDTA |
| Capecitabine/ 5-Fluorouracil |
Human plasma/K3EDTA |
| Carbamazepine/ Carbamazepine 10,11-epoxide |
Human plasma/sodium EDTA |
| Clopidogrel/ Clopidogrel Acid/ Clopidogrel Active Metabolite (H4 diastereomer) |
Human plasma/K2EDTA |
| Clopidogrel Active Metabolite (H4 diastereomer only) | Human plasma/K2EDTA |
| Cyclosporine A | Human blood/K2EDTA |
| Cytarabine | Human plasma/sodium heparin |
| Cytarabine/ Ara-Uridine |
Human plasma/K2EDTA |
| Cytarabine/ Ara-Uridine |
Human plasma/K2EDTA |
| Danazol | Human plasma/K2EDT |
| Desipramine/2-Hydroxydesipramine | Human plasma/K2EDTA |
| Daunorubicin; Daunorubicinol | Human plasma/K2EDTA |
| Decitabine | Human plasma/K2EDTA |
| Dextromethorphan/ Dextrorphan |
Human plasma/K2EDTA |
| Digoxin |
Human serum Human plasma/K2EDTA |
| Digoxin | Human serum |
| Digoxin | Human urine |
| Digoxin | Human urine |
| Docetaxel | Human plasma/K2EDTA |
| Duloxetine/ Atomoxetine; S,S-Reboxetine |
Human plasma/K3EDTA |
| Epinephrine | Human plasma/K2EDTA |
| Erlotinib | Human plasma/sodium EDTA |
| 5-Fluorouracil (5-FU) | Human plasma/sodium EDTA |
| 5-Fluorouracil (5-FU) | Human plasma/sodium EDTA and K2EDTA |
| Fenofi bric Acid | Human plasma/sodium EDTA |
| Fluconazole | Human plasma/K2EDTA |
| Flurbiprofen | Human plasma/K2EDTA |
| Gemcitabine | Human plasma/lithium heparin |
| Gemcitabine; 2',2'-Difluorodeoxyuridine | Human plasma/lithium heparin |
| Glyburide (total) | Human plasma/sodium heparin |
| Imatinib/ N-Desmethyl Imatinib |
Human plasma/K2EDTA |
| Itraconazole; Hydroxy Itraconazole | Human plasma/K2EDTA |
| Ketoconazole | Human plasma/K2EDTA |
| Lamivudine (as part of Combivir®) | Human plasma/sodium heparin |
| Lamivudine (as part of Combivir®) | Human urine |
| Lovastatin; Lovastatin Acid | Human plasma/sodium heparin |
| Lovastatin; Lovastatin Acid | Human plasma/K2EDTA |
| Lumefantrine | Human plasma/K2EDTA |
| Metformin | Human plasma/sodium heparin |
| Methotrexate (Low Range)/ 7-Hydroxymethotrexate |
Human plasma/lithium heparin and K2EDTA |
| Methotrexate (Low Range)/ 7-Hydroxymethotrexate |
Human plasma/lithium heparin and K2EDTA |
| Methotrexate | Human plasma/K2EDTA |
| Methotrexate (Low Curve) | Human urine |
| Methotrexate (High Curve)/ 7-Hydroxymethotrexate |
Human urine |
| Methotrexate (Low Curve)/ 7-Hydroxymethotrexate |
Human urine |
| Methylphenidate; α-Phenyl-α-(2-Piperidyl)Acetic Acid | Human plasma/acid citrate dextrose |
| Metoprolol; α-Hydroxymetoprolol | Human plasma/K2EDTA |
| Midazolam; 1ʹ-Hydroxymidazolam | Human plasma/K2EDTA |
| Midazolam; 1ʹ-Hydroxymidazolam | Human plasma/sodium and lithium heparin |
| Montelukast | Human plasma/sodium heparin and K2EDTA |
| Montelukast/36-Hydroxy Montelukast | Human plasma/K2EDTA |
| Moxifloxacin | Human plasma/K2EDTA, K3EDTA, sodium EDTA, sodium heparin, and lithium heparin |
| Nisoldipine | Human plasma/K2EDTA |
| Omeprazole/ 5ʹ-Hydroxyomeprazole; Omeprazole Sulfone |
Human plasma/K2EDTA and sodium heparin |
| Paclitaxel; 6-Hydroxypaclitaxel | Human plasma/K2EDTA |
| Paliperidone | Human plasma/K2EDTA |
| Paroxetine | Human plasma/K2EDTA |
| Pemetrexed | Human plasma/K2EDTA |
| Repaglinide | Human plasma/sodium heparin |
| Rifampicin (Rifampin) | Human plasma/K2EDTA |
| Risperidone | Human plasma/K2EDTA |
| Ritonavir | Human plasma/K3EDTA |
| Rivastigmine | Human plasma/potassium oxalate/sodium fluoride |
| Rosiglitazone | Human plasma/K3EDTA |
| Rosuvastatin/ Rosuvastatin Lactone; N-Desmethyl Rosuvastatin |
Human plasma/K2EDTA |
| Sildenafil | Human plasma/K2EDTA |
| Sildenafil; N-Desmethyl Sildenafil | Human plasma/K2EDTA |
| Simvastatin; Simvastatin Acid | Human plasma/K3EDTA |
| Sunitinib/ Desethyl Sunitinib |
Human plasma/K2EDTA |
| Telaprevir | Human plasma/K2EDTA |
| Tenofovir | Human plasma/K2EDTA |
| Tolbutamide; 4-Hydroxytolbutamide | Human plasma/K2EDTA |
| Tolterodine; 5-Hydroxymethyl Tolterodine | Human plasma/sodium heparin |
| Valproic Acid | Human serum |
| Verapamil; Norverapamil | Human plasma/K2EDTA |
| R-Warfarin; S-Warfarin (chiral) | Human PFF (non-protein bound) |
| R-Warfarin; S-Warfarin (chiral) | Human plasma (total)/sodium heparin |
| Zidovudine (as part of Combivir®) | Human plasma/sodium heparin |
| Zidovudine (as part of Combivir®) | Human urine |
| Ziprasidone | Human plasma/sodium heparin |
Immunoassay Biomarker Methods
Biomarker/ Analyte on ELISA platform |
Matrix |
|---|---|
| HER-2/neu | Human serum |
| β-NGF (free) | Human serum |
| IGF-1 (total) | Human serum |
| IGF-1 (free) | Human serum |
| sECAD | Human serum |
| sEGFr | Human serum |
| VEGF | Human plasma/sodium citrate |
LC-MS Biomarker Methods
Biomarker Method Development and Validation Expertise |
|
|---|---|
| Amino Acids, Lipids, Neurotransmitters, Nucleotides, Hormones, Peptides, Proteins – immunoprecipitation, digestion, immunoaffinity LC/LC/nano LC-MS/MS | |
Biomarker Non-Proprietary Methods |
|
| Biomarker | Matrix |
| 9 Essential Amino Acid Panel | Human plasma/K2EDTA |
| 4β-Hydroxycholesterol | Human plasma/K2EDTA |
| β-Nerve Growth Factor (NGF) | Human serum |
| Cholesterol | Human plasma/K2EDTA |
| Citrulline | Human plasma/K2EDTA |
| 7α-Hydroxy-4-cholesten-3-one (C4) | Human serum |
| Insulin | Human serum |
| Rat Hepcidin | Rat serum |
| TL1A | Human serum |
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