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Science Innovation

Uniquely positioned to shape, validate, and deliver biomarker assessments that strive to improve patient outcomes across diverse Therapeutic Areas

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Bioanalytical Services

Validated Assays

Your Trusted Bioanalytical Partner

With over 30 years of expertise in bioanalytical services, IQVIA Laboratories is your go-to resource for robust methods that support every stage of drug discovery and development. Our team has meticulously developed and validated assays for a wide range of applications, including:

  • Pharmacokinetics and Drug Metabolism: Understanding how drugs behave in the body.
  • Biomarker Analysis and Characterization: Identifying key markers for precision medicine.
  • Biosimilars Testing: Ensuring safety and efficacy of biosimilar products.

Our methodologies cover the spectrum, including LC-MS bioanalysis, LC-MS/MS analysis, hybrid LC-MS assays, and immunoassay and MS-based biomarker assays. Before validation, each assay undergoes a rigorous pre-qualification process, where our scientists review preliminary data and make necessary modifications to ensure accuracy and reliability.

 

We are leading with science, and as one of the world’s largest and most respected bioanalytical laboratory networks, we’re equipped to tailor customized methods specifically for your unique challenges. Trust IQVIA to deliver the vital data you need to advance your research and improve patient outcomes.

 

Explore our available bioanalytical assays below and let’s embark on a successful scientific journey together.

Assays to Support COVID-19 Trials

COVID-19 Assays

Azithromycin Ritonavir
Chloroquine, hydroxychloroquine, and desethylhydroxychloroquine Tocaticinib
Remdesivir Tenofovir

 

LC-MS/MS Methods

Compound/Metabolite

Matrix/Anticoagulant

Acyclovir; Valaciclovir Human plasma/K3EDTA
Amlodipine Human plasma/K2EDTA
D-Amphetamine; L-Amphetamine (chiral) Human plasma/sodium EDTA
Amphetamine (achiral) Human plasma/sodium EDTA
Aprepitant Human plasma/K2EDTA
Asenapine and Desmethylasenapine Human plasma/K2EDTA
Atorvastatin; o-Hydroxyatorvastatin; p-Hydroxyatorvastatin Human plasma/sodium heparin and K3EDTA
Bortezomib Human plasma/K2EDTA, K3EDTA, and sodium heparin
Bupropion; Hydroxybupropion Human plasma/K2EDTA
Caffeine; Paraxanthine Human plasma/K2EDTA (surrogate matrix Bovine Serum
Albumin (BSA) Phosphate Buffered Saline (PBS))
Capecitabine; 5'-DFCR/
5'-DFUR/
5-FU/
FBAL
Human plasma/sodium EDTA and K3EDTA
Capecitabine/
5-Fluorouracil
Human plasma/K3EDTA
Carbamazepine/
Carbamazepine 10,11-epoxide
Human plasma/sodium EDTA
Clopidogrel/
Clopidogrel Acid/
Clopidogrel Active Metabolite (H4 diastereomer)
Human plasma/K2EDTA
Clopidogrel Active Metabolite (H4 diastereomer only) Human plasma/K2EDTA
Cyclosporine A Human blood/K2EDTA
Cytarabine Human plasma/sodium heparin
Cytarabine/
Ara-Uridine
Human plasma/K2EDTA
Cytarabine/
Ara-Uridine
Human plasma/K2EDTA
Danazol Human plasma/K2EDT
Desipramine/2-Hydroxydesipramine Human plasma/K2EDTA
Daunorubicin; Daunorubicinol Human plasma/K2EDTA
Decitabine Human plasma/K2EDTA
Dextromethorphan/
Dextrorphan
Human plasma/K2EDTA
 
Digoxin
 
Human serum
Human plasma/K2EDTA
Digoxin Human serum
Digoxin Human urine
Digoxin Human urine
Docetaxel Human plasma/K2EDTA
Duloxetine/
Atomoxetine; S,S-Reboxetine
Human plasma/K3EDTA
Epinephrine Human plasma/K2EDTA
Erlotinib Human plasma/sodium EDTA
5-Fluorouracil (5-FU) Human plasma/sodium EDTA
5-Fluorouracil (5-FU) Human plasma/sodium EDTA and K2EDTA
Fenofi bric Acid Human plasma/sodium EDTA
Fluconazole Human plasma/K2EDTA
Flurbiprofen Human plasma/K2EDTA
Gemcitabine Human plasma/lithium heparin
Gemcitabine; 2',2'-Difluorodeoxyuridine Human plasma/lithium heparin
Glyburide (total) Human plasma/sodium heparin
Imatinib/
N-Desmethyl Imatinib
Human plasma/K2EDTA
Itraconazole; Hydroxy Itraconazole Human plasma/K2EDTA
Ketoconazole Human plasma/K2EDTA
Lamivudine (as part of Combivir®) Human plasma/sodium heparin
Lamivudine (as part of Combivir®) Human urine
Lovastatin; Lovastatin Acid Human plasma/sodium heparin
Lovastatin; Lovastatin Acid Human plasma/K2EDTA
Lumefantrine Human plasma/K2EDTA
Metformin Human plasma/sodium heparin
Methotrexate (Low Range)/
7-Hydroxymethotrexate
Human plasma/lithium heparin and K2EDTA
Methotrexate (Low Range)/
7-Hydroxymethotrexate
Human plasma/lithium heparin and K2EDTA
Methotrexate Human plasma/K2EDTA
Methotrexate (Low Curve) Human urine
Methotrexate (High Curve)/
7-Hydroxymethotrexate
Human urine
Methotrexate (Low Curve)/
7-Hydroxymethotrexate
Human urine
Methylphenidate; α-Phenyl-α-(2-Piperidyl)Acetic Acid Human plasma/acid citrate dextrose
Metoprolol; α-Hydroxymetoprolol Human plasma/K2EDTA
Midazolam; 1ʹ-Hydroxymidazolam Human plasma/K2EDTA
Midazolam; 1ʹ-Hydroxymidazolam Human plasma/sodium and lithium heparin
Montelukast Human plasma/sodium heparin and K2EDTA
Montelukast/36-Hydroxy Montelukast Human plasma/K2EDTA
Moxifloxacin Human plasma/K2EDTA, K3EDTA, sodium EDTA,
sodium heparin, and lithium heparin
Nisoldipine Human plasma/K2EDTA
Omeprazole/
5ʹ-Hydroxyomeprazole; Omeprazole Sulfone
Human plasma/K2EDTA and sodium heparin
Paclitaxel; 6-Hydroxypaclitaxel Human plasma/K2EDTA
Paliperidone Human plasma/K2EDTA
Paroxetine Human plasma/K2EDTA
Pemetrexed Human plasma/K2EDTA
Repaglinide Human plasma/sodium heparin
Rifampicin (Rifampin) Human plasma/K2EDTA
Risperidone Human plasma/K2EDTA
Ritonavir Human plasma/K3EDTA
Rivastigmine Human plasma/potassium
oxalate/sodium fluoride
Rosiglitazone Human plasma/K3EDTA
Rosuvastatin/
Rosuvastatin Lactone; N-Desmethyl Rosuvastatin
Human plasma/K2EDTA
Sildenafil Human plasma/K2EDTA
Sildenafil; N-Desmethyl Sildenafil Human plasma/K2EDTA
Simvastatin; Simvastatin Acid Human plasma/K3EDTA
Sunitinib/
Desethyl Sunitinib
Human plasma/K2EDTA
Telaprevir Human plasma/K2EDTA
Tenofovir Human plasma/K2EDTA
Tolbutamide; 4-Hydroxytolbutamide Human plasma/K2EDTA
Tolterodine; 5-Hydroxymethyl Tolterodine Human plasma/sodium heparin
Valproic Acid Human serum
Verapamil; Norverapamil Human plasma/K2EDTA
R-Warfarin; S-Warfarin (chiral) Human PFF (non-protein bound)
R-Warfarin; S-Warfarin (chiral) Human plasma (total)/sodium heparin
Zidovudine (as part of Combivir®) Human plasma/sodium heparin
Zidovudine (as part of Combivir®) Human urine
Ziprasidone Human plasma/sodium heparin

 

Immunoassay Biomarker Methods

Biomarker/ Analyte on ELISA platform

Matrix

HER-2/neu Human serum
β-NGF (free) Human serum
IGF-1 (total) Human serum
IGF-1 (free) Human serum
sECAD Human serum
sEGFr Human serum
VEGF Human plasma/sodium citrate

 

LC-MS Biomarker Methods

Biomarker Method Development and Validation Expertise

Amino Acids, Lipids, Neurotransmitters, Nucleotides, Hormones, Peptides, Proteins – immunoprecipitation, digestion, immunoaffinity LC/LC/nano LC-MS/MS

Biomarker Non-Proprietary Methods

Biomarker Matrix
9 Essential Amino Acid Panel Human plasma/K2EDTA
4β-Hydroxycholesterol Human plasma/K2EDTA
β-Nerve Growth Factor (NGF) Human serum
Cholesterol Human plasma/K2EDTA
Citrulline Human plasma/K2EDTA
7α-Hydroxy-4-cholesten-3-one (C4) Human serum
Insulin Human serum
Rat Hepcidin Rat serum
TL1A Human serum

 

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