Translational Science and Innovations Laboratory Services (TSAIL)

In the rapidly evolving landscape of clinical development, IQVIA Laboratories is at the forefront of innovation, bridging the gap between pre-clinical research and early clinical trials. Our state-of-the-art Translational Science and Innovation Laboratory (TSAIL) is designed to accelerate drug development through early assay development and the adoption of emerging technologies.

Working with TSAIL provides several benefits including:

Accelerated Biomarker Discovery: From histopathologic diagnostics to multiplexed biomarker assessments, TSAIL ensures rapid deployment of the most effective predictive biomarkers and technologies.
Cutting-Edge Technology Platforms: Leverage our diverse portfolio, including Cytek Aurora Spectral Flow Cytometers, Thermo Fisher Genexus System, and more, to enhance your research capabilities.
Expertise and Collaboration: Work alongside experienced biomarker development scientists, board-certified pathologists, and immunologists to overcome challenges and achieve clinical trial success.
Holistic AI/ML Integration: Utilize artificial intelligence and machine learning for advanced whole slide imaging analytics and digital image processing.
Comprehensive Molecular-Genetic Pathology: Access fixed tissue and liquid DNA/RNA genetic profiling, solid tumor molecular minimal residual disease analysis, and clinical variant curation.

Anatomic and Digital Pathology

Histopathologic diagnostics and morphometry
Single and multiplexed biomarker assessments

Artificial intelligence (AI) and machine learning (ML) assisted whole slide imaging analytics
Spatial RNA expression profiling

Immune Monitoring

Intracellular Cytokine Staining (ICS) assays
Multi-parametric ELISpot/ FluoroSpot assays
Cultured Immune cell assays
Alpha assays/Multimode plate assays
Cytokine quantitation
Spectral Flow Cytometry and Cell Sorting
Novel assay development and POC biomarker validation

Knowledge Base

Experienced biomarker development scientists
Broad-certified anatomic and molecular-genetic patologists

Experienced immunologists and ASCP certified flow cytometry scientists
Vast experience immune monitoring pre-clinical and clinical vaccine, oncology and cell and gene therapy trials
Off-the Shelf and custom informatic pipelines

Molecular-Genetic Pathology

Fixed tissue and liquid DNA/RNA genetic profiling, with clinical variant curation
Solid tumor molecular minimal residual disease

Anatomic and Digital Pathology

Fully stocked histology laboratory for wet or formalin-fixed, paraffin embedded (FFPE) tissue processing
End-to-end test oversight by board-certified pathologists
Open chromogenic and fluorescence staining platforms, including Leica Bond Rx, Ventana Discovery and Agilent Omnis
Aperlo and Epredia light and fluorescent whole slide imaging
Goodness-of-fit AI/ML algorithm development for digital image analytics
RNAScope and Nanostring GeoMX RNA profiling
Greater IQVIA Laboratories adjacencies and global deployment for scaling

Immune Monitoring

Cytek Aurora(R) Spectral Flow Cytometers and CS Cell sorter (64 parameter, 5 lasers)
MabTech IRIS (ELISpot/FluoroSpot reader)
Meso Scale Discover (MSD) reader
Victor Nivo Alpha assay/Multimode reader
Curiox Pluto cellular assay automation system
End-to-end assay development, qualification, testing, and analysis by a team of skilled and experienced Immunologists
Greater IQVIA Laboratories adjacencies and global deployment for scaling

Molecular-Genetic Pathology

Thermo Fisher Genexus System automated nucleic acid extraction and Next Generation Sequencing (NGS)
Thermo Fisher Oncoming Precision and Comprehensive Assay amplicon-based FFPE tissue NGS panels
Liquid DNA/RNA NGS for solid tumor molecular minimal residual disease (~0.1%)
Board-certified molecular-genetic pathologist for variant curation and clinical interpretation

TSAIL Laboratories can help

At its core, TSAIL provides early, nimble collaboration with translational scientists with broad expertise in new biomarker discovery to help bridge the gap between pre-clinical and clinical trials and seamlessly transfer assays and deploy technologies into our large-scale global laboratory network quickly.

Watch this video to learn more about our Translational Science and Innovation Laboratory and how we can help accelerate the adoption of assays in clinical trials through new technology evaluation and early biomarker discovery.

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Factsheet

Translational Science and Innovation Laboratory (TSAIL)

Translational biomarker solutions to accelerate the adoption of assays into clinical trials though new technology evaluation and early biomarker discovery