In vitro ADME screening during the lead optimization stage of drug discovery positively impacts drug candidate selection with an enhanced probability of success in clinical trials. Since most new drug candidates fail during preclinical and clinical development, and the late stage of the drug development cycle can be a lengthy and costly process, any means of identifying drug candidates with optimized ADME and pharmacokinetics properties in the discovery stage will have a significant impact on the drug discovery process overall.
IQVIA Laboratories highly automated in vitro ADME laboratory partners with small, mid and large pharmaceutical customers around the world to perform large-scale ADME screening assays using in-house or client-customized protocols. Our rapid ADME assay development turnaround time enables parallel optimization of the ADME properties of your chemical platform, alongside your potency and selectivity targets, thereby enabling you to make important decisions about your potential candidates.
Partner with us for your preclinical ADME screening needs to realize:
- Increased Speed: Establishment of high-throughput ADME assays allows for the prioritization of your drug candidates by their ADME properties in parallel with optimization of their efficacy at early discovery phases. This approach improves the overall quality of your drug candidates and the probability of their success, thereby shortening the drug discovery and development process.
- Reduced Cost and Development Cycle Times: We generate in vitro screening data that customers can use in their in-silico models. This combination of in vitro screening and in-silico alternatives helps customers generate ADME data that can lead to a reduction in animal studies, and a more efficient and potentially less expensive study.
- Optimized Discovery Cycle Time: By ensuring that only the most promising candidates are progressed through to clinical trials, the drug discovery pipeline can become more streamlined and efficient once clinical trials begin. Optimizing drug leads early on reduces the cost and time of progressing unsuccessful compounds through to the later stages of development.
- Detailed Dose Levels: Pharmacokinetic (PK) parameters are extrapolated from measurement of drug concentration in the plasma, blood, or other biological matrices over a selected period. This provides information that can guide your future animal and clinical studies for the selection of the dose levels and frequency of administration.
Compound Management for HT-ADME Screening (using comPOUND® -20°C, +4°C, or ambient storage)
- Can store up to 200,000 compounds in bar-coded tubes
- Compounds can be retrieved within a few minutes
- Can store solubilized compounds for clients for ease and speed of use
Our experienced scientists perform a range of high-throughput screening services, routinely conducting industry-standard in vitro ADME assays and continuously developing novel in vitro assays to address current metabolism issues and the evolving needs of our customers.
