Clinical Genomics Laboratory Services

Anatomic pathology

• Fresh tissue and FFPE capabilities
• H&E creation/assessment and digital slide imaging available
• Pathologists onsite
• Located in USA, China, UK, and Singapore.

Isolations

• DNA and RNA extraction capabilities from a large spectrum of original material, including FFPE, blood, tissue, cells, plasma, and saliva
• Location availability in USA, China, UK, and Singapore.

Whole human genome sequencing

• Optimized method for FFPE and intact material, using low input and minimal amplification
• Illumina NovaSeq system available
• Location availability in USA, China, and UK.

DNA exome sequencing

• Low input procedure optimized for intact and FFPE material
• Flexible hybridization method that allows for use of various standard and customized ROI probe sets
• Illumina NovaSeq system available
• Location availability in USA, China, UK, and Singapore.

RNA sequencing

• Globin removal method to remove globin mRNA from blood
• Library preparation from both intact and degraded RNA from FFPE, blood, tissue, and cells
• Hybridization-based method targeting the human transcriptome
  Poly-A selection method for intact material
• Ribosomal RNA depletion method for degraded and non-coding RNA
• Illumina NovaSeq system available
• Location availability in USA, China, and UK.

Targeted sequencing

• Library preparations from RNA/DNA from FFPE, blood, tissues, cells, and plasma
• Hybridization-based methods targeting different panels of interest
• NovaSeq system
• Location availability in USA, China, and UK.

Thermo Fisher sequencing

• Manual and Genexus library preparation with various panels
• Customizable with DNA, RNA, or simultaneous profiling available
• Genexus, Ion Chef, S5 XL and PGM Dx platforms available
• Location availability in USA, China, UK, and Singapore.

Single cell RNA sequencing

• Simultaneous analysis of the transcriptome and cell surface proteome
• Various assays including immune repertoire, surface protein profiling, and single-nucleus
• 10X Chromium and Illumina NovaSeq systems available
• Location availability in USA

Spatial RNA and protein profiling

• Customizable, spatially restricted hybridization- and antibody-based RNA and protein quantification, respectively
• Immunofluorescence-guided cell selection and stratification performed by qualified pathologists
• Targeted NanoString nCounter or whole transcriptome (i.e., 18,000+ protein-coding genes) Illumina next-generation sequencing readouts available
• Location availability in USA

PCR assays

• Customizable probe amplification assays for different targets of interest
• Multiple platforms for expression profiling, genotyping, and copy number analysis
• ddPCR and qPCR systems available
• Fluidigm system available at USA site
• Location availability in USA, China

NanoString nCounter panels

• Probe Hybridization based capture, RNA copies counted by nCounter
• No amplification required
• Customizable
• Up to 800 targets in a single reaction
• Location availability in USA, China

Bioinformatics

• A range of analyses to support all service lines
• Custom analysis and algorithm development including biostatistics support
• Standard pipeline analysis available globally (including China)
• Location availability in USA (Centralized in RTP location)