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Meeting the demands of today’s drug, device and diagnostics development environment requires a next generation service provider.
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We offer a range of genomic laboratory services to support drug discovery, precision medicine and clinical development. Our industry-leading team advances research by delivering scientific insights that help clients maximize the value of their data.
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Discovery Sciences

Our labs bring expertise in protein production, antibody discovery, and immunogenicity to help you select the most promising candidates and reduce risk as you move toward IND-enabling studies.
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One of the world's largest and most respected bioanalytical and ADME laboratory networks. From our global locations, we serve many of the largest pharmaceutical, specialty pharmaceutical and biotechnology companies worldwide.
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a CLIA-certified biomarker testing laboratory developing immunoassays used to quantify protein biomarkers in support of drug mechanism of action, pharmacodynamic, prognostic, and predictive clinical studies across all stages of drug discovery and development.
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Combining cutting-edge technology platforms and state-of-the-art laboratories with over 35 years of clinical vaccine development.
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We have a dedicated Digital Innovation department focused on driving operational improvements and quality of our services. We’ve helped create agile and impactful solutions across the organization with the underpinnings of traceability, productivity, quality, and efficiency.
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Insight

Evaluation of Single Cell RNA Sequencing from FFPE Tissue using 10x Genomics Chromium Gene Expression Flex Assay
Home / Insights / Evaluation of Single Cell RNA Sequencing from FFPE Tissue using 10x Genomics Chromium Gene Expression Flex Assay

Single cell RNA sequencing (scRNA-seq) uncovers tissue heterogeneity by providing gene expression measurements in individual cells within a tissue.  A current limitation of scRNA-seq is the requirement to isolate viable cells from fresh or cryopreserved solid tumor biopsies, especially given that formalin-fixed paraffin embedded (FFPE) materials are ubiquitously utilized for long-term tissue preservation. Tissue fixation fragments genetic material, which introduces challenges for RNA-seq methods due to the reduced size of template material.

 

The objective of this study was to describe and characterize the utilization of single cells prepared from FFPE tissue sections to establish sample requirements, key quality control metrics, and reproducibility of the 10x Genomics Gene Expression Flex workflow. Download poster to learn more.

 

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