AACR 2022 Poster presentations
Automated liquid biopsy pan-cancer genomic profiling panel demonstrates utility for screening of targeted biomarkers
Advances in the analysis of circulating-free DNA (cfDNA) obtained from the plasma fraction of peripheral whole blood are facilitating minimally invasive methods to monitor health and disease. As a potential tool for the detection of cancer-specific biomarkers, liquid biopsy has considerable diagnostic and prognostic applications and has demonstrated the utility of capturing solid tumor heterogeneity and relevant actionable mutations. This analytical validation characterizes The Oncomine™ Precision Assay’s detection of hotspot mutations (substitutions, insertions, deletions, and copy number variations [CNVs]) for liquid biopsy samples. Download this poster to explore the methods, results, and conclusions of this study.
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Characterization of SARS-CoV-2 using the Ion AmpliSeq SARS-CoV-2 research panel
The Thermo Fisher Ion AmpliSeq SARS-CoV-2 Research Panel is a targeted NGS solution that facilitates sequence analysis of the SARS-CoV-2 genome. This assay’s performance and the Pangolin lineage caller were analytically validated for the detection of mutations (SNVs, indels) in RNA derived from nasopharyngeal swabs. Download this poster to explore the methods, results, and conclusions of this study.
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Quick turnaround NGS assay for the characterization of biomarkers in FFPE tissue
Genomic profiling of a tumor to characterize clinically relevant variants has become critically important for cancer diagnosis and prognosis, as well as in driving therapeutic decision making. This analytical validation addresses The Oncomine™ Precision Assay’s detection of hotspot mutations (substitutions, insertions, deletions, copy number variations [CNVs], and fusions) in FFPE tissue. Download this poster to explore the methods, results, and conclusions of this study.
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Sample management for enabling successful single-cell RNAseq processing
Analysis of single cells by sequencing (scRNAseq) provides insight into the impact of cellular heterogeneity on biological mechanisms and proper sample management is a critical aspect of large-scale clinical research studies, directly influencing downstream sample quality and the subsequent ability to interrogate specific cell populations of interest. Download this poster to explore the methods, results, and conclusions of this study.
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