TruSight Oncology 500 ctDNA(TSO500 ctDNA)

A Hybrid-Capture Approach for Target Enrichment of 523 Genes Across Various Tumor Types​

Gain an expansive view of your liquid biopsy samples by targeting 523 cancer-related genes using the TruSight Oncology 500 ctDNA assay. Not only does this assay identify all relevant variants (DNA fusions, SNVs, CNVs, insertions, and deletions) across various tumor types, but it also reports tumor mutational burden (TMB) and microsatellite instability (MSI) scores.

Our comprehensive genomic panel has advantages over individual biomarker assays in its ability to detect multiple biomarkers with one test, saving time, money, and samples. IQVIA Laboratories can meet your profiling needs by leveraging trusted technology from Illumina® in combination with our global laboratory network and expert support team.

An Efficient, Reliable Solution for Non-Invasive Tumor Characterization

Minimal input, extensive results

Obtain full exon coverage of 522 out of 523 genes using as little as 3 mL of plasma, 20-30 ng of cfDNA, or 10 mL of whole blood. TSO500 ctDNA can detect biomarkers without the need of a matched normal sample.

Simple, cost-effective workflow

Detect multiple biomarkers with a single assay to save time, money, and samples. The distributable kit enables global implementation.

Confident variant detection

Obtain a high-resolution view of variants enabled by TSO500 ctDNA’s hybrid-capture chemistry and unique molecular indices (UMIs).

Measurement of key immuno-oncology biomarkers

Gain insight into TMB score and MSI score in addition to variant calls. TruSight Oncology 500 ctDNA can reproducibly assess TMB.

Expansive services enabled by our global network

Our centralized, scientific operational oversight combined with our global laboratory footprint enable comprehensive, large-scale trial support. We enable clinical development support irrespective of geography.

Flexible customization to satisfy specific needs

We work with you to understand your specific needs, and our team provides cost-effective recommendations from custom assay development to specialized bioinformatics support.

Deep Sequencing Enabled by IQVIA's Subject Matter Expertise

Feel confident in your results with the trusted Illumina® software pipeline. Our software teams validate the most up-to-date software to ensure you are receiving optimal results. IQVIA Laboratories can develop custom reporting and filtering to meet your specific research needs. IQVIA Laboratories was one of the earliest adopters of DRAGEN™. Our technical support teams help you understand your deep sequencing data with our superior bioinformatics knowledge.

IQVIA Laboratories provides a text-delimited, combined variant output file for all biomarkers

• QC Metrics​
• CNV Outputs​
• DNA Fusion Report​
• Genomic VCFs (SNVs & Indels)​
• Variant Call Annotations

• MSI Scores​
• TMB Scores​
• FASTQs Upon Request​
• BAMs Upon Request

Our centralized, scientific, and operational oversight combined with our global laboratory footprint enables comprehensive, large-scale trial support. You will be supported every step of the way by our scientific project management team who will work with you to understand the most cost-effective recommendations to meet your specific needs. We are committed to transparency so you can feel confident in our promises of quality and timely delivery. We can expert support team can meet your research needs from nearly anywhere in the world with our genomic centers in the United States, China, United Kingdom, and Singapore.

Learn More About TSO500 with IQVIA

Posters

• TMB Standardization by Alignment to Reference Standards
• Panel-based TMB Analysis of Matched Tumor and Plasma Specimens Using Illumina’s TSO500 NGS Assay
• Comprehensive Genomic Profiling in FFPE Tissue Sample using TruSight Oncology 500 Assay

Presentations

• Approaches to Demonstrating Commutability of Various NGS Reference Standards for Targeted ctDNA Analysis
• Analytical Validation of Illumina’s TSO500 ctDNA Assay

Whitepaper

• The Importance of TMB Standardization for Diagnostic Assays 

Fact Sheets

• TSO500 Fact Sheet
• TSO500 ctDNA Fact Sheet

• Webinars

  • Bridging the Gap in Liquid Biopsies with CTCs and ctDNA
  • Comprehensive Genomic Profiling from Liquid Biopsy Samples: Clinical Trial Considerations

  Podcasts

  • The Standardization of TMB by Alignment to Reference Standards
  • Liquid Biopsy Collection in Clinical Development Programs

  Press Release

  • IQVIA launched Illumina’s TSO500 tumor profiling assay serves for the analysis of TMB

  Videos

  • Evaluation of a comprehensive genomic profiling assay for characterization of biomarkers in FFPE tissue

Request a Quote

Request a quote today to discover how TSO500 with IQVIA can advance your research.

Ship Samples

Ship your samples to one of our global genomic laboratory centers.​

Get Results

Obtain in-depth data revealing insights into your solid tumor samples.