TruCulture: Case studies

TruCulture has been utilized in dozens of clinical trials with demonstrated utility in understanding innate immunity, evaluating immune response to oncology treatments, understanding longitudinal changes in immunity and vaccine development. Open the case studies below for an overview of different studies that utilized TruCulture.

Below the case studies is a bibliography of publications that utilized TruCulture.

Restoration of innate immune function in chronic lymphocytic leukemia (CLL)

Chroniclymphocytic leukemia (CLL) is a cancer of mature B cells associated with immune dysregulation.

A 2024 study examined the innate immune function in chronic lymphocytic leukemia (CLL) patients treated with acalabrutinib or ibrutinib + venetoclax. The study utilized TruCulture tubes to assess cytokine release in response to standardized stimuli and characterized innate immune phenotypes via flow cytometry. At baseline, patients exhibited impaired cytokine responses and elevated pro-inflammatory cytokines.

However, after two to three cycles of targeted therapy, these responses normalized, correlating with a decrease in infection duration and frequency. The study highlights the potential of targeted treatments to restore innate immune function and reduce infection risk in CLL patients, with ongoing investigations in the PreVent-ACaLL phase 2 trial.

It also underscores the crucial role of TruCulture tubes in providing a standardized method to assess innate immune function, ensuring consistent and reliable measurement of cytokine responses.

Reference: Svanberg Teglgaard R, Marquart HV, HartlingHJ, Bay JT, da Cunha-Bang C, Brieghel C, et al. Improved innate immune functionin patients with chronic lymphocytic leukemia treated with targeted therapy inclinical trials. Clin Cancer Res. 2024;30(9):1959-1971. Available from: https://doi:10.1158/10780432.CCR-23-2522

Tailoring non-small cell lung cancer (NSCLC) treatment, including PD-L1 immune checkpoint inhibitors

In an open-label clinical study, 37 patients with inoperable non-small cell lung cancer (NSCLC) were observed to evaluate the immune response to different treatments, including PD-L1 immune checkpoint inhibitors (ICI), chemotherapy (CT), and chemo-radiotherapy (CT/RT).

Blood samples were collected at several intervals and immune responses were analyzed using TruCulture tubes and a standardized immunoassay. TruCulture enabled precise monitoring of cytokine release as a measure of immune function for both intracellular and extracellular pathways, with researchers identifying an evolving immune response triggered by both immune checkpoint inhibitors and chemotherapy.

Higher cytokine levels were observed prior to therapy and lower cytokines were observed after therapy, suggesting immune activation. The immune response from patients receiving chemotherapy correlated with 12-month survival, suggesting the prognostic value of this method.

These results indicate that TruCulture maybe an effective tool for early evaluation of response to immune check point inhibitors in NSCLC and other cancers, emphasizing the critical role of timing and understanding of immune function for precise immunomonitoring.

Reference: Ryssel H, Egebjerg K, Nielsen SD, LundgrenJ, Pøhl M, Langer SW, et al. Innate immune function during antineoplastic treatment is associated with 12-months survival in non-small cell lung cancer. Front Immunol. 2022;13:1024224. Available from: https://doi:10.3389/fimmu.2022.1024224

RIPK1 inhibition in inflammatory diseases

Receptor-interacting protein kinase 1 (RIPK1) plays a crucial role in mediating necroptosis, a form of programmed necrosis implicated in various inflammatory diseases, including rheumatoid arthritis and psoriasis. GSK2982772, a selective RIPK1 inhibitor, has shown promise in preventing RIPK1-mediated cell death and cytokine production.

Researchers used TruCulture tubes to determine the pharmacodynamics (PD) of single and repeated doses of GSK2982772 in healthy adult males. TruCulture tubes were supplemented with a cocktail (TNF-αα, zVAD, and Smac mimetic) to stimulate necroptosis.

Volunteers received, across 14 days:

1) placebo,

2) 20mg once daily,

3) 60mg once daily,

4) 60mg twice daily, or

5) 120mg twice daily.

Whole blood samples collected at multiple time points were incubated in TruCulture tubes. Supernatants analyzed for MIP-1αα production demonstrated that GSK2982772 inhibited RIPK1-dependent MIP-1αα production, with maximum inhibition observed at 1.5- and 8-hours post-treatment across all dosing groups.

This study demonstrated TruCulture’s effectiveness in assessing pharmacodynamic responses.

Reference: Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, et al. Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers. Pharmacol Res Perspect. 2017 Dec;5(6):e00365. Available from: https://doi.org/10.1002/prp2.365

Enhancing anti-cancer immunity through NK cell modulation

Natural killer (NK) cell activation and killing of tumor cells are important innate responses in anti-cancer immunity. Modulating NK cell function by stimulating to ll-like receptors has been shown to enhance therapeutic efficacy of biologics. VTX-2337 is a TLR-8 agonist that activates NK cells by enhancing antibody dependent cell-mediated cytotoxicity in the presence of other clinical therapeutics (trastuzumab, rituximab, cetuximab).

In a 2016 study, whole blood was collected from healthy donors using TruCulture tubes containing 2 concentrations of VTX-2337 (0.3 or 1 μM) and incubated for 24 hours. Supernatant analysis showed that VTX-2337 stimulated IL-18 and IL-1ββ production, indicating cytokine production via TLR-8 engagement.

These results demonstrate the potential of VTX-2337 to boost anti-cancer immunity and highlight TruCulture’s advantage in studying immune responses.

Reference: Dietsch GN, Lu H, Yang Y, Morishim C, ChowLQ, Disis ML, et al. Coordinated activation of toll-like receptor8 (TLR8) andNLRP3 by the TLR8 agonist, VTX-2337, ignites tumoricidal natural killer cellactivity. PLOS One. Feb 29, 2016. Available from: https://doi.org/10.1371/journal.pone.0148764

Impact of smoking on immune responses

In a 2024 study published in Nature, researchers explored factors contributing to variability in immune responses.

Researchers examined 136 variables and identified smoking, latent cytomegalovirus infection, and body mass index as major contributors to cytokine response variability, comparable to age, sex and genetics.

Whole blood samples from 1,000 healthy donors were collected and stimulated using TruCulture tubes with various immune agonists, and cytokine levels were measured using our internally developed Luminex-based assays.

Smoking was found to influence cytokine secretion, affecting both innate and adaptive immune responses. While the impact on innate responses diminishes rapidly after quitting smoking, the effect on adaptive responses remains long after cessation and is tied to epigenetic memory.

The study identified specific cytokines and immune responses affected by smoking, including associations with plasma levels of CEACAM6 and DNA methylation changes. The findings reveal that smoking has both short- and long-term effects on immune responses, with potential clinical implications for the risk of developing infections, cancers or autoimmune diseases.

TruCulture tubes provided a controlled environment for accurately assessing these immune responses.

Reference: Saint-André V, Charbit B, Biton A, RouillyV, Possémé C, Bertrand A, et al. Smoking changes adaptive immunity withpersistent effects. Nature. 2024;626(8000):827-835. Available from: https://doi:10.1038/s41586-023-06968-8

Safety and immunogenicity of SARS-CoV-2 vaccines

In this study, TruCulture tubes were used as a standardized whole‑blood stimulation system to assess antigen‑specific T‑cell responses after two doses of an adjuvanted SARS‑CoV‑2 recombinant protein vaccine.

Blood samples collected at multiple time points were drawn directly into three types of TruCulture tubes:

- spike‑antigen tubes

- negative‑control tubes

- positive‑control tubes (SEB + CD28)

to measure cytokine secretion profiles ex vivo.

Using TruCulture provided high‑fidelity immune response readouts, enabling the researchers to profile Th1‑associated cytokines (IFN‑γ, IL‑2, TNF‑α), which increased after vaccination. TruCulture minimized pre-analytical variability, enabled high-throughput immune profiling at our lab, and differentiated between immune signatures, enabling clear comparison of cytokine profiles across vaccine arms and timepoints.

Reference: Goepfert PA, Fu B,Chabanon AL, et al. Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study. Lancet Infect Dis.2021;21(9):1257-1270. doi:10.1016/S1473-3099(21)00147-X

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Uromodulin levels associate with a common UMOD variant and risk for incident CKD (2010) K?ttgen A, Hwang SJ, Larson MG, Van Eyk JE, Fu Q, Benjamin EJ, Dehghan A, Glazer NL, Kao WH, Harris TB, Gudnason V, Shlipak MG, Yang Q, Coresh J, Levy D, Fox CS J Am Soc Nephrol 21: 337-344.

Heterosubtypic anti-avian H5N1 influenza antibodies in intravenous immunoglobulins from globally separate populations protect against H5N1 infection in cell culture (2009) Sullivan JS, Selleck PW, Downton T, Boehm I, Axell AM, Ayob Y, Kapitza NM, Dyer W, Fitzgerald A, Walsh B, Lynch GW J Mol Genet Med 3: 217-224.

Distinct functions of activated protein C differentially attenuate acute kidney injury (2009) Gupta A, Gerlitz B, Richardson MA, Bull C, Berg DT, Syed S, Galbreath EJ, Swanson BA, Jones BE, Grinnell BW J Am Soc Nephrol. 20: 267-77.

Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin (2009) Bromberg-White JL, Boguslawski E, Duesbery NS PLoS ONE 4: e6956.

Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice (2009) Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, Hamelmann E, Schulz H, Stoeger T Part Fibre Toxicol. 6: 31.

Value of new biomarkers for safety testing in drug development (2009) Hewitt P and Herget T Expert Rev Mol Diagn.9: 531-6.

A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome (2009) van Dijk SJ, Feskens EJ, Bos MB, Hoelen DW, Heijligenberg R, Bromhaar MG, de Groot LC, de Vries JH, M?ller M, Afman LA Am J Clin Nutr. 90: 1656-64.

Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile (2009) Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, Murphy TF, Sethi S, St?mpfli MR. Am J Respir Crit Care Med. 179: 666-75.

Western-style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer (2009) Erdelyi I, Levenkova N, Lin EY, Pinto JT, Lipkin M, Quimby FW, Holt PR J Nutr. 139: 2072-8.

Analysis of Renal Biomarkers in Samples of Rat Urine Samples Frozen for 44 months From a Study on Puromycin Amino Nucleoside (PAN) (2009) Perron MF, Burnett R, Reiniche A, Briffaux JP, Eisinger D, K?sters S and Mapes J Toxicology LettersVolume 189, Supplement 1, S159

High content analysis of human fibroblast cell cultures after exposure to space radiation (2009) Dieriks B, De Vos W, Meesen G, Van Oostveldt K, De Meyer T, Ghardi M, Baatout S, Van Oostveldt P Radiat Res. 172: 423-36.

The multiplex bead array approach to identifying serum biomarkers associated with breast cancer (2009) Kim BK, Lee JW, Park PJ, Shin YS, Lee WY, Lee KA, Ye S, Hyun H, Kang KN, Yeo D, Kim Y, Ohn SY, Noh DY, Kim CW Breast Cancer Res. 11: R22.

Identifying early markers of Alzheimers disease using quantitative multiplex proteomic immunoassay panels (2009) Soares HD, Chen Y, Sabbagh M, Roher A, Schrijvers E, Breteler M Ann N Y Acad Sci. 1180 :56-67.

Growth Characteristics of the Nonhuman Primate Embryonic Stem Cell Line Cjes001 Depending on Feeder Cell Treatment. (2009) Fleischmann G, M?ller T, Blasczyk R, Sasaki E, Horn PA Cloning Stem Cells 11: 225-233.

Chronic Treatment with Clenbuterol Modulates Endothelial Progenitor Cells and Circulating Factors in a Murine Model of Cardiomyopathy. (2009) Rider JE, Polster SP, Lee S, Charles NJ, Adhikari N, Mariash A, Tadros G, Stangland J, Smolenski RT, Terracciano CM, Barton PJR, Birks EJ, Yacoub MH, Miller LW, Hall JL Journal of Cardiovascular Translational Research 2: 182?190.

Brain-derived neurotrophic factor levels in Alzheimers disease. (2009) OBryant SE, Hobson V, Hall JR, Waring SC, Chan W, Massman P, Lacritz L, Cullum CM, Diaz-Arrastia R; Texas Alzheimers Research Consortium J Alzheimers Dis 17: 337-341.

A Novel ENU-induced Mutation, Peewee, Causes Dwarfism in the Mouse. (2009) Lee B, Kano K, Young J, John SW, Nishina PM, Naggert JK, Naito K Mamm Genome 20: 404-413.

Matrix metalloproteinases during and outside of migraine attacks without aura. (2009) Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M, Olesen J Cephalalgia 30: 303-310.

Molecular Analyte Profiling of the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder Cancer. (2009) Bisiaux A, Thiounn N, Timsit MO, Eladaoui A, Chang HH, Mapes J, Mogenet A, Bresson JL, Pri? D, B?chet S, Baron C, Sadorge C, Thomas S, Albert EB, Albert PS, Albert ML J Urol 181: 1571-1580.

Immune Activation in Advanced Cancer Patients Treated with Recombinant IL-21: Multianalyte Profiling of Serum Proteins. (2009) Dodds MG, Frederiksen KS, Skak K, Hansen LT, Lundsgaard D, Thompson JA, Hughes SD Cancer Immunol Immunother 58: 843-854.

A Multianalyte Profile of Serum Proteins to Screen for Toxicological Effects of Anticholinesterase Insecticides in the Rat. (2009) Gordon CJ, Ward WO Neurotoxicology 30: 377-381.

Strain-Dependent Increases in Retinal Inflammatory Proteins and Photoreceptor FGF-2 Expression in Streptozotocin-Induced Diabetic Rats. (2009) Kirwin SJ, Kanaly ST, Linke NA, Edelman JL Invest Ophthalmol Vis Sci 50: 5396-5404.

Bead-based Multiplexed Immunoassays to Identify New Biomarkers in Maternal Serum to Improve First Trimester Down Syndrome Screening. (2009) Koster MP, Pennings JL, Imholz S, Rodenburg W, Visser GH, de Vries A, Schielen PC Prenat Diagn 29: 857-862.

Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program. (2009) Radonjic M, de Haan JR, van Erk MJ, van Dijk KW, van den Berg SA, de Groot PJ, M?ller M, van Ommen B PLoS ONE 4: e6646.

RIP4 Regulates Epidermal Differentiation and Cutaneous Inflammation. (2009) Rountree RB, Willis CR, Dinh H, Blumberg H, Bailey K, Dean C Jr, Peschon JJ, Holland PM J Invest Dermatol 130: 102-112.

Muscular Dystrophy Therapy by Nonautologous Mesenchymal Stem Cells: Muscle Regeneration Without Immunosuppression and Inflammation. (2009) Shabbir A, Zisa D, Leiker M, Johnston C, Lin H, Lee T Transplantation 87: 1275-1282.

Heart Failure Therapy Mediated by the Trophic Activities of Bone Marrow Mesenchymal Stem Cells: A Non-invasive Therapeutic Regimen. (2009) Shabbir A, Zisa D, Suzuki G, Lee T Am J Physiol Heart Circ Physiol 296: H1888-H1897.

Vaccination with an Attenuated Strain of Francisella novicida Prevents T-Cell Depletion and Protects Mice Infected with the Wild-Type Strain from Severe Sepsis. (2009) Sharma J, Li Q, Mishra BB, Georges MJ, Teale JM Infect Immun 77: 4314-4326.

Lethal Pulmonary Infection with Francisella Novicida is Associated with Severe Sepsis. (2009) Sharma J, Li Q, Mishra BB, Pena C, Teale JM J Leukoc Biol 86: 491-504.

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System. (2009) Sutton SW, Shelton J, Smith C, Williams J, Yun S, Motley T, Kuei C, Bonaventure P, Gundlach A, Liu C, Lovenberg T Ann N Y Acad Sci 1160: 242-249.

Regression of Human Pancreatic Tumor Xenografts in Mice After a Single Systemic Injection of Recombinant Vaccinia Virus GLV-1h68. (2009) Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA Mol Cancer Ther 8: 141-151.

Atorvastatin Restores Endothelial Function in Offspring of Protein-Restricted Rats in a Cholesterol-Independent Manner. (2009) Torrens C, Kelsall CJ, Hopkins LA, Anthony FW, Curzen NP, Hanson MA Hypertension 53: 661-667.

The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - a mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide. (2009) Steger-Hartmann T, Raschke M, Riefke B, Pietsch H, Sieber MA, Walter J Exp Toxicol Pathol 61: 537-552.

Multiplex Immunoassay Analysis of Biomarkers in Clinically Accessible Quantities of Human Aqueous Humor. (2009) Sharma RK, Rogojina AT, Chalam KV Mol Vis 15: 60-69.

Myocardial Oxidative Stress, Osteogenic Phenotype, and Energy Metabolism are Differentially Involved in the Initiation and Early Progression of d-sarcoglycan-null Cardiomyopathy. (2009) Missihoun C, Zisa D, Shabbir A, Lin H, Lee T Mol Cell Biochem 321: 45-52.

The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results. (2009) McBurney RN, Hines WM, Von Tungeln LS, Schnackenberg LK, Beger RD, Moland CL, Han T, Fuscoe JC, Chang CW, Chen JJ, Su Z, Fan XH, Tong W, Booth SA, Balasubramanian R, Courchesne PL, Campbell JM, Graber A, Guo Y, Juhasz PJ, Li TY, Lynch MD, Morel NM, Plasterer TN, Takach EJ, Zeng C, Beland FA Toxicol Pathol 37: 52-64.

The Link Between Heightened Thrombogenicity and Inflammation: Pre-Procedure Characterization of the Patient at High Risk for Recurrent Events After Stenting. (2009) Gurbel PA, Bliden KP, Kreutz RP, Dichiara J, Antonino MJ, Tantry US Platelets 20: 97-104.

Molecular Response to Cetuximab and Efficacy of Preoperative Cetuximab-Based Chemoradiation in Rectal Cancer. (2009) Debucquoy A, Haustermans K, Daemen A, Aydin S, Libbrecht L, Gevaert O, De Moor B, Tejpar S, McBride WH, Penninckx F, Scalliet P, Stroh C, Vlassak S, Sempoux C, Machiels JP J Clin Oncol 27: 2751-2757.

CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation. (2009) Camargo JF, Quinones MP, Mummidi S, Srinivas S, Gaitan AA, Begum K, Jimenez F, VanCompernolle S, Unutmaz D, Ahuja SS, Ahuja SK J Immunol 182: 171-182.

Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer. (2009) Amonkar SD, Bertenshaw GP, Chen TH, Bergstrom KJ, Zhao J, Seshaiah P, Yip P, Mansfield BC PLoS ONE 4: e4599.

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke (2009) Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ Jr, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I Am J Respir Cell Mol Biol 40: 147-158.

"Host Tissue Damage" Signal ATP Impairs IL-12 and IFNgamma Secretion in LPS Stimulated Whole Human Blood. (2008) Nalos M, Huang S, Sluyter R, Khan A, Santner-Nanan B, Nanan R, McLean AS Intensive Care Med 34: 1891-1897.

Biomarker Sample Collection and Handling in the Clinical Setting to Support Early-Phase Drug Development (2008) Russell CB, Suggs S, Patterson SD Methods in Pharmacology and Toxicology; Biomarker Methods in Drug Discovery and Development

TGF-beta signalling-related markers in cancer patients with bone metastasis. (2008) Baselga J, Rothenberg ML, Tabernero J, Seoane J, Daly T, Cleverly A, Berry B, Rhoades SK, Ray CA, Fill J, Farrington DL, Wallace LA, Yingling JM, Lahn M, Arteaga C, Carducci M Biomarkers 13: 217-236.

Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. (2008) Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM J Neurosci 28: 14156-14164.

Mechanisms of oncostatin M-induced pulmonary inflammation and fibrosis. (2008) Mozaffarian A, Brewer AW, Trueblood ES, Luzina IG, Todd NW, Atamas SP, Arnett HA J Immunol 181: 7243-7253.

Multianalyte profiling of serum antigens and autoimmune and infectious disease molecules to identify biomarkers dysregulated in epithelial ovarian cancer. (2008) Bertenshaw GP, Yip P, Seshaiah P, Zhao J, Chen TH, Wiggins WS, Mapes JP, Mansfield BC Cancer Epidemiol Biomarkers Prev 17: 2872-81.

Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. (2008) Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R PLoS Biol 6: e123.

Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma. (2008) Ding Y, Boguslawski EA, Berghuis BD, Young JJ, Zhang Z, Hardy K, Furge K, Kort E, Frankel AE, Hay RV, Resau JH, Duesbery NS Mol Cancer Ther 7: 648-658.

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma. (2008) Duan H, Fleming J, Pritchard DK, Amon LM, Xue J, Arnett HA, Chen G, Breen P, Buckner JH, Molitor JA, Elkon KB, Schwartz SM Arthritis Rheum 58: 1465-1474.

A mouse to human search for plasma proteome changes associated with pancreatic tumor development. (2008) Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM PLoS Med 5: e123.

IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. (2008) Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE Int Immunol 20: 1019-1030.

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. (2008) Thompson WL, Karpus WJ, Van Eldik LJ J Neuroinflammation 5: 35.

Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease. (2008) Torrence AE, Brabb T, Viney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L Inflamm Bowel Dis 14: 480-490.

Fibroblast growth factor 21 corrects obesity in mice. (2008) Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A Endocrinology 149: 6018-6027.

Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response. (2008) Richardson MA, Gupta A, OBrien LA, Berg DT, Gerlitz B, Syed S, Sharma GR, Cramer MS, Heuer JG, Galbreath EJ, Grinnell BW J Pharmacol Exp Ther 325: 17-26.

Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. (2008) Puthawala K, Hadjiangelis N, Jacoby SC, Bayongan E, Zhao Z, Yang Z, Devitt ML, Horan GS, Weinreb PH, Lukashev ME, Violette SM, Grant KS, Colarossi C, Formenti SC, Munger JS Am J Respir Crit Care Med 177: 82-90.

Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis. (2008) Pulichino AM, Wang IM, Caron A, Mortimer J, Auger A, Boie Y, Elias JA, Kartono A, Xu L, Menetski J, Sayegh CE Am J Respir Cell Mol Biol 39: 324-36.

Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer. (2008) Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G J Clin Oncol 26: 1135-1141.

Dexamethasone inhibits high glucose-, TNF-alpha-, and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes. (2008) Nehm? A, Edelman J Invest Ophthalmol Vis Sci 49: 2030-2038.

Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns. (2008) Mares CA, Ojeda SS, Morris EG, Li Q, Teale JM Infect Immun 76: 3001-3010.

Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice. (2008) Liao B, McCall E, Cox K, Lee CW, Huang S, Higgs RE, Chio LC, Zhen E, Hale JE, Jackson NK, Rutherford PG, Huang XD, Gifford-Moore D, Hui K, Duffin K, Gould KE, Rekhter M Biomark Insights 3: 147-157.

Two distinct activation states of plasmacytoid dendritic cells induced by influenza virus and CpG 1826 oligonucleotide. (2008) Iparraguirre A, Tobias JW, Hensley SE, Masek KS, Cavanagh LL, Rendl M, Hunter CA, Ertl HC, von Andrian UH, Weninger W J Leukoc Biol 83: 610-620.

Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression. (2008) Gurbel PA, Kreutz RP, Bliden KP, DiChiara J, Tantry US Am Heart J 155: 56-61.

Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. (2008) Fabian E, Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, van Ravenzwaay B Arch Toxicol 82: 151-157.

Biomarker profiles in serum and saliva of experimental Sj?grens syndrome: associations with specific autoimmune manifestations. (2008) Delaleu N, Immervoll H, Cornelius J, Jonsson R Arthritis Res Ther 10: R22.

Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. (2008) Cuaz-P?rolin C, Billiet L, Baug? E, Copin C, Scott-Algara D, Genze F, B?chele B, Syrovets T, Simmet T, Rouis M Arterioscler Thromb Vasc Biol 28: 272-277.

Endothelial activation markers in anemic non-dialysis chronic kidney disease patients. (2008) Patel TV, Mittal BV, Keithi-Reddy SR, Duffield JS, Singh AK Nephron Clin Pract 110: c244-250.

The Protective Effect of the Blood Brain Barrier from Systemic Cytokines in an Animal Femur Fracture Model. (2007) Ott M, Davis AT, Vanderkolk W, Resau JH, Deheer DH, Jones CB, Stouffer C, Kubek EW J Trauma 63: 591-595.

Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. (2007) Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I Am J Physiol Lung Cell Mol Physiol 292: L567-L576.

Lysosomal dysfunction results in altered energy balance. (2007) Woloszynek JC, Coleman T, Semenkovich CF, Sands MS J Biol Chem 282: 35765-35771.

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. (2007) Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, OShea JJ, Hunter CA Nat Immunol 8: 1363-1371.

Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. (2007) Sakamori R, Takehara T, Ohnishi C, Tatsumi T, Ohkawa K, Takeda K, Akira S, Hayashi N Hepatology 46: 1564-1573.

Pulmonary delivery of adenovirus vector formulated with dexamethasone-spermine facilitates homologous vector re-administration. (2007) Price AR, Limberis MP, Wilson JM, Diamond SL Gene Ther 14: 1594-1604.

Phase I study of eptifibatide in patients with sickle cell anaemia. (2007) Lee SP, Ataga KI, Zayed M, Manganello JM, Orringer EP, Phillips DR, Parise LV Br J Haematol 139: 612-620.

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. (2007) Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ Endocrinology 148: 774-81.

Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. (2007) Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J, Grosse J, Vadrucci S, Cogoli A, Derradji H, Neefs M, K?sters S, Spain M, Paul M, Grimm D J Cell Biochem 101: 1439-1455.

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2. (2007) Gupta A, Rhodes GJ, Berg DT, Gerlitz B, Molitoris BA, Grinnell BW Am J Physiol Renal Physiol 293: F245-F254.

Multi-Analyte Profiling of Post-Myocardial Infarction Plasma Samples. (2007) Escobar GP and Lindsey ML FASEB J. 21: 746.11.

Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells. (2007) Caers J, Deleu S, Belaid Z, De Raeve H, Van Valckenborgh E, De Bruyne E, Defresne MP, Van Riet I, Van Camp B, Vanderkerken K Leukemia 21: 1580-1584.

Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. (2007) Blumberg H, Dinh H, Trueblood ES, Pretorius J, Kugler D, Weng N, Kanaly ST, Towne JE, Willis CR, Kuechle MK, Sims JE, Peschon JJ J Exp Med 204: 2603-2614.

Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- mice. (2007) Basi DL, Adhikari N, Mariash A, Li Q, Kao E, Mullegama SV, Hall JL Am J Physiol Heart Circ Physiol 292: H516-H521.

Cutting edge: interleukin 17 signals through a heteromeric receptor complex. (2006) Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J J Immunol 177: 36-39.

A Phase II Pilot Trial of Low Dose, Continuous Infusion, or "Metronomic", Paclitaxel and Oral Celecoxib in Patients with Metastatic Melanoma (2006) McDermott DF, Cho DC, Merchan JR, Bhatt RS, Seery V, Mosher JL, Farquhar MB, Mier JW, Atkins MB, Sukhatme VP Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 24(18S)

Testing the Viability of Stored Frozen Serum Samples from the Air Force Health Study Using Human Multi-Analyte Profiles (MAPS) (2006) Fox K, Pavuk M Organohalogen Compounds. 2006 68: 1390-1393

Using genetically engineered mouse models of cancer to aid drug development: an industry perspective. (2006) Singh M, Johnson L Clin Cancer Res 12: 5312-5328.

Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. (2006) Schilling S, Goelz S, Linker R, Luehder F, Gold R Clin Exp Immunol 145: 101-117.

Strain differences influence murine pulmonary responses to Stachybotrys chartarum. (2006) Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Brain JD Am J Respir Cell Mol Biol 35: 415-423.

Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy--preliminary results. (2006) Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C Biomed Pharmacother 60: 463-467.

TWEAK is a novel arthritogenic mediator. (2006) Perper SJ, Browning B, Burkly LC, Weng S, Gao C, Giza K, Su L, Tarilonte L, Crowell T, Rajman L, Runkel L, Scott M, Atkins GJ, Findlay DM, Zheng TS, Hess H J Immunol 177: 2610-2620.

Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection. (2006) Knorr CW, Allen SD, Torres AR, Smee DF Antiviral Res 72: 125-133.

Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness. (2006) Heuer JG, Sharma GR, Zhang T, Ding C, Bailey DL, Stephens EJ, Holmes KC, Grubbs RL, Fynboe KA, Chen YF, Jakubowski JA J Trauma 60: 865-872.

Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells. (2006) Guo Y, Graham-Evans B, Broxmeyer HE Stem Cells 24: 850-856.

Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity. (2006) Dietsch GN, Dipalma CR, Eyre RJ, Pham TQ, Poole KM, Pefaur NB, Welch WD, Trueblood E, Kerns WD, Kanaly ST Toxicol Pathol 34: 39-51.

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. (2005) Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER J Exp Med 201: 105-115.

Prophylactic administration of abatacept prevents disease and bone destruction in a rat model of collagen-induced arthritis. (2005) Kliwinski C, Kukral D, Postelnek J, Krishnan B, Killar L, Lewin A, Nadler S, Townsend R J Autoimmun 25: 165-171.

Multiplex proteomic approaches to sepsis research: case studies employing new technologies. (2005) Heuer JG, Cummins DJ, Edmonds BT Expert Rev Proteomics 2: 669-680.

Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis. (2005) Heuer JG, Zhang T, Zhao J, Ding C, Cramer M, Justen KL, Vonderfecht SL, Na S J Immunol 174: 7141-7146.

Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. (2005) Fath MA, Mullins RF, Searby C, Nishimura DY, Wei J, Rahmouni K, Davis RE, Tayeh MK, Andrews M, Yang B, Sigmund CD, Stone EM, Sheffield VC Hum Mol Genet 14: 1109-1118.

Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment. (2004) Motley ST, Morrow BJ, Liu X, Dodge IL, Vitiello A, Ward CK, Shaw KJ Cell Microbiol 6: 849-865.

LXR-dependent gene expression is important for macrophage survival and the innate immune response. (2004) Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, Oconnell RM, Cheng G, Saez E, Miller JF, Tontonoz P Cell 119: 299-309.

Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. (2004) Heuer JG, Sharma GR, Gerlitz B, Zhang T, Bailey DL, Ding C, Berg DT, Perkins D, Stephens EJ, Holmes KC, Grubbs RL, Fynboe KA, Chen YF, Grinnell B, Jakubowski JA Crit Care Med 32: 1570-1578.

Validation of a new highly standardised, lab-independent whole-blood leukocyte function assay for clinical trials (ILCS). (2004) Schmolz M, Hurst TL, Bailey DM, Powell JR, Forsey RJ, Thompson JM, Williams C, Pawelec G Exp Gerontol 39: 667-671.

Screening for New Biomarkers for Subcortical Vascular Dementia and Alzheimer?s Disease (2011) ?hrfelt A, Andreasson U, Simon A, Zetterberg H, Edman A, Potter W, Holder D, Devanarayan V, Seeburger J, Smith AD, Blennow K, Wallin A Dement Geriatr Cogn Disord Extra 1: 31?42.

Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy (2011) VanGuilder HD, Bixler GV, Kutzler L, Brucklacher RM, Bronson SK, Kimball SR, Freeman WM PLoS ONE 6: e16271.

Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV (2011) Casrouge A, Decalf J, Ahloulay M, Lababidi C, Mansour H, Vallet-Pichard A, Mallet V, Mottez E, Mapes J, Fontanet A, Pol S, Albert ML J Clin Invest. 121: 308-317.

Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects (2010) van Dijk SJ, Feskens EJM, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LCPGM, Muller M, Afman LA PLoS ONE 12: e14422.

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Assessment of Biomarkers of Drug-induced Kidney Injury in Cynomolgus Monkeys Treated with a Triple Re-uptake Inhibitor (2011) Guha M, Heier A, Price S, Bielenstein M, Caccese RG, Heathcote DI, Simpson TR, Stong DB, Bodes E Toxicol Sci. 2011 Jan 22. [Epub ahead of print]

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Blood Profile of Proteins and Steroid Hormones Predicts Weight Change after Weight Loss with Interactions of Dietary Protein Level and Glycemic Index (2011) Wang P, Holst C, Andersen MR, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WKWH, van Baak MA, Larsen TM, Jebb SA, Kafatos A, Pfeiffer AFH, Martinez JA, Handjieva-Darlenska T, Kunesova M, Saris WHM, Mariman ECM PLoS ONE 6: e16773.

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Modulation of Inflammatory and Lipoprotein Pathways in Skin and Serum from Patients with Psoriasis (2011) Faha NNM, Li K, Szapary PO, Krueger J, Brodmerkel C J Am Coll Cardiol; 57: 576

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Identification of a biological signature for schizophrenia in serum (2011) Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S Mol Psychiatry. 2012 May;17(5):494-502

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Molecular Markers for Diagnosis of Periprosthetic Joint Infection (2011) Jacovides CL, Parvizi J, Adeli B, Jung KA J Arthroplasty. 2011 May 12. [Epub ahead of print]

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Validation of the Tetracycline Regulatable Gene Expression System for the Study of the Pathogenesis of Infectious Disease (2011) Chaturvedi AK, Lazzell AL, Saville SP, Wormley Jr.FL, Monteagudo C, Lopez-Ribot JL PLoS ONE 6(5): e20449

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Tumor Microenvironment-Derived Proteins Dominate the Plasma Proteome Response During Breast Cancer Induction and Progression (2011) Pitteri SJ, Kelly-Spratt KS, Gurley KE, Kennedy J, Busald Buson T, Chin A, Wang H, Zhang Q, Wong CH, Chodosh LA, Nelson PS, Hanash SM, Kemp CJ Cancer Res. 2011 Jun 8. [Epub ahead of print]

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Increased Disease Severity of Parasite-Infected TLR2-/- Mice Is Correlated with Decreased Central Nervous System Inflammation and Reduced Numbers of Cells with Alternatively Activated Macrophage Phenotypes in a Murine Model of Neurocysticercosis (2011) Gundra UM, Mishra BB, Wong K, Teale JM Infect Immun. 2011 Jul;79(7):2586-96

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Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis (2011) Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, Biamonte F, Bartalucci N, Gattoni E, Lupo ML, Finazzi G, Pancrazzi A, Antonioli E, Susini MC, Pieri L, Malevolti E, Usala E, Occhini U, Grossi A, Caglio S, Paratore S, Bosi A, Barbui T, Vannucchi AM Blood. 2011 Jul 1. [Epub ahead of print]

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Efficient Colonization and Therapy of Human Hepatocellular Carcinoma (HCC) Using the Oncolytic Vaccinia Virus Strain GLV-1h68 (2011) Gentschev I, M?ller M, Adelfinger M, Weibel S, Grummt F, Zimmermann M, Bitzer M, Heisig M, Zhang Q, Yu YA, Chen NG, Stritzker J, Lauer UM, Szalay AA PLoS ONE 6(7): e22069

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia (2011) Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, Zimmers TA PLoS ONE 6(7): e22538

Mark B. Coventry Award: Synovial C-reactive Protein: A Prospective Evaluation of a Molecular Marker for Periprosthetic Knee Joint Infection (2011) Parvizi J, Jacovides C, Adeli B, Jung KA, Hozack WJ Clin Orthop Relat Res. 2011 Jul 23. [Epub ahead of print]

Clinical and Plasma Proteomic Markers Correlating With Chronic Kidney Disease After Liver Transplantation (2011) Levitsky J, Salomon DR, Abecassis M, Langfelder P, Horvath S, Friedewald J, Wang E, Kurian SM, Mondala T, Gil S, McDade R, Ballard K, Gallon L Am J Transplant. 2011 Jul 27.

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Rapidly Progressive, Fatal, Inhalation Anthraxlike Infection in a Human: Case Report, Pathogen Genome Sequencing, Pathology, and Coordinated Response (2011) Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM Arch Pathol Lab Med. 2011 Aug 9. [Epub ahead of print]

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Modeling of pathological traits in Alzheimers disease based on systemic extracellular signaling proteome (2011) Britschgi M, Rufibach K, Bauer Huang SL, Clark CM, Kaye JA, Li G, Peskind ER, Quinn JF, Galasko DR, Wyss-Coray T Mol Cell Proteomics. 2011 Jul 8. [Epub ahead of print]

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Building an integrated neurodegenerative disease database at an academic health center (2011) Xie SX, Baek Y, Grossman M, Arnold SE, Karlawish J, Siderowf A, Hurtig H, Elman L, McCluskey L, Van Deerlin V, Lee VM, Trojanowski JQ Alzheimers Dement. 2011 Jul;7(4):e84-e93

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Urinary cystatin C as a biomarker for acute kidney injury and its immunohistochemical localization in kidney in the CDDP-treated rats (2011) Togashi Y, Sakaguchi Y, Miyamoto M, Miyamoto Y Exp Toxicol Pathol. 2011 Mar 4. [Epub ahead of print]

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Associations between body mass, radiographic joint damage, adipokines and risk factors for bone loss in rheumatoid arthritis (2011) Baker JF, George M, Baker DG, Toedter G, Von Feldt JM, Leonard MB Rheumatology (Oxford). 2011 Sep 2. [Epub ahead of print]

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Deletion of a Malaria Invasion Gene Reduces Death and Anemia, in Model Hosts (2011) G?mez ND, Safeukui I, Adelani AA, Tewari R, Reddy JK, Rao S, Holder A, Buffet P, Mohandas N, Haldar K PLoS ONE 6(9): e25477

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Molecular profiling and gene expression analysis in cutaneous sarcoidosis: The role of interleukin-12, interleukin-23, and the T-helper 17 pathway (2011) Judson MA, Marchell RM, Mascelli M, Piantone A, Barnathan ES, Petty KJ, Chen D, Fan H, Grund H, Ma K, Baribaud F, Brodmerkel C J Am Acad Dermatol. 2011 Sep 15. [Epub ahead of print]

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Peripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis (2011) Richards TJ, Kaminski N, Baribaud F, Flavin S, Brodmerkel C, Horowitz D, Li K, Choi J, Vuga LJ, Lindell KO, Klesen M, Zhang Y, Gibson KF Am J Respir Crit Care Med. 2011 Oct 20. [Epub ahead of print]

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Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging (2011) Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z J Gerontol A Biol Sci Med Sci. 2011 Nov 10. [Epub ahead of print]

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Bone Marrow Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo (2011) Xu S, Menu E, De Becker A, Van Camp B, Vanderkerken K, Van Riet I Stem Cells. 2011 Nov 18. [Epub ahead of print]

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Matrix Metalloproteinase-28 Deletion Amplifies Inflammatory and Extracellular Matrix Responses to Cardiac Aging (2011) Ma Y, Chiao YA, Zhang J, Manicone AM, Jin YF, Lindsey ML Microsc Microanal. 2011 Dec 8:1-10. [Epub ahead of print]

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Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus (2011) Safronetz D, Zivcec M, LaCasse R, Feldmann F, Rosenke R, Long D, Haddock E, Brining D, Gardner D, Feldmann H, Ebihara H PLoS Pathog 7(12): e1002426

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Biomarkers and Depressive Symptoms in a Sample of Cognitively Intact and Alzheimer?s Disease Elderly Males (2011) Hall JR, Vo HT, Johnson LA, Winter S, Barber RC, O?Bryant SE Neuroscience & Medicine, 2011, 2, 306-312

Plasma biomarkers of depressive symptoms in older adults (2012) Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VMY, Mackin RS, Trojanowski JQ, Wilson RS, Shaw LM Translational Psychiatry (2012) 2, e65;

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Bronchial and Bronchiolar Fibrosis in Rats Exposed to 2,3-Pentanedione Vapors: Implications for Bronchiolitis Obliterans in Humans (2012) Morgan DL, Jokinen MP, Price HC, Gwinn WM, Palmer SM, Flake GP Toxicol Pathol. 2012 Jan 3. [Epub ahead of print]

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Proteomic approaches to unravel the complexity of schizophrenia (2012) Martins-de-Souza D, Guest PC, Rahmoune H, Bahn S Expert Rev Proteomics. 2012 Feb;9(1):97-108

STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma (2012) Looyenga BD, Hutchings D, Cherni I, Kingsley C, Weiss GJ, MacKeigan JP PLoS ONE 7(2): e30820

Pharmacokinetics and Pharmacodynamics of Pegylated Interferon Lambda-1 in Cynomolgus Monkeys (2012) Byrnes-Blake KA, Pederson S, Klucher KM, Anderson-Haley M, Miller DM, Lopez-Talavera JC, Freeman JA J Interferon Cytokine Res. 2012 Jan 26. [Epub ahead of print]

Association between lead and cadmium and reproductive hormones in peripubertal U.S. girls (2010) Lenberg AL, Hediger ML, Lee PA, Himes JH, Louis G Environ Health Perspect. 2010 Dec;118(12):1782-7

Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies (2008) Adibhatla RM, Hatcher JF CNS Neurol Disord Drug Targets. 2008 Jun;7(3):243-53

Synthetic Ligands Against TLR2-9 in TruCulture - whole blood assays distinguish clinical stages of SIRS (trauma) and sepsis (2010) Bindja J, Weiss ME, Schmolz M, Stein GM, Mapes J, Schneiderhan-Marra N, Joos TO, Schneider EM TSIS Mar 9-13th

Effects of Echinaforce? treatment on ex vivo-stimulated blood cells (2011) Ritchie MR, Gertsch J, Klein P, Schoop R Phytomedicine. 2011 Jul 15;18(10):826-31

Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients (2012) Schwarz E, Guest PC, Steiner J, Bogerts B, Bahn S Translational Psychiatry (2012) 2, e82

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis (2012) Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, Catalano JV, Deininger M, Miller C, Silver RT, Talpaz M, Winton EF, Harvey JH Jr, Arcasoy MO, Hexner E, Lyons RM, Paquette R, Raza A, Vaddi K, Erickson-Viitanen S, Koumenis IL, Sun W, Sandor V, Kantarjian HM N Engl J Med. 2012 Mar;366(9):799-807

Preferential Replication of Systemically Delivered Oncolytic Vaccinia Virus in Focally Irradiated Glioma Xenografts (2012) Advani SJ, Buckel L, Chen NG, Scanderbeg DJ, Geissinger U, Zhang Q, Yu YA, Aguilar RJ, Mundt A, Szalay AA Clin Cancer Res. 2012 Feb 29. [Epub ahead of print]

Evaluation of multiple variate selection methods from a biological perspective: a nutrigenomics case study (2012) Tapp HS, Radonjic M, Kate Kemsley E, Thissen U Genes Nutr. 2012 Mar 2. [Epub ahead of print]

A small animal peripheral challenge model of yellow fever using interferon-receptor deficient mice and the 17D-204 vaccine strain (2012) Thibodeaux BA, Garbinoa NC, Lissb NM, Piper J, Blair CD, Roehrig JT Vaccine

RN486, a Selective Brutons Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents (2012) Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, Srinivasan D, Woods J, Levin A, OMahony A, Owens TD, Lou Y, Hill RJ, Narula S, Demartino J, Fine JS J Pharmacol Exp Ther. 2012 Apr;341(1):90-103

Inhibin B and luteinizing hormone levels in girls aged 6-11 years from NHANES III, 1988-1994 (2012) Sims EK, Addo OY, Gollenberg AL, Himes JH, Hediger ML, Lee PA Clin Endocrinol (Oxf). 2012 Mar 24

Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes (2012) Willard MD, Lajiness ME, Wulur IH, Feng B, Swearingen ML, Uhlik MT, Kinzler KW, Velculescu VE, Sj?blom T, Markowitz SD, Powell SM, Vogelstein B, Barber TD Mol Cancer Res. 2012 Apr 19

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors (2012) Tolcher AW, Messersmith WA, Mikulski SM, Papadopoulos KP, Kwak EL, Gibbon DG, Patnaik A, Falchook GS, Dasari A, Shapiro GI, Boylan JF, Xu ZX, Wang K, Koehler A, Song J, Middleton SA, Deutsch J, Demario M, Kurzrock R, Wheler JJ J Clin Oncol. 2012 Apr 23

Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia (2012) Pedroso FE, Spalding PB, Cheung MC, Yang R, Gutierrez JC, Bonetto A, Zhan R, Chan HL, Namias N, Koniaris LG, Zimmers TA J Cachexia Sarcopenia Muscle. 2012 Mar 29

Multivariate Protein Signatures of Pre-Clinical Alzheimers Disease in the Alzheimers Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset (2012) Johnstone D, Milward EA, Berretta R, Moscato P PLoS One. 2012;7(4):e34341

Candidate Proteins, Metabolites and Transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) Clinical Study (2012) Finkel RS, Crawford TO, Swoboda KJ, Kaufmann P, Juhasz P, Li X, Guo Y, Li RH, Trachtenberg F, Forrest SJ, Kobayashi DT, Chen KS, Joyce CL, Plasterer T PLoS ONE 7(4): e35462

Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) as Predictors of Incident CKD Stage 3: The Atherosclerosis Risk in Communities (ARIC) Study (2012) Bhavsar NA, K?ttgen A, Coresh J, Astor BC Am J Kidney Dis. 2012 Apr 27. [Epub ahead of print]

Increased serum ?2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus (2012) Hermansen ML, Hummelsh?j L, Lundsgaard D, Hornum L, Keller P, Fleckner J, Fox B, Poulsen LK, Jacobsen S Lupus. 2012 May 10. [Epub ahead of print]

Biomarkers of Basic Activities of Daily Living in Alzheimers Disease (2012) Hall JR, Johnson LA, Barber RC, Vo HT, Winter AS, OBryant SE J Alzheimers Dis. 2012 May 9. [Epub ahead of print]

Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses (2012) Joubert MK, Hokom M, Eakin C, Zhou L, Deshpande M, Baker MP, Goletz TJ, Kerwin BA, Chirmule N, Narhi LO, Jawa V J Biol Chem. 2012 Jul 20;287(30):25266-79

Identification of cis- regulatory variation influencing protein abundance levels in human plasma (2012) Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S; on behalf of the AddNeuroMed Consortium, Dobson R; for the Alzheimer?s Disease Neuroimaging Initiative Hum Mol Genet. 2012 May 16. [Epub ahead of print]

First-Trimester Prediction of Preeclampsia in Nulliparous Women at Low Risk (2012) Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, Thorp JM Jr, Mercer BM, Peaceman AM, Ramin SM, Carpenter MW, Iams JD, Sciscione A, Harper M, Tolosa JE, Saade G, Sorokin Y, Anderson GD Obstet Gynecol. 2012 Jun;119(6):1234-1242

Consumption of a High Monounsaturated-Fat Diet Reduces Oxidative Phosphorylation Gene Expression in Peripheral Blood Mononuclear Cells of Abdominally Overweight Men and Women (2012) van Dijk SJ, Feskens EJ, Bos MB, de Groot LC, de Vries JH, M?ller M, Afman LA J Nutr. 2012 May 23. [Epub ahead of print]

Analysis of serum and plasma identifies differences in molecular coverage, measurement variability and candidate biomarker selection (2012) Alsaif M, Guest PC, Schwarz E, Reif A, Kittel-Schneider S, Spain M, Rahmoune H, Bahn S Proteomics Clin Appl. 2012 May 29

Association of Estimated Glomerular Filtration Rate and Urinary Uromodulin Concentrations with Rare Variants Identified by UMOD Gene Region Sequencing (2012) K?ttgen A, Yang Q, Shimmin LC, Tin A, Schaeffer C, Coresh J, Liu X, Rampoldi L, Hwang S, Boerwinkle E, Hixson JE, Linda Kao WH, Fox CS PLoS ONE 7(5): e38311

Biomarkers and Depressive Symptoms in Older Women with and without Cognitive Impairment (2012) Hall JR, Johnson LA, Vo HT, Barber RC, Winter AS, O?Bryant SE Journal of Behavioral and Brain Science, 2012, 2, 276-281

Evaluations of Tear Protein Markers in Dry Eye Disease: Repeatability of Measurement and Correlation with Disease (2012) Huang JF, Zhang Y, Rittenhouse KD, Pickering EH, McDowell MT Invest Ophthalmol Vis Sci. 2012 Jun 13. [Epub ahead of print]

Interleukin-7 aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation (2012) Hartgring SA, Willis CR, Bijlsma JW, Lafeber FP, van Roon JA Arthritis Res Ther. 2012 Jun 7;14(3):R137

Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals (2012) Song F, Poljak A, Crawford J, Kochan NA, Wen W, Cameron B, Lux O, Brodaty H, Mather K, Smythe GA, Sachdev PS PLoS One. 2012;7(6):e34078

Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods (2012) Jokerst JV, Thangaraj M, Kempen P, Sinclair R, Gambhir SS ACS Nano. 2012 Jun 10. [Epub ahead of print]

Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype (2012) Ringman JM, Elashoff D, Geschwind DH, Welsh BT, Gylys KH, Lee C, Cummings JL, Cole GM Arch Neurol. 2012 Jun 1;69(6):757-64

Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity (2012) Cockayne DA, Cheng DT, Waschki B, Sridhar S, Ravindran P, Hilton H, Kourteva G, Bitter H, Pillai SG, Visvanathan S, M?ller KC, Holz O, Magnussen H, Watz H, Fine JS PLoS One. 2012;7(6):e38629

The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis (2011) Macauley SL, Pekny M, Sands MS J Neurosci. 2011 Oct 26;31(43):15575-85

Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses (2012) Racioppi L, Noeldner PK, Lin F, Arvai S, Means AR J Biol Chem. 2012 Feb 14. [Epub ahead of print]

Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity (2012) Schuurhof A, Bont L, Hodemaekers HM, de Klerk A, de Groot H, Hofland RW, van de Pol AC, Kimpen JL, Janssen R Eur Respir J. 2012 Jun;39(6):1475-81

Cox-2 expression, PGE2 and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice (2011) Gravaghi C, La Perle KM, Ogrodwski P, Kang JX, Quimby F, Lipkin M, Lamprecht SA J Nutr Biochem. 2011 Apr;22(4):360-5

Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis (2012) Su?rez-Fari?as M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG J Invest Dermatol. 2012 Jul 5

Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: a controlled phase 2B trial (2011) Quoix E, Ramlau R, Westeel V, Papai Z, Madroszyk A, Riviere A, Koralewski P, Breton JL, Stoelben E, Braun D, Debieuvre D, Lena H, Buyse M, Chenard MP, Acres B, Lacoste G, Bastien B, Tavernaro A, Bizouarne N, Bonnefoy JY, Limacher JM Lancet Oncol. 2011 Nov;12(12):1125-33

Identification of blood protein biomarkers that aid in the clinical assessment of patients with malignant glioma (2012) Xu BJ, An QA, Srinivasa Gowda S, Yan W, Pierce LA, Abel TW, Rush SZ, Cooper MK, Ye F, Shyr Y, Weaver KD, Thompson RC Int J Oncol. 2012 Jun;40(6):1995-2003

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB (2011) Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L Brain. 2011 Sep;134(Pt 9):2722-35

Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells (2007) Farahi N, Cowburn AS, Upton PD, Deighton J, Sobolewski A, Gherardi E, Morrell NW, Chilvers ER J Immunol. 2007 Jul 15;179(2):1264-73

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease (2012) Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, Mondal A, Bedo J, Bush AI, Brown B, De Ruyck K, Ellis KA, Fowler C, Gupta VB, Head R, Macaulay SL, Pertile K, Rowe CC, Rembach A, Rodrigues M, Rumble R, Szoeke C, Taddei K, Taddei T, Trounson B, Ames D, Masters CL, Martins RN; for the Alzheimers Disease Neuroimaging Initiative and Australian Imaging Biomarker and Lifestyle Research Group Arch Neurol. 2012 Jul 16:1-8

Urinary cystatin C as a biomarker for diabetic nephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty (ZDF) rats (2012) Togashi Y, Miyamoto Y Exp Toxicol Pathol. 2012 Jul 11

Immunomodulatory Effect of the Topical Ophthalmic Janus Kinase Inhibitor Tofacitinib (CP-690,550) in Patients with Dry Eye Disease (2012) Huang JF, Yafawi R, Zhang M, McDowell M, Rittenhouse KD, Sace F, Liew SH, Cooper SR, Pickering EH Ophthalmology. 2012 Jul;119(7):e43-50

Cerebrospinal fluid APOE levels, an endophenotype for genetic studies for Alzheimers disease (2012) Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A; the Alzheimer?s Disease Neuroimaging Initiative, Fagan AM, Holtzman DM, Morris JC, Goate AM Hum Mol Genet. 2012 Jul 20. [Epub ahead of print]

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival (2012) Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M, Brugger W, Dietrich PY, Mendrzyk R, Hilf N, Schoor O, Fritsche J, Mahr A, Maurer D, Vass V, Trautwein C, Lewandrowski P, Flohr C, Pohla H, Stanczak JJ, Bronte V, Mandruzzato S, Biedermann T, Pawelec G, Derhovanessian E, Yamagishi H, Miki T, Hongo F, Takaha N, Hirakawa K, Tanaka H, Stevanovic S, Frisch J, Mayer-Mokler A, Kirner A, Rammensee HG, Reinhardt C, Singh-Jasuja H Nat Med. 2012 Jul 29. doi: 10.1038/nm.2883. [Epub ahead of print]

Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences (2012) Eve HE, Carey S, Richardson SJ, Heise CC, Mamidipudi V, Shi T, Radford JA, Auer RL, Bullard SH, Rule SA Br J Haematol. 2012 Aug 9.

A multicenter phase II study of single-agent enzastaurin in previously treated Waldenstrom macroglobulinemia (2012) Ghobrial IM, Moreau P, Harris B, Poon T, Jourdan E, Maisonneuve HM, Benhadji KA, Hossain A, Nguyen T, Wooldridge JE, Leblond V Clin Cancer Res. 2012 Aug 9

Altered lung function relates to inflammation in an acute LPS mouse model (2012) H?kansson HF, Smailag A, Brunmark C, Miller-Larsson A, Lal H Pulmonary Pharmacology & Therapeutics

Effects of Stimulation of Soluble Guanylate Cyclase on Diabetic Nephropathy in Diabetic eNOS Knockout Mice on Top of Angiotensin II Receptor Blockade (2012) Ott IM, Alter ML, von Websky K, Kretschmer A, Tsuprykov O, Sharkovska Y, Krause-Relle K, Raila J, Henze A, Stasch JP, Hocher B PLoS One. 2012;7(8):e42623. Epub 2012 Aug 10

A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation (2012) Scalley-Kim ML, Hess BW, Kelly RL, Krostag AR, Lustig KH, Marken JS, Ovendale PJ, Posey AR, Smolak PJ, Taylor JD, Wood CL, Bienvenue DL, Probst P, Salmon RA, Allison DS, Foy TM, Raport CJ PLoS One. 2012;7(8):e43332

Early Urinary and Plasma Biomarkers for Experimental Diabetic Nephropathy (2012) Alter ML, Kretschmer A, Von Websky K, Tsuprykov O, Reichetzeder C, Simon A, JP Stasch, Hoche B Clin. Lab. 2012;58:659-671

Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial (2012) Chiva-Blanch G, Urpi-Sarda M, Ros E, Valderas-Martinez P, Casas R, Arranz S, Guill?n M, Lamuela-Ravent?s RM, Llorach R, Andres-Lacueva C, Estruch R Clinical Nutrition (online September 3)

Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease (2012) Soares HD, Potter WZ, Pickering E, Kuhn M, Immermann FW, Shera DM, Ferm M, Dean RA, Simon AJ, Swenson F, Siuciak JA, Kaplow J, Thambisetty M, Zagouras P, Koroshetz WJ, Wan HI, Trojanowski JQ, Shaw LM; for the Biomarkers Consortium Alzheimers Disease Plasma Proteomics Project Arch Neurol. 2012 Jul 16:1-8

Serum Granulocyte Colony-Stimulating Factor and Alzheimers Disease (2012) Barber RC, Edwards MI, Xiao G, Huebinger RM, Diaz-Arrastia R, Wilhelmsen KC, Hall JR, OBryant SE, for the Texas Alzheimers Research and Care Consortium Dement Geriatr Cogn Disord Extra 2012;2:353-360

Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 is Linked to TNF-Alpha Pharmacology (2012) Erickson RI, Tarrant J, Cain G, Lewin-Koh SC, Dybdal N, Wong H, Blackwood E, West K, Steigerwalt R, Mamounas M, Flygare JA, Amemiya K, Dambach D, Fairbrother WJ, Diaz D Toxicol Sci. 2012 Sep 5. [Epub ahead of print]

The Relation between Inflammation and Neuropsychological Test Performance (2012) Balldin VH, Hall JR, Barber RC, Hynan L, Diaz-Arrastia R, O?Bryant SE International Journal of Alzheimer?s Disease Volume 2012, Article ID 703871

Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice (2010) Duval C, Thissen U, Keshtkar S, Accart B, Stienstra R, Boekschoten MV, Roskams T, Kersten S, M?ller M Diabetes. 2010 Dec;59(12):3181-91

Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease (2012) Llano DA, Devanarayan V, Simon AJ; The Alzheimer?s Disease Neuroimaging Initiative (ADNI) Alzheimer Dis Assoc Disord. 2012 Sep 27

Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab (2012) Wagner CL, Visvanathan S, Elashoff M, McInnes IB, Mease PJ, Krueger GG, Murphy FT, Papp K, Gomez-Reino JJ, Mack M, Beutler A, Gladman D, Kavanaugh A Ann Rheum Dis. 2012 Sep 12. [Epub ahead of print]

Plasma Based Markers of [(11)C] PiB-PET Brain Amyloid Burden (2012) Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; for the Alzheimers Disease Neuroimaging Initiative PLoS One. 2012;7(9):e44260.

Preferential Colonization of Metastases by Oncolytic Vaccinia Virus Strain GLV-1h68 in a Human PC-3 Prostate Cancer Model in Nude Mice (2012) Donat U, Weibel S, Hess M, Stritzker J, H?rtl B, Sturm JB, Chen NG, Gentschev I, Szalay AA PLoS ONE 7(9): e45942

In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts (2012) Le Bihan MC, Bigot A, Jensen SS, Dennis J, Rogowska-Wrzesinska A, Lain? J, Gache V, Furling D, Jensen ON, Voit T, Mouly V, Coulton GR, Butler-Browne G J Proteomics. 2012 Sep 20. pii: S1874-3919(12)00652-5

Neuroinflammatory phenotype in early Alzheimers disease (2012) Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM Neurobiol Aging. 2012 Oct 9. pii: S0197-4580(12)00468-X

Proteomic analysis of the maternal protein restriction rat model for schizophrenia: Identification of translational changes in hormonal signalling pathways and glutamate neurotransmission (2012) Guest PC, Urday S, Ma D, Stelzhammer V, Harris LW, Amess B, Pietsch S, Oheim C, Ozanne SE, Bahn S Proteomics. 2012 Oct 16

Identification of factors associated with cancer related fatigue syndrome in disease-free breast cancer patients after completing primary treatment (2012) Minton O, Alexander S, Stone PC Breast Cancer Res Treat. 2012 Oct 14. [Epub ahead of print]

DPP-4 Inhibition on Top of Angiotensin Receptor Blockade Offers a New Therapeutic Approach for Diabetic Nephropathy (2012) Altera ML, Ottb IM, von Webskyb K, Tsuprykovb O, Sharkovska Y, Krause-Relle K, Raila, J, Henze A, Klein T, Hocher B Kidney Blood Press Res 2012;36:119-130

Neural progenitor cells regulate microglia functions and activity (2012) Mosher KI, Andres RH, Fukuhara T, Bieri G, Hasegawa-Moriyama M, He Y, Guzman R, Wyss-Coray T Nat Neurosci. 2012 Nov;15(11):1485-7

Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimers disease (2012) Verdile G, Laws SM, Henley D, Ames D, Bush AI, Ellis KA, Faux NG, Gupta VB, Li QX, Masters CL, Pike KE, Rowe CC, Szoeke C, Taddei K, Villemagne VL, Martins RN Mol Psychiatry. 2012 Oct 23

Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index (2012) Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC Br J Nutr. 2012 Jan;107(1):106-19

Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side application (2012) Mueller SC, M?rz R, Schmolz M, Drewelow B BMC Med Res Methodol. 2012 Aug 1;12(1):112

Characterization of AQX-1125, a small molecule SHIP1 activator Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo (2012) Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, Macrury T, Szabo C Br J Pharmacol. 2012 Nov 2

Quantitative Proteomic Analysis of Niemann-Pick Disease, Type C1 Cerebellum Identifies Protein Biomarkers and Provides Pathological Insight (2012) Cologna SM, Jiang X-S, Backlund PS, Cluzeau CVM, Dail MK, Yanjanin NM, Siebel S, Toth CL, Jun H, Wassif CA, Yergey AL, Porter FD PLoS ONE 7(10): e47845

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of A? amyloidosis (2012) Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM J Exp Med. 2012 Nov 5. [Epub ahead of print]

Cardiovascular risk factors, cortisol, and amyloid-? deposition in Alzheimers Disease Neuroimaging Initiative (2012) Toledo JB, Toledo E, Weiner MW, Jack CR Jr, Jagust W, Lee VM, Shaw LM, Trojanowski JQ; Alzheimers Disease Neuroimaging Initiative Alzheimers Dement. 2012 Nov;8(6):483-9

Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly (2012) Rajagopalan P, Refsum H, Hua X, Toga AW, Jack CR Jr, Weiner MW, Thompson PM; Alzheimers Disease Neuroimaging Initiative Neurobiol Aging. 2012 Nov 19. pii: S0197-4580(12)00533-7

Adipocytokine signaling is altered in flinders sensitive line rats, and adiponectin correlates in humans with some symptoms of depression (2012) Wilhelm CJ, Choi D, Huckans M, Manthe L, Loftis JM Pharmacol Biochem Behav. 2012 Nov 12. pii: S0091-3057(12)00312-7

Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients (2012) Stelzhammer V, Guest PC, Rothermundt M, Sondermann C, Michael N, Schwarz E, Rahmoune H, Bahn S Eur Neuropsychopharmacol. 2012 Nov 22. pii: S0924-977X(12)00303-3

Aging Exacerbates Obesity-Induced Oxidative Stress and Inflammation in Perivascular Adipose Tissue in Mice: A Paracrine Mechanism Contributing to Vascular Redox Dysregulation and Inflammation (2012) Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, Csiszar A, Ungvari Z J Gerontol A Biol Sci Med Sci. 2012 Dec 3. [Epub ahead of print]

Molecular Sex Differences in Human Serum (2012) Ramsey JM, Schwarz E, Guest PC, van Beveren NJM, Leweke FM; Rothermundt M, Bogerts B, Steiner J, Ruta L, Baron-Cohen S, Bahn S PLoS ONE 7(12): e51504

Differences in the Association of Peripheral Insulin and Cognitive Function in Non-Diabetic Alzheimers Disease Cases and Normal Controls (2012) Pavlik V, Massman P, Barber R, Doody R J Alzheimers Dis. 2012 Dec 14. [Epub ahead of print]

The Link Between C-Reactive Protein and Alzheimers Disease Among Mexican Americans (2013) OBryant SE, Johnson L, Edwards M, Soares H, Devous MD, Ross S, Rohlfing G, Hall J J Alzheimers Dis. 2013;34(3):701-6

Comparison of protein concentrations in serum versus plasma from Alzheimer?s patients (2012) Huebinger RM, Xiao G, Wilhelmsen KC, Diaz-Arrastia R, Zhang F, O?Bryant SE, Barber RC Advances in Alzheimer?s Disease Vol.1, No.3, 51-58 (2012)

Monitoring biomarkers after pediatric heart surgery: a new paradigm on the horizon (2013) Aqirbasli M, Undar A. Artif Organs. 2013 Jan;37(1):10-5.

Biomarkers of Alzheimers Disease Among Mexican Americans (2013) OBryant SE, Xiao G, Edwards M, Devous M, Gupta VB, Martins R, Zhang F, Barber R J Alzheimers Dis. 2013 Jan 11. [Epub ahead of print]

Sweet Bing Cherries Lower Circulating Concentrations of Markers for Chronic Inflammatory Diseases in Healthy Humans (2013) Kelley DS, Adkins Y, Reddy A, Woodhouse LR, Mackey BE, Erickson KL J Nutr. 2013 Jan 23. [Epub ahead of print]

Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre-eclampsia in a low-risk nulliparous patient population? (2013) Myatt L, Clifton R, Roberts J, Spong C, Wapner R, Thorp J Jr, Mercer B, Peaceman A, Ramin S, Carpenter M, Sciscione A, Tolosa J, Saade G, Sorokin Y, Anderson G; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network BJOG. 2013 Jan 18

Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function (2013) Gordon CJ, Jarema KA, Lehmann JR, Ledbetter AD, Schladweiler MC, Schmid JE, Ward WO, Kodavanti UP, Nyska A, Macphail RC. Inhal Toxicol. 2013 Feb;25(3):141-59.

Assessment of Inhibin B as a Biomarker of Testicular Injury Following Administration of Carbendazim, Cetrorelix, or 1,2-Dibromo-3-Chloropropane in Wistar Han Rats (2013) Moffit JS, Her LS, Mineo AM, Knight BL, Phillips JA, Thibodeau MS Birth Defects Research Part B Developmental and Reproductive Toxicology

Biomarkers of Vascular Risk, Systemic Inflammation, and Microvascular Pathology and Neuropsychiatric Symptoms in Alzheimers Disease. (2013) Hall JR, Wiechmann AR, Johnson LA, Edwards M, Barber RC, Winter AS, Singh M, OBryant SE. Journal of Alzheimers Disease

Relationship between Plasma Analytes and SPARE-AD Defined Brain Atrophy Patterns in ADNI (2013) Toledo JB, Da X, Bhatt P, Wolk DA, Arnold SE, Shaw LM, Trojanowski JQ, Davatzikos C PLoS One. 2013;8(2):e55531

Plasma apolipoprotein A1 as a biomarker for parkinsons disease (2013) Qiang JK, Wong YC, Siderowf A, Hurtig HI, Xie SX, Lee VM, Trojanowski JQ, Yearout D, Leverenz J, Montine TJ, Stern M, Mendick S, Jennings D, Zabetian C, Marek K, Chen-Plotkin AS Ann Neurol. 2013 Feb 27

Evaluation of Serum Biomarkers Associated with Radiographic Progression in Methotrexate-naive Rheumatoid Arthritis Patients Treated with Methotrexate or Golimumab (2013) Wagner C, Chen D, Fan H, Hsia EC, Mack M, Emery P, Fleischmann RM J Rheumatol. 2013 Mar 1. [Epub ahead of print]

The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes (2013) Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O PLoS One. 2013;8(3):e58164

Multiplexed protein profiling after bariatric surgery: characterization of improved endothelial dysfunction (2013) Bachmayer C, Hammes HP, Hasenberg T, Lammert A, Crowther D, Hess S Experimental and Clinical Endocrinology & Diabetes

Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia (2013) Mishra BB, Li Q, Steichen AL, Binstock BJ, Metzger DW, Teale JM, Sharma J PLoS One. 2013;8(3):e59616

The effects of stress on hypothalamic-pituitary-adrenal (HPA) axis function in subjects with schizophrenia (2013) Guest FL, Martins-de-Souza D, Rahmoune H, Bahn S, Guest PC Rev Psiq Cl?n. 2013;40(1):20-7

The effects of vitamin A on cells of innate immunity in vitro (2013) Wojtal K, Wolfram L, Frey-Wagner I, Lang S, Scharl M, Vavricka SR, Rogler G Toxicology in Vitro,

SMA-MAP: A Plasma Protein Panel for Spinal Muscular Atrophy (2013) Kobayashi DT, Shi J, Stephen L, Ballard KL, Dewey R, Mapes J, Chung B, McCarthy K, Swoboda KJ, Crawford TO, Li R, Plasterer T, Joyce C; Biomarkers for Spinal Muscular Atrophy Study Group, Chung WK, Kaufmann P, Darras BT, Finkel RS, Sproule DM, Martens WB, McDermott MP, De Vivo DC; Pediatric Neuromuscular Clinical Research Network, Walker MG, Chen KS PLoS ONE 8(4): e60113.

Newborn screening for autism: in search of candidate biomarkers (2013) Mizejewski GJ, Lindau-Shepard B, Pass KA Biomark Med. 2013 Apr;7(2):247-60

Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study (2013) Schilte C, Staikovsky F, Couderc T, Madec Y, Carpentier F, Kassab S, Albert ML, Lecuit M, Michault A PLoS Negl Trop Dis. 2013 Mar;7(3):e2137

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease (2012) Hu WT, Holtzman DM, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M, Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin VM, McCluskey L, Elman L, Karlawish J, Chen-Plotkin A, Hurtig HI, Siderowf A, Swenson F, Lee VM, Morris JC, Trojanowski JQ, Soares H; Alzheimers Disease Neuroimaging Initiative Neurology. 2012 Aug 28;79(9):897-905

Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study (2013) Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T BMC Neurol. 2013 Apr 8;13(1):32

Heart-type fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer?s disease (2013) Guo L, Alexopoulos P, Perneczky R European Archives of Psychiatry and Clinical Neuroscience

Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4 (2013) OShannessy DJ, Somers EB, Palmer LM, Thiel RP, Oberoi P, Heath R, Marcucci L Journal of Ovarian Research 2013, 6:29

RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke (2013) Tokamia H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, Kiyohara Y, Kamouchi M, Kitazono T Brain Research, Available online 18 April 2013

Application of meta-analysis methods for identifying proteomic expression level differences (2013) Amess B, Kluge W, Schwarz E, Haenisch F, Alsaif M, Yolken RH, Leweke FM, Guest PC, Bahn S. Proteomics. 2013 Apr 14.

Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator (2013) Patel OV, Wilson WB, Qin Z BioMetals, April 2013

A blood-based predictor for neocortical A? burden in Alzheimer?s disease: results from the AIBL study (2013) Burnham SC, Faux NG, Wilson W, Laws SM, Ames D, Bedo J, Bush AI, Doecke JD, Ellis KA, Head R, Jones G, Kiiveri H, Martins RN, Rembach A, Rowe CC, Salvado O, Macaulay SL, Masters CL, Villemagne VL; Alzheimer?s Disease Neuroimaging Initiative; Australian Imaging, Biomarkers and Lifestyle Study Research Group Mol Psychiatry. 2013 Apr 30

Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1 (2013) Cologna SM, Cluzeau CV, Yanjanin NM, Blank PS, Dail MK, Siebel S, Toth CL, Wassif CA, Lieberman AP, Porter FD. J Inherit Metab Dis. 2013 May 8.

CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients (2013) Ragab D, Laird M, Duffy D, Casrouge A, Mamdouh R, Abass A, Shenawy DE, Shebl AM, Elkashef WF, Zalata KR, Kamal M, Esmat G, Bonnard P, Fontanet A, Rafik M, Albert ML Cytokine. 2013 May 7. pii: S1043-4666(13)00181-6

EFFECTS OF CONTRAST MEDIA ON DIFFERENT URINARY BIOMARKERS OF KIDNEY INJURY (2013) Steffgen J, Blaschke S, Brun-Schulte-Wissing N, Pagel P, Huber F, Mapes J, Jaehnige A, Pestel S Nephrol. Dial. Transplant. (2013) 28 (suppl 1): i331-i351.

Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin (2013) Andrews DA, Hamadeh HK, He YD, Boren BM, Turk JR, Boyce RW, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM Toxicol Pathol. 2013 May 14. [Epub ahead of print]

Dose-related Differences in the Pharmacodynamic and Toxicologic Response to a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin in Sprague-Dawley Rats with Similarly High Hematocrit (2013) Andrews DA, Boren BM, Turk JR, Boyce RW, He YD, Hamadeh HK, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM Toxicol Pathol. 2013 May 14. [Epub ahead of print]

CD47 fusion protein targets CD172a+ cells in Crohn?s disease and dampens the production of IL-1? and TNF (2013) Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Sch?kel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M J Exp Med. 2013 May 13. [Epub ahead of print]

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs Without GBA Mutations (2013) Chahine LM, Qiang J, Ashbridge E, Minger J, Yearout D, Horn S, Colcher A, Hurtig HI, Lee V M-Y, Van Deerlin VM, Leverenz JB, Siderowf AD, Trojanowski JQ, Zabetian CP, Chen-Plotkin A JAMA Neurol. 2013;():1-7

Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders (2013) Ernst A, Sharma AN, Elased KM, Guest PC, Rahmoune H, Bahn S Transl Psychiatry. 2013 May 28;3:e263

Multi-analyte profiling and pathway analysis of plasma for proteins associated with cancer-related fatigue syndrome in disease-free breast cancer patients after primary treatment (2013) Minton O, Coulton GR, Stone P BMJ Support Palliat Care doi:10.1136/bmjspcare-2013-000452

Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques (2013) Li S,Kievit P, Robertson A-K, Kolumam G. Li X, von Wachenfeldt K, Valfridsson C, Bullens S, Messaoudi I, Bader L, Cowan KJ, Kamath A, van Bruggen N, Bunting S, Frend?us B, Grove KL Molecular Metabolism, Available online 11 June 2013

A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma (2013) Nowak AK, Brown C, Millward MJ, Creaney J, Byrne MJ, Hughes B, Kremmidiotis G, Bibby DC, Leske AF, Mitchell PL, Pavlakis N, Boyer M, Stockler MR Lung Cancer. 2013 Jun 17. pii: S0169-5002(13)00218-3

Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats (2013) Togashi Y, Imura N, Miyamoto Y Exp Toxicol Pathol. 2013 Jun 20. pii: S0940-2993(13)00076-6

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys (2013) Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Meyers SR, Reynolds VL, Smith HW, Wroblewski VJ, Kharitonenkov A PLoS ONE 8(6): e65763

Plasma biomarkers for Alzheimers disease: much needed but tough to find (2012) Bazenet C, Lovestone S Biomark Med. 2012 Aug;6(4):441-54

Type I interferon and pattern recognition receptor signaling following particulate matter inhalation (2012) Erdely A, Antonini JM, Salmen-Muniz R, Liston A, Hulderman T, Simeonova PP, Kashon ML, Li S, Gu JK, Stone S, Chen BT, Frazer DG, Zeidler-Erdely PC Part Fibre Toxicol. 2012 Jul 9;9:25

Biomarkers for drug-induced renal damage and nephrotoxicity-an overview for applied toxicology (2011) Fuchs TC, Hewitt P AAPS J. 2011 Dec;13(4):615-31

Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant (2011) Ghosn CR, Li Y, Orilla WC, Lin T, Wheeler L, Burke JA, Robinson MR, Whitcup SM Invest Ophthalmol Vis Sci. 2011 May 2;52(6):2917-23

Intracellular Aggregation of Multimodal Silica Nanoparticles for (2013) Jokerst JV, Khademi C, Gambhir SS Sci Transl Med. 2013 Mar 20;5(177):177ra35

Increased accumulation of regulatory granulocytic myeloid cells in mannose receptor C type 1-deficient mice correlates with protection in a mouse model of neurocysticercosis (2013) Mishra PK, Morris EG, Garcia JA, Cardona AE, Teale JM Infect Immun. 2013 Apr;81(4):1052-63

Efficacy and safety of lanthanoids as X-ray contrast agents (2011) Pietsch H, Jost G, Frenzel T, Raschke M, Walter J, Schirmer H, H?tter J, Sieber MA Eur J Radiol. 2011 Nov;80(2):349-56

Plasma methionine sulfoxide in persons with familial Alzheimers disease mutations (2012) Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G Dement Geriatr Cogn Disord. 2012;33(4):219-25

Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis (2012) Wong H, Budha NR, West K, Blackwood E, Ware JA, Yu R, Darbonne WC, Gould SE, Steigerwalt R, Erickson R, Hop CE, LoRusso P, Eckhardt SG, Wagner A, Chan IT, Mamounas M, Flygare JA, Fairbrother WJ Toxicol Sci. 2012 Nov;130(1):205-13

The role of LOX and LOXL2 in scar formation after glaucoma surgery (2013) Van Bergen T, Marshall D, Van de Veire S, Vandewalle E, Moons L, Herman J, Smith V, Stalmans I Invest Ophthalmol Vis Sci. 2013 Jul 2. pii: iovs.13-11696v1

Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-a Receptor 1 (2013) Holland MC, Wurthner JU, Morley PJ, Birchler MA, Lambert J, Albayaty M, Serone AP, Wilson R, Chen Y, Forrest RM, Cordy JC, Lipson DA, Bayliffe AI Journal of Clinical Immunology, July 2013

Influence of Genetic Variation on Plasma Protein Levels in Older Adults Using a Multi-Analyte Panel (2013) Kim S, Swaminathan S, Inlow M, Risacher SL, Nho K, Shen L, Foroud TM, Petersen RC, Aisen PS, Soares H, Toledo JB, Shaw LM, Trojanowski JQ, Weiner MW, McDonald BC, Farlow MR, Ghetti B, Saykin AJ; Alzheimer?s Disease Neuroimaging Initiative (ADNI) PLoS One. 2013 Jul 23;8(7):e70269

Impact of Sunitinib on Human Thyroid Cancer Cells (2013) Grosse J, Warnke E, Pohl F, Magnusson NE, Wehland M, Infanger M, Eilles C, Grimm D Cell Physiol Biochem. 2013 Jul 12;32(1):154-170

Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin (2013) Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R Ann Rheum Dis. 2013 Jul 19

Elevated Carbon Monoxide in the Exhaled Breath of Mice during a Systemic Bacterial Infection (2013) Barbour AG, Hirsch CM, Ghalyanchi Langeroudi A, Meinardi S, Lewis ER, Estabragh AS, Blake DR PLoS One. 2013 Jul 31;8(7):e69802

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models (2013) Thomson TM, Sewer A, Martin F, Belcastro V, Frushour B, Gebel S, Park J, Schlage WK, Talikka M, Vasilyev D, Westra JW, Hoeng J, Peitsch MC Toxicol Appl Pharmacol. 2013 Aug 7. pii: S0041-008X(13)00310-4

Case study: the role of mechanistic network models in systems toxicology (2013) Hoeng J, Talikka M, Martin F, Sewer A, Yang X, Iskandar A, Schlage WK, Peitsch MC Drug Discovery Today, Available online 9 August 2013

Systemic sRAGE is a Biomarker of Emphysema and Associated with AGER Genetic Variants in COPD Patients (2013) Cheng DT, Kim DK, Cockayne DA, Belousov A, Bitter H, Cho, MH, Duvoix A, Edwards LD, Lomas DA, Miller BE, Reynaert N, Tal-Singer R, Wouters E, Agusti A, Fabbri LM, Rames A, Visvanathan S, Rennard SI, Jones P, Parmar H, MacNee W, Wolff G, Silverman EK, Mayer RJ, Pillai SG, and on Behalf of the TESRA and ECLIPSE Investigators American Journal of Respiratory And Critical Care Medicine ja (2013)

IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis (2013) Wang J, Platt A, Upmanyu R, Germer S, Lei G, Rabe C, Benayed R, Kenwright A, Hemmings A, Martin M, Harari O BMJ Open. 2013 Aug 19;3(8):e003199

CSF protein biomarkers predicting longitudinal reduction of CSF ?-amyloid42 in cognitively healthy elders (2013) Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M Transl Psychiatry. 2013 Aug 20;3:e293

Modulation of cardiometabolic pathways in skin and serum from patients with psoriasis (2013) Mehta NN, Li K, Szapary P, Krueger J, Brodmerkel C J Transl Med. 2013 Aug 22;11(1):194.

Investigation of molecular serum profiles associated with predisposition to antipsychotic-induced weight gain (2013) Schwarz E, Steiner J, Guest PC, Bogerts B, Bahn S World J Biol Psychiatry. 2013 Sep 3. [Epub ahead of print]

Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases (2013) Van Rompaey L, Galien R, van der Aar EM, Clement-Lacroix P, Nelles L, Smets B, Lepescheux L, Christophe T, Conrath K, Vandeghinste N, Vayssiere B, De Vos S, Fletcher S, Brys R, van t Klooster G, Feyen JH, Menet C J Immunol. 2013 Sep 4. [Epub ahead of print]

Interleukin 17F Level and Interferon Beta Response in Patients With Multiple Sclerosis (2013) Hartung HP, Steinman L, Goodin DS, Comi G, Cook S, Filippi M, OConnor P, Jeffery DR, Kappos L, Axtell R, Knappertz V, Bogumil T, Schwenke S, Croze E, Sandbrink R, Pohl C JAMA Neurol. 2013 Aug 1;70(8):1017-21

Does ethnicity moderate dementias biomarkers (2013) Royall DR, Palmer RF; Texas Alzheimers Research and Care Consortium Neurobiol Aging. 2013 Sep 18. pii: S0197-4580(13)00340-0

Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults (2013) Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack Jr. CR, Tosun D, Weiner M, Alzheimers Disease Neuroimaging Initiative Neurobiology of Aging, Available online 1 October 2013

Cigarette smoke induces molecular responses in respiratory tissues of ApoE-/- mice that are progressively deactivated upon cessation (2013) Bou? S, De Le?n H, Schlage WK, Peck MJ, Weiler H, Berges A, Vuillaume G, Martin F, Friedrichs B, Lebrun S, Meurrens K, Schracke N, Moehring M, Steffen Y, Schueller J, Vanscheeuwijck P, Peitsch MC, Hoeng J Toxicology, Available online 1 October 2013

Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism (2013) DeLeon-Pennell KY,de Castro Br?s LE, Lindsey ML Physiological Reports Volume 1, Issue 5, October 2013

Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia (2013) Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI J Neurosci. 2013 Oct 2;33(40):16016-16032

The Innate Immune Response May Be Important For Surviving Plague In Wild Gunnisons Prairie Dogs (2013) Busch JD, Van Andel R, Stone NE, Cobble KR, Nottingham R, Lee J, VerSteeg M, Corcoran J, Cordova J, Van Pelt W, Shuey MM, Foster JT, Schupp JM, Beckstrom-Sternberg S, Beckstrom-Sternberg J, Keim P, Smith S, Rodriguez-Ramos J, Williamson JL, Rocke TE, Wagner DM Journal of Wildlife Diseases 2013 49:4, 920-931

Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis (2013) Belingheri M, Lazzari L, Parazzi V, Groppali E, Biagi E, Gaipa G, Giordano R, Rastaldi MP, Croci D, Biondi A, Rebulla P, Edefonti A, Ghio L Biologicals. 2013 Oct 14. pii: S1045-1056(13)00111-5. doi: 10.1016/j.biologicals.2013.09.004

Integrative Omics Approach Identifies Interleukin-16 as a Biomarker of Emphysema (2013) Bowler RP, Bahr TM, Hughes G, Lutz S, Kim YI, Coldren CD, Reisdorph N, Kechris KJ OMICS. 2013 Oct 19. [Epub ahead of print]

Prognostic/predictive value of 207 serum factors in colorectal cancer treated with cediranib and/or chemotherapy (2013) Spencer SK, Pommier AJ, Morgan SR, Barry ST, Robertson JD, Hoff PM, J?rgensmeier JM Br J Cancer. 2013 Oct 22

The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis (2013) Duffy D, Saleh R, Laird M, Soneson C, Fouler LL, El-Daly M, Casrouge A, Decalf J, Abbas A, Eldin NS, Fontes M, Hamid MA, Mohamed MK, Rafik M, Fontanet, Albert, M. L. Hepatology

Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology (2013) Erdely A, Dahm M, Chen BT, Zeidler-Erdely PC, Fernback JE, Birch ME, Evans DE, Kashon ML, Deddens JA, Hulderman T, Bilgesu SA, Battelli L, Schwegler-Berry D, Leonard HD, McKinney W, Frazer DG, Antonini JM, Porter DW, Castranova V, Schubauer-Berigan MK Part Fibre Toxicol. 2013 Oct 21;10(1):53

Identification of a molecular profile associated with immune status in first onset schizophrenia patients (2013) Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S Clin Schizophr Relat Psychoses

Impaired glycemia increases disease progression in mild cognitive impairment (2013) Morris JK, Vidoni ED, Honea RA, Burns JM Neurobiology of Aging, Available online 23 October 2013

C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production (2014) Chand D, Colacci M, Dixon K, Kollara A, Brown TJ, Lovejoy DA Histochem Cell Biol. 2014 Feb;141(2):191-211

A Multicenter Phase II Study of Single-agent Enzastaurin in Previously Treated Multiple Myeloma (2013) Jourdan E, Leblond V, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Moreau P Leuk Lymphoma. 2013 Nov 3. [Epub ahead of print]

Biomarker identification in serum samples from patients with recurrent cervical cancer treated with ADXS11-001 immunotherapy (2013) Molli P, Malinina I, Wallecha A Journal for ImmunoTherapy of Cancer 2013, 1(Suppl 1):P61

Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space (2013) Ma X, Pietsch J, Wehland M, Schulz H, Saar K, H?bner N, Bauer J, Braun M, Schwarzw?lder A, Segerer J, Birlem M, Horn A, Hemmersbach R, Wa?er K, Grosse J, Infanger M, Grimm D FASEB J. 2013 Nov 6. [Epub ahead of print]

Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever (2010) Gowen BB, Julander JG, London NR, Wong MH, Larson D, Morrey JD, Li DY, Bray M Virol J. 2010 Sep 16;7:240

Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole blood (2012) Schmohl M, Schneiderhan-Marra N, Baur N, Hefner K, Blum M, Stein GM, Joos TO, Schmolz M Int Immunopharmacol. 2012 Dec;14(4):722-8

The Proton-Activated Receptor GPR4 Modulates Glucose Homeostasis by Increasing Insulin Sensitivity (2013) Giudici L, Velic A, Daryadel A, Bettoni C, Mohebbi N, Suply T, Seuwen K, Ludwig MG, Wagner CA Cell Physiol Biochem. 2013 Nov 28;32(5):1403-1416

Development of a small animal peripheral challenge model of Japanese encephalitis virus using interferon deficient AG129 mice and the SA14-14-2 vaccine virus strain (2013) Calvert AE, Dixon KL, Delorey MJ, Blair CD, Roehrig JT Vaccine. 2013 Nov 17. pii: S0264-410X(13)01533-8

Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory (2013) Liu B, Zupan B, Laird E, Klein S, Gleason G, Bozinoski M, Gal Toth J, Toth M Nat Neurosci. 2013 Dec 1

Transient inflammatory-like state and microbial dysbiosis are pivotal in establishment of mucosal homeostasis during colonisation of germ-free mice (2013) Aidy SE, Derrien M, Aardema R, Hooiveld G, Richards SE, Dane A, Dekker J, Vreeken R, Levenez F, Dor? J, Zoetendal EG, van Baarlen P, Kleerebezem M Benef Microbes. 2013 Dec 9:1-11.

Cytokine Profile Changes In 309 Myelofibrosis Patients: Comparison Of JAK1/JAK2 Inhibitor Therapy Vs. Placebo ? Correlative Analysis From The Comfort-I Trial (2013) Dueck AC, Cleeland CS, Dantzer R, Sloan J, Verstovsek S, Emanuel RM, Geyer HL, Mesa RA Blood October 21, 2013 vol. 122 no. 21 4074

Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model (2013) Kobayashi SD, Olsen RJ, Lacasse RA, Safronetz D, Ashraf M, Porter AR, Braughton KR, Feldmann F, Clifton DR, Kash JC, Bailey JR, Gardner DJ, Otto M, Brining DL, Kreiswirth BN, Taubenberger JK, Parnell MJ, Feldmann H, Musser JM, Deleo FR Virulence. 2013 Oct 8;4(8). [Epub ahead of print]

First-in-Human Phase I Study of PRS-050 (Angiocal), an Anticalin Targeting and Antagonizing VEGF-A, in Patients with Advanced Solid Tumors (2013) Mross K, Richly H, Fischer R, Scharr D, B?chert M, Stern A, Gille H, Audoly LP, Scheulen ME PLoS One. 2013 Dec 13;8(12):e83232

Short sleep duration is associated with decreased serum leptin, increased energy intake, and decreased diet quality in postmenopausal women (2013) Stern JH, Grant AS, Thomson CA, Tinker L, Hale L, Brennan KM, Woods NF, Chen Z Obesity (Silver Spring). 2013 Dec 17

Protective role of Mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation (2013) Sharma A, Steichen AL, Jondle CN, Mishra BB, Sharma J J Infect Dis. 2013 Dec 17. [Epub ahead of print]

Suppression of soluble T cell-associated proteins by an anti-interferon-a monoclonal antibody in adult patients with dermatomyositis or polymyositis (2013) Guo X, Higgs BW, Rebelatto M, Zhu W, Greth W, Yao Y, Roskos LK, White WI Rheumatology (Oxford). 2013 Dec 19

REG3-gamma-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum (2013) Loonen LM, Stolte EH, Jaklofsky MT, Meijerink M, Dekker J, van Baarlen P, Wells JM Mucosal Immunol. 2013 Dec 18

The Senescence-Associated Secretory Phenotype In Multiple Myeloma (2013) Wildes TM, Paasch J, Fiala MA, Chen L, Vij R, Stockerl-Goldstein KE, Stewart S, Colditz GA,Tomasson M Blood October 21, 2013 vol. 122 no. 21 5357

A Canonical Transforming Growth Factor Beta-Dependent Signaling Pathway is Present in Peripheral Blood Cells of Cancer Patients with Skeletal Metastasis (2013) Kadam S, Cleverly AL, Farmen M, Grondin J, Cox YI, Lahn M J Mol Biomark Diagn 2013, 4:3

Multi-analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection (2013) Huckans M, Fuller BE, Olavarria H, Sasaki AW, Chang M, Flora KD, Kolessar M, Kriz D, Anderson JR, Vandenbark AA, Loftis JM Brain and Behavior

Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3? signaling in bipolar patients (2013) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S Journal of Affective Disorders

Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation (2013) Sauer UG, Vogel S, Aumann A, Hess A, Kolle SN, Ma-Hock L, Wohlleben W, Dammann M, Strauss V, Treumann S, Gr?ters S, Wiench K, van Ravenzwaay B, Landsiedel R Toxicol Appl Pharmacol. 2013 Dec 29. pii: S0041-008X(13)00570-X

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study (2014) ONeal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R, Woodruff PG, Couper DJ, Davis SM J Transl Med. 2014 Jan 8;12(1):9

Distinct Roles For Hepcidin and Interleukin 6 In The Recovery From Anemia Following Administration Of Heat-Killed Brucella Abortus (2013) Gardenghi S, Renaud TM, Meloni A, Casu C, Crielaard BJ, Bystrom LM, Greenberg-Kushnir N, Sasu BJ, Cooke KS, Rivella S Blood. 2013 Dec 19. [Epub ahead of print]

CSF Apo-E levels associate with cognitive decline and MRI changes (2014) Toledo JB, Da X, Weiner MW, Wolk DA, Xie SX, Arnold SE, Davatzikos C, Shaw LM, Trojanowski JQ; For the Alzheimer?s Disease Neuroimaging Initiative Acta Neuropathol. 2014 Jan 3. [Epub ahead of print]

The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins (2014) Yassine HN, Jackson AM, Borges CR, Billheimer D, Koh H, Smith D, Reaven P, Lau SS, Borchers CH Lipids Health Dis. 2014 Jan 8;13(1):8

Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation (2014) Blonder JP, Mutka SC, Sun X, Qiu J, Green LH, Mehra NK, Boyanapalli R, Suniga M, Look K, Delany C, Richards JP, Looker D, Scoggin C, Rosenthal GJ BMC Pulm Med. 2014 Jan 10;14(1):3

Implementing lessons learned from previous bronchial biopsy trials in a new randomized controlled COPD biopsy trial with roflumilast (2014) Barnes NC, Saetta M, Rabe KF BMC Pulm Med. 2014 Jan 31;14(1):9

Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome (2014) Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S Mol Autism. 2014 Jan 27;5(1):4

Immunomodulatory Activities of a Concentrated Fruit and Vegetable Juice Tested in a Randomized, Placebo-Controlled, Double-Blind Clinical Trial in Healthy Volunteers (2014) Schmolz M, M?rz RW, Schaudt M, Schaudt C, Lauster C Food and Nutrition Sciences, Vol. 5 No. 4, 2014, pp. 341-350

Altered Macrophage-Phenotype Transition Impairs Skeletal Muscle Regeneration (2014) Wang H, Melton D, Porter L, Sarwar ZU, McManus LM, Shireman PK Am J Pathol. 2014 Feb 10. pii: S0002-9440(14)00025-X

Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men with and without Alzheimers Disease (2014) Cunningham RL1, Singh M1, OBryant SE2, Hall JR3, Barber RC J Alzheimers Dis. 2014 Feb 4. [Epub ahead of print]

Phosphorylated tau-A?42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimers Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid. (2014) Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM; Alzheimer?s Disease Neuroimaging Initiative Biol Psychiatry. 2014 Jan 19. pii: S0006-3223(14)00018-3

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Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface car (2013) Ma-Hock L, Strauss V, Treumann S, K?ttler K, Wohlleben W, Hofmann T, Gr?ters S, Wiench K, van Ravenzwaay B, Landsiedel R Part Fibre Toxicol. 2013 Jun 17;10(1):23

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Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment (2014) de Witte L, Tomasik J, Schwarz E, Guest PC, Rahmoune H, Kahn RS, Bahn S Schizophr Res. 2014 Feb 26. pii: S0920-9964(14)00071-1

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors (2014) Weekes CD, Beeram M, Tolcher AW, Papadopoulos KP, Gore L, Hegde P, Xin Y, Yu R, Shih LM, Xiang H, Brachmann RK, Patnaik A Invest New Drugs. 2014 Mar 7. [Epub ahead of print]

Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke (2014) Wakisakaa Y, Agoa T, Kamouchib M, Kurodaa J, Matsuoa R, Hataa J, Gotoha S, Isomurad T, Awanod H, Suzukid, K, Fukudaa K, Okadaf Y, Kiyoharac Y, Ooboshig H, Kitazonoa T, on behalf of the REBIOS Investigators Journal of the Neurological Sciences 04 Mar 2014

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS?) (2014) Xiang Y, Kogel U, Gebel S, Peck MJ, Peitsch MC, Akmaev VR, Hoeng J Gene Regul Syst Bio. 2014 Feb 19;8:45-61

Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product (2014) Ruff KJ, DeVore DP Modern Research in Inflammation, 3, 19-25

The Impact of APOE Status on Relationship of Biomarkers of Vascular Risk and Systemic Inflammation to Neuropsychiatric Symptoms in Alzheimers Disease (2014) Hall JR, Wiechmann AR, Johnson LA, Edwards M, Barber RC, Cunningham R, Singh M, OBryant SE J Alzheimers Dis. 2014 Feb 20. [Epub ahead of print]

MRI signal and texture features for the prediction of MCI to Alzheimers disease progression (2014) Mart?nez -Torteya A, Rodr?guez-Rojas J, Celaya-Padilla JM, Galv?n-Tejada JI, Trevi?o V, Tamez-Pe?a JG Proc. SPIE 9035

Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential (2013) Johnston J, Hu W, Fardo D, Greco S, Perry G, Montine T, Trojanowski J, Shaw L, Ashford J, Tezapsidis N, For The Alzheimers Disease Neuroimaging Initiative Curr Alzheimer Res. 2013 Dec 11. [Epub ahead of print]

Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli (2014) Duffy D, Rouilly V, Libri V, Hasan M, Beitz B, David M, Urrutia A, Bisiaux A, LaBrie ST, Dubois A, Boneca IG, Delval C, Thomas S, Rogge L, Schmolz M, Quintana-Murci L, Albert ML Immunity Volume 40, Issue 3, 20 March 2014, Pages 436?450

Normal Ranges and Variability of Novel Urinary Renal Biomarkers in Sprague-Dawley Rats (2014) Gautier JC, Gury T, Guffroy M, Khan-Malek R, Hoffman D, Pettit S, Harpur E Toxicol Pathol. 2014 Apr 7. [Epub ahead of print]

Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection (2014) Riva A, Laird M, Casrouge A, Ambrozaitis A, Williams R, Naoumov NV, Albert ML, Chokshi S Hepatology. 2014 Mar 26

Rapid Onset Clinical and Mechanistic Effects of anti-C5aR Treatment in the Mouse Collagen Induced Arthritis Model (2014) Andersson C, Wenander CS, Usher PA, Hebsgaard JB, Sondergaard BC, R?n? B, Mackay C, Friedrichsen B, Chang C, Tang R, Hornum L Clin Exp Immunol. 2014 Mar 25

The Human Salivary Proteome is Radiation Responsive (2014) Moore HD, Ivey RG, Voytovich UJ, Lin C, Stirewalt DL, Pogosova-Agadjanyan EL, Paulovich AG Radiat Res. 2014 Apr 10. [Epub ahead of print]

Comparison between Male and Female Sprague-Dawley Rats in the Response of Urinary Biomarkers to Injury Induced by Gentamicin (2014) Gautier JC, Gury T, Guffroy M, Masson R, Khan-Malek R, Hoffman D, Pettit S, Harpur E Toxicol Pathol. 2014 Apr 9. [Epub ahead of print]

Evaluation of antidepressant properties of the p38 MAP kinase inhibitor losmapimod (GW856553) in Major Depressive Disorder: Results from two randomised, placebo-controlled, double-blind, multicentre studies using a Bayesian approach (2014) Inamdar A, Merlo-Pich E, Gee M, Makumi C, Mistry P, Robertson J, Steinberg E, Zamuner S, Learned S, Alexander R, Ratti E J Psychopharmacol. 2014 Apr 2. [Epub ahead of print]

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease (2014) Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2786

Inflammatory Molecular Signature Associated With Infectious Agents in Psychosis (2014) Hayes LN, Severance EG, Leek JT, Gressitt KL, Rohleder C, Coughlin JM, Leweke FM, Yolken RH, Sawa A Schizophr Bull. 2014 Apr 17. [Epub ahead of print]

Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns (2014) Mikerov AN, Phelps DS, Gan X, Umstead TM, Haque R, Wang G, Floros J Toxicol Lett. 2014 Apr 21. pii: S0378-4274(14)00167-2

Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects (2014) Ramirez TA, Iyer RP, Ghasemi O, Lopez EF, Levin DB, Zhang J, Zamilpa R, Chou YM, Jin YF, Lindsey ML J Mol Cell Cardiol. 2014 Apr 22. pii: S0022-2828(14)00118-7

Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) (2014) Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T BMC Neurol. 2013 Apr 8;13:32

Therapeutic Potential of Cerium Oxide Nanoparticles for the Treatment of Peritonitis Induced by Polymicrobial Insult in Sprague-Dawley Rats. (2015) Manne ND, Arvapalli R, Nepal N, Thulluri S, Selvaraj V, Shokuhfar T, He K, Rice KM, Asano S, Maheshwari M, Blough ER Crit Care Med.

A Phase 1 Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma (2015) Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA Mol Cancer Ther.

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice (2015) Mardare C, Kr?ger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC J Diabetes Res

Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia (2015) Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB Schizophr Bull

Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining (2015) Yoshimura K, Okanoue T, Ebise H, Iwasaki T, Mizuno M, Shima T, Ichihara J, Yamazaki K Hepatology.

Lipoprotein-associated phospholipase A2, homocysteine, and Alzheimer?s disease (2015) Doody RS, Demirovic J, Ballantyne CM, Chan W, Barber R, Powell S, Pavlik V Alzheimers Dement (Amst)

New biomarkers for primary mitral regurgitation (2015) Deroyer C, Magne J, Moonen M, Le Goff C, Dupont L, Hulin A, Radermecker M, Colige A, Cavalier E, Kolh P, Pierard L, Lancellotti P, Merville MP, Fillet M Clin Proteomics

Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data (2015) Parkitny L, Middleton S, Baker K, Younger J BMC Immunology

Neuropilin 1 (NRP1) may be prognostic and identify a subgroup of Patients with Metastatic Colorectal Cancer (mCRC) who Benefit from Tivozanib + mFOLFOX6 compared to Bevacizumab + mFOLFOX6 (2015) Benson A, Krivoshik A, Van Sant C, Needle M Annals of Oncology

Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use (2015) Srivastava AK, Jaganathan S, Stephen L, Hollingshead MG, Govindharajulu JP, Layhee A, Damour E, Donohue J, Esposito D, Mapes JP, Kinders R, Takebe N, Tomaszewski JE, Kummar S, Doroshow JH, Parchment RE Clinical Cancer Research

A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression (2015) Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ J Immunol.

Responses to Bacteria, Virus and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia (2015) Valim C, Ahmad R, Lanaspa M, Tan Y, Ac?cio S, Gillette MA, Almendinger KD, Milner DA Jr, Madrid L, Pell? K, Harezlak J, Silterra J, Alonso PL, Carr SA, Mesirov JP, Wirth DF, Wiegand RC, Bassat Q Am J Respir Crit Care Med.

Cerium oxide nanoparticles attenuate acute kidney injury induced by intra-abdominal infection in Sprague?Dawley rats (2015) Manne ND, Arvapalli R, Nepal N, Shokuhfar T, Rice KM, Asano S, Blough ER J Nanobiotechnology

Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients (2015) Tomasik J, Schwarz E, Lago SG, Rothermundt M, Leweke FM, van Beveren NJ, Guest PC, Rahmoune H, Steiner J, Bahn S. Brain Behav Immun.

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages (2015) Rosati A, Basile A, DAuria R, dAvenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC. Nat Commun.

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis (2015) Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest

Markers of inflammation are associated with clinical outcomes in patients with metastatic renal cell carcinoma treated with nivolumab (2015) Sznol M, Fishman M, Escudier B, McDermott DF, Kluger H, Stadler WM, Perez-Gracia J, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Drake CG, Young TC, Chasalow SD, Ross-MacDonald P, Simon JS, Walker D, Choueiri TK J Immunother Cancer

Identification of circulatory biomarkers from clinical trial samples (2015) Brunet LR, Bodman-Smith K, Bodman-Smith M, Kassam Z, Dalgleish A, LaBrie S and Hagemann T J Immunother Cancer

Plasma Biomarkers for Neuronal Ceroid Lipofuscinosis. (2015) Hersrud SL, Geraets RD, Weber KL, Chan CH, Pearce DA FEBS J.

Serum biomarkers predictive of depressive episodes in panic disorder (2015) Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BWJH, Bahn S Journal of Psychiatric Research

Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders (2015) Ramsey JM, Guest PC, Broek JA, Glennon JC, Rommelse N, Franke B, Rahmoune H, Buitelaar JK, Bahn S. Mol Autism

A Phase 1 Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX 2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma (2014) Northfelt DW, Ramanathan RK, Cohen PA, Von Hoff DD, Weiss GJ, Dietsch GN, Manjarrez KL, Randall TD, Hershberg RM Clin Cancer Res. 2014 May 7

Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross sectional study (2014) Andersen, M., Boesen, M., Ellegaard, K., Christensen, R., S?derstr?m, K., S?e, N., & Bliddal, H Arthritis Research & Therapy, 16(3), R107

Spheroid formation of human thyroid cancer cells (2014) Warnke E, Pietsch J, Wehland M, Bauer J, Infanger M, G?r?g M, Hemmersbach R, Braun M, Ma X, Sahana J, Grimm D Cell Communication and Signaling 2014, 12:32

Nonclinical Safety Profile of BMS-986001, a Nucleoside Transcriptase Inhibitor for Combination Retroviral Therapy (2014) Mausumee G, Frank S, Shawn C, Dara H, Zhao Y, Soleil PM, Sanderson TP, Michael G, Marc D Int J Toxicol. 2014 May 20;33(3):204-218

A prospective assessment of the effect of aminophylline therapy on urine output and inflammation in critically ill children (2014) Tamburro RF, Thomas NJ, Ceneviva GD, Dettorre MD, Brummel GL, Lucking SE Front. Pediatr. 2:59

A Phase 2, Randomized, Double-blind, Multicenter Study Comparing Siltuximab Plus Best Supportive Care With Placebo Plus Best Supportive Care in Anemic Patients With International Prognostic Scoring System Low- or Intermediate-1?Risk Myelodysplastic Syndrome (2014) Garcia-Manero G, Gartenberg G, Steensma DP, Schipperus MR, Breems DA, de Paz R, Valc?rcel D, Kranenburg B, Reddy M, Komrokji RS Am J Hematol. 2014 May 31

Altered microglial response to A? plaques in APPPS1-21 mice heterozygous for TREM2 (2014) Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, Jiang H, Stewart FR, Piccio L, Colonna M, Holtzman DM Mol Neurodegener. 2014 Jun 3;9(1):20

Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT (2014) Pilat C, Frech T, Wagner A, Kr?ger K, Hillebrecht A, Pons-K?hnemann J, Scheibelhut C, B?deker RH, Mooren FC Scand J Med Sci Sports. 2014 Jun 12

Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study (2014) Brana I, Calles A, LoRusso PM, Yee LK, Puchalski TA, Seetharam S, Zhong B, de Boer CJ, Tabernero J, Calvo E Target Oncol. 2014 Jun 15

Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment (2014) Toledo JB, Korff A, Shaw LM, Trojanowski JQ, Zhang J Alzheimers Research & Therapy 2014, 6:36

CD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model (2014) Lin Y, Manning PT, Jia J, Gaut JP, Xiao Z, Capoccia BJ, Chen CC, Hiebsch RR, Upadhya G, Mohanakumar T, Frazier WA, Chapman WC Transplantation. 2014 Jun 30. [Epub ahead of print]

Total Cholesterol and Neuropsychiatric Symptoms in Alzheimers Disease: The Impact of Total Cholesterol Level and Gender (2014) Hall JR, Wiechmann AR, Johnson LA, Edwards M, Barber RC, Cunningham R, Singh M, OBryant SE Dementia and Geriatric Cognitive Disorders Vol. 38, No. 5-6, 2014

Combination treatment with oncolytic Vaccinia virus and cyclophosphamide results in synergistic antitumor effects in human lung adenocarcinoma bearing mice (2014) Hofmann E, Weibel S, Szalay AA Journal of Translational Medicine 2014 Jul 17;12:197. doi: 10.1186/1479-5876-12-197

Vitamin D Binding Protein as a Serum Biomarker of Alzheimers Disease. (2014) Bishnoi RJ, Palmer RF, Royall DR. Journal of Alzheimers Disease 2014 Jul 30. [Epub ahead of print]

Plasma protein biomarkers enhance the clinical prediction of kidney injury recovery in patients undergoing liver transplantation. (2014) Levitsky J, Baker TB, Jie C, Ahya S, Levin M, Friedewald J, Al-Saden P, Salomon DR, Abecassis MM. Hepatology 2014 Jul 31. doi: 10.1002/hep.27346. [Epub ahead of print]

Ethnicity Moderates Dementias Biomarkers. (2014) Royall DR, Palmer RF Journal of Alzheimers Disease 2014 Jul 30. [Epub ahead of print]

Neutrophils release extracellular DNA traps in response to exercise. (2014) Beiter T, Fragasso A, Hudemann J, Schild M, Steinacker J, Mooren FC, Niess AM. Journal of Applied Physiology 2014 Aug 1;117(3):325-33. doi: 10.1152/japplphysiol.00173.2014

Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: a randomized feeding trial (2014) Chiva-Blancha G, Magraner E, Condines X, Valderas-Mart?nez P, Roth I, Arranz S, Casa R, Navarro M, Hervas A, Sis? A, Mart?nez-Hu?lamo M, Vallverd?-Queralt A, Quifer-Rada P, Lamuela-Raventos R-M, Estruch R Elsevier - Nutrition, Metabolism and Cardiovascular Diseases 2014 Aug 2; doi: 10.1016/j.numecd.2014.07.008

Are Blood-Based Protein Biomarkers for Alzheimers Disease also Involved in Other Brain Disorders? A Systematic Review (2014) Chiam JTW, Dobson RJB, Kiddle SJ, Sattlecker M Journal of Alzheimers Disease 2014 Aug 5; 1875-8908 doi:10.3233/JAD-140816

An integrated omics analysis: impact of microgravity on host response to lipopolysaccharide in vitro (2014) Chakraborty N, Gautam A, Muhie S, Miller SA, Jett M, Hammamieh R. BMC Genomics 2014 Aug 7;15(1):659. [Epub ahead of print]

Disrupted TH17/Treg Balance in Patients with Chronic Low Back Pain. (2014) Luchting B, Rachinger-Adam B, Zeitler J, Egenberger L, M?hnle P, Kreth S, Azad SC PLoS ONE 2014 Aug 14;9(8):e104883. doi: 10.1371/journal.pone.0104883

Serum protein profiling reveals baseline and pharmacodynamic biomarker signatures associated with clinical outcome in mCRC patients treated with chemotherapy ? cediranib. (2014) Pommier AJ, Shaw R, Spencer SK, Morgan SR, Hoff PM, Robertson JD, Barry ST, J?rgensmeier JM. British Journal of Cancer 2014 Aug 14. doi: 10.1038/bjc.2014.436. [Epub ahead of print]

Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats. (2014) Zeidler-Erdely PC, Meighan TG, Erdely A, Fedan JS, Thompson JA, Bilgesu S, Waugh S, Anderson S, Marshall NB, Afshari A, McKinney W, Frazer DG, Antonini JM. Inhalation Toxicology 2014 Aug 20:1-11. [Epub ahead of print]

Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia. (2014) van Beveren NJ, Schwarz E, Noll R, Guest PC, Meijer C, de Haan L, Bahn S. Translational Psychiatry 2014 Aug 26;4:e430. doi: 10.1038/tp.2014.52.

Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the neural cardiac therapy for heart failure (NECTAR-HF) randomized controlled trial. (2014) Zannad F, De Ferrari GM, Tuinenburg AE, Wright D, Brugada J, Butter C, Klein H, Stolen C, Meyer S, Stein KM, Ramuzat A, Schubert B, Daum D, Neuzil P, Botman C, Caste MA, DOnofrio A, Solomon SD1, Wold N, Ruble SB. European Heart Journal 2014 Aug 31. pii: ehu345. [Epub ahead of print]

Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults (2014) Chiu S, Williams PT, Dawson T, Bergman RN, Stefanovski D, Watkins SM, Krauss RM Journal of Nutrition September 3, 2014, doi: 10.3945/?jn.114.197624

Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome. (2014) Cheng JM, Oemrawsingh RM, Akkerhuis KM, Garcia-Garcia HM, de Boer SP, Battes LC, Buljubasic N, Lenzen MJ, de Jaegere PP, van Geuns RJ, Serruys PW, Kardys I, Boersma E. Informa Healthcare Biomarkers 2014 Sep 8:1-9. [Epub ahead of print]

Fat Quality and Incident Cardiovascular Disease, All-Cause Mortality and Cancer Mortality (2014) Rosenquist KJ, Massaro JM, Pedley A, Long MT, Kreger BE, Vasan RS, Murabito JM, Hoffmann U, Fox CS. Journal of Clinical Endocrinology & Metabolism 2014 Sep 16:jc20134296. [Epub ahead of print]

Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension (2014) Kolli MB, Manne ND, Para R, Nalabotu SK, Nandyala G, Shokuhfar T, He K, Hamlekhan A, Ma JY, Wehner PS, Dornon L, Arvapalli R, Rice KM, Blough ER. Biomaterials. 2014 Sep 12. pii: S0142-9612(14)00962-4. doi: 10.1016/j.biomaterials.2014.08.037. [Epub ahead of print]

Multiplex Screen of Serum Biomarkers in (2014) Statlanda J, Donlin-Smithb CM, Tapscottc SJ, van der Maarel S, Tawil, R Journal of Neuromuscular Diseases DOI 0.3233/JND-140034

A phase I dose-escalation study to a predefined dose of a transforming growth factor-?1 monoclonal antibody (T?M1) in patients with metastatic cancer (2014) Cohn A, Lahn MM, Williams KE, Cleverly AL, Pitou C, Kadam SK, Farmen MW, Desaiah D, Raju R, Conkling P, Richards D International Journal of Oncology 10.3892/ijo.2014.2679

An Anti-Neuroinflammatory That Targets Dysregulated Glia Enhances the Efficacy of CNS-Directed Gene Therapy in Murine Infantile Neuronal Ceroid Lipofuscinosis. (2014) Macauley SL, Wong AMS, Shyng C, Augner DP, Dearborn JT, Pearse Y, Roberts MS, Fowler SC, Cooper JD, Watterson DM, Sands MS Journal of Neuroscience 2014 Sep 24;34(39):13077-82. doi: 10.1523/JNEUROSCI.2518-14.2014.

Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (XL765), an orally administered PI3K/mTOR inhibitor: a phase 1 expansion cohort in patients with relapsed or refractory lymphoma. (2014) Papadopoulos KP, Egile C, Ruiz-Soto R, Jiang J, Shi W, Bentzien F, Rasco D, Abrisqueta P, Vose JM, Tabernero J. Informa Healthcare Leuk Lymphoma. 2014 Oct 10:1-32. [Epub ahead of print]

The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes (2014) Carolan BJ, Hughes G, Morrow J, Hersh CP, ONeal WK, Rennard S, Pillai SG, Belloni P, Cockayne DA, Comellas AP, Han M, Zemans RL, Kechris K, Bowler RP. Respiratory Research 2014 Oct 12;15(1):127. doi: 10.1186/s12931-014-0127-9.

Predicting therapeutic efficacy of intravenous immunoglobulin (IVIG) in individual patients with relapsing remitting multiple sclerosis (RRMS) by functional genomics (2014) Berger T, Jacob C, Haas J, Ransmayr G, Guger M, Zettl UK, Di Pauli F, Taumberger B, Wietek S, Meuer S, Reindl M, Giese T Journal of Neuroimmunology DOI: 10.1016/j.jneuroim.2014.10.001

Genome-Wide Association Study of CSF Levels of 59 Alzheimers Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation (2014) Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S; Alzheimers Disease Neuroimaging Initiative, Fagan AM, Holtzman DM, Morris JC, Goate AM PLoS Genet

Bone marrow from blotchy mice is nonessential to regulate blood copper and aortic pathologies in LDLR deficient mice during chronic angiotensin II infusion (2014) Harris D, Liang Y, Chen C, Li S, Patel O, Qin Z Annals of Vascular Surgery

TRAMP Prostate Tumor Growth Is Slowed by Walnut Diets Through Altered IGF-1 Levels, Energy Pathways, and Cholesterol Metabolism (2014) Kim H, Yokoyama W, Davis PA. J Med Food. 2014 Oct 29. [Epub ahead of print]

Plasma leptin levels are not predictive of dementia in patients with mild cognitive impairment. (2014) Oania R, McEvoy LK. Age Ageing. 2014 Oct 27. pii: afu160. [Epub ahead of print]

Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease. (2014) Suzuki M, Makita H, Ostling J, Thomsen LH, Konno S, Nagai K, Shimizu K, Pedersen JH, Ashraf H, Bruijnzeel PL, Maciewicz RA, Nishimura M; for the Hokkaido COPD cohort study and DLCST investigators. Ann Am Thorac Soc. 2014 Nov 5. [Epub ahead of print]

Circulating acute phase proteins in relation to extent and composition of coronary atherosclerosis and cardiovascular outcome: results from the ATHEROREMO-IVUS study (2014) Battes LC, Akkerhuis KM, Cheng JM, Garcia-Garcia HM, Oemrawsingh RM, de Boer SPM, Reger E, van Geuns R-J, Serruys PW, Boersma E, Kardys I International Journal of Cardiology

A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases/phosphatases in rat brain. (2014) Wesseling H, Rahmoune H, Tricklebank M, Guest PC, Bahn S. J Proteome Res. 2014 Nov 2. [Epub ahead of print]

Multiplexed protein profiling after aneurysmal subarachnoid hemorrhage: Characterization of differential expression patterns in cerebral vasospasm. (2014) Walcott BP, Patel AP, Stapleton CJ, Trivedi RA, Young AM, Ogilvy CS. J Clin Neurosci. 2014 Jul 28. pii: S0967-5868(14)00318-X. doi: 10.1016/j.jocn.2014.06.004. [Epub ahead of print]

FASTKD2 is associated with memory and hippocampal structure in older adults. (2014) Ramanan VK, Nho K, Shen L, Risacher SL, Kim S, McDonald BC, Farlow MR, Foroud TM, Gao S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, De Jager PL, Yu L, Bennett DA, Saykin AJ. Mol Psychiatry. 2014 Nov 11. doi: 10.1038/mp.2014.142. [Epub ahead of print]

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors. (2014) Schultheis B, Strumberg D, Santel A, Vank C, Gebhardt F, Keil O, Lange C, Giese K, Kaufmann J, Khan M, Drevs J. J Clin Oncol. 2014 Nov 17. pii: JCO.2013.55.0376. [Epub ahead of print]

Multi-analyte profiling of inflammatory mediators in COPD sputum ? The effects of processing (2014) Pedersen F, Holz O, Lauer G, Quintini G, Kiwull-Schone H, Kirsten A-M, Magnussen H, Rabe KF, Goldmann T, Watz H Cytokine. 2014 Nov 15. doi:10.1016/j.cyto.2014.10.008

Deferasirox effect on renal haemodynamic parameters in patients with transfusion-dependent ? thalassaemia. (2014) Piga A, Fracchia S, Lai ME, Cappellini MD, Hirschberg R, Habr D, Wegener A, Bouillaud E, Forni GL. Br J Haematol. 2014 Nov 17. doi: 10.1111/bjh.13217. [Epub ahead of print]

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. (2014) Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, Bellmunt J, Burris HA, Petrylak DP, Teng SL, Shen X, Boyd Z, Hegde PS, Chen DS, Vogelzang NJ. Nature. 2014 Nov 26;515(7528):558-62. doi: 10.1038/nature13904.

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. (2014) Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS. Nature. 2014 Nov 26;515(7528):563-7. doi: 10.1038/nature14011.

Cardiac mMCP-4+ mast cell expansion and elevation of IL-6, and CCR1/3 and CXCR2 signaling chemokines in an adjuvant-free mouse model of tree nut allergy. (2014) Gonipeta B, Para R, He Y, Srkalovic I, Ortiz T, Kim E, Parvataneni S, Gangur V. Immunobiology. 2014 Dec 2. pii: S0171-2985(14)00237-X. doi: 10.1016/j.imbio.2014.11.012. [Epub ahead of print]

Biomarkers of Central Nervous System Inflammation in Infantile and Juvenile Gangliosidoses. (2014) Utz JR, Crutcher T, Schneider J, Sorgen P, Whitley CB. Mol Genet Metab. 2014 Dec 6. pii: S1096-7192(14)00376-X. doi: 10.1016/j.ymgme.2014.11.015. [Epub ahead of print]

Assessment of serum biomarkers in rats after exposure to pesticides of different chemical classes. (2014) Moser VC, Stewart N, Freeborn DL, Crooks J, MacMillan DK, Hedge JM, Wood CE, McMahen RL, Strynar MJ, Herr DW. Toxicol Appl Pharmacol. 2014 Dec 9;282(2):161-174. doi: 10.1016/j.taap.2014.11.016. [Epub ahead of print]

Obesity superimposed on aging magnifies inflammation and delays the resolving response following myocardial infarction. (2014) Lopez EF, Kabarowski J, Ingle KA, Kain V, Barnes S, Crossman DK, Lindsey ML, Halade GV. Am J Physiol Heart Circ Physiol. 2014 Dec 5:ajpheart.00604.2014. doi: 10.1152/ajpheart.00604.2014. [Epub ahead of print]

Citrus limonin glucoside supplementation decreased biomarkers of liver disease and inflammation in overweight human adults. (2014) Kelley DS, Adkins YC, Zunino SJ, Woodhouse LR, Bonnel EL, Breksa III AP, Manners GD, Mackey BE Journal of Functional Foods

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction. (2014) B?r C, de Jesus BB, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert KC, Bosch F, Blasco MA. Nat Commun. 2014 Dec 18;5:5863. doi: 10.1038/ncomms6863.

Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-? receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer. (2014) Rod?n J, Carducci M, Sepulveda-S?nchez JM, Azaro A, Calvo E, Seoane J, Bra?a I, Sicart E, Gueorguieva I, Cleverly A, Pillay NS, Desaiah D, Estrem ST, Paz-Ares L, Holdhoff M, Blakeley J, Lahn MM, Baselga J. Invest New Drugs. 2014 Dec 23. [Epub ahead of print]

High fidelity between saliva proteomics and the salivary glands biological state defines biomarker-signatures for primary Sj?grens syndrome. (2014) Delaleu N, Mydel P, Kwee I, Brun JG, Jonsson MV, Jonsson R. Arthritis Rheumatol. 2014 Dec 29. doi: 10.1002/art.39015. [Epub ahead of print]

CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney. (2014) Siddiqi FS, Chen L, Advani SL, Thai K, Batchu SN, Alghamdi TA, White KE, Sood MM, Gibson IW, Connelly KA, Marsden PA, Advani A. Endocrinology. 2014 Dec 30:en20141650. [Epub ahead of print]

Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation (2014) Adage T, Konya V, Weber C, Strutzmann E, Fuchs T, Zankl C, Gerlza T, Jeremic D, Heinemann A, Kungl AJ. Eur J Pharmacol. 2014 Dec 29. pii: S0014-2999(14)00889-9. doi: 10.1016/j.ejphar.2014.12.019. [Epub ahead of print]

Basal inflammation and innate immune response in chronic multisite musculoskeletal pain. (2014) Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, Dekker J, Penninx BW. Pain. 2014 Aug;155(8):1605-12. doi: 10.1016/j.pain.2014.05.007. Epub 2014 May 9.

The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis. (2014) Peterson JL, Phelps ED, Doll MA, Schaal S, Ceresa BP. Invest Ophthalmol Vis Sci. 2014 May 1;55(5):2870-80. doi: 10.1167/iovs.13-12943.

Proteomic changes in serum of first onset, antidepressant drug-na?ve major depression patients. (2014) Stelzhammer V, Haenisch F, Chan MK, Cooper JD, Steiner J, Steeb H, Martins-de-Souza D, Rahmoune H, Guest PC, Bahn S. Int J Neuropsychopharmacol. 2014 Oct;17(10):1599-608. doi: 10.1017/S1461145714000819. Epub 2014 Jun 5.

Effects of Ruxolitinib Treatment on Metabolic and Nutritional Parameters in Patients With Myelofibrosis From COMFORT-I. (2014) Mesa RA, Verstovsek S, Gupta V, Mascarenhas J, Atallah E, Burn T, Sun W, Sandor V, Gotlib J. Clin Lymphoma Myeloma Leuk [Epub ahead of print]

Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. (2014) Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF. Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1398-407. doi: 10.1152/ajpheart.00090.2014. Epub 2014 Mar 21.

Towards a Psychosis Risk Blood Diagnostic for Persons Experiencing High-Risk Symptoms: Preliminary Results From the NAPLS Project. (2014) Perkins DO, Jeffries CD, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Heinssen R. Schizophr Bull. 2014 Aug 6. pii: sbu099. [Epub ahead of print]

Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression. (2014) Diniz BS, Sibille E, Ding Y, Tseng G, Aizenstein HJ, Lotrich F, Becker JT, Lopez OL, Lotze MT, Klunk WE, Reynolds CF, Butters MA. Mol Psychiatry. 2014 Aug 5. doi: 10.1038/mp.2014.76. [Epub ahead of print]

Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats. (2014) Erdely A, Antonini JM, Young SH, Kashon ML, Gu JK, Hulderman T, Salmen R, Meighan T, Roberts JR, Zeidler-Erdely PC. Part Fibre Toxicol. 2014 Aug 15;11:34. doi: 10.1186/s12989-014-0034-8.

The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results From a Phase 3, Randomized, Placebo-Controlled Trial (PALACE 1). (2015) Schafer P, Chen P, Fang L, Wang A, Chopra R. J Immunol Res 2015 Jan 10 [Epub ahead of print]

Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods. (2015) Morrow JD, Qiu W, Chhabra D, Rennard SI, Belloni P, Belousov A, Pillai SG, Hersh CP. BMC Med Genomics. 2015 Jan 13;8(1):1. [Epub ahead of print]

Anti-inflammatory T-cell shift in neuropathic pain. (2015) Luchting B, Rachinger-Adam B, Heyn J, Hinske L, Kreth S, Azad S. J Neuroinflammation. 2015 Jan 21;12(1):12. [Epub ahead of print]

Acute and chronic plasma metabolomic and liver transcriptomic stress effects in a mouse model with features of post-traumatic stress disorder. (2015) Gautam A, DArpa P, Donohue DE, Muhie S, Chakraborty N, Luke BT, Grapov D, Carroll EE, Meyerhoff JL, Hammamieh R, Jett M. PLoS One. 2015 Jan 28;10(1):e0117092. doi: 10.1371/journal.pone.0117092. eCollection 2015.

Evaluation of thymosin alpha 1 (Ta1) in nonclinical models of the immune-suppressing indications melanoma and sepsis. (2015) King RS, Tuthill C. Expert Opin Biol Ther. 2015 Feb 2:1-9. [Epub ahead of print]

Phase II Evaluation of IPI-926, an Oral Hedgehog Inhibitor, in Patients with Myelofibrosis. (2015) Sasaki K, Gotlib JR, Mesa RA, Newberry KJ, Ravandi F, Cortes JE, Kelly P, Kutok JL, Kantarjian HM, Verstovsek S. Leuk Lymphoma. 2015 Feb 2:1-20. [Epub ahead of print]

Nox4 supports proper capillary growth in exercise and retina neo-vascularization. (2015) Vogel J, Kruse C, Zhang M, Schr?der K. J Physiol. 2015 Feb 4. doi: 10.1113/jphysiol.2014.284901. [Epub ahead of print]

Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes. (2015) Looker HC, Colombo M, Agakov F, Zeller T, Groop L, Thorand B, Palmer CN, Hamsten A, de Faire U, Nogoceke E, Livingstone SJ, Salomaa V, Leander K, Barbarini N, Bellazzi R, van Zuydam N, McKeigue PM, Colhoun HM; on behalf of the SUMMIT Investigators. Diabetologia. 2015 Mar 5. [Epub ahead of print]

The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses. (2015) Christiansson L, Soderlund S, Mangsbo SM, Hjorth-Hansen H, H?glund M, Markevarn B, Richter J, Stenke L, Mustjoki S, Loskog A, Olsson-Stromberg U. Mol Cancer Ther. 2015 Mar 11. pii: molcanther.0849.2014. [Epub ahead of print]

Study of cardiovascular disease biomarkers among tobacco consumers, part 2: biomarkers of biological effect. (2015) Nordskog BK, Brown BG, Marano KM, Campell LR, Jones BA, Borgerding MF. Inhal Toxicol. 2015 Mar 19:1-10. [Epub ahead of print]

Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory. (2015) Kim A, Fagan AM, Goate AM, Benzinger TL, Morris JC, Head D; Alzheimer?s Disease Neuroimaging Initiative. Cogn Affect Behav Neurosci. 2015 Mar 18. [Epub ahead of print]

Detection of Rheumatoid Arthritis-Interstitial Lung Disease is Enhanced by Serum Biomarkers. (2015) Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Am J Respir Crit Care Med. 2015 Mar 30. [Epub ahead of print]

The long-acting ?2-agonist olodaterol attenuates pulmonary inflammation. (2015) Wex E, Kollak I, Duechs MJ, Naline E, Wollin L, Devillier P. Br J Pharmacol. 2015 Mar 30. doi: 10.1111/bph.13143. [Epub ahead of print]

Novel first-dose adverse drug reactions during a phase I trial of olipudase alfa (recombinant human acid sphingomyelinase) in adults with Niemann-Pick disease type B (acid sphingomyelinase deficiency). (2015) McGovern MM, Wasserstein MP, Kirmse B, Duvall WL, Schiano T, Thurberg BL, Richards S, Cox GF. Genet Med. 2015 Apr 2. doi: 10.1038/gim.2015.24. [Epub ahead of print]

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product. (2015) Phillips B, Veljkovic E, Peck MJ, Buettner A, Elamin A, Guedj E, Vuillaume G, Ivanov NV, Martin F, Bou?b S, Schlage WK, Schneider T, Titz B, Talikka M, Vanscheeuwijck P, Hoeng J, Peitsch MC. Food Chem Toxicol. 2015 Apr 2. pii: S0278-6915(15)00088-5. doi: 10.1016/j.fct.2015.03.009. [Epub ahead of print]

Temporal phenotypic features distinguish polarized macrophages in vitro. (2015) Melton DW, McManus LM, Gelfond JA, Shireman PK. Autoimmunity. 2015 Mar 31:1-16. [Epub ahead of print]

Serum IGF-BP2 Strongly Moderates Age?s Effect on Cognition: A MIMIC Analysis. (2015) Royall DR, Bishnoi RJ, Palmer RF Neurobiol. Aging. 14 April 2015. [Epub ahead of print]

Mechanism-based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy. (2015) Hawkins-Salsbury JA, Shea L, Jiang X, Hunter DA, Guzman AM, Reddy AS, Qin EY, Li Y, Gray SJ, Ory DS, Sands MS. J Neurosci. 2015 Apr 22;35(16):6495-505. doi: 10.1523/JNEUROSCI.4199-14.2015.

Alarmin function of galectin-9 in murine respiratory tularemia. (2015) Steichen AL, Simonson TJ, Salmon SL, Metzger DW, Mishra BB, Sharma J. PLoS One. 2015 Apr 21;10(4):e0123573. doi: 10.1371/journal.pone.0123573. eCollection 2015.

Plasma BDNF levels associate with Pittsburgh Compound B binding in the brain. (2015) Hwang KS, Lazaris AS, Eastman JA, Teng E, Thompson PM, Gylys KH, Cole GM, Apostolova LG, for the Alzheimers Dement (Amst) 2015 Apr 22. [Epub ahead of print]

Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study. (2015) Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, de Geus EJ, Penninx BW, Dekker J. Ann Rheum Dis. 2015 Apr 22. pii: annrheumdis-2014-206741. doi: 10.1136/annrheumdis-2014-206741. [Epub ahead of print]

CHOP Links Endoplasmic Reticulum Stress to NF-kB Activation in the Pathogenesis of Nonalcoholic Steatohepatitis. (2015) Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC. Mol Biol Cell. 2015 Apr 22. pii: mbc.E15-01-0036. [Epub ahead of print]

Discovery of serum biomarkers predicting development of a subsequent depressive episode in social anxiety disorder. (2015) Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BW, Bahn S. Brain Behav Immun. 2015 Apr 28. pii: S0889-1591(15)00118-X. doi: 10.1016/j.bbi.2015.04.011. [Epub ahead of print]

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. (2015) Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L. Autoimmunity. 2015 Apr 27:1-11. [Epub ahead of print]

Total testosterone and neuropsychiatric symptoms in elderly men with Alzheimer?s disease. (2015) Hall JR, Wiechmann AR, Cunningham RL, Johnson LA, Edwards M, Barber RC, Singh M, Winter S, O?Bryant SE, and for the Texas Alzheimer?s Research and Care Consortium. Alzheimers Res Ther. 2015; 7(1): 24. Published online 2015 May 1. doi: 10.1186/s13195-015-0107-4

Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study. (2015) Hoeven TA, Kavousi M, Ikram AM, van Meurs JB, Bindels PJ, Hofman A, Franco OH, Bierma-Zeinstra SM. Rheumatology (Oxford). 2015 May 6. pii: kev106. [Epub ahead of print]

Effect of cerium oxide nanoparticles on sepsis induced mortality and NF-?B signaling in cultured macrophages. (2015) Selvaraj V, Manne ND, Arvapalli R, Rice KM, Nandyala G, Fankenhanel E, Blough ER. Nanomedicine (Lond). 2015 Apr;10(8):1275-88. doi: 10.2217/nnm.14.205.

Blood Protein Markers of Neocortical Amyloid-? Burden: A Candidate Study Using SOMAscan Technology. (2015) Voyle N, Baker D2, Burnham SC, Covin A, Zhang Z, Sangurdekar DP, Tan Hehir CA, Bazenet C, Lovestone S, Kiddle S, Dobson RJ. J Alzheimers Dis. 2015 Apr 16. [Epub ahead of print]

Development, manufacturing and characterization of a highly purified, liquid immunoglobulin g preparation from human plasma. (2014) Laursen IA, Blou L, Sullivan JS, Bang P, Balstrup F, Houen G. Transfus Med Hemother. 2014 Jun;41(3):205-12. doi: 10.1159/000357982. Epub 2014 Apr 14.

Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles. (2015) Selvaraj V, Nepal N1, Rogers S, Manne ND, Arvapalli R, Rice KM, Asano S, Fankhanel E, Ma JJ, Shokuhfar T, Maheshwari M, Blough ER. Biomaterials. 2015 May 8;59:160-171. doi: 10.1016/j.biomaterials.2015.04.025. [Epub ahead of print]

Ferritin levels in the cerebrospinal fluid predict Alzheimers disease outcomes and are regulated by APOE. (2015) Ayton S, Faux NG, Bush AI; Alzheimers Disease Neuroimaging Initiative. Nat Commun. 2015 May 19;6:6760. doi: 10.1038/ncomms7760.

Hippocampal proteomic and metabonomic abnormalities in neurotransmission, oxidative stress and apoptotic pathways in a chronic phencyclidine rat model. (2015) Wesseling H, Want EJ, Guest PC, Rahmoune H, Holmes E, Bahn S. J Proteome Res. 2015 Jun 4. [Epub ahead of print]

Immune cell profiling to guide therapeutic decisions in rheumatic diseases. (2015) Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S. Nat Rev Rheumatol. 2015 Jun 2. doi: 10.1038/nrrheum.2015.71. [Epub ahead of print]

Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial. (2015) Tomasik J, Yolken RH, Bahn S, Dickerson FB. Biomark Insights. 2015 Jun 1;10:47-54. doi: 10.4137/BMI.S22007. eCollection 2015.

Multiplex immunoassay analysis of plasma shows differences in biomarkers related to manic or mixed mood states in bipolar disorder patients. (2015) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Yolken R, Dickerson F, Bahn S. Journal of Affective Disorders. 2015 Jun 24. doi:10.1016/j.jad.2015.05.065. [Epub ahead of print]

Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in Adult Patients with Systemic Sclerosis. (2015) Guo X, Higgs BW, Bay-Jensen AC, Karsdal MA, Yao Y, Roskos LK, White WI. J Invest Dermatol. 2015 May 20. doi: 10.1038/jid.2015.188. [Epub ahead of print]

Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of TNF-a receptor 1 (2015) Cordy JC, Morley PJ, Wright TJ, Birchler MA, Lewis AP, Emmins R, Chen YZ, Powley WM, Bareille PJ, Wilson R, Tonkyn J, Bayliffe AI, Lazaar AL. Clin Exp Immunol.

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans (2015) Saykin A, Shen L, Xiohui Y, Kim S, Kwangsik N, Risacher SL, Ramanan VK, Foroud T, Faber KM, Sarwar N, Minsie L, Xiaolan H, Soares HD, Potkin S, Thompson PM, Kauwe JSK, Kaddurah-Daouk R, Green RC, Toga AW, Weiner MW Alzheimers & Dementia

Perspective: The Alzheimers Disease Neuroimaging Initiative and the role and contributions of the Private Partner Scientific Board (PPSB) (2015) Liu E, Luthman J, Cedarbaum JM, Scmidt ME, Cole PE, Hendrix J, Carillo MC, Jones-Davis D, Tarver E, Novak G, De Santi S, Soares HD, Potter QZ, Siemers E, Schwarz AJ Alzheimers & Dementia

Biomarkers of rapid chronic kidney disease progression in type 2 diabetes (2015) Looker HC, Colombo M, Hess S, Brosnan MJ, Farran B, Dalton RN, Wong MC, Turner C, Palmer CNA, Nogceke E, Groop L, Salomaa V, Dunger DB, Agakov F, McKeigue PM, Colhoun HM Kidney International

Identifying amyloid pathology?related cerebrospinal fluid biomarkers for Alzheimers disease in a multicohort study (2015) Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, Soares HD, Kling MA, Mailman M, Arnold SE, Narayan VA, Lee VMY, Shaw LM, Baker D, Wittenberg GM, Trojanowski JQ, Wang LS Alzheimers & Dementia

Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia (2015) Shaikh H, Boudes E, Khoja Z, Shevell M, Wintermark P PLOS One

Late Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337) (2015) Dietsch GN, Randall TD, Gottardo R, Northfelt DW, Ramanathan RK, Cohen PA, Manjarrez KL, Newkirk M, Bryan JK, Hershberg RM Clinical Cancer Research

A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis (2015) Pardanani A, Tefferi A, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, Xu C, Cao H and Talpaz M Blood Cancer Journal

THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab (2015) Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B Ann Rheum Dis

Identification of plasma biomarker concentration changes resulting from the administration of the Vascular Disrupting Agent BNC105 across 3 clinical trials in mesothelioma, ovarian and renal cancer (2015) Kremmidiotis G, Leske A, Simpson J, Doolin E, Iglesias J AACR 2015

Biomarker results from a clinical trial of nivolumab in patients (pts) with metastatic renal cell carcinoma (mRCC) (CA209-009): Gene expression, serum profiling for immune markers, and multiplex tissue immunohistochemistry (IHC) (2015) Choueiri TK, Fishman MN, Escudier B, Stadler WM, Chasalow S, Ross-Macdonald P, Jure-Kunkel M, Sznol M, and Simon JS Cancer Res

Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease (2015) Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC Pediatr Res.

Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat (2015) Svejgaard B, Wehland M, Ma X, Kopp S, Sahana J, Warnke E, Aleshcheva G, Hemmersbach R, Hauslage J, Grosse J, Bauer J, Corydon TJ, Islam T, Infanger M, Grimm D PLoS One

Central and peripheral changes underlying susceptibility and resistance to social defeat stress ? a proteomic profiling study (2015) Stelzhammer V, Ozcan S, Gottschalk MG, Steeb H, Hodes GE, Guest PC, Rahmoune H, Wong EHF, Russo SJ, Bahn S Diagnostics in Neuropsychiatry

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Predicting Progression from Mild Cognitive Impairment to Alzheimers Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification (2016) Korolev IO, Symonds LL, Bozoki AC; Alzheimers Disease Neuroimaging Initiative PLoS One

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Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity (2016) Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM PLoS ONE

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The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy (2016) Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenf?hrer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S, Hocher B Kidney International

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System-Based Proteomic and Metabonomic Analysis of the Df(16)a+/- Mouse Identifies Potential Mir-185 Targets and Molecular Pathway Alterations (2016) Wesseling H, Xu B, Want EJ, Holmes E, Guest PC, Karayiorgou M, Gogos JA, Bahn S Molecular Psychiatry

A Sputum Proteomic Signature That Associates with Increased Il-1? Levels and Bacterial Exacerbations of COPD (2016) Damera G, Pham T-H, Zhang J, Ward CK, Newbold P, Ranade K, Sethi S Lung

Evaluation of Novel Biomarkers of Nephrotoxicity in Cynomolgus Monkeys Treated with Gentamicin (2016) Gautier J-C, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, L?onard J-F, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BHJ, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li B Toxicology and Applied Pharmacology

Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial (2016) Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG Neuromodulation: Technology at the Neural Interface

Plasma Egf and Cognitive Decline in Parkinsons Disease and Alzheimers Disease (2016) Lim NS, Swanson CR, Cherng H-R, Unger TL, Xie SX, Weintraub D, Marek K, Stern MB, Siderowf A, Pars Investigators, Alzheimers Disease Neuroimaging Initiative, Trojanowski JQ, Chen-Plotkin AS Annals of Clinical and Translational Neurology

Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on Bmd among Young Childhood Cancer Survivors: A Randomized Clinical Trial (2016) Mogil RJ, Kaste SC, Ferry Jr RJ, Hudson MM, Mulrooney DA, Howell CR, Partin RE, Srivastava DK, Robison LL, Ness KK JAMA Oncology

A Novel Approach for Emerging and Antibiotic Resistant Infections: Innate Defense Regulators as an Agnostic Therapy (2016) North JR, Takenaka S, Rozek A, Kielczewska A, Opal S, Morici LA, Finlay BB, Schaber CJ, Straube R, Donini O Journal of Biotechnology

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High false-positive rate of a putative biomarker test to aid in the diagnosis of schizophrenia (2016) Wehler CA, Preskorn, SH Journal of Clinical Psychiatry

A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis (2016) Rovin B, van Vollenhoven R, Aranow C, Wagner C, Gordon R, Zhuang Y, Belkowski S, Hsu B Arthritis & Rheumatology

Characterization of Renal Biomarkers for Use in Clinical Trials: Effect of Preanalytical Processing and Qualification Using Samples from Subjects with Diabetes (2015) Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N Drug Design, Development and Therapy

Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time (2016) Schild M, Eichner G, Beiter T, Zuegel M, Niess AM, Steinacker JM, Mooren FC Mediators of Inflammation

Altered Cerebrospinal Fluid Proteins in Smith?Lemli? (2016) Cologna SM, Shieh C, Toth CL, Cougnoux A, Burkert KR, Bianconi SE, Wassif CA, Porter FD American Journal of Medical Genetics Part A

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology

Predictors of Asthma Following Severe Respiratory Syncytial Virus (Rsv) Bronchiolitis in Early Childhood (2016) Lu S, Hartert TV, Everard ML, Giezek H, Nelsen L, Mehta A, Patel H, Knorr B, Reiss TF Pediatric Pulmonology

Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2-O-Methoxyethyl Modified Antisense Oligonucleotide (2016) Shen L, Engelhardt JA, Hung G, Yee J, Kikkawa R, Matson J, Tayefeh B, Machemer T, Giclas PC, Henry SP Nucleic Acid Therapeutics

Type I Ifns Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-Versus-Host Disease (2016) Delaney TA, Morehouse C, Brohawn PZ, Groves C, Colonna M, Yao, Y, Sanjuan M, Coyle AJ The Journal of Immunology

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Inflammatory Profile in Lrrk2-Associated Prodromal and Clinical Pd (2016) Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos TO, Gasser T, Sch?le B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W Journal of Neuroinflammation

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C-Type Lectin Receptor Clec4d Plays a Protective Role in Resolution of Gram-Negative Pneumonia (2013) Steichen AL, Binstock BJ, Mishra BB, Sharma J Journal of Leukocyte Biology

Update on the Safety and Efficacy of the Pan Class I Pi3k Inhibitor Sar245408 (Xl147) in Chronic Lymphocytic Leukemia and Non-Hodgkin?s Lymphoma Patients (2013) Davids MS, Rodon J, Abrisqueta P, Egile C, Ruiz-Soto R, Awan F Blood

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Identifying Novel Biomarkers for Cardiovascular Events or Death in People with Dysglycemia (2015) Gerstein HC, Par? G, Mcqueen MJ, Haenel H, Lee SF, Pogue J, Maggioni AP, Yusuf S, Hess S Circulation

Candidate Blood Proteome Markers of Alzheimers Disease Onset and Progression: A Systematic Review and Replication Study (2014) Kiddle SJ, Sattlecker M, Proitsi P, Simmons A, Westman E, Bazenet C, Nelson SK, Williams S, Hodges A, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Newhouse S, Lovestone S, Dobson RJ Journal of Alzheimers Disease

Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin

The Application of Multiple Reaction Monitoring to Assess Apoa-I Methionine Oxidations in Diabetes and Cardiovascular Disease (2014) Yassine HN, Jackson AM, Reaven PD, Nedelkov D, Nelson RW, Lau SS, Borchers CH Translational Proteomics

Mesenteric Ischemia-Reperfusion Injury up-Regulates Certain Cc, Cxc, and Xc Chemokines and Results in Multi-Organ Injury in a Time-Dependent Manner (2013) Jawa RS, Quist E, Boyer CW, Shostrom VK, Mercer DW European Cytokine Network

Reduced Bdnf Attenuates Inflammation and Angiogenesis to Improve Survival and Cardiac Function Following Myocardial Infarction in Mice (2013) Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O, Jin Y-F, Lindsey ML American Journal of Physiology - Heart and Circulatory Physiology

Rg7212 Anti-Tweak Mab Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response (2013) Yin X, Luistro L, Zhong H, Smith M, Nevins T, Schostack K, Hilton H, Lin T-A, Truitt T, Biondi D, Wang X, Packman K, Rosinski J, Berkofsky-Fessler W, Tang J-P, Pant S, Geho D, Vega-Harring S, Demario M, Levitsky H, Simcox M American Association for Cancer Research

Plasma Lipid Profiling across Species for the Identification of Optimal Animal Models of Human Dyslipidemia (2012) Yin W, Carballo-Jane E, Mclaren DG, Mendoza VH, Gagen K, Geoghagen NS, Mcnamara LA, Gorski JN, Eiermann GJ, Petrov A, Wolff M, Tong X, Wilsie LC, Akiyama TE, Chen J, Thankappan A, Xue J, Ping X, Andrews G, Wickham LA, Gai CL, Trinh T, Kulick AA, Donnelly MJ, Voronin GO, Rosa R, Cumiskey A-M, Bekkari K, Mitnaul LJ, Puig O, Chen F, Raubertas R, Wong PH, Hansen BC, Koblan KS, Roddy TP, Hubbard BK, Strack AM Journal of Lipid Research

Serum Proteomic Profiling of Major Depressive Disorder (2015) Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH Translational Psychiatry

An Adaptive Genetic Algorithm for Selection of Blood-Based Biomarkers for Prediction of Alzheimers Disease Progression (2015) Vandewater L, Brusic V, Wilson W, Macaulay L, Zhang P BMC Bioinformatics

Distinctive Colonic Mucosal Cytokine Signature in New-Onset, Untreated Pediatric Crohn Disease (2014) Sylvester FA, Draghi A, Menoret A, Fernandez ML, Wang Z, Vella AT Journal of Pediatric Gastroenterology and Nutrition

Phase I Trial of the Pan-Pi3k Inhibitor Pilaralisib (Sar245408/Xl147) in Patients with Chronic Lymphocytic Leukemia (Cll) or Relapsed/Refractory Lymphoma (2015) Brown JR, Davids MS, Rodon J, Abrisqueta P, Kasar SN, Lager J, Jiang J, Egile C, Awan FT American Association for Cancer Research

Circulating Cytokines in Relation to the Extent and Composition of Coronary Atherosclerosis: Results from the Atheroremo-Ivus Study (2014) Battes LC, Cheng JM, Oemrawsingh RM, Boersma E, Garcia-Garcia HM, De Boer SPM, Buljubasic N, Mieghem NaV, Regar E, Geuns R-JV, Serruys PW, Akkerhuis KM, Kardys I Atherosclerosis

Sj?gren?s Syndrome Patients with Ectopic Germinal Centers Present with a Distinct Salivary Proteome (2016) Delaleu N, Mydel P, Brun JG, Jonsson MV, Alimonti A, Jonsson R Rheumatology

Inflammatory Mediator Profiling Reveals Immune Properties of Chemotactic Gradients and Macrophage Mediator Production Inhibition During Thioglycollate Elicited Peritoneal Inflammation (2013) Lam D, Harris D, Qin Z Mediators of Inflammation

Elevated Carbon Monoxide to Carbon Dioxide Ratio in the Exhaled Breath of Mice Treated with a Single Dose of Lipopolysaccharide (2014) Langeroudi AG, Hirsch CM, Estabragh AS, Meinardi S, Blake DR, Barbour AG Open Forum Infectious Diseases

Dipeptidyl Peptidase-4 Inhibition Improves Left Ventricular Function in Chronic Kidney Disease (2014) Connelly KA, Bowskill BB, Advani SL, Thai K, Chen L-H, Kabir MG, Gilbert RE, Advani A Clinical & Investigative Medicine

Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma (2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer

Cytokine Production Capacity in Depression and Anxiety (2016) Vogelzangs N, De Jonge P, Smit JH, Bahn S, Penninx BW Translational Psychiatry

The Effect Trial: Evaluating Exacerbations, Biomarkers, and Safety Outcomes with Two Dose Levels of Fluticasone Propionate/Formoterol in Copd (2015) Papi A, Jones PW, Dalvi PS, Mcaulay K, Mciver T, Dissanayake S International Journal of COPD

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk (2015) Cannon TD, Chung Y, He G, Sun D, Jacobson A, Van Erp TGM, Mcewen S, Addington J, Bearden CE, Cadenhead K, Cornblatt B, Mathalon DH, Mcglashan T, Perkins D, Jeffries C, Seidman LJ, Tsuang M, Walker E, Woods SW, Heinssen R Biological Psychiatry

Development of a Blood-Based Molecular Biomarker Test for Identification of Schizophrenia before Disease Onset (2015) Chan MK, Krebs MO, Cox D, Guest PC, Yolken RH, Rahmoune H, Rothermundt M, Steiner J, Leweke FM, Van Beveren NJM, Niebuhr DW, Weber NS, Cowan DN, Suarez-Pinilla P, Crespo-Facorro B, Mam-Lam-Fook C, Bourgin J, Wenstrup RJ, Kaldate RR, Cooper JD, Bahn S Translational Psychiatry

Apolipoprotein H Expression Is Associated with Il28b Genotype and Viral Clearance in Hepatitis C Virus Infection (2014) Laird ME, Mohsen A, Duffy D, Mamdouh R, Lefouler L, Casrouge A, El-Daly M, Rafik M, Abdel-Hamid M, Soulier A, Pawlotsky J-M, H?zode C, Rosa I, Renard P, Mohamed MK, Bonnard P, Izopet J, Mallet V, Pol S, Albert ML, Fontanet A Journal of Hepatology

Towards a Blood-Based Diagnostic Panel for Bipolar Disorder (2016) Haenisch F, Cooper JD, Reif A, Kittel-Schneider S, Steiner J, Leweke FM, Rothermundt M, Van Beveren NJM, Crespo-Facorro B, Niebuhr DW, Cowan DN, Weber NS, Yolken RH, Penninx BWJH, Bahn S Brain, Behavior, and Immunity

Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports

Behavioural Traits Propagate across Generations Via Segregated Iterative-Somatic and Gametic Epigenetic Mechanisms (2016) Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, Van Den Brink M, Toth M Nature Communications

Intratumoral Inf-g Triggers an Antiviral State in Gl261 Tumor Cells: A Major Hurdle to Overcome for Oncolytic Vaccinia Virus Therapy of Cancer (2015) Kober C, Weibel S, Rohn S, Kirscher L, Szalay AA*2015*Intratumoral Inf-G Triggers an Antiviral State in Gl261 Tumor Cells: A Major Hurdle to Overcome for Oncolytic Vaccinia Virus Therapy of Cancer Molecular Therapy ? Oncolytics

Sublytic Concentrations of Staphylococcus Aureus Panton-Valentine Leukocidin Alter Human Pmn Gene Expression and Enhance Bactericidal Capacity (2012) Graves SF, Kobayashi SD, Braughton KR, Whitney AR, Sturdevant DE, Rasmussen DL, Kirpotina LN, Quinn MT, Deleo FR Journal of Leukocyte Biology

Defining Map3 Kinases Required for Mda-Mb-231 Cell Tumor Growth and Metastasis (2012) Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL Oncogene

Significance of Plasma Adiponectin for Diagnosis, Neurological Severity and Functional Outcome in Ischemic Stroke ? Research for Biomarkers in Ischemic Stroke (Rebios) (2014) Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T Metabolism

Distinct Molecular Phenotypes in Male and Female Schizophrenia Patients (2013) Ramsey JM, Schwarz E, Guest PC, Van Beveren NJM, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S PLoS ONE

An Antiinflammatory Dietary Mix Modulates Inflammation and Oxidative and Metabolic Stress in Overweight Men: A Nutrigenomics Approach (2010) Bakker GC, Van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, Van Ommen B, Hendriks HF The American Journal of Clinical Nutrition

A Potential Endophenotype for Alzheimers Disease: Cerebrospinal Fluid Clusterin (2016) Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C Neurobiology of Aging

Metronomic Gemcitabine Suppresses Tumour Growth, Improves Perfusion, and Reduces Hypoxia in Human Pancreatic Ductal Adenocarcinoma (2010) Cham KKY, Baker JHE, Takhar KS, Flexman JA, Wong MQ, Owen DA, Yung A, Kozlowski P, Reinsberg SA, Chu EM, Chang CWA, Buczkowski AK, Chung SW, Scudamore CH, Minchinton AI, Yapp DTT, Ng SSW British Journal of Cancer

Clinical and Preclinical Characterization of the Histamine H4 Receptor Antagonist Jnj-39758979 (2014) Thurmond RL, Chen B, Dunford PJ, Greenspan AJ, Karlsson L, La D, Ward P, Xu XL Journal of Pharmacology and Experimental Therapeutics

Targeting Tnf-? to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy (2012) Calcinotto A, Grioni M, Jachetti E, Curnis F, Mondino A, Parmiani G, Corti A, Bellone M Journal of Immunology

Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and Cognitive Problems in Adults with and without Methamphetamine Dependence: An Exploratory Protein Array Study (2015) Huckans M, Fuller BE, Chalker ALN, Adams M, Loftis JM Frontiers in Psychiatry

Altered Levels of Circulating Insulin and Other Neuroendocrine Hormones Associated with the Onset of Schizophrenia (2011) Guest PC, Schwarz E, Krishnamurthy D, Harris LW, Leweke FM, Rothermundt M, Van Beveren N, Spain M, Barnes A, Steiner J, Rahmoune H, Bahn S Psychoneuroendocrinology

Leucine-Rich Repeat Kinase 2 (Lrrk2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis (2013) Ness D, Ren Z, Gardai S, Sharpnack D, Johnson VJ, Brennan RJ, Brigham EF, Olaharski AJ PLoS ONE

Brown Norway Chromosome 1 Congenic Reduces Symptoms of Renal Disease in Fatty Zucker Rats (2014) Warden CH, Slupsky C, Griffey SM, Bettaieb A, Min E, Le A, Fisler JS, Hansen S, Haj F, Stern JS PLoS ONE

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Moderate Alcohol Consumption Alters Both Leucocyte Gene Expression Profiles and Circulating Proteins Related to Immune Response and Lipid Metabolism in Men (2012) Joosten MM, Van Erk MJ, Pellis L, Witkamp RF, Hendriks HFJ British Journal of Nutrition

Dysregulation of Serum Gamma Interferon Levels in Vascular Chronic Q Fever Patients Provides Insights into Disease Pathogenesis (2015) Pennings JLA, Kremers MNT, Hodemaekers HM, Hagenaars JCJP, Koning OHJ, Renders NHM, Hermans MHA, De Klerk A, Notermans DW, Wever PC, Janssen R Clinical and Vaccine Immunology

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Early Role of Vascular Dysregulation on Late-Onset Alzheimers Disease Based on Multifactorial Data-Driven Analysis (2016) Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Perez JM, Evans AC, The Alzheimers Disease Neuroimaging Initiative Nature Communications

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Contribution of Staphylococcus Aureus Coagulases and Clumping Factor a to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection (2016) Malachowa N, Kobayashi SD, Porter AR, Braughton KR, Scott DP, Gardner DJ, Missiakas DM, Schneewind O, Deleo FR PLoS ONE

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Bone Marrow from Blotchy Mice Is Dispensable to Regulate Blood Copper and Aortic Pathologies but Required for Inflammatory Mediator Production in Ldlr-Deficient Mice During Chronic Angiotensin Ii Infusion (2015) Harris D, Liang Y, Chen C, Li S, Patel O, Qin Z Annals of Vascular Surgery

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The Different Effects of Strength and Endurance Exercise Training on Cox-2 and Mpges-Expression in Mouse Brain Are Independent of Peripheral Inflammation (2016) Kr?ger K, Bredeh?ft J, Mooren FC, Rummel C Journal of Applied Physiology

Placebo-Controlled Randomized Clinical Trial on the Immunomodulating Activities of Low- and High-Dose Bromelain after Oral Administration ? New Evidence on the Antiinflammatory Mode of Action of Bromelain (2013) M?ller S, M?rz R, Schmolz M, Drewelow B, Eschmann K, Meiser P Phytotherapy Research

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Pilot Study of Younger and Older Hiv-Infected Adults Using Traditional and Novel Functional Assessments (2013) Sandkovsky U, Robertson KR, Meza JL, High RR, Bonasera SJ, Fisher CM, Marsh AJ, Sheehy MK, Fox HS, Swindells S HIV Clinical Trials

Regional Neurovascular Inflammation and Apoptosis Are Detected after Electrical Contact Injury (2014) Prindeze NJ, Jo DY, Paul DW, Ortiz RT, Carney BC, Bullock RM, Moffatt LT, Shupp JW Journal of Burn Care & Research

Plasma Protein Profiling of Mild Cognitive Impairment and Alzheimers Disease across Two Independent Cohorts (2015) Muenchhoff JP, Anne; Song, Fei; Raftery, Mark; Brodaty, Henry; Duncan, Mark; Mcevoy, Mark; Attia, John; Schofield, Peter W.; Sachdev, Perminder S. Journal of Alzheimers Disease

Endometriosis Leads to an Increased Trefoil Factor 3 Concentration in the Peritoneal Cavity but Does Not Alter Systemic Levels (2016) Henze D, Doecke W-D, Hornung D, Agueusop I, Von Ahsen O, Machens K, Schmitz AA, Gashaw I Reproductive Sciences

BAFF (B Cell Activating Factor) Transcript Level in Peripheral Blood of Patients with SLE Is Associated with Same-Day Disease Activity as Well as Global Activity over the Next Year (2015) Zollars E, Bienkowska J, Czerkowicz J, Allaire N, Ranger AM, Magder L, Petri M Lupus Science

Comprehensive Systems Biology Analysis of a 7-Month Cigarette Smoke Inhalation Study in C57bl/6 (2016) Ansari S, Baumer K, Bou? S, Dijon S, Dulize R, Ekroos K, Elamin A, Foong C, Guedj E, Hoeng J, Ivanov NV, Krishnan S, Leroy P, Martin F, Merg C, Peck MJ, Peitsch MC, Phillips B, Schlage WK, Schneider T, Talikka M, Titz B, Vanscheeuwijck P, Veljkovic E, Vihervaara T, Vuillaume G, Woon CQ Scientific Data

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A Phase I/Ii Trial of Bnc105p with Everolimus in Metastatic Renal Cell Carcinoma (2015) Pal S, Azad A, Bhatia S, Drabkin H, Costello B, Sarantopoulos J, Kanesvaran R, Lauer R, Starodub A, Hauke R, Sweeney CJ, Hahn NM, Sonpavde G, Richey S, Breen T, Kremmidiotis G, Leske A, Doolin E, Bibby DC, Simpson J, Iglesias J, Hutson T Clinical Cancer Research

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Plasma Angiopoietin-2 Outperforms Other Markers of Endothelial Injury in Prognosticating Pediatric ARDS Mortality (2015) Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A American Journal of Physiology - Lung Cellular and Molecular Physiology

The Relationship between Complement Factor C3, Apoe ?4, Amyloid and Tau in Alzheimer?s Disease (2016) Bonham LW, Desikan RS, Yokoyama JS Acta Neuropathologica Communications

Variants in Ccl16 Are Associated with Blood Plasma and Cerebrospinal Fluid Ccl16 Protein Levels (2016) Ebbert MTW, Staley LA, Parker J, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JSK BMC Genomics

Blood Biomarkers of Chronic Inflammation in Gulf War Illness (2016) Johnson GJ, Slater BCS, Leis LA, Rector TS, Bach RR PLoS ONE

Identification of Plexin A4 as a Novel Clusterin Receptor Links Two Alzheimers Disease Risk Genes (2016) Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD Human Molecular Genetics

Vagus Nerve Stimulation Inhibits Cytokine Production and Attenuates Disease Severity in Rheumatoid Arthritis (2016) Koopman FA, Chavan SS, Miljko S, Grazio S, Sokolovic S, Schuurman PR, Mehta AD, Levine YA, Faltys M, Zitnik R, Tracey KJ, Tak PP PNAS

Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT (2016) Muders K, Pilat C, Deuster V, Frech T, Kruger K, Pons-Kuhnemann J, Mooren F-C Mediators of Inflammation

Characterizing the Inflammatory Response in Esophageal Mucosal Biopsies in Children with Eosinophilic Esophagitis (2016) Sayej WN, Menoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT Clinical & Translational Immunology

Genome-Wide Association Study of Prolactin Levels in Blood Plasma and Cerebrospinal Fluid (2016) Staley LA, Ebbert MTW, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JSK BMC Genomics

Serum Proteomic Profiles of Depressive Subtypes (2016) Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BWJH Translational Psychiatry

Peripheral Blood Cell Gene Expression Diagnostic for Identigying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures (2016) Kurian SM, Novais M, Whisenant T, Gelbart T, Buxbaum JN, Kelly JW, Coelho T, Salomon DR Theranostics

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children (2016) Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, Von Mutius E, Vercelli D, Ober C, Sperling AI New England Journal of Medicine

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD (2016) Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen T-H, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O?neal WK, Bowler RP, Group SR, Investigators CO PLOS Genetics

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (Am0010) in Patients with Advanced Solid Tumors (2016) Naing A, Papadopoulos KP, Autio KA, Ott PA, Patel MR, Wong DJ, Falchook GS, Pant S, Whiteside M, Rasco DR, Mumm JB, Chan IH, Bendell JC, Bauer TM, Colen RR, Hong DS, Van Vlasselaer P, Tannir NM, Oft M, Infante JR Journal of Clinical Oncology

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses (2016) Urrutia A, Duffy D, Rouilly V, Posseme C, Djebali R, Illanes G, Libri V, Albaud B, Gentien D, Piasecka B, Hasan M, Fontes M, Quintana-Murci L, Albert Matthew l, Abel L, Alcover A, Astrom K, Bousso P, Bruhns P, Cumano A, Demangel C, Deriano L, Di santo J, Dromer F, Eberl G, Enninga J, Fellay J, Freitas A, Gelpi O, Gomperts-Boneca I, Hercberg S, Lantz O, Leclerc C, Mouquet H, Pellegrini S, Pol S, Rogge L, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Soumelis V, Tangy F, Tartour E, Toubert A, Ungeheuer M-N, Quintana-Murci L, Albert Matthew Cell Reports

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Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer (2016) Saif MW, Knost JA, Chiorean EG, Kambhampati SR, Yu D, Pytowski B, Qin A, Kauh JS, ONeil BH Cancer Chemother Pharmacol

Plasma cystatin C and neutrophil gelatinase-associated lipocalin in relation to coronary atherosclerosis on intravascular ultrasound and cardiovascular outcome: Impact of kidney function (ATHEROREMO-IVUS study). (2016) Brankovic M, Akkerhuis KM, Buljubasic N, Cheng JM, Oemrawsingh RM, Garcia-Garcia HM, Regar E, Serruys PW, van Geuns RJ, Boersma E, Kardys I. Atherosclerosis

Enhanced Molecular Aging in Late-Life Depression: the Senescent Associated Secretory Phenotype (2016) Diniz BS, Reynolds III CF, Sibille E, Lin C, Tseng G, Lotrich F, Aizenstein HJ, Butters MA The American Journal of Geriatric Psychiatry

Pathogen and Host Response Dynamics in a Mouse Model of Borrelia hermsii Relapsing Fever (2016) Crowder CD, Langeroudi AG, Estabragh AS, Lewis ERG, Marcsisin RA, Barbour AG Veterinary Sciences

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A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. (2016) Jimeno A, Posner MR, Wirth LJ, Saba NF, Cohen RB, Popa EC, Argiris A, Grossmann KF, Sukari A, Wilson D, Zhang X, Sun J, Glasser C, Attie KM, Sherman ML, Pandya SS, Weiss J. Cancer

Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli. (2016) S?derlund S, Christiansson L, Persson I, Hjorth-Hansen H, Richter J, Simonsson B, Mustjoki S, Olsson-Str?mberg U, Loskog A. Leuk Res

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Do Single or Sequential Measurements of Leptin and Adiponectin in Plasma Have Prognostic Value in Pulmonary Arterial Hypertension? (2016) Tonelli AR, Fares WH, Dakkak W, Rao Y, Dweik RA Pulmonary Circulation

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke (2016) Wong ET, Kogel U, Veljkovic E, Martin F, Xiang Y, Boue S, Vuillaume G, Leroy P, Guedj E, Rodrigo G, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P. Regul Toxicol Pharmacol.

Primary Analysis Of A Phase II Open-Label Trial Of INCB039110, A Selective JAK1 Inhibitor, In Patients With Myelofibrosis (2016) Mascarenhas JO, Talpaz M, Gupta V, Foltz LM, Savona MR, Paquette R, Turner AR, Coughlin P, Winton E, Burn TC, ONeill P, Clark J, Hunter D10, Assad A, Hoffman R, Verstovsek S Haematologica

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Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke (2016) Oviedo A, Lebrun S, Kogel U, Ho J, Tan WT, Titz B, Leroy P, Vuillaume G, Bera M, Martin F, Rodrigo G, Esposito M, Dempsey R, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P. Regul Toxicol Pharmacol.

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Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor (2016) Gill M, Horn K, Hennan J, White R, Bounous D, Clark S, Megill JR, Janovitz E, Davies M, Sanderson T, Graziano M. Toxicol Sci

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Growth Differentiation Factor 15 as a Novel Biomarker for Metformin (2016) Gerstein HC, Pare G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee S, Haenel H, Steinberg GR; ORIGIN Investigators. Diabetes Care

Mindfulness-Based Cognitive Therapy Associated with Decreases in C-Reactive Protein in Major Depressive Disorder: A Pilot Study (2016) Eisendrath SJ, Gillung E, Hartzler A, James-Myers M, Wolkowitz O, Sipe W, Ramanatham D, Delucchi K J. Altern. Complement. Med.

Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study (2016) Inman RD, Baraliakos X, Hermann KA, Braun J, Deodhar A, Heijde D, Xu S, and Hsu B Arthritis Res Ther.

Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study (2016) Brahimaj A, Ligthart S, Ikram MA, Hofman A, Franco OH, Sijbrands EJ, Kavousi M, Dehghan A Diabetes Care

Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinsons disease (2017) Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W. Eur J Neurol

Protein Biomarker Druggability Profiling (2017) Mani S, Cannon D, Ohls R, Oprea T, Mathias S, Ballard K, Ursu O, Bologa C J Biomed Inform

Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CR-8 ISS space mission - The SPHEROIDS project. (2017) Pietsch J, Gass S2, Nebuloni S, Echegoyen D, Riwaldt S, Baake C, Bauer J, Corydon TJ, Egli M, Infanger M, Grimm D Biomaterials

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The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility. (2017) van den Broek TJ, Kremer BH, Marcondes Rezende M, Hoevenaars FP, Weber P, Hoeller U, van Ommen B, Wopereis S Genes Nutr

Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients. (2017) Luchting B, Hinske LC, Rachinger-Adam B, Celi LA, Kreth S, Azad SC Biomark Med

Effects of Traumeel (Tr14) on recovery and inflammatory immune response after repeated bouts of exercise: a double-blind RCT. (2017) Muders K, Pilat C, Deuster V, Frech T, Kr?ger K, Pons-Kuhnemann J, Mooren FC Eur J Appl Physiol.

Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular (2017) Thimraj TA, Birru RL, Mitra A, Schulz H, Leikauf GD, Ganguly K Lung

PH20 is not expressed in murine CNS and oligodendrocyte precursor cells (2017) Marella M, Ouyang J, Zombeck J, Zhao C, Huang L, Connor RJ, Phan KB, Jorge MC, Printz MA, Paladini RD, Gelb AB, Huang Z, Frost GI, Sugarman BJ, Steinman L, Wei G, Shepard HM, Maneval DC, Lapinskas PJ Ann Clin Transl Neurol

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study (2017) Brahimaj A, Ligthart S, Ghanbari M, Ikram MA, Hofman A, Franco OH, Kavousi M, Dehghan A Eur. J. Epidemiol.

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Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Ployunsaturated Fatty Acids in a Dose Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. (2017) Lefort N, LeBlanc R, Surette M Nutrients

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. (2017) Steele NZ, Carr JS, Bonham LS, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS PloS Med.

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Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Undergoing Diagnostic Coronary Angiography (From the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study) (2017) McCarthy CP, Van Kimmenade R, Gaggin HK, Simon ML, Ibrahim NE, Gandhi P, Kelly N, Motiwala SR, Belcher AM, Harisiades J, Magaret CA, Rhyne RF, Januzzi Jr. JL Am J Cardiol

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The REAnimation Low Immune Status Markers (REALISM) project: a protocol for broad characterisation and follow-up of injury-induced immunosuppression in intensive care unit (ICU) critically ill patients (2017) Rol ML, Venet F, Rimmele T, Moucadel V, Cortez P, Quemeneur L, Gardiner D, Griffiths A, Pachot A, Textoris J, Monneret G, On behalf of the REALISM study group BMJ Open

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden. CETP mice (2017) Landlinger C, Pouwer MG, Juno C, van der Hoorn J, Pieterman EJ, Jukema JW, Staffler G, Princen H, and Galabova, G Eur. Heart J.

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Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension? (2017) Tonelli AR, Fares WH, Dakkak W, Rao Y, Zhou X, Dweik RA Pulm Circ

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Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach (2017) Nassan M, Jia Y, Jenkins G, Colby C, Feeder S, Choi D, Veldic M, McElroy SL, Bond DJ, Weinshilboum R, Biernacka JM, Frye MA J Psychiatr Res

Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimers disease spectrum. (2017) Swanson A, Willette AA; Alzheimer?s Disease Neuroimaging Initiative. Brain Behav Immun.

Proteomics to predict the response to tumour necrosis factor-a inhibitors in rheumatoid arthritis using a supervised cluster-analysis based protein score (2017) Cuppen BVJ, Fritsch-Stork RDE, Eekhout, W de Jager I, Marijnissen AC, Bijlsma JWJ, Custers M, Van Laar JM, Lafeber FPJG, Welsing PMJ & on behalf of all Society for Rheumatology Research Utrecht (SRU) investigators Scand J Rheumatol

Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension. (2017) Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W Pulm Circ.

Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats. (2017) Manne NDPK, Arvapalli R, Graffeo VA, Bandarupalli VVK, Shokuhfar T, Patel S, Rice KM, Ginjupalli GK, Blough ER Cell Physiol Biochem

Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks (2017) Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, Trivedi MH J Affect Disord

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A multivariate predictive modeling approach reveals a novel CSF peptide signature for both Alzheimer ?s Disease state classification and for predicting future disease progression (2017) Llano DA, Bundela S, Mudar RA, Devanarayan V Plos One

A randomised, placebo-controlled trial of anti-interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease. (2017) Calverley PMA, Sethi S, Dawson M, Ward CK, Finch DK, Penney M, Newbold P, van der Merwe R Respir Res.

Nintedanib macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis (2017) Huang J, Maier C, Zhang Y, Soare A, Dees C, Beyer C, Harre U, Chen CW, Distler O, Schett G, Wollin L, Distler JHW Ann Rheum Dis.

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine. (2017) Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, Kr?ger M, Hemmersbach R, Infanger M, L?tzenberg R, Grimm D Cell Physiol Biochem.

IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD. (2017) Briend E, Ferguson GJ, Mori M, Damera G, Stephenson K, Karp NA, Sethi S, Ward CK, Sleeman MA, Erjef?lt JS, Finch DK Respir Res.

Assessment of Proteomic Measures Across Serious Psychiatric Illness. (2017) Schulz SC, Overgaard S, Bond DJ, Kaldate R. Clin Schizophr Relat Psychoses

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints. (2017) Phillips B, Titz B, Kogel U, Sharma D, Leroy P, Xiang Y, Vuillaume G, Lebrun S, Sciuscio D2, Ho J, Nury C2, Guedj E, Elamin A, Esposito M, Krishnan S, Schlage WK, Veljkovic E, Ivanov NV, Martin F, Peitsch MC, Hoeng J, Vanscheeuwijck P Food Chem Toxicol.

In Vivo Toxicity Assessment of Occupational Components of the Carbon Nanotube Life Cycle To Provide Context to Potential Health Effects. (2017) Bishop L, Cena L, Orandle M, Yanamala N, Dahm MM, Birch ME, Evans DE, Kodali VK, Eye T1, Battelli L, Zeidler-Erdely PC, Casuccio G, Bunker K, Lupoi JS, Lersch TL, Stefaniak AB, Sager T, Afshari A, Schwegler-Berry D, Friend S, Kang J, Siegrist KJ, Mitchell CA, Lowry DT, Kashon ML, Mercer RR, Geraci CL, Schubauer-Berigan MK, Sargent LM, Erdely A. ACS Nano.

Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study (2017) Duffy D, Rouilly V, Braudeau C, Corbi?re V, Djebali R, Ungeheuer MN, Josien R, LaBrie ST, Lantz O, Louis D, Martinez-Caceres E, Mascart F, Ruiz de Morales JG, Ottone C, Redjah L, Guen N, Savenay A, Schmolz M, Toubert A, Albert ML Clin Immunol

Changes in IL-17A, macrophage-derived chemokine and adiponectin following treatment of psoriasis with calcipotriol plus betamethasone dipropionate aerosol foam: results from the PSO-ABLE study. (2017) R?pke M, Bulai Livideanu C, Kaldate R, Snel A, Paul C Br J Dermatol.

Altered Immune Activation and IL-23 Signaling in Response to Candida albicans in Autoimmune Polyendocrine Syndrome Type 1 (2017) Bruserud O, Bratland E, Hellesen A, Delaleu N, Reikvam H, Oftedal BE, and Wolff A Front Immunol.

Inflammatory proteins in nasal lavage of workers exposed to occupational agents. (2017) Castano R, Yucesoy B, Johnson VJ, Castellanos L, Cartier A Clin Exp Allergy

Intrathecal 2-hydroxypropyl-?-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial. (2017) Ory DS, Ottinger EA, Farhat NY, King KA, Jiang X, Weissfeld L, Berry-Kravis E, Davidson CD, Bianconi S, Keener LA, Rao R, Soldatos A, Sidhu R, Walters KA, Xu X, Thurm A, Solomon B, Pavan WJ, Machielse BN, Kao M, Silber SA, McKew JC, Brewer CC, Vite CH, Walkley SU, Austin CP, Porter FD Lancet

Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons. (2017) Parviainen L, Dihanich S, Anderson GW, Wong AM, Brooks HR, Abeti R, Rezaie P, Lalli G, Pope S, Heales SJ, Mitchison HM, Williams BP, Cooper JD Acta Neuropathol Commun.

Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer. (2017) Yeh CY, Adusumilli R, Kullolli M, Mallick P, John EM, Pitteri SJ Biomark Res.

Perspectives on using a multiplex human kidney safety biomarker panel to detect cisplatin-induced tubular toxicity in male and female Cynomolgus monkeys. (2017) Chen Y, Dale Thurman J, Kinter LB, Bialecki R, Eric McDuffie J Toxicol Appl Pharmacol.

Biomarker-guided stratification of autoimmune patients for biologic therapy. (2017) Ivison S, Des Rosiers C, Lesage S, Rioux JD, Levings MK. Curr Opin Immunol.

Exercise training reverses inflammation and muscle wasting after tobacco smoke exposure. (2017) Kr?ger K, Seimetz M, Ringseis R, Wilhelm J, Pichl A, Couturier A, Eder K, Weissmann N, Mooren FC Am J Physiol Regul Integr Comp Physiol.

Randomized clinical study of safety, pharmacokinetics, andpharmacodynamics of RIPK1 inhibitor GSK2982772 in healthyvolunteers (2017) Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JE, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang M Pharmacol Res Perspect.

Differential expression of P2X7 receptor and IL-1? in nociceptive and neuropathic pain. (2016) Luchting B, Heyn J, Woehrle T, Rachinger-Adam B, Kreth S, Hinske LC, Azad SC J Neuroinflammation

Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats. (2017) Chen G, Xu Y Mater Sci Eng C Mater Biol Appl.

The role of anxious distress in immune dysregulation in patients with major depressive disorder. (2017) Gaspersz R, Lamers F, Wittenberg G, Beekman ATF, van Hemert AM, Schoevers RA, Penninx BWJH Transl Psychiatry

Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers. (2017) Sgambato JA, Jones BA, Caraway JW, Prasad GL Cytokine

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. (2017) Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI J Immunother Cancer

The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia. (2017) Quiros-Roldan E, Castelli F, Lanza P, Pezzoli C, Vezzoli M; Inflammation in HIV Study Group, Biasiotto G, Zanella I J Transl Med.

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges. (2017) Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L, Milieu Int?rieur Consortium Proc Natl Acad Sci U S A

Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study (2018) Wolters F, Boender J, de Vries P, Sonneveld M, Koudstaal P, de Maat M, Franco O, Ikram M, Leebeek F, Ikram MA Scientific Reports 2018 Apr

A Multi-site In-depth Evaluation of the Qunaterix Simoa from a Users Perspective (2018) Chunyk A, Joyce A, Fischer S, Dysinger M, Mikulskis A, Jeromin A, Lawrence-Henderson R, Baker D, Yeung D The AAPS Journal 2018

Comparison of a microsphere-based platform with a multiplex flow cytometric assay for determination of circulating cytokines in the mouse (2018) Stricker-Krongrad A, Shoemake C, Zhong M, Liu J, Bouchard G BMC Clinical Pathology Jan 2018

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle (2018) Stein MM, Thempson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Morin A, Washinton C, Nicolae D, Bonnelykke K, Ober C J Allergy Clin Immunol 2018

Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease (2018) Gu JM, Yuam S, Sim D, Abe K, Liu P, Rosenbruch M, Bringmann P, Kauser K Experimental Hematology 2018

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury (2018) Proudfood A, Bayliffe A, OKane C, Wright T, Serone A, Bareille P, Brown V, Hamid U, Chen Y, Wilson R, Cordy J, Morley P, de Wildt Ruud, Elborn S, Hind M, Chilvres E, Griffiths M, Summers C, McAuley D Thorax

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One

Allostatic load is associated with psychotic symptoms and decreases withantipsychotic treatment in patients with schizophrenia and ?rst-episodepsychosis (2018) Berger M, Juster RP, Westphal S, Amminger P, Bogerts B, Schiltz K, Bahn S, Steiner J, Sarnyai Z Psychoneuroendocrinology

Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in (2018) Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, OConnell A, Chan G, Cortes JE Clinical Cancer Research

Embelin and its derivatives unravel the signaling, proin?ammatoryand antiatherogenic properties of GPR84 receptor (2018) Gaidarov I, Anthony T, Gatlin J, Chen X, Mills D, Solomon M, Han S, Semple G, Unett DJ Pharmacological Research

Biomarkers of diabetic kidney disease (2018) Colhoun HM, Marcovecchio ML Diabetologia

Effects of canagliflozin versus glimepiride on adipokines and in inflammatory biomarkers in type 2 diabetes (2018) Garvey WT, Van Gaal L, Leiter LA, Vijapurkar U, List J, Cuddihy R, Ren J, Davies M Metabolism Clinical and Experimenta

The Orally Available Selective Axl Inhibitor BGB324 Induces Diversification of the Immune Repertoire and Specific Changes in Plasma Biomarker Profiles (2017) Loges S, Gjertsen BT, Heuser M, Chromik J, Ben-Batalla I, Akyuz N, Micklem D, Brown A, Lorens J, Yule M, Kebenko M, Janning M, Binder M, Fiedler W, Cortes J Blood

S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome (2018) Wang L, Rose CD, Foley KP, Anton J, Bader-Meunier B, Brissaud P, Chedeville G, Cimaz R, Fernandez-Martin J, Guly C, Hachulla E, Harjacek M, Mackensen F, Merino R, Modesto C, Hernandez A, Pajot C, Ramanan A, Thatayatikom A, Thomee C, Vastert S, Votta B, Bertin J, Wouters CH Rheumatology

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study (2017) Maher TM, Oballa E, Simpson JK, Porte J, Habgood A, Fahy WA, Flynn A, Monlyneaux PL, Braybrooke R, Divyateja H, Parfrey H, Rassl D, Russell AM, Saini G, Renzoni EA, Duggan AM, Hubbard R, Wells AU, Lukey PT, Marshall RP, Jenkins RG Lancet Respir Med

Toxoplasma gondii inactivates human plasmacytoid dendritic cells by functional mimicry of IL-10 (2018) Piotr L, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P The Journal of Immunology

Pharmacokinetics of Telavancin at Fixed Doses in Normal-Body-Weight and Obese (Classes I, II and III) Adult Subjexts (2018) Bunnell KL, Pai MP, Sikka M, Bleasdale S, Wenzler E, Danziger LH, Rodvold KA Antimicrobial Agents and Chemotherapy

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS (2018) Putcha N, Paul GG, Azar A, Wise RA, ONeal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R 3rd, Han MK, Martinez FJ, Bowler RP, Barr RG, Hansel NN, SPIROMICS investigators PLoS One

Carbon nanotube and nanofiber exposure and sputum and blood biomarkers of early effect among U.S. workers (2018) Beard JD, Erdely A, Dahm MM, de Perio MA, Birch ME, Evans DE, Fernback JE, Eye T, Kodali V, Mercer RR, Bertke SJ, Schubauer-Berigan MK Environmental Internation 116 (2018)

CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype (2018) Candido J, Morton JP, Bailey P, Barry ST, Balkwill FR, Sansom OJ Cell Reports

Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease (2018) Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E Journal of Inherited Metabolic Disease

Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study (2018) Andersen M, Boesen M, Ellegaard K, Soderstrom K, Soe NH, Spee P, Morch UGW, Torp-Pedersen S, Bartels EM, Danneskiold-Samsoe B, Karlsson L, Bliddal H Plos One

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort (2018) Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine III R, Ortega VE, Peters SP, Krishnan JA, Bowler RP Respiratory Medicine

IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses (2018) van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICP, de Jong HM, Fluri IA, Latuhihin TE, van Kuijk AWR, Rogge L, Yeremenko NG, Baeten DLP Arthritis Rheumatol

A clinical and proteomics approach to predict the presense of obstructive peripheral arterial disease (From CASABLANCA) (2018) McCarthy CP, Ibrahim NE, van Kimmenade RRJ, Gaggin HK, Simon ML, Gandhi P, Kelly N, Motiwala SR, Mukai R, Magaret CA, Barnes G, Rhyne RF, Garasic JM, Januzzi JL Jr Clin Cardiol

Networks of blood proteins in the neuroimmunology of schizophrenia (2018) Jeffries CD, Perkins DO, Fournier M, Do KQ, Cuenod M, Khadimallah I, Domenici E, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang M, Walker EF, Woods SW Transl Psychiatry

Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis (2018) Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG Journal of Allergy and Clinical Immunology

Cellular toxicity of silicon carbide nanomaterials as a function of morphology (2018) Chen F, Li G, Zhao ER, Li J, Hableel G, Lemaster JE, Bai Y, Sen GL, Jokerst JV Biomaterials

Cereblon modulator iberdomide induces degradation of the transcription factor Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus (2018) Schafer PH, Ye Y, Wu L, Kosek J, Ringheim G, Yang Z, Liu L, Thomas M, Palmisano M, Chopra R Ann Rheum Dis

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer (2018) Calcinottoa A, Spataro C, Zagato E, Di Mitri D, Gil V, Crespo M, De Bernardis G, Losa M, Mirenda M, Pasquini E, Rinaldi A, Sumanasuriya S, Lambros MB, Neeb A, Luciano R, Bravi CA, Nava-Rodriques D, Dolling D, Prayer-Galetti T, Ferreira A, Briganti A, Esposito A, Barry S, Yuan W, Sharp A, de Bono J, Alimonti A Nature

Standardized Immunomonitoring: Separating the Signals from the Noise (2018) Duffy D Trends in Biotechnology

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome (2018) Lal C, Hardiman G, Kumbhare S, Strange C Sleep and Breathing

Effects of an FcyRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies (2018) Stein MM, Hrusch CL, Sperling AI, Ober C Genes and Immunity

Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease (2018) Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, Hess S, Pare G Journal of the American College of Cardiology

Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project (2018) Vonaesch P, Randremanana R, Gody JC, Collard JM, Giles-Vernick T, Doria M, Vigan-Womas I, Rubbo PA, Etienne A, Andriatahirintsoa EJ, Kapel N, Brown E, Huus KE, Duffy D, Finlay BB, Hasan M, Hunald FA, Robinson A, Manirakiza A, Wegener-Parfrey L, Vray M, Sansonetti PJ BMC Pediatrics

Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension (2018) Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A Pulmonary Circulation

Testing a multivariate proteomic panel for TBI biomarker discovery: A track-TBI pilot study (2018) Huie JR, Diaz-Arrastia R, Yue JK, Sorani M, Puccio A, Okonkwo DO, Manley GT, Ferguson AR Journal of Neurotrauma

Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrom (2018) Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A American Journal of Respiratory and Critical Care Medicine

Circulating biomarkers from the phase I trial of sirolimus and autophagy inhibition for patients with lymphangioleiomyomatosis (SAIL). (2018) Lamattina AM, Taveira-Dasilva A, Goldberg HJ, Bagwe S, Cui Y, Rosas IO, Moss J, Henske EP, El-Chemaly S Chest Journal

Altered regulation of the T-cell system in patients with CRPS (2018) Heyn J, Azad SC, Luchting B Inflammation Research

A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis (2018) Palmer SM, Snyder L, Todd JL, Soule B, Christian R, Anstrom K, Luo Y, Gagnon R, Rosen G Chest Journal

The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and -negative subjects. A post-hoc analysis of the ORIGIN-trial (2018) Birkeland KI, Grill V, Wium C, McQueen MJ, Lopez-Jaramillo P, Lee SF, Gerstein HC Diabetes, Obesity and Metabolism

Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions (2018) Mozaffari SV, Stein MM, Magnaye KM, Nicolae DL, Ober C PLoS One

Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy) (2018) Anroedh SS, Akkerhuis KM, Oemrawsingh RM, Garcia-Garcia HM, Brankovic M, Regar E, van Geuns RJ, Serruys PW, Daemen J, Van Mieghem NM, Boersma E, Kardys I Current Atherosclerosis Reports

Adiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome (2018) Marino BCA, Buljubasic N, Akkerhuis M, Cheng JM, Garcia-Garcia HM, Regar E, van Guens RJ, Serruys PW, Boersma E, Kardys I Sociedade Brasileira De Cardiologia

Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction (2018) Lindsey ML, Ma Y, Flynn ER, Winniford MD, Hall ME, DeLeon-Pennell KY BBA - Molecular Basis of Disease

Dose escalation results from a first-in-human, phase I study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors (2018) Tran B, Carvajal RD, Marabelle A, Patel SP, LoRusso PM, Rasmussen E, Juan G, Upreti VV, Beers C, Ngarmchamnanrith G, Schoffski P Journal for ImmunoTherapy of Cancer

Amygdalar activity predicts future incident diabetes independently of adiposity (2019) Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A Psychoneuroendocrinology

Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants (2018) Timmers M, Ravenstijn P, Xi L, Triana-Baltzer G, Furey M, Van Hemelryck S, Biewenga J, Ceusters M, Bhattacharya A, van den Boer M, van Nueten L, de Boer P Journal of Psychopharmacology

Peripheral immune system in aging and Alzheimers disease. (2018) Cao W, Zheng H Molecular Neurodegeneartion

Serum kidney injury molecule 1 and B2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes (2018) Colombo M, Looker HC, Farran B, Hess S, Groop L, Palmer CNA, Brosnan MJ, Dalton RN, Wong M, Turner C, Ahlqvist E, Dunger D, Agakov F, Durrington P, Livingstone S, Betteridge J, McKeigue PM, Colhoun HM Diabetologia

Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines (2018) Dandekar MP, Saxena A, Scaini G, Shin JH, Migut A, Giridharan VV, Zhou Y, Barichello T, Soares JC, Quevedo J, Fenoy AJ Molecular Neurobiology

Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103) (2018) Lindemann K, Beale PJ, Rossi E, Goh JC, Vaughan MM, Tenney ME, Martyn JK, Sommeijer D, Iglesias JL, Kremmidiotis G, Simpson J, Doolin E, Lavranos TC, Veillard AS, Espinoza D, Stockler MR, Rischin D Cancer Chemotherapy and Pharmacology

Multiple biomarker panel to screen for severe aortic stenosis: results from the CASABLANCA study (2018) Elmariah S, McCarthy C, Ibrahim N, Furman D, Mukai R, Magaret C, Rhyne R, Barnes G, van Kimmenade RRJ, Januzzi Jr JL Open Heart

Phase I/II trial of combination of anti-CD3/CD7 immunotoxins for steroid-refractory acute graft-versus-host disease (2018) Groth C, van Groningen LFJ, Matos TR, Bremmers ME, Preijers FWMB, Dolstra H, Reicherts C, Schaap NPM, van Hooren EHG, IntHout J, Masereeuw R, Netea MG, Levine JE, Morales G, Ferrara JL, Blijlevens NMA, van Oosterhout YVJM, Stelljes M, van der Velden WJFM Biology of Blood and Marrow Transplantation

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients (2018) Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Autio KA, Wong DJ, Patel MR, Ott PA, Falchook GS, Pant S, Hung A, Pekarek KL, Wu V, Adamow M, McCauley S, Mumm JB, Wong P, Van Vlasselaer P, Levegue J, Tannir NM, Oft M Cancer Cell

Elevated circulating MMP-9 is linked to increased COPD exacerbation in SPIROMICS and COPDGene (2018) Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, ONeal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A JCI Insight

Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE (2018) Casey KA, Guo X, Smith MA, Wang S, Sinibaldi D, Sanjuan MA, Wang L, Illei GG, White WI Lupus Science and Medicine

Association of baseline inflammatory markers and the development of negative symptoms in individuals at clinical high risk for psychosis (2018) Goldsmith DR, Haroon E, Miller AH, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Mathalon D, McGlashan T, Seidman L, Tsunag M, Woods SW, Walker EF, Perkins DO Brain, Behavior, and Immunity

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Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition (2020) Laino AS, Woods D, Vassallo M, Qian X, Tang H, Wind-Rotolo M, Weber J Journal for ImmunoTherapy of Cancer

Proteomic profiling as a diagnotic biomarker for discriminating between bipolar and unipolar depression (2020) Kittel-Schneider S, Hahn T, Haenisch F,McNeill R, Reif A, Bahn S Frontiers in Psychiatry

Elevated plasma cortisol associated with larger ventricles and smaller hippocampal volumes - a study in 2 independent elderly cohorts (2020) Rajagopalan P, Nho K, Risacher SL, Jahanshad N, Boyle CP, Saykin AJ, Thompson PM bioRxiv

The effects of rare SERPINA1 variants on lung function and emphysema in SPIROMICS (2020) Ortega VE, Li X, ONeal WK, Lackey L, Ampleford E, Hawkins GA, Grayeski P, Laederach A, Barjaktarevic I, Barr RG, Cooper C, Douper D, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Paine R III, Peters SP, Pirozzi C, Rennard SI, Woodruff PG, Hoffman EA, Meyers DA, Bleecker ER American Journal of Respiratory and Critical Care Medicine

Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties (2020) Barrera LN, Evans A, Lane B, Brumskill S, Oldfield FE, Campbell F, Andrews T, Lu Z, Perez-Mancera PA, Liloglou T, Ashworth M, Jalali M, Dawson R, Nunes Q, Phillips PA, Timms JF, Halloran C, Greenhalf W, Neoptolemos JP, Costello E Cancer Research

Predicting and elucidating the etiology of fatty liver disease: a machine learning modeling and validation study in the IMI DIRECT cohorts (2020) Atabaki-Pasdar N, Ohlsson M, Vinuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chaanova E, Dale M, De Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong MG, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Haussler RS, Sharma S, Thomsen HS, Vangipurapu J, Vestergaard H, t Hart LM, Adamski J, Musholt P, Brage S, Brunak S, Dermitzakis E, Frost G, Hansen T, Laakso M, pedersen O, Ridderstrale M, Ruetten H, Hattersley AT, Walker M, Beulens JWJ, Mari A, Schwenk JM, Gupta R, McCarthy MI, Pearson ER, Bell JD, Pavo I, Franks PW PLoS Medicine

A phase I study of ASTX660, an antagonist of inhibitors of apoptosis proteins, in adults with advanced cancers or lymphoma (2020) Mita MM, LoRusso PM, Papadopoulos KP, Gordon MS, Mita AC, Ferraldeschi R, Keer H, Oganesian A, Su XY, Jueliger S, Tolcher AW Clinical Cancer Research

Towards standardization of immune functional assays (2020) Mouton W, Albert-Vega C, Boccard M, Bartolo F, Oriol G, Lopez J, Pachot A, Textoris J, Mallet F, Brengel-Pesce K, Trouillet-Assant S Clinical Immunology

Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium bacillus calmette guerin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy (2020) Rentsch CA, Bosshard P, Mayor G, Rieken M, Puschel H, Wirth G, Cathomas R, Parzmair GP, Grode L, Eisele B, Sharma H, Gupta M, Gairola S, Shaligram U, Goldenberger D, Spertini F, Audran R, Enoui M, Beradi S, Hayoz S, Wicki A Oncoimmunology

An integrative study of five biological clocks in somatic and mental health (2020) Jansen R, Verhoeven J, Han LKM, Aberg KA, van den Oord ECGJ, Milaneschi Y, Penninx BWJH bioRxiv

Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus (2020) Smith MA, Chiang CC, Zerrouki K, Rahman S, White W, Streicher K, Rees WA, Schiffenbauer A, Rider LG, Miller FW, Manna Z, Hasni S, Kaplan M, Siegel R, Sinibaldi D, Sanjuan MA, Casey KA Scientific Reports

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitnes in old age (2020) Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbaren N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A Nature Metabolism

Impact of carbohydrate-reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial (2020) Rahmel T, Hubner M, Koos B, Wolf A, Willemsen KM, Straub G, Effinger D, Adamzik M, Kreth S BMJ Open

Preoperative TruCulture whole blood cytokine response predicts postoperative inflammation in pancreaticoduodenectomy patients - a pilot cohort study (2020) Aasvang EK, Pitter S, Hansen CP, Storkholm JH, Krohn PS, Burgdorf SK, Von Stemann JH, Lundgren JD, Nielsen SD, Kehlet H, Ostrowski SR Scandinavian Journal of Immunology

Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression (2020) van Eeden WA, van Hemert AM, Carlier IVE, Penninx BWJH, Fried EI, Schoevers R, Giltay EJ Translational Psychiatry

Immune transriptome of cells infected with enterovirus strains obtained from cases of type 1 diabetes (2020) Poma AM, Genoni A, Broccolo F, Denaro M, Pugliese A, Basolo F, Toniolo A Microorganisms

Inexpensive, non-invasive biomarkers predict Alzheimer transition using machine learning analysis of the Alzheimers Disease Neuroimaging (ADNI) database (2020) Beltran JF, Wahba BM, Hose N, Shasha D, Kline RP, ADNI PLoS One

Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study (2020) Genovese MC, Gaylis NB, Sikes D, Kivitz A, Horowitz DL, Peterfy C, Glass EV, Levine YA, Chernoff D The Lancet Rheumatology

Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration (2020) Lashkari K, Teague GC, Beattie U, Betts J,Kumar S, McLaughlin MM, Lopez FJ PLOS One

Model informed dosing regimen and phase I results of the anti-PD-1 antibody budigalimab (ABBV-181) (2020) Powderly J, Spira A, Kondo S, Doi T, Luke JL, Rasco D, Gao B, Tanner M, Cassier PA, Gazzah A, Italiano A, Tosi D, Afar DE, Parikh A, Engelhardt B, Englert S, Lambert SL, Kasichayanula S, Mensing S, Menon R, Vosganian G, Tolcher A Clinical and Translational Science

Reduced chronic toxicity and carcinogenicity in A/J mice in response to life-time exposure to aerosol from a heated tobacco product compared with cigarette smoke (2020) Wong ET, Luettch K, Krishan S, Wong SK, Lim WT, Yeo D, Buttner A, Leroy P, Vuillaume G, Boue S, Hoeng J, Vansheeuwijck P, Peitsch M Toxicological Sciences

Investigating data-driven biological subtypes of sychiatric disorders using specification-curve analysis (2020) Beijers L, van Loo HM, Romeijn JW, Lamers F, Schoevers RA, Wardenaar KJ Psychological Medicine

Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes (2020) Adams SF, Grimm AJ, Chiang CLL, Mookerjee A, Flies D, Jean S, McCann GA, Michaux J, Pak H, Huber F, Neal C, Dangaj D, Bassani-Sternberg M, Rusakiewicz S, Facciabene A, Coukos G, Gimotty PA, Kandalaft LE Journal for ImmunoTherapy of Cancer

Molecular biomarkers of anti-TNF response in patients with rheumatoid arthritis (2020) Yoosuf N, Maciejewski M, Ziemek D, Jelinsky S, Folkersen, Muller M, Sahlstrom P, Vivar N, Catrina A, Berg L, Klareskog L, Padyukov L, Brynedal B Arthritis Research & Therapy

Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,30dioxygenase 2, in patients with advanced solid tumors (2020) Naing A, Eder JP, Piha-Paul SA, Gimmi C, Hussey E, Zhang S, Hildebrand V, Hosagrahara V, Habermehl C, Moisan J, Papadopoulos KP Journal for ImmunoTherapy of Cancer

Genetics meets proteomics: perspectives for large population-based studies (2020) Suhre K, McCarthy MI, Schwenk JM Nature Reviews Genetics

Modulation of cardiometabolic disease markers by type I interferon inhibition in systemic lupus erythematosus (2020) Casey KA, Smith MA, Sinibaldi D, Seto NL, Playford MP, Wang X, Carlucci PM, Wang L, Illei G, Yu B, Wang S, Remaley AT, Mehta NH, Kaplan MJ, White WI Arthritis Rheumatology

Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimers disease (2020) Pillai JA, Bena J, Bebek Gurkan, Bekris LM, Bonner-Jackson A, Kou L, Pai A, Sorensen L, Neilsen M, Rao SM, Chance M, Lamb BT, Leverenz JB, Alzheimers Disease Neuroimaging Initiative Annals of Clinical and Translational Neurology

HepatoScore-14: Measures of biological heterogeneity significantly improve prediction of hepatocellular carcinoma risk (2020) Morris JS, Hassan MM, Zohner YE, Wang Z, Xiao L, Rashid A, Haque A, Abdel-Wahab R, Mohamed YA, Ballard KL, Wolff RA, George B, Li L, Allen G, Weylandt M, Li D, Wang W, Raghav K, Yao J, Amin HM, Kaseb AO Heptology

Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab - a study protocol (2020) Takeshi N, Kenji I, Daisuke O, Satoshi N, Risa TM, Koji M, Susumu I, Hidehisa S, Yudai K, Riichiro A, Mamitaro O, Koji K, Tatsuro O, Tomomitsu M, Yozo I, Akihiko a, Hiroshi K, Keiji T, Hiroshi M, Tatsuyoshi K, Takuya T, Masashi A, Emi N, Akimchi M, Kyoko t, Yukinobu N, Koji S, Chicharu T, YOko K, Rai F, Sakae K, Eishin M, Akio T, Mchihiro H, Natsuko A, Shigetoshi S, Haruna M, Yutaka H, Motoi T, Hiroyuki M, Norito K, Masutaka F Medicine

First-in-human, single- and multiple-ascending dose studies in healthy subjects to assess pharmacokinetics, pharmacodynamics, and safety/tolerability of iberdomide, a novel cereblon E3 ligase modulator (2020) Ye Y, Gaudy A, Schafer P, Thomas M, Weiss D, Chen N, Liu L, Xue Y, Carayannopoulos L, Palmisano M Clinical Pharmacology in Drug Development

Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study (2020) Albert Vega C, Oriol G, Bartolo F, Lopez J, Pachot A, Rimmele T, Venet F, Leray V, Monneret G, Delwarde B, Brengel-Pesce K, Textoris J, Mallet F, Trouillet-Assant S Scientific Reports

Immune profiling enables stratification of patients with active TB disease or M. tuberculosis infection (2020) Duffy D, Nemes E, Llibre A, Rouilly V, Musvosvi M, Smith N, Filander E, Africa H, Mabwe S, Jaxa L, Charbit B, Mulenga H, the Milieu Interieur Consortium, Tameris M, Walzl G, Malherbe S, Thomas S, Hatherill M, Bilek N, Scriba TJ, Albert ML Clinical Infectious Diseases

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals (2020) Fokersen L, Gustafsson S, Qang Q, Hansen DH, Hedman AK, Schork A, Page K, Zhernakova DV, Wu Y, Peteres J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Entroth S, Kalnapenkis A, Gadin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Smith GD, de Masi F, Elmstahl S, Engstrom G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson A, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Magi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Palsson E, Qi T, Sjogren M, Sundstrom J, Surendran P, Vosa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Arnlov J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Homes MV, Ingelsson E, Malarstig A Nature Metabolism

Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial (2020) Aranow C, Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos TP, Datta-Chaundhuri T, Bouton C, Tracey KJ, Diamond B Annals of the rheumatic diseases

Methamphetamine increases the proportion of SIV-infected microglia/macrophases, alters metabolic pathways, and elevates cell death pathways: a single-cell analysis (2020) Niu M, Morsey B, Lamberty BG, Emanuel K, Yu F, Leon-Rivera R, Berman JW, Gaskill PJ, Matt SM, Ciborowski PS, Fox HS Viruses

Efficacy and safety of abatacept in active primary Sj?grens syndrome: results of a phase III, randomised, placebo-controlled trial (2020) Baer AN, Gottenberg JE, St Clair EW, Sumida T, Takeuchi T, Seror R, Foulks G, Nys M, Mukherjee S, Wong R, Ray N, Boothsma H Annals of the Rheumatic Disease

Basal forebrain degeneration and cortisol as biomarkers mediating Alzheimers disease pathology: a machine learning approach (2020) Nakirikanti AS Research Thesis

The utility of novel urinary biomarkers in mice for drug development studies (2020) Adedeji AO, Gu YZ, Pourmohamad T, Kanerva J, Chen Y, Atabakhsh E, Tackett MR, Chen F, Bhatt B, Gury T, Dorchies O, Sonee M, Morgan M, Burkey J, Gautier JC, McDuffie JE International Journal of Toxicology

Left and right atrial biomarker analysis in atrial fibrillation (2020) Goldberger JJ, Green D, Ringwala S, Andrei AC, Xu Y, Passman R JACC Clinical Electrophysiology

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo (2020) Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermuller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot G, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S, Milieu interieur Consortium, Sellam J, Berenbaum F, Miceli C, Dougados M, Bianchi E, Rogge L Ann Rheum Dis

Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort (2020) Bauer Y, de Bernard S, Hickey P, Ballard K, Cruz J, Cornelisse P, Chadha-Boreham H, Distler O, Rosenberg D, Doelberg M, Roux S, Nayler O, Lawrie A European Respiratory Journal

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker for COPD (2020) Pratte KA, Curtis JL, Kechris K, Couper D, Cho MH, Silverman EK, DeMeo DL, Sciurba FC, Zhang Y, Ortega VE, ONeal W, Gillenwater LA, Lynch DA, Newell Jr JD, Comellas AP, Castaldi PJ, Miller B, Pouwels SD, ten Hacken NHT, Bischoff R, Klont F, Woodruff P, Paine R, Barr RG, Hoidal J, Doerschuk CM, Charbonnier JP, Sung R, Locantore N, Yonchuk J, Tal-Singer R, Jacobson S, Merrill D, Bowler RP Research Square

Characterization of LY2775240, a selective phosphodiesterase-4 inhibitor, in nonclinical models and in healthy subjects (2020) Patel DR, Urva S, Ho S, Buckman CJ, Ma Y, Lim J, Sissons SE, Zuniga MS, Philips D, Cox K, Dairaghi D Clinical and Translational Science

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Assessment of advanced glycation end products and receptors and the risk of dementia (2021) Chen J, Mooldijk SS, Licher S, Waqas K, Ikram MK, Uitterlinden AG, Zillikens MC, Ikram MA JAMA Network Open

Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes (2021) Stein MM, Conery M, Magnaye KM, Clay SM, Billstrand C, Nicolae R, Naughton K, Ober C, Thompson EE Scientific Reports

A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy (2021) Choueiri TK, Atkins MB, Rose TL, Alter RS, Yawen J, Niland K, Wang Y, Arbeit R, Parasuraman S, Gan L, McDermott DF Investigational New Drugs

First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects (2021) Yang J, Lickliter JD, Hilson JL, Means GD, Sanderson RJ, Carley K, Tercero A, Manjarrez KL, Wiley JR, Peng SL Clinical and Translational Science

LY3022855, an anti-colony stimulating factor-1 receptor (CSF-1R) monoclonal antibody, in patients with advanced solid tumors refractory to standard therapy: phase 1 dose-escalation trial (2021) Dowlati A, Jarvey RD, Carvajal RD, Hamid O, Klempner SJ, Wook Kauh JS, Peterson DA, Yu D, CHapman SC, Szpurka AM, Carlsen M, Quinlan T, Wesolowski R Investigational New Drugs

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers (2021) Mezghiche I, Yahia-Cherbal H, Rogge L, Bianchi E Expert Review of Clinical Immunology

Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response (2021) Aevermann B, Shannon CP, Novotny M, Ben-Othman R, Cai B, Zhang Y, Ye JC, Kobor MS, Gladish N, Lee A, Blimke TM, Hancock RE, Llibre A, Duffy D, Koff WC, Sadarangani M, Tebbutt SJ, Kollmann TR, Scheuermann RH medRxiv

Novel signatures associated with systemic lupus erythematosus clinical response to IFN-a/-? inhibition (2021) Seridi L, Cesaroni M, Orillion A, Schreiter J, Chevrier M, Marciniak S, Migone TS, Stohl W, Chatham WW, Furie RA, Benson J, Jordan J Lupus

TNFRSF1B gene variants and related soluble TNFR2 levels impact reilience in Alzheimers disease (2021) Pillai JA, Bebek G, Khrestian M, Bena J, Bergmann CC, Bush WS, Leverenz JB, Bekris LM Frontiers in Aging Neuroscience

Influence of cell quality on inflammatory biomarkers in COPD sputum supernatant (2021) Pedersen F, Trinkmann F, Abdo M, Kirsten AM, Rabe KF, Watz H, Baraldo S, Saetta M, Hohlfeld JM, Holz O International Journal of Chronic Obstructive Pulmonary Disease

Molecular correlates of response to nivolumab at baseline and on treatment in patients with RCC (2021) Ross-Macdonald P, Walsh AM, Chasalow SD, Ammar R, Papillon-Cavanagh S, Szabo pm, Choueiri TK, Sznol M, Wind-Rotolo M Journal for Immunotherapy for Cancer

Identifying associations among genomic, proteomic and imaging biomarkers via adaptive sparse multi-view canonical correlation analysis (2021) Du L, Zhang J, Liu F, Wang H, Guo L, Han J, the Alzheimers Disease Neuroimaging Initiative Medical Image Analysis

Primary human dendritic cells and whole-blood based assays to evaluate immuno-modulatory properties of heat-killed commensal bacteria (2021) Norton JE Jr., Kommineni S, Akrivoulis P, Gutierrez DA, Hazuda DJ, Swaminathan G Vaccines

Correlative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma (2021) Lee CH, Motzer RJ, Glen H, Michaelson MD, Larkin J, Minoshima Y, Kanekiyo M, Ikezawa H, Sachdev P, Dutcus CE, Funashashi Y, Voss MH British Journal of Cancer

Muscle damage in systemic sclerosis and CXCL10: The potential therapeutic role of PDE5 inhibition (2021) Corinalesi C, Ross RL, Abignano G, Antinozzi C, Marampon F, di Luigi L, Buch MH, Riccieri V, Lenzi A, Crescioli C, Del Galdo F International Journal of Molecular Sciences

Differential response induced by LPS and MPLA in immunocompetent and septic individuals (2021) Vega CA, Karakike E, Bartolo F, Mouton W, Cerrato E, Brengel-Pesce K, Giamarellos-Bourboulis EJ, Mallet F, Trouillet-Assant S Clinical Immunology

Characterization of the pathophysiological determinants of diarrheagenic Escherichia coli infection using a challenge model in healthy adults (2021) van Hoffen E, Mercenier A, Vidal K, Benyacoub J, Schloesser J, Kardinaal A, Lucas-van de Bos E, van Alen I, Rogero I, Duintjer K, Berendts A, Albers R, Kleerebezem M, Bruggencate ST Scientific Reports

Development of an affordable, sustainable and efficacious plant-based immunomodulatory food ingredient based on bell pepper or carrot RG-I pectic polysaccharides (2021) McKay S, Oranje P, Helin J, Koek JH, Kreijveld E, van den Abbeele P, Phol u, Bothe G, Tzoumaki M, Aparicio-Vergara M Nutrients

Nonclinical development of SRK-181: An anti-latent TGFb1 monoclonal antibody for the treatment of locally advanced or metastatic solid tumors (2021) Welsh BT, Faucette R, Bilic S, Martin CJ, Schurpf T, Chen D, Nicholls S, Lansita J, Kalra A International Journal of Toxicology

Functional immune reconstitution early after allogeneic hematopoietic cell transplantation: A comparison of pre- and post-transplantation cytokine responses in stimulated whole-blood (2021) Gjaerde LK, Brooks PT, Andersen NS, Friss LS, Kornblit B, Petersen SL, Schjodt I, Nielsen SD, Ostrowski SR, Sengelov H Scandinavaian Journal of Immunology

Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results (2021) Advani R, Moskowitz AJ, Bartlett NL, Vose J, Ramchandren R, Feldman T, LaCasce AS, Christian B, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF Blood

NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia ? A brief report from the ORIGIN trial (2021) Wijkman MO, Claggett BL, Pfeffer MA, Pare G, McQueen M, Hess S, Fu Lee S, Gerstein HC Journal of Diabetes and its Complications

Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study (2021) Goepfert PA, Fu B, Chabanon AL, Bonaparte MI, Davis MG, Essink BJ, Frank I, Haney O, Janosczyk H, Keefer MC, koutsoukos M, Kimmel MA, Masotti R, Savarino SJ, Schuerman L, Schwarts H, Sher LD, Smith J, Tavares-Da-Silva F, Gurunathan S, DiazGranados CA, de Bruyn G The Lancet, Infectious Disease

The Effect of a natural oral nutritional supplement on the level of intra-articular inflammatory mediators in patients with osteoarthritis of the knee (2021) Sharkey P, Shah Z, Gross M, Meade T, Davidoff S, Shohat N, Parvizi J Journal of Orthopaedic Experience and Innovation

Regional relationships between CSF VEGF levels and Alzheimers disease brain biomarkers and cognition (2021) Tubi MA, Kothapalli D, Hapenney M, Feingold FW, Mack WJ, King KS, Thompson PM, Braskie MN Neurobiology of Aging

Pretreatment with ibrutinib reduces cytokine secretion and limits the risk of obinutuzumab-induced infusion-related reactions in patients with CLL: analysis from the iLLUMINATE study (2021) Greil R, Tedeschi A, Moreno C, Anz B, Larratt L, Simkovic M, Gill D, Gribben JG, Flinn IW, Wang Z, Cheung LWK, Nguyen AN, Zhou C, Styles L, Demirkan F Annals of Hematology

Safety, pharmacokinetics, and efficacy of budigalimab with rovalpituzumab teserine in patients with small cell lung cancer (2021) Calvo E, Spira A, de Miguel M, Kondo S, Gazzah A, Millward M, Prenen H, Rottey S, Warburon L, Alanko T, Cassier PA, Yoh K, Italiano A, Moreno V, Peltola K, Seto T, Toyozawa R, Afar DE, Englert S, Komarnitsky P, Lambert S, Parikh A, Vosganian G, Gao B Cancer Treatment and Research Communities

Preclinical and clinical characterization of the ROR?t inhibitor JNJ-61803534 (2021) Xue X, De Leon-Tabaldo A, Luna-Roman R, Castro G, Albers M, Shoetens F, DePrimo S, Devineni D, Wilde T, Goldberg S, Hoffmann T, Fourie AM, Thurmond RL Scientific Reports

Ligand conjugate structure activity relationships and enhanced endosomal escape with a targeted polymer micelle in non-human primates (2021) Holland RJ, Lam K, Ye X, Martin AD, Wood MC, Palmer L, Fraser D, McClintock K, Majeski S, Jarosz A, Lee ACH, Thi EP, Judge A, Heyes J Molecular Therapy

Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons (2021) Anderson JA, Lea AJ, Voyles TN, Akinyi MY, Nyakundi R, Ochola L, Omondi M, Nyundo F, Zhang Y, Campos FA, Alberts SC, Archie EA, Tung J bioRxiv preprint

The migration of human follicular dendritic cell-like cell is facilitated by matrix metalloproteinase 3 expression that is mediated through TNFa-ERK1/2-AP1 signaling (2021) Pak HK, Kim YW, Nam B, Lee AN, Roh J, Gil M, Liu C, Chung YS, Park CS Journal of Immunology Research

Anti-interleukin-6 antibody clazakizumab in late antibody-mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism (2021) Muhlbacher J, Schorgenhofer C, Doberer K, Durr M, Budde K, Eskandary F, Mayer KA, Schranza S, Ely S, Reiter B, Chong E, Adler SH, Jilma B, Bohmig GA Transplant Internatinoal

Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming (2021) Hirschberger S, Straub G, Effinger D, Marstaller X, Ferstl A, Muller MB, Wu T, Hubner M, Rahmel T, Mascolo H, Exner N, Heb J, Kreth FW, Unger K, Kreth S EMBO Molecular Medicine

First-in-human phase 1 study of budigalimab, an anti-PD-1 inhibitor, in patients with non-small cell lung cancer and head and neck squamous cell carcinoma (2021) Italiano A, Cassier PA, Lin CC, Alanko T, Peltola KJ, Gazzah A, Shiah HS, Calvo E, Cervantes A, Roda D, Tosi D, Gao B, Millward M, Warburton L, Tanner M, Englert S, Lambert S, Parikh A, Afar DE, Vosganian G, Moreno V Cancer Immunology, Immunotherapy

Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid 1-42 (2021) Ekblad LL, Visser PJ, Tijims BM, for the Alzheimers Disease Neuroimaging Initiative Neurobiology of Aging

Improving the power to detect indirect effects in mediation analysis (2021) Kidd J, Lin DY Conrell University

CSF proteomic Alzheimers disease-predictive subtypes in cognitively intact amyloid negative individuals (2021) Tijms BM, Gobom J, Teunissen C, Dobricic V, Tsolaki M, Verhey F, Popp J, Martinex-Lage P, Vandenberghe R, Lleo A, Luis-Molineuvo J, Engelborghs S, Freund-Levi Y, Foelich L, Bertram L, Lovestone S, Streffer J, Vos S, ADNI, Blennow K, Scheltens P, Zetterberg H, Jelle Visser P Proteomes

Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice (2021) Yun JH, Lee CH, Liu S, Kim EY, Xu S, Curtis JL, Pinello L, Bowler RP, Silverman EK, Hersh CP, Zhou X JCI Insight

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Associations of the cerebrospinal fluid hepatocyte growth factor with Alzheimers disease pathology and cognitive function (2021) Zhao LJ, Wang ZT, Ma YH, Zhang W, Dong Q, Yu JT, Tan L, ADNI BMC Neurology

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Dissection of depression heterogeneity using proteomic clusters (2022) van Haeringen M, Milaneschi Y, Lamers F, Penninx BWJH, Jansen R Psychological Medicine

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Antibody profiles in COVID-19 convalescent plasma prepared with amotosalen/UVA pathogen reduction treatment (2022) Bagri A, de Assis RR, Tsai CT, Simmons G, Mei ZW, Von Goetz M, Gatmaitan M, Stone M, Di Germanio C, Martinelli R, Darst O, Rioveros J, Robinson PV, Ward D, Ziman A, Settel D, Khan S, Busch MP, Felgner PL, Corash LM Transfusion

Platelet-derived growth factor-BB and white matter hyperintensity burden in APOE4 carriers (2022) Arunima Kapoor, Daniel A Nation Cerebral Circulation - Cognition and Behavior

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Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients (2022) Marion Cremoni, S?bastien Cuozzo, Emanuela Martinuzzi, Susana Barbosa, Nadia Ben Hassen, Filippo Massa, Elisa Demonchy, Matthieu Durand, Olivier Thaunat, Vincent Esnault, Moglie Le Quintrec, Sophie Caillard, Nicolas Glaichenhaus, and Antoine Sicard Viruses

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Peripheral lymphocyte signaling pathway deficiencies predict treatment response in first-onset drug-na?ve schizophrenia (2022) Santiago G. Lago, Jakub Tomasik, Geertje F. Rees, Nitin Rustogi, Javier Vazquez-Bourgon, Sergi Papiol, Paula Suarez-Pinilla, Benedicto Crespo-Facorro, Sabine Bahn Brain Behavior and Immunity

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Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults (2022) DidacVidal-Pi?eiro, ?ysteinS?rensen, KajBlennow, Elettra Capogna, Nathalie Bodd Halaas, Ane-VictoriaId, Athanasia Monica Mowinckel, Joana Braga Pereira, Leiv Otto Watne, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell Neurobiology of Aging

Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation (2022) Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Li Tao, Catherine Demery-Poulos, Marcia Arenas-Hernandez, Gaurav Bhatti, Zhenjie Liu, Naoki Kawahara, Tomi Kanninen, Zachary Shaffer, Tinnakorn Chaiworapongsa, Kevin R. Theis, Adi L. Tarca & Nardhy Gomez-Lopez Inflammation Research

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Childhood trauma and LPS-stimulated inflammation in adulthood: Results from the Netherlands Study of Depression and Anxiety (2022) Ricki M.de Koning, Erika Kuzminskaite, Christiaan H.Vinkers, Erik J. Giltay, Brenda W.J.H.Penninx Brain, Behavior, and Immunity

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Distinct Immune Reconstitution Profiles Captured by Immune Functional Assays at 6 Months Post Allogeneic Hematopoietic Stem Cell Transplantation (2022) William Mouton, Anne Conrad, Vincent Alcazer, Mathilde Boccard, Maxime Bodinier, Guy Oriol, Fabien Subtil, Helene Labussiere-Wallet, Sophie Ducastelle-Lepretre, Fiorenza Barraco, Marie Balsat, Gaelle Fossard, Karen Brengel-Pesce, Florence Adler, Sophie Trouillet-Assant Transplantation and Cellular Therapy

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Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs (2022) Nickolas Chelyapov, Toai T Nguyen, Rafael Gonzalez Biochemistry and Biophysics Reports

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity (2022) Nika?a Smith, C?line Poss?m?, Vincent Bondet, Jamie Sugrue, Liam Townsend, Bruno Charbit, Vincent Rouilly, Violaine Saint-Andr?, Tom Dott, Andre Rodriguez Pozo, Nader Yatim, Olivier Schwartz, Minerva Cervantes-Gonzalez, Jade Ghosn, Paul Bastard, Jean Laurent Casanova, Tali-Anne Szwebel, Benjamin Terrier, Niall Conlon, Cliona OFarrelly, Cl?ona N? Cheallaigh, Nollaig M Bourke, Darragh Duffy Nature Communciations

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Elevated Levels of the Cytokine LIGHT in Pediatric Crohns Disease (2023) Christopher J Cardinale, Debra J Abrams, Frank D Mentch, John A Cardinale, Xiang Wang, Charlly Ka, Patrick M A Sleiman, Hakon Hakonarson Journal of Immunology

Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis (2023) Ahmad Akhgar, Dominic Sinibaldi, Lingmin Zeng, Alton B Farris III, Jason Cobb, Monica Battle, David Chain, Jennifer A Cann, Gabor G Illei, S Sam Lim , Wendy I White Lupis Science and Medicine

Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD (2023) Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, , Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas O. Joos, Thomas Knorpp, Nicole Schneiderhan-Marra and Kathrin Brockmann Nature

Hybrid and vaccine-induced immunity against SARS-CoV-2 in MS patients on different disease-modifying therapies (2022) Ilya Kister , Ryan Curtin, Jinglan Pei, Katherine Perdomo, Tamar E. Bacon, Iryna Voloshyna, Annals of Clinical and Translational Neurology

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Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF (2023) Elizabeth S Hickford, James O?Connell , Alison Maloney, Peter Florian, Geoffrey I Bioanalysis

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Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans (2023) Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan Brain Stimulation

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Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline (2023) Neel H. Mehta, Liangdong Zhou, Yi Li, Laura Beth McIntire, Anna Nordvig, Tracy Butler, Mony de Leon & Gloria C. Chiang Nature

Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas (2023) Andrew L Coveler, David C Smith, Tycel Phillips, Brendan D Curti, Sanjay Goel, Amitkumar N Mehta, Timothy M Kuzel, Svetomir N Markovic, Olivier Rixe, David L Bajor, Thomas F Gajewski, Martin Gutierrez, Hun Ju Lee, Ajay K Gopal, Paolo Caimi, Elisabeth I Heath, John A Thompson, Sahar Ansari, Celine Jacquemont, Ariel Topletz-Erickson, Peigen Zhou, Michael W Schmitt, Juneko E Grilley-Olson Journal for ImmunoTherapy of Cancer

Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers?In cognitively unimpaired older adults (2023) Elettra Capogna, Leiv Otto Watne, ?ystein S?rensen, Carlijn Jamila Guichelaar, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Pi?eiro Brain Behavior Immunology

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