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Olink — Scalable, multiplexed biomarkers

IQVIA Laboratories Protein Biomarkers performs Olink testing to support efficiency and precision in your clinical trials.
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IQVIA Laboratories Protein Biomarkers — formerly know as Rules-Based Medicine —  a leader in testing soluble proteins for 25 years — performs Olink testing to support efficiency and precision in your clinical trials. 

 

Olink’s proximity extension assay (PEA®) technology delivers the throughput you need without compromising specificity or scalability.

 

Whether you need a small panel of focused biomarkers or a comprehensive exploratory assessment, RBM has an Olink option to meet your needs.
Exceptional sensitivity and specificity

Detect proteins at femtograms per mililiter
Low sample volume

Numerous assays performed from a single sample
Built-in quality controls

Internal and external controls in all biomarker panels
Scalability

Take your findings from discovery toward clinical translation
Disease-specific panels

Measure the markers relevant to your therapeutic area

Target 48 Immune Surveillance

 

Target 48 Cytokine

 

Target 96 Immuno-Oncology

 

Target 96 Oncology II

 

Target 96 Cadiovascular II

 

Target 96 Cadiovascular III

 

Target 96 Immune Response

 

Target 96 Inflammation

 

Target 96 Metabolism

 

Target 96 Neuro Exploratory

 

 

Proven Performance, Proven Results

Tap each area to view examples across scalability, quality and sensitivity.

Exceptional Sensitivity and Specificity

Exceptional Sensitivity and Specificity

Detect proteins at femtograms per mililiter
Low sample volume

Low sample volume

Numerous assays performed from a single sample
Built-in quality controls

Built-in quality controls

Internal and external controls in all biomarker panels
Scalability

Scalability

Take your findings from discovery toward clinical translation
Disease-specific panels

Disease-specific panels

Measure the markers relevant to your therapeutic area

Proximity extension assay (PEA®) technology

RBM_OlinkBrochure_Final_Digital (3)-23

 

diagram1The Olink PEA technology employs a dual-recognition approach using antibody pairs labeled with complementary DNA oligonucleotides. 

RBM_OlinkBrochure_Final_Digital (3)-2

 

diagram2

When the antibody pair binds to the target protein, the oligonucleotides are brought into proximity and hybridize, creating a unique DNA barcode for each protein.

RBM_OlinkBrochure_Final_Digital (3)-4

 

Iconography_Finals_Color_BarcodeThis DNA barcode is then extended and amplified by polymerase chain reaction (PCR) and measured by quantitative PCR (qPCR) or next-generation sequencing (NGS).

Olink is well suited to:

RBM_OlinkBrochure_Final_Digital (3)-2Evaluate therapeutic effects

Accurately measure at baseline and after treatment to understand the dynamic changes associated with a therapeutic candidate.
RBM_OlinkBrochure_Final_Digital (3)-2Understand disease onset and mechanism of action

Certain biomarkers are present years before diagnosis. Olink can help identify the relevant proteomic changes.
RBM_OlinkBrochure_Final_Digital (3)-2Develop biomarker signatures

Explore HT measures thousands of proteins at once. Longitudinal studies can help you understand proteomic profiles for different diseases.
RBM_OlinkBrochure_Final_Digital (3)-2Identify drug targets

Disease-specific proteomic signatures can help identify potential drug targets.

Available Olink products
Explore HT
Target 48
Target 98

5400+ proteins from a single sample

  • High-throughput, scalable biomarker discovery and analysis
  • Integrates with other omics data for a comprehensive picture
  • Useful for identifying disease targets, pharmacokinetics, longitudinal and population-based studies

Carefully selected biomarkers for a comprehensive view:

Choose RBM for exceptional science and service excellence

Service excellence

handshakeService excellence

 

  • RBM is an Olink service provider 
  • Responsive client services team 
  • My Green Lab® – bronze certification 
  • Hands-on project managers who have experience working in the lab 
  • 20+ years of expertise in delivering high-quality results on a timeline that meets your requirements. 

Exceptional Science

Iconography_Finals_Color_Olink proteomics platformExceptional Science

 

  • Dual-recognition approach uses antibody pairs labeled with DNA oligonucleotides 
  • Hybridization creates a unique barcode that is amplified using PCR 
  • Readouts by qPCR or NGS based on platform 

Meaningful Insights

icon_graphMeaningful Insights

 

Disease-specific insights: 

  • Oncology 
  • Inflammation/Immunology 
  • Cardiovascular 

Broad biosignatures (Explore HT) 

  • Deeper understanding of biological pathways and multi-omics interactions 
  • Scalable without compromising quality