IQVIA Laboratories Protein Biomarkers — founded in 2002 as Rules-Based Medicine — has been internally developing and validating assays utilizing the Luminex multi-analyte profile (MAP) technology for more than 25 years. This bead-based platform enables simultaneous detection and quantification of up to 200+ targets in a single sample. Our comprehensive menu of quantitative, multiplex immunoassays enables you to measure multiple clinically relevant proteins using a small sample volume.
We offer validated multiplexed MAP-based profiles for various therapeutic areas. Our MAP technology combines the sensitivity and dynamic range of microsphere-based immuno-multiplexing with the precision and reliability of automated liquid handling to deliver high-quality, cost-effective immunoassay measurements. For MAP-based services, serum and plasma are the most common sample types, but we can also analyze other biological fluids including cerebrospinal fluid (CSF), urine, tissue culture supernatants, bronchoalveolar lavage, synovial fluid, tissue extracts, tears, and skin washings.
Our menu of internally developed Luminex-based MAPs includes:
- Cytokine MAP A – 16 biomarkers focused on immune-signaling and cytokine profiling, including interleukins, TNFs
- Cytokine MAP B – 13 biomarkers focused on immune-signaling and cytokines, including interleukins, matrix metalloproteinase and VEGF
- Discovery MAP – >200 analytes, offering our most comprehensive Luminex-based MAP; includes interleukins, cancer antigens, CDs, chemokines, endocrine markers, macrophage inflammatory proteins, matrix metalloproteinase, TNFs, and VEGF
- Human MAP – >75 biomarkers providing systems-level view of general human biology and disease, rather than a single pathway
- Inflammation MAP – > 54 analytes associated with inflammatory pathways and immune responses, targeting cytokines, chemokines and acute-phase proteins
- Kidney MAP –10 9 biomarkers focused on renal injury and disease, including creatinine and cystatin-C
Sample volumes range from 60-500 µL(serum or plasma) to 125 µL to 3 mL for other fluids.
