card-3216_Biochemistry expert scientific with eyeglasses
Digital innovation

Driving operational improvements and quality of our services

Learn more card-3210_Laboratory technicians conduct a series of tests on a chemical analyzer
Science Innovation

Uniquely positioned to shape, validate, and deliver biomarker assessments that strive to improve patient outcomes across diverse Therapeutic Areas

Learn more card-3242_Scientist using tablet while colleagues working behind
Download our Corporate brochure

We are IQVIA Laboratories, a leading clinical trial laboratory services organization with end-to-end laboratory services and secure, enterprise-wide biospecimen and consent management solutions.

Download card-3233_Laboratory scientist working at lab with micropipette, and 96 well plate
Corporate Video

Our commitment to customer success is embedded in every facet of our operations.

Learn more card-3210_Laboratory technicians conduct a series of tests on a chemical analyzer
Science Innovation

Uniquely positioned to shape, validate, and deliver biomarker assessments that strive to improve patient outcomes across diverse Therapeutic Areas

Learn more card-3216_Biochemistry expert scientific with eyeglasses
Digital Innovation

Driving operational improvements and quality of our services

Learn more
WE'RE HIRING

Improving human health requires brave thinkers who are willing to explore new ideas and build on successes. Unleash your potential with us.

Search jobs website-featured_jpg-2213_cheerful-young-colleagues-using-laptop
Download our Corporate brochure

We are IQVIA Laboratories, a leading clinical trial laboratory services organization with end-to-end laboratory services and secure, enterprise-wide biospecimen and consent management solutions.

Download card-3242_Scientist using tablet while colleagues working behind
2768_CentralLaboratory

Central laboratories

Meeting the demands of today’s drug, device and diagnostics development environment requires a next generation service provider.
2502_Abstract-big-data-connection-technology-concept

Digital Technologies

Labmatrix® is an industry-leading solution developed to address some of the biggest challenges related to clinical trial sample management.
182_genomics-1

Genomics

We offer a range of genomic laboratory services to support drug discovery, precision medicine and clinical development. Our industry-leading team advances research by delivering scientific insights that help clients maximize the value of their data.
3233_discovery

Discovery Sciences

Our labs bring expertise in protein production, antibody discovery, and immunogenicity to help you select the most promising candidates and reduce risk as you move toward IND-enabling studies.
3253_bioa

Biosciences

One of the world's largest and most respected bioanalytical and ADME laboratory networks. From our global locations, we serve many of the largest pharmaceutical, specialty pharmaceutical and biotechnology companies worldwide.
card-3275_Young scientist works in modern laboratory

Specialty immunoassays

a CLIA-certified biomarker testing laboratory developing immunoassays used to quantify protein biomarkers in support of drug mechanism of action, pharmacodynamic, prognostic, and predictive clinical studies across all stages of drug discovery and development.
3214_vaccines

Vaccines

Combining cutting-edge technology platforms and state-of-the-art laboratories with over 35 years of clinical vaccine development.
card-3242_Scientist using tablet while colleagues working behind

Digital innovation

We have a dedicated Digital Innovation department focused on driving operational improvements and quality of our services. We’ve helped create agile and impactful solutions across the organization with the underpinnings of traceability, productivity, quality, and efficiency.
2768_therapeutic_expertise

Therapeutic expertise
Contact Us
English You are about to exit for another IQVIA country or region specific website Please be aware that the website you have requested is intended for the residents of a particular country or region, as noted on that site. Ok Open in new tab Search

Insight

Quantitative Measurement of a Candidate Antibody Therapeutic in Human Plasma

Demonstration that a 2% formic acid digestion can produce a selective signature peptide for antibody quantification using nano-LC/MS/MS
Home / Insights / Quantitative Measurement of a Candidate Antibody Therapeutic in Human Plasma

Presented at the 2016 American Society for Mass Spectroscopy Sanibel Conference, this presentation highlights the IQVIA Laboratories team’s efforts in providing a tailored method for a challenging biotherapeutic drug compound.  The IQVIA Laboratories team was tasked with developing a liquid chromatography with tandem mass spectrometry (LC-MS/MS) assay for quantification of a candidate antibody therapeutic in human plasma. Using formic acid digestion the IQVIA Laboratories team was able to obtain good assay statistics, including inter-individual selectivity and accuracy.

IQVIA Laboratories is one of the few bioanalytical laboratories successfully employing immunoprecipitation techniques and multi-dimensional LC for the quantitation of biotherapeutics, peptides, proteins, and biomarkers. Our team has the experience and knowledge in development and validation of small and mid-size peptides to proteins, fusion proteins and monoclonal antibodies. The development of these assays is followed by method validation and sample analysis consistent with global regulatory requirements and governed by SOPs.

Authors: 
Lian Shan, Robert M. Sturm, Raymond F. Biondolillo, John E. Buckholz, Barry R. Jones, John R. Perkins, Ryan Faucette and Daniel J. Sexton

Complete the form below to access this scientific poster