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Insight

Mass Spectrometry to Enable Sensitive Quantitation of a Small Molecule Therapeutic

Overcoming Triple Quadrupole Selectivity Challenges by Use of High-Resolution Accurate Mass Spectrometry to Enable Sensitive Quantitation of a Small Molecule Therapeutic in Rabbit Plasma
Home / Insights / Mass Spectrometry to Enable Sensitive Quantitation of a Small Molecule Therapeutic

Download our scientific poster to learn about triple quadrupole rat and human plasma methods for the small molecule GSKA were challenged by high chemical noise due to isobaric interference. Validated triple quadrupole rat and human plasma methods were used as starting points for the development of a rabbit plasma method for the small molecule GSKA.  High-resolution accurate mass spectrometry (HRAMS) was investigated as an alternative technique to enable higher sensitivity by increased selectivity. An LLOQ of 2 pg/mL using 200 μL of rabbit plasma was achieved and the method was validated to full regulatory compliance. As a key methodology in today’s PK studies, we offer a number of tailored LC/MS services in support of your trial.  Our highly experienced staff utilizes leading-edge technology including AB SCIEX™ / Thermo Scientific triple quadrupole mass spectrometers, Thermo Scientific High Resolutions mass spectrometers, and state-of-the-art extraction techniques.  Contact us to learn more about IQVIA Laboratories and how we can put our tailored solutions, delivery excellence, and shaping outcomes to work for you.

Authors: Daniel Mulvana, Robert Sturm, Chet Bowen, John Buckholz, Raymond Biondolillo, Kathlyn McCardle, Chris Evans, Barry Jones

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