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Insight

Long-Term Disease-Free Survival in High Grade Serous Ovarian Cancer (HGSOC) is Dependent on Immune Microenvironment Characteristics of Primary Tumor

Application of RNA-based immune signatures in predicting disease-free survival
Home / Insights / Long-Term Disease-Free Survival in High Grade Serous Ovarian Cancer (HGSOC) is Dependent on Immune Microenvironment Characteristics of Primary Tumor

Patient outcome in high grade serous ovarian cancer (HGSOC) has had mixed success in associating the presence of intra-tumoral T cells and an “immunoreactive” subtype using RNA profiling. In particular, the TCGA OV study was not able to correlate expression-related immunogenicity with outcomes. Important factors associated with prognosis and long-term survivors of HGSOC include residual disease after cytoreductive surgery (RDCS), age and disease-stage.

In this poster, we explore 2 hypotheses:

  1. Primary: Primary tumors from HGSOC patients who have long-term disease-free survival (DFS) harbor a more active adaptive immune cell response.
  2. Secondary: The RNA-based immune signatures found following analysis of pan-cancer TCGA solid tumor samples have application to predict survival in independent cohorts od HGSOC and beyond.


Authors: Wendell Jones, IQVIA Laboratories; Mahrukh Ganapathi, Levine Cancer Institute; Chad Michener, Cleveland Clinic and Ram Ganapathi, Levine Cancer Institute

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