This poster presents how we used LC-MS/MS methods to assess inhibitor selectivity for CYP Phenotyping in Human Liver Microsomes and Hepatocytes. This resulted in a 7-fold decrease in analysis time per study, thus enabling rapid verification of the effectiveness and selectivity of each inhibitor while estimating fm, CYP for new drug candidates.
As a key methodology in today’s PK studies, we offer a number of bioanalytical testing services in support of your trial, including tailored Liquid chromatography-mass spectrometry (LC/MS). Our highly experienced staff utilizes leading-edge technology including AB SCIEX™ / Thermo Scientific triple quadrupole mass spectrometers, Thermo Scientific High Resolutions mass spectrometers, and state of-the-art extraction techniques.
Author:
J Matthew Hutzler, Ph.D., Director of In Vitro Metabolism, Bioanalytical and ADME Labs
Complete the form below to access this scientific poster
Related Insights
ADME Services
Accelerating your drug discovery, preclinical and clinical programs
Developing Assays for Novel Drugs
Current science regarding hybrid assays, why they are considered the next "big thing," the technical challenges, and the regulatory impact of these assays.
Hybrid Assays for Protein Bioanalysis
Assays and Why Are They Essential for Protein Bioanalysis?
Bioanalysis for Immuno Oncology with Mike Brown
I-O clinical development podcast series
High Throughput ADME Testing
Minimizing turnaround time for ADME assays
ADME Services
Accelerating your drug discovery, preclinical and clinical programs with ADME services
Assay Development for Large-Scale Clinical Studies
Bioanalytical expertise to support large-scale, international studies
Early Hit-to-Lead ADME Screening Bundle
Bundled Screening Assays to Accelerate Candidate Selection in Drug Discovery
High Throughput ADME Screening Services
Capabilities that accelerate preclinical studies
IND-Enabling Bundle of In Vitro Assays to Assess Drug-Drug Interaction Risk
DDI Fact Sheet
