Matthieu Daugan, Director of the Cell-Mediated Immunity Platform at IQVIA Laboratories, delves into his background in immunology and virology, the intricacies of his current role, and the challenges and advancements in the field of vaccine development. Matthieu shares insights into the complexity of cell-mediated immunity, the importance of detailed scientific analysis, and the evolution of vaccine evaluation, particularly in light of recent global health challenges such as COVID-19. This discussion provides a comprehensive overview of the processes involved in analyzing immune responses and the significance of his team’s work at different stages of vaccine development.