Published in Cytometry Part B: Clinical Cytometry
In clinical flow cytometry, real-world scenarios often demand flexibility. The latest manuscript by Christopher Groves and co-authors, "Ad hoc antibody modification of a validated flow cytometric immunophenotyping panel—recommendations and safeguards for clinical laboratories", provides essential guidance for laboratories facing unique patient needs.
This work addresses a critical gap in current standards, offering practical recommendations beyond CLSI H62 for temporary, case-specific assay modifications. It emphasizes:
- Preserving assay integrity while adapting to clinical demands
- Evaluating impact on fluorescence compensation, antibody binding, and sensitivity
- Safeguarding performance without permanent protocol changes
These best practices empower labs to maintain diagnostic excellence while responding to complex clinical situations—ultimately optimizing patient care.
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