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Insight

Development and optimization of cost-effective Non-Human Primate in vitro assays for immunogenicity screening and functional evaluation of immuno-oncology drug candidates

 Development and optimization of cost-effective Non-Human Primate in vitro assays for immunogenicity screening and functional evaluation of immuno-oncology drug candidates
Home / Insights / Development and optimization of cost-effective Non-Human Primate in vitro assays for immunogenicity screening and functional evaluation of immuno-oncology drug candidates

Presented by:  Christoph Schifflers, Martijn Vlaming, Emmanuelle Sidot, Jezabel Lefèvre, Elise Pepermans (ImmuneSpec, Niel, Belgium), Ellen Boelen and Sofie Pattyn

 

Presented at: American Association for Cancer Research (AACR) Annual Meeting, April 25-30, 2025, Chicago, IL

 

Researchers are actively looking for alternatives to using animals (including non-human primates). This poster highlights the development of cost-effective NHP in vitro assays with predictive value for the assessment of unwanted immunogenicity as well as the functionality of drug candidates. IQVIA Laboratories In Vitro Immunology team developed custom in vitro assays based on cynomolgus monkey PBMCs, determining that assay optimization and portfolio expansion can improve drug candidate screening capacity and lower NHP material needs in pre-clinical testing.

 

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