Bioinformatics Services

Genomic Alterations – DNA & RNA

A comprehensive understanding of the genomic alterations found in your sample is critical to understanding your disease of interest. IQVIA has various solutions to help maximize the full value out of your data.

Solutions
SNPs and Indels – Germline, Tumor-normal, Tumor-only*
Copy Number Alterations – Germline, Somatic
Structural Variants
TMB
Neoantigen
Fusions
RNA SNPs and Indels – Germline and Somatic*

^{*Inquire on availability}

DNA variant calling is offered across a variety of service types, ranging from small targeted panels on Thermo-Fisher sequencing instruments to Whole Genome Sequencing done on Illumina instruments.
Our proprietary WES TMB algorithm is one of the few in the industry that can operate with or without a matched normal pair.
Our proprietary Gene Fusion algorithm (STAR-SEQR) is among the most accurate and sensitive algorithms on the market.

Quantification & Identification

With nearly a decade of NGS experience, IQVIA Laboratories has developed tools and procedures for accurate identification and quantification of data.

Custom two group comparison methodology providing superior results in comparison to other algorithms publicly available.
Our Influenza Sequencing pipeline has been demonstrated to be 100% accurate in strain identification.
HLA calling by either RNA Sequencing or DNA Sequencing with equivalent accuracy.

Solutions
Gene and Isoform Quantification
Two Group Comparisons
B-cell and T-cell Repertoire
IgHV Identification
HLA Typing
Flu Strain Identification

Customized Services and Signatures

IQVIA Laboratories has extensive experience with custom analyses, including standard Pathway and Gene Set Enrichment Analysis all the way through Biomarker discovery.

We can generate customized RNA signatures or replicate published RNA Signatures upon request.
Our Immune Landscape Signatures characterize the activity and type of immune cell infiltrate in the tumor.
Analysis of treatment response and survival using multiple clinical features or using signatures such as predicted Cytotoxic Immune Infiltration.

Solutions
Biomarker Discovery
RNA signature identification and interpretation
DNA-based signatures and identification
Immune Landscape/Tumor Microenvironment signatures
Gene Set Enrichment Analysis
Pathway Analysis