PBSS: Drug Metabolism Fundamentals and Metabolite Identification

Connect with the IQVIA Laboratories team of experts at this year’s event to discuss how your new modalities can benefit from our innovative approaches and strategies in both the regulated and non-regulated bioanalytical laboratory.

Drug Metabolism, a process by which the body converts a drug into metabolites generally favoring excretion, is a major clearance mechanism for drugs and plays a key role in a drug’s pharmacokinetic and pharmacodynamic profiles. Identification of the metabolites is a major component in drug metabolism studies and is critical for both drug discovery and drug development. At the discovery stage, when metabolic stability becomes an issue for the compound’s PK profiles, the medicinal chemists would demand the identification of the precise structural locations of the metabolic modifications, so that analog compounds can be designed to address the metabolic liability issue. For the development stage, it is critical to know the metabolites and the metabolic pathways of the drug as the metabolites can also play some biological and pharmacological roles such as efficacy, toxicity and drug-drug interaction. This workshop will discuss the fundamentals of drug metabolism, commonly used methods for studying drug metabolism, and techniques for identifying metabolites.

List of Topics:

• Fundamentals of drug metabolism and drug metabolizing enzymes (including phenotyping)
• Metabolite identification overview, metabolite isolation and separation techniques
• MS/MS interpretation
• NMR techniques for metabolite identification
• Metabolism and metabolite identification for new modalities (ADCs, PROTACs and Oligos)
• In vivo metabolite profiling and case studies

Learn more:

• ADME Services from IQVIA Laboratories
• Small Molecule Bioanalytical and ADME Solutions
• Large Molecule bioanalytical and ADME Solutions
• IND-Enabling Bundle of In Vitro Assays to Assess Drug-Drug Interaction Risk
• Challenging Bioanalytical Work