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Tissue Inhibitor of Metalloproteinases 1
Tissue Inhibitor of Metalloproteinases 1
Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) is a member of a family of secreted proteolytic enzymes that are involved in the biosynthesis of connective tissue. The synthesis and secretion of matrix metalloproteinases (MMPs) is induced in various cell types by a number of cytokines. Metalloproteinases degrade constituents of the basal membrane and the extracellular matrix, including collagens, proteoglycans, gelatin, fibronectin, laminin, and elastin, under physiological and pathological conditions. The biological activities of the proteases are subject to a complex regulation also involving specific inhibitors, called TIMP (Tissue inhibitor of metalloproteinases). Many proforms of these metalloproteinases form complexes with these inhibitors. TIMP-1 is a major regulator of extracellular matrix synthesis and degradation. A certain balance of MMPs and TIMPs is essential for tumor growth and health. It complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1 also mediates erythropoiesis in vitro but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16 though it does not act on MMP-14.
Swiss-Prot Accession Number: P01033
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Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival
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Attenuated Response of Aged Mice to Respiratory Francisella novicida Is Characterized by Reduced Cell Death and Absence of Subsequent Hypercytokinemia
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Inflammatory and Hemostatic Response to Cardiopulmonary Bypass in Pediatric Population: Feasibility of Seriological Testing of Multiple Biomarkers
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Magnetic Resonance Imaging Predictors of Treatment Response in First-Episode Schizophrenia
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Metabolomics of Prolonged fasting in humans reveals new catabolic markers
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Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study
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Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)
(2010)
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Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF
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Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
(2010)
Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, Estrov Z, Fridman JS, Bradley EC, Erickson-Viitanen S, Vaddi K, Levy R, Tefferi A
N Engl J Med. 363: 1117-27.
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A Semi-Targeted Plasma Proteomics Discovery Workflow Utilizing Two-Stage Protein Depletion and Off-Line LC-MALDI MS/MS
(2010)
Juhasz P, Lynch M, Sethuraman M, Campbell J, Hines W, Paniagua M, Song L, Kulkarni M, Adourian A, Guo Y, Li X, Martin S, Gordon N
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The Role of Residual Gadolinium in the Induction of Nephrogenic Systemic Fibrosis-Like Skin Lesions in Rats
(2011)
Pietsch H, Raschke M, Ellinger-Ziegelbauer H, Jost G, Walter J, Frenzel T, Lenhard D, H?tter J, Sieber MA
Invest Radiol. 46: 48-56.
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Quantitative Proteomic Plasma Profiling Reveals Activation of Host Defense to Oxidative Stress in Chronic SIV and Methamphetamine Comorbidity
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Pendyala G, Trauger SA, Siuzdak G, Fox HS
AIDS Res Hum Retroviruses 2010 Oct 7. [Epub ahead of print]
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Luteinizing hormone, Testosterone and Inhibin B Levels in the Peripubertal Period and Racial/ethnic Differences among Boys Aged 6-11 years: Analyses from NHANES III, 1988-1994
(2010)
Lee PA, Gollenberg AL, Hediger ML, Himes JH, Zhang Z, Buck Louis GM
Clin Endocrinol (Oxf). 2010 Sep 2
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Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response
(2010)
Kovalchin J, Krieger J, Genova M, Collins K, Augustyniak M, Masci A, Hittinger T, Kuca B, Edan G, Braudeau C, Rimbert M, Patel U, Mascioli E, Zanelli E
J Neuroimmunol. 225: 153-63.
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IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis
(2010)
Blumberg H, Dinh H, Dean C Jr, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE
J Immunol 185:4354-62.
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Sample size and statistical power considerations in high-dimensionality data settings: a comparative study of classification algorithms
(2010)
Guo Y, Graber A, McBurney RN, Balasubramanian R
BMC Bioinformatics 11: 447.
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Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers
(2010)
Ottervald J, Franz?n B, Nilsson K, Andersson LI, Khademi M, Eriksson B, Kjellstr?m S, Marko-Varga G, V?gv?ri A, Harris RA, Laurell T, Miliotis T, Matusevicius D, Salter H, Ferm M, Olsson T
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A Serum Protein-Based Algorithm for the Detection of Alzheimer Disease
(2010)
OBryant SE, Xiao G, Barber R, Reisch J, Doody R, Fairchild T, Adams P, Waring S, Diaz-Arrastia R; for the Texas Alzheimers Research Consortium
Arch Neurol 67: 1077-1081.
Therapy Indications
Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury
(2010)
Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R.
PLoS ONE 5: e12106.
Therapy Indications
Lower Respiratory Tract Infection in Cynomolgus Macaques (Macaca fascicularis) Infected with Group A Streptococcus
(2010)
Olsen RJ, Ashraf M, Gonulal VE, Ayeras AA, Cantu C, Shea PR, Carroll RK, Humbird T, Greaver JL, Swain JL, Chang E, Ragasa W, Jenkins L, Lally KP, Blasdel T, Cagle P, Musser JM
Microb Pathog 49: 336-47.
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Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
(2010)
Woo JM, Lin Z, Navab M, Van Dyck C, Trejo-Lopez Y, Woo KM, Li H, Castellani LW, Wang X, Iikuni N, Rullo OJ, Wu H, La Cava A, Fogelman AM, Lusis AJ, Tsao BP
Arthritis Res Ther 12: R93.
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Evidence for Endotoxin Contamination in Plastic Na+-Heparin Blood Collection Tube Lots
(2010)
Newhall KJ, Diemer GS, Leshinsky N, Kerkof K, Chute HT, Russell CB, Rees W, Welcher AA, Patterson SD, Means GD
Clin Chem 56: 1483-91.
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Biomarker discovery for Alzheimers disease, frontotemporal lobar degeneration, and Parkinsons disease
(2010)
Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ
Acta Neuropathol 120: 385-99.
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Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality
(2010)
Marchlik E, Thakker P, Carlson T, Jiang Z, Ryan M, Marusic S, Goutagny N, Kuang W, Askew GR, Roberts V, Benoit S, Zhou T, Ling V, Pfeifer R, Stedman N, Fitzgerald KA, Lin LL, Hall JP
J Leukoc Biol. 88: 1171-80.
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Validation of a Multivariate Serum Profile for Epithelial Ovarian Cancer Using a Prospective Multi-Site Collection
(2010)
Seshaiah P, Bertenshaw GP, Chen TH, Bergstrom KJ, Zhao J, Mapes JP, Stephen LL, Amonkar S, McCollum ME, Miller BE, Roman LD, Karlan BY, Chalas E, DiSilvestro PA, Barter JF, Orr Jr JW, Bigsby IV GE, Holloway RW, Alvarez RD, Yip PF, Mansfield BC
Nature Precedings Jul 2010.
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In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation
(2010)
Marballi K, Quinones MP, Jimenez F, Escamilla MA, Ravent?s H, Soto-Bernardini MC, Ahuja SS, Walss-Bass C
J Mol Med. 88: 1133-41.
Therapy Indications
Cholesterol in human atherosclerotic plaque is a marker for underlying disease state and plaque vulnerability
(2010)
Chen Z, Ichetovkin M, Kurtz M, Zycband E, Kawka D, Woods J, He X, Plump AS, Hailman E
Lipids Health Dis 11: 61.
Therapy Indications
Recommendations to qualify biomarker candidates of drug-induced liver injury
(2010)
Ozer JS, Chetty R, Kenna G, Koppiker N, Karamjeet P, Li D, Palandra J, Lanevschi A, Souberbielle BE, Ramaiah S
Biomark Med 4: 475-483.
Therapy Indications
Urinary clusterin, cystatin C, ?2-microglobulin and total protein as markers to detect drug-induced kidney injury
(2010)
Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G
Nat Biotechnol 28: 463-469.
Therapy Indications
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
(2010)
Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, Muniappa N, Thudium D, Gerhold D, Holder DJ, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goering PL, Sistare FD, Bonventre JV
Nat Biotechnol. 28: 478-85.
Therapy Indications
Significant growth inhibition of canine mammary carcinoma xenografts following treatment with oncolytic vaccinia virus GLV-1h68
(2010)
Gentschev I, Ehrig K, Donat U, Hess M, Rudolph S, Chen N, Yu YA, Zhang Q, Bullerdiek J, Nolte I, Stritzker J, Szalay AA
J Oncol. 2010:736907. Epub 2010 Jun 23
Therapy Indications
Identification of distinct plasma biomarker signatures in patients with rapid and slow declining forms of COPD
(2010)
Devanarayan V, Scholand MB, Hoidal J, Leppert MF, Crackower MA, ONeill GP, Gervais FG
COPD 7: 51-58.
Therapy Indications
Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia
(2010)
Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, (JM) van Beveren N, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S
Biomark Insights5: 39?47.
Therapy Indications
A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function
(2010)
Ozer JS, Dieterle F, Troth S, Perentes E, Cordier A, Verdes P, Staedtler F, Mahl A, Grenet O, Roth DR, Wahl D, Legay F, Holder D, Erdos Z, Vlasakova K, Jin H, Yu Y, Muniappa N, Forest T, Clouse HK, Reynolds S, Bailey WJ, Thudium DT, Topper MJ, Skopek TR, Sina JF, Glaab WE, Vonderscher J, Maurer G, Chibout SD, Sistare FD, Gerhold DL
Nat Biotechnol.28: 444-5.
Therapy Indications
Peripheral Blood Biomarkers Predict Disease Progression And Mortality In IPF
(2010)
Richards TJ, Lindell KO, Klesen M, Kaminski N, Zhang Y, Gibson KF
Am J Respir Crit Care Me 181: A1120.
Therapy Indications
How informatics can potentiate precompetitive open-source collaboration to jump-start drug discovery and development
(2010)
Perakslis ED, Van Dam J, Szalma S
Clin Pharmacol Ther 87: 614-616.
Therapy Indications
Novel CSF biomarkers for Alzheimers disease and mild cognitive impairment
(2010)
Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ
Acta Neuropathol 119: 669-678.
Therapy Indications
Human cytokine response to Texas crotaline envenomation before and after antivenom administration.
(2010)
Crocker P, Zad O, Milling T, Maxson T, King B, Whorton E
Am J Emerg Med. 28: 871-9.
Therapy Indications
A Dual-Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass.
(2010)
Umstead TM, Lu CJ, Freeman WM, Myers JL, Clark JB, Thomas NJ, Chinchilli VM, Vrana KE, Undar A, Phelps DS
Pediatr Res 67: 641-9.
Therapy Indications
Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: Results of the Thrombotic RIsk Progression (TRIP) Study.
(2010)
Tantry US, Bliden KP, Suarez TA, Kreutz RP, Dichiara J, Gurbel PA
Platelets 21: 360-7.
Therapy Indications
Plasma biomarkers in carbon monoxide poisoning.
(2010)
Thom SR, Bhopale VM, Milovanova TM, Hardy KR, Logue CJ, Lambert DS, Troxel AB, Ballard K, Eisinger D
Clin Toxicol (Phila) 48: 47-56.
Therapy Indications
Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes.
(2010)
Gregory AD, Capoccia BJ, Woloszynek JR, Link DC
J Leukoc Biol 88: 123-31.
Therapy Indications
Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma.
(2010)
Huang D, Ding Y, Zhou M, Rini BI, Petillo D, Qian CN, Kahnoski R, Futreal PA, Furge KA, Teh BT
Cancer Res 70: 1063-1071.
Therapy Indications
Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates.
(2010)
Olsen RJ, Kobayashi SD, Ayeras AA, Ashraf M, Graves SF, Ragasa W, Humbird T, Greaver JL, Cantu C, Swain JL, Jenkins L, Blasdel T, Cagle PT, Gardner DJ, DeLeo FR, Musser JM
Am J Pathol 176: 1346-1354.
Therapy Indications
Classification of Alcohol Abuse by Plasma Protein Biomarkers.
(2010)
Freeman WM, Salzberg AC, Gonzales SW, Grant KA, Vrana KE
Biol Psychiatry 68: 219-22.
Therapy Indications
Identification of targeted analyte clusters for studies of schizophrenia.
(2010)
Cheng TM, Lu YE, Guest PC, Rahmoune H, Harris LW, Wang L, Ma D, Stelzhammer V, Umrania Y, Wayland MT, Li? P, Bahn S
Mol Cell Proteomics 9: 510-522.
Therapy Indications
Interleukin-15 enhances proliferation and chemokine secretion of human follicular dendritic cells.
(2010)
Gil M, Park SJ, Chung YS, Park CS
Immunology 130: 536-44.
Therapy Indications
Decreased C-Reactive Protein Levels in Alzheimer Disease.
(2010)
OBryant SE, Waring SC, Hobson V, Hall JR, Moore CB, Bottiglieri T, Massman P, Diaz-Arrastia R
J Geriatr Psychiatry Neurol 23: 49-53.
Therapy Indications
Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects.
(2008)
Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S
Dev Biol 322: 302-313.
Therapy Indications
Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis
(2009)
Kirby PJ, Shines CJ, Taylor GJ, Bousquet RW, Price HC, Everitt JI, Morgan DL
Exp Lung Res. 2009 Dec;35(10):858-82
Therapy Indications
Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina.
(2010)
Rogers IS, Nasir K, Figueroa AL, Cury RC, Hoffmann U, Vermylen DA, Brady TJ, Tawakol A
JACC Cardiovasc Imaging 3: 388-397.
Therapy Indications
Key Proteins Involed in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity
(2018)
Dittrich A, Grimm D, Sahana J, Bauer J, Kruger M, Infanger M, Magnusson N
Cellular Physiology and Biochemistry 2018
Therapy Indications
Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study
(2025)
Monique Hinchcliff, MD, Prof Dinesh Khanna, MD, Enrico De Lorenzis, MD, Stefano Di Donato, MD, Antonio Carriero, MD, Rebecca L Ross, PhD, Suiyuan Huang, MPH, Kathleen A Aren, MPH, Elana J Bernstein, MD, Mary Carns, MS, Flavia V Castelino, MD, Robyn T Domsic, MD, Tracy M Frech, MD, Jessica K Gordon, MD, Faye N Hant, MD, Prof Ami A Shah, MD, Victoria K Shanmugam, MBBS, Prof Virginia D Steen, MD, Prof Shervin Assassi, MD, Prof Francesco Del Galdo, PhD
The Lancet Rheumatology
Therapy Indications
Identifying Neuroimaging and Proteomic Biomarkers for MCI and AD via the Elastic Net
(2011)
Shen L, Kim S, Qi Y, Inlow M, Swaminathan S, Nho K, Wan J, Risacher SL, Shaw LM, Trojanowski JQ, Weiner M, Saykin AJ, ADNI
Lecture Notes in Computer Science, 2011, Volume 7012/2011, 27-34
Therapy Indications
Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza.
(2010)
Zavitz CC, Bauer CM, Gaschler GJ, Fraser KM, Strieter RM, Hogaboam CM, Stampfli MR
J Immunol 184: 2001-2013.
Therapy Indications
Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: biomarker analysis of a phase I dose-escalation study.
(2010)
Tabernero J, Cervantes A, Rivera F, Martinelli E, Rojo F, von Heydebreck A, Macarulla T, Rodriguez-Braun E, Eugenia Vega-Villegas M, Senger S, Ramos FJ, Rosell? S, Celik I, Stroh C, Baselga J, Ciardiello F
J Clin Oncol 28: 1181-1189.
Therapy Indications
Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome.
(2010)
Krone W, Hanefeld M, Meyer HF, Jung T, Bartlett M, Yeh CM, Rajman I, Prescott MF, Dole WP
J Hum Hypertens [Epub ahead of print]
Therapy Indications
A guidance for renal biomarker lead optimization and use in translational pharmacodynamics
(2010)
Ozer JS
Drug Discov Today15: 142-7.
Therapy Indications
Aged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infections
(2010)
Mares CA, Ojeda SS, Li Q, Morris EG, Coalson JJ, Teale JM
Exp Gerontol. 45: 91-6.
Therapy Indications
Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study.
(2010)
van Erk MJ, Wopereis S, Rubingh C, van Vliet T, Verheij E, Cnubben NH, Pedersen TL, Newman JW, Smilde AK, van der Greef J, Hendriks HF, van Ommen B
BMC Med Genomics 3: 5.
Therapy Indications
Identification of breast cancer biomarkers in transgenic mouse models: a proteomics approach.
(2010)
Rodenburg W, Pennings JLA, van Oostrom CTM, Roodbergen M, Kuiper RV, Luijten M, de Vries A
Proteomics Clin Appl. 4: 602-612.
Therapy Indications
The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes.
(2010)
Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Sch?ller J, Xu H, Taguchi K, Yamamoto M, M?ller T
Toxicol Sci 115: 238-252.
Therapy Indications
Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections.
(2010)
Domenici E, Will? DR, Tozzi F, Prokopenko I, Miller S, McKeown A, Brittain C, Rujescu D, Giegling I, Turck CW, Holsboer F, Bullmore ET, Middleton L, Merlo-Pich E, Alexander RC, Muglia P
PLoS ONE 5: e9166.
Therapy Indications
A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma.
(2010)
Bhatt RS, Merchan J, Parker R, Wu HK, Zhang L, Seery V, Heymach JV, Atkins MB, McDermott D, Sukhatme VP
Cancer 116: 1751-1756.
Therapy Indications
Defining the optimal biological dose of NGR-hTNF, a selective vascular targeting agent, in advanced solid tumours
(2010)
Gregorc V, Citterio G, Vitali G, Spreafico A, Scifo P, Borri A, Donadoni G, Rossoni G, Corti A, Caligaris-Cappio F, Del Maschio A, Esposito A, De Cobelli F, DellAcqua F, Troysi A, Bruzzi P, Lambiase A, Bordignon C
Eur J Cancer. 46: 198-206.
Therapy Indications
Quantitative Multiplexed Patterning of Immune-related Biomarkers
(2010)
Eisenger D, McDade R, Joos T
Biomarkers in Drug Development: A Handbook of Practice, Application, and Strategy . Ch. 6, p. 121-134
Therapy Indications
Protein microarrays for personalized medicine
(2010)
Yu X, Schneiderhan-Marra N, Joos TO
Clin Chem. 56: 376-87.
Therapy Indications
Uromodulin levels associate with a common UMOD variant and risk for incident CKD
(2010)
K?ttgen A, Hwang SJ, Larson MG, Van Eyk JE, Fu Q, Benjamin EJ, Dehghan A, Glazer NL, Kao WH, Harris TB, Gudnason V, Shlipak MG, Yang Q, Coresh J, Levy D, Fox CS
J Am Soc Nephrol 21: 337-344.
Therapy Indications
Heterosubtypic anti-avian H5N1 influenza antibodies in intravenous immunoglobulins from globally separate populations protect against H5N1 infection in cell culture
(2009)
Sullivan JS, Selleck PW, Downton T, Boehm I, Axell AM, Ayob Y, Kapitza NM, Dyer W, Fitzgerald A, Walsh B, Lynch GW
J Mol Genet Med 3: 217-224.
Therapy Indications
Distinct functions of activated protein C differentially attenuate acute kidney injury
(2009)
Gupta A, Gerlitz B, Richardson MA, Bull C, Berg DT, Syed S, Galbreath EJ, Swanson BA, Jones BE, Grinnell BW
J Am Soc Nephrol. 20: 267-77.
Therapy Indications
Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin
(2009)
Bromberg-White JL, Boguslawski E, Duesbery NS
PLoS ONE 4: e6956.
Therapy Indications
Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice
(2009)
Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, Hamelmann E, Schulz H, Stoeger T
Part Fibre Toxicol. 6: 31.
Therapy Indications
Value of new biomarkers for safety testing in drug development
(2009)
Hewitt P and Herget T
Expert Rev Mol Diagn.9: 531-6.
Therapy Indications
A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome
(2009)
van Dijk SJ, Feskens EJ, Bos MB, Hoelen DW, Heijligenberg R, Bromhaar MG, de Groot LC, de Vries JH, M?ller M, Afman LA
Am J Clin Nutr. 90: 1656-64.
Therapy Indications
Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile
(2009)
Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, Murphy TF, Sethi S, St?mpfli MR.
Am J Respir Crit Care Med. 179: 666-75.
Therapy Indications
Western-style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer
(2009)
Erdelyi I, Levenkova N, Lin EY, Pinto JT, Lipkin M, Quimby FW, Holt PR
J Nutr. 139: 2072-8.
Therapy Indications
Analysis of Renal Biomarkers in Samples of Rat Urine Samples Frozen for 44 months From a Study on Puromycin Amino Nucleoside (PAN)
(2009)
Perron MF, Burnett R, Reiniche A, Briffaux JP, Eisinger D, K?sters S and Mapes J
Toxicology LettersVolume 189, Supplement 1, S159
Therapy Indications
High content analysis of human fibroblast cell cultures after exposure to space radiation
(2009)
Dieriks B, De Vos W, Meesen G, Van Oostveldt K, De Meyer T, Ghardi M, Baatout S, Van Oostveldt P
Radiat Res. 172: 423-36.
Therapy Indications
The multiplex bead array approach to identifying serum biomarkers associated with breast cancer
(2009)
Kim BK, Lee JW, Park PJ, Shin YS, Lee WY, Lee KA, Ye S, Hyun H, Kang KN, Yeo D, Kim Y, Ohn SY, Noh DY, Kim CW
Breast Cancer Res. 11: R22.
Therapy Indications
Identifying early markers of Alzheimers disease using quantitative multiplex proteomic immunoassay panels
(2009)
Soares HD, Chen Y, Sabbagh M, Roher A, Schrijvers E, Breteler M
Ann N Y Acad Sci. 1180 :56-67.
Therapy Indications
Growth Characteristics of the Nonhuman Primate Embryonic Stem Cell Line Cjes001 Depending on Feeder Cell Treatment.
(2009)
Fleischmann G, M?ller T, Blasczyk R, Sasaki E, Horn PA
Cloning Stem Cells 11: 225-233.
Therapy Indications
Chronic Treatment with Clenbuterol Modulates Endothelial Progenitor Cells and Circulating Factors in a Murine Model of Cardiomyopathy.
(2009)
Rider JE, Polster SP, Lee S, Charles NJ, Adhikari N, Mariash A, Tadros G, Stangland J, Smolenski RT, Terracciano CM, Barton PJR, Birks EJ, Yacoub MH, Miller LW, Hall JL
Journal of Cardiovascular Translational Research 2: 182?190.
Therapy Indications
Brain-derived neurotrophic factor levels in Alzheimers disease.
(2009)
OBryant SE, Hobson V, Hall JR, Waring SC, Chan W, Massman P, Lacritz L, Cullum CM, Diaz-Arrastia R; Texas Alzheimers Research Consortium
J Alzheimers Dis 17: 337-341.
Therapy Indications
A Novel ENU-induced Mutation, Peewee, Causes Dwarfism in the Mouse.
(2009)
Lee B, Kano K, Young J, John SW, Nishina PM, Naggert JK, Naito K
Mamm Genome 20: 404-413.
Therapy Indications
Matrix metalloproteinases during and outside of migraine attacks without aura.
(2009)
Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M, Olesen J
Cephalalgia 30: 303-310.
Therapy Indications
Molecular Analyte Profiling of the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder Cancer.
(2009)
Bisiaux A, Thiounn N, Timsit MO, Eladaoui A, Chang HH, Mapes J, Mogenet A, Bresson JL, Pri? D, B?chet S, Baron C, Sadorge C, Thomas S, Albert EB, Albert PS, Albert ML
J Urol 181: 1571-1580.
Therapy Indications
Immune Activation in Advanced Cancer Patients Treated with Recombinant IL-21: Multianalyte Profiling of Serum Proteins.
(2009)
Dodds MG, Frederiksen KS, Skak K, Hansen LT, Lundsgaard D, Thompson JA, Hughes SD
Cancer Immunol Immunother 58: 843-854.
Therapy Indications
A Multianalyte Profile of Serum Proteins to Screen for Toxicological Effects of Anticholinesterase Insecticides in the Rat.
(2009)
Gordon CJ, Ward WO
Neurotoxicology 30: 377-381.
Therapy Indications
Strain-Dependent Increases in Retinal Inflammatory Proteins and Photoreceptor FGF-2 Expression in Streptozotocin-Induced Diabetic Rats.
(2009)
Kirwin SJ, Kanaly ST, Linke NA, Edelman JL
Invest Ophthalmol Vis Sci 50: 5396-5404.
Therapy Indications
Bead-based Multiplexed Immunoassays to Identify New Biomarkers in Maternal Serum to Improve First Trimester Down Syndrome Screening.
(2009)
Koster MP, Pennings JL, Imholz S, Rodenburg W, Visser GH, de Vries A, Schielen PC
Prenat Diagn 29: 857-862.
Therapy Indications
Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program.
(2009)
Radonjic M, de Haan JR, van Erk MJ, van Dijk KW, van den Berg SA, de Groot PJ, M?ller M, van Ommen B
PLoS ONE 4: e6646.
Therapy Indications
RIP4 Regulates Epidermal Differentiation and Cutaneous Inflammation.
(2009)
Rountree RB, Willis CR, Dinh H, Blumberg H, Bailey K, Dean C Jr, Peschon JJ, Holland PM
J Invest Dermatol 130: 102-112.
Therapy Indications
Muscular Dystrophy Therapy by Nonautologous Mesenchymal Stem Cells: Muscle Regeneration Without Immunosuppression and Inflammation.
(2009)
Shabbir A, Zisa D, Leiker M, Johnston C, Lin H, Lee T
Transplantation 87: 1275-1282.
Therapy Indications
Heart Failure Therapy Mediated by the Trophic Activities of Bone Marrow Mesenchymal Stem Cells: A Non-invasive Therapeutic Regimen.
(2009)
Shabbir A, Zisa D, Suzuki G, Lee T
Am J Physiol Heart Circ Physiol 296: H1888-H1897.
Therapy Indications
Vaccination with an Attenuated Strain of Francisella novicida Prevents T-Cell Depletion and Protects Mice Infected with the Wild-Type Strain from Severe Sepsis.
(2009)
Sharma J, Li Q, Mishra BB, Georges MJ, Teale JM
Infect Immun 77: 4314-4326.
Therapy Indications
Lethal Pulmonary Infection with Francisella Novicida is Associated with Severe Sepsis.
(2009)
Sharma J, Li Q, Mishra BB, Pena C, Teale JM
J Leukoc Biol 86: 491-504.
Therapy Indications
Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System.
(2009)
Sutton SW, Shelton J, Smith C, Williams J, Yun S, Motley T, Kuei C, Bonaventure P, Gundlach A, Liu C, Lovenberg T
Ann N Y Acad Sci 1160: 242-249.
Therapy Indications
Regression of Human Pancreatic Tumor Xenografts in Mice After a Single Systemic Injection of Recombinant Vaccinia Virus GLV-1h68.
(2009)
Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA
Mol Cancer Ther 8: 141-151.
Therapy Indications
Atorvastatin Restores Endothelial Function in Offspring of Protein-Restricted Rats in a Cholesterol-Independent Manner.
(2009)
Torrens C, Kelsall CJ, Hopkins LA, Anthony FW, Curzen NP, Hanson MA
Hypertension 53: 661-667.
Therapy Indications
The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - a mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide.
(2009)
Steger-Hartmann T, Raschke M, Riefke B, Pietsch H, Sieber MA, Walter J
Exp Toxicol Pathol 61: 537-552.
Therapy Indications
Multiplex Immunoassay Analysis of Biomarkers in Clinically Accessible Quantities of Human Aqueous Humor.
(2009)
Sharma RK, Rogojina AT, Chalam KV
Mol Vis 15: 60-69.
Therapy Indications
Myocardial Oxidative Stress, Osteogenic Phenotype, and Energy Metabolism are Differentially Involved in the Initiation and Early Progression of d-sarcoglycan-null Cardiomyopathy.
(2009)
Missihoun C, Zisa D, Shabbir A, Lin H, Lee T
Mol Cell Biochem 321: 45-52.
Therapy Indications
The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results.
(2009)
McBurney RN, Hines WM, Von Tungeln LS, Schnackenberg LK, Beger RD, Moland CL, Han T, Fuscoe JC, Chang CW, Chen JJ, Su Z, Fan XH, Tong W, Booth SA, Balasubramanian R, Courchesne PL, Campbell JM, Graber A, Guo Y, Juhasz PJ, Li TY, Lynch MD, Morel NM, Plasterer TN, Takach EJ, Zeng C, Beland FA
Toxicol Pathol 37: 52-64.
Therapy Indications
The Link Between Heightened Thrombogenicity and Inflammation: Pre-Procedure Characterization of the Patient at High Risk for Recurrent Events After Stenting.
(2009)
Gurbel PA, Bliden KP, Kreutz RP, Dichiara J, Antonino MJ, Tantry US
Platelets 20: 97-104.
Therapy Indications
Molecular Response to Cetuximab and Efficacy of Preoperative Cetuximab-Based Chemoradiation in Rectal Cancer.
(2009)
Debucquoy A, Haustermans K, Daemen A, Aydin S, Libbrecht L, Gevaert O, De Moor B, Tejpar S, McBride WH, Penninckx F, Scalliet P, Stroh C, Vlassak S, Sempoux C, Machiels JP
J Clin Oncol 27: 2751-2757.
Therapy Indications
CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation.
(2009)
Camargo JF, Quinones MP, Mummidi S, Srinivas S, Gaitan AA, Begum K, Jimenez F, VanCompernolle S, Unutmaz D, Ahuja SS, Ahuja SK
J Immunol 182: 171-182.
Therapy Indications
Development and Preliminary Evaluation of a Multivariate Index Assay for Ovarian Cancer.
(2009)
Amonkar SD, Bertenshaw GP, Chen TH, Bergstrom KJ, Zhao J, Seshaiah P, Yip P, Mansfield BC
PLoS ONE 4: e4599.
Therapy Indications
RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke
(2009)
Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ Jr, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I
Am J Respir Cell Mol Biol 40: 147-158.
Therapy Indications
"Host Tissue Damage" Signal ATP Impairs IL-12 and IFNgamma Secretion in LPS Stimulated Whole Human Blood.
(2008)
Nalos M, Huang S, Sluyter R, Khan A, Santner-Nanan B, Nanan R, McLean AS
Intensive Care Med 34: 1891-1897.
Therapy Indications
Biomarker Sample Collection and Handling in the Clinical Setting to Support Early-Phase Drug Development
(2008)
Russell CB, Suggs S, Patterson SD
Methods in Pharmacology and Toxicology; Biomarker Methods in Drug Discovery and Development
Therapy Indications
TGF-beta signalling-related markers in cancer patients with bone metastasis.
(2008)
Baselga J, Rothenberg ML, Tabernero J, Seoane J, Daly T, Cleverly A, Berry B, Rhoades SK, Ray CA, Fill J, Farrington DL, Wallace LA, Yingling JM, Lahn M, Arteaga C, Carducci M
Biomarkers 13: 217-236.
Therapy Indications
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.
(2008)
Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM
J Neurosci 28: 14156-14164.
Therapy Indications
Mechanisms of oncostatin M-induced pulmonary inflammation and fibrosis.
(2008)
Mozaffarian A, Brewer AW, Trueblood ES, Luzina IG, Todd NW, Atamas SP, Arnett HA
J Immunol 181: 7243-7253.
Therapy Indications
Multianalyte profiling of serum antigens and autoimmune and infectious disease molecules to identify biomarkers dysregulated in epithelial ovarian cancer.
(2008)
Bertenshaw GP, Yip P, Seshaiah P, Zhao J, Chen TH, Wiggins WS, Mapes JP, Mansfield BC
Cancer Epidemiol Biomarkers Prev 17: 2872-81.
Therapy Indications
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.
(2008)
Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R
PLoS Biol 6: e123.
Therapy Indications
Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma.
(2008)
Ding Y, Boguslawski EA, Berghuis BD, Young JJ, Zhang Z, Hardy K, Furge K, Kort E, Frankel AE, Hay RV, Resau JH, Duesbery NS
Mol Cancer Ther 7: 648-658.
Therapy Indications
Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma.
(2008)
Duan H, Fleming J, Pritchard DK, Amon LM, Xue J, Arnett HA, Chen G, Breen P, Buckner JH, Molitor JA, Elkon KB, Schwartz SM
Arthritis Rheum 58: 1465-1474.
Therapy Indications
A mouse to human search for plasma proteome changes associated with pancreatic tumor development.
(2008)
Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM
PLoS Med 5: e123.
Therapy Indications
IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells.
(2008)
Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE
Int Immunol 20: 1019-1030.
Therapy Indications
MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult.
(2008)
Thompson WL, Karpus WJ, Van Eldik LJ
J Neuroinflammation 5: 35.
Therapy Indications
Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease.
(2008)
Torrence AE, Brabb T, Viney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L
Inflamm Bowel Dis 14: 480-490.
Therapy Indications
Fibroblast growth factor 21 corrects obesity in mice.
(2008)
Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A
Endocrinology 149: 6018-6027.
Therapy Indications
Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response.
(2008)
Richardson MA, Gupta A, OBrien LA, Berg DT, Gerlitz B, Syed S, Sharma GR, Cramer MS, Heuer JG, Galbreath EJ, Grinnell BW
J Pharmacol Exp Ther 325: 17-26.
Therapy Indications
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.
(2008)
Puthawala K, Hadjiangelis N, Jacoby SC, Bayongan E, Zhao Z, Yang Z, Devitt ML, Horan GS, Weinreb PH, Lukashev ME, Violette SM, Grant KS, Colarossi C, Formenti SC, Munger JS
Am J Respir Crit Care Med 177: 82-90.
Therapy Indications
Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis.
(2008)
Pulichino AM, Wang IM, Caron A, Mortimer J, Auger A, Boie Y, Elias JA, Kartono A, Xu L, Menetski J, Sayegh CE
Am J Respir Cell Mol Biol 39: 324-36.
Therapy Indications
Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer.
(2008)
Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G
J Clin Oncol 26: 1135-1141.
Therapy Indications
Dexamethasone inhibits high glucose-, TNF-alpha-, and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes.
(2008)
Nehm? A, Edelman J
Invest Ophthalmol Vis Sci 49: 2030-2038.
Therapy Indications
Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns.
(2008)
Mares CA, Ojeda SS, Morris EG, Li Q, Teale JM
Infect Immun 76: 3001-3010.
Therapy Indications
Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice.
(2008)
Liao B, McCall E, Cox K, Lee CW, Huang S, Higgs RE, Chio LC, Zhen E, Hale JE, Jackson NK, Rutherford PG, Huang XD, Gifford-Moore D, Hui K, Duffin K, Gould KE, Rekhter M
Biomark Insights 3: 147-157.
Therapy Indications
Two distinct activation states of plasmacytoid dendritic cells induced by influenza virus and CpG 1826 oligonucleotide.
(2008)
Iparraguirre A, Tobias JW, Hensley SE, Masek KS, Cavanagh LL, Rendl M, Hunter CA, Ertl HC, von Andrian UH, Weninger W
J Leukoc Biol 83: 610-620.
Therapy Indications
Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression.
(2008)
Gurbel PA, Kreutz RP, Bliden KP, DiChiara J, Tantry US
Am Heart J 155: 56-61.
Therapy Indications
Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats.
(2008)
Fabian E, Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, van Ravenzwaay B
Arch Toxicol 82: 151-157.
Therapy Indications
Biomarker profiles in serum and saliva of experimental Sj?grens syndrome: associations with specific autoimmune manifestations.
(2008)
Delaleu N, Immervoll H, Cornelius J, Jonsson R
Arthritis Res Ther 10: R22.
Therapy Indications
Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.
(2008)
Cuaz-P?rolin C, Billiet L, Baug? E, Copin C, Scott-Algara D, Genze F, B?chele B, Syrovets T, Simmet T, Rouis M
Arterioscler Thromb Vasc Biol 28: 272-277.
Therapy Indications
Endothelial activation markers in anemic non-dialysis chronic kidney disease patients.
(2008)
Patel TV, Mittal BV, Keithi-Reddy SR, Duffield JS, Singh AK
Nephron Clin Pract 110: c244-250.
Therapy Indications
The Protective Effect of the Blood Brain Barrier from Systemic Cytokines in an Animal Femur Fracture Model.
(2007)
Ott M, Davis AT, Vanderkolk W, Resau JH, Deheer DH, Jones CB, Stouffer C, Kubek EW
J Trauma 63: 591-595.
Therapy Indications
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.
(2007)
Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I
Am J Physiol Lung Cell Mol Physiol 292: L567-L576.
Therapy Indications
Lysosomal dysfunction results in altered energy balance.
(2007)
Woloszynek JC, Coleman T, Semenkovich CF, Sands MS
J Biol Chem 282: 35765-35771.
Therapy Indications
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.
(2007)
Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, OShea JJ, Hunter CA
Nat Immunol 8: 1363-1371.
Therapy Indications
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice.
(2007)
Sakamori R, Takehara T, Ohnishi C, Tatsumi T, Ohkawa K, Takeda K, Akira S, Hayashi N
Hepatology 46: 1564-1573.
Therapy Indications
Pulmonary delivery of adenovirus vector formulated with dexamethasone-spermine facilitates homologous vector re-administration.
(2007)
Price AR, Limberis MP, Wilson JM, Diamond SL
Gene Ther 14: 1594-1604.
Therapy Indications
Phase I study of eptifibatide in patients with sickle cell anaemia.
(2007)
Lee SP, Ataga KI, Zayed M, Manganello JM, Orringer EP, Phillips DR, Parise LV
Br J Haematol 139: 612-620.
Therapy Indications
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.
(2007)
Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ
Endocrinology 148: 774-81.
Therapy Indications
Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells.
(2007)
Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J, Grosse J, Vadrucci S, Cogoli A, Derradji H, Neefs M, K?sters S, Spain M, Paul M, Grimm D
J Cell Biochem 101: 1439-1455.
Therapy Indications
Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2.
(2007)
Gupta A, Rhodes GJ, Berg DT, Gerlitz B, Molitoris BA, Grinnell BW
Am J Physiol Renal Physiol 293: F245-F254.
Therapy Indications
Multi-Analyte Profiling of Post-Myocardial Infarction Plasma Samples.
(2007)
Escobar GP and Lindsey ML
FASEB J. 21: 746.11.
Therapy Indications
Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells.
(2007)
Caers J, Deleu S, Belaid Z, De Raeve H, Van Valckenborgh E, De Bruyne E, Defresne MP, Van Riet I, Van Camp B, Vanderkerken K
Leukemia 21: 1580-1584.
Therapy Indications
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation.
(2007)
Blumberg H, Dinh H, Trueblood ES, Pretorius J, Kugler D, Weng N, Kanaly ST, Towne JE, Willis CR, Kuechle MK, Sims JE, Peschon JJ
J Exp Med 204: 2603-2614.
Therapy Indications
Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- mice.
(2007)
Basi DL, Adhikari N, Mariash A, Li Q, Kao E, Mullegama SV, Hall JL
Am J Physiol Heart Circ Physiol 292: H516-H521.
Therapy Indications
Cutting edge: interleukin 17 signals through a heteromeric receptor complex.
(2006)
Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J
J Immunol 177: 36-39.
Therapy Indications
A Phase II Pilot Trial of Low Dose, Continuous Infusion, or "Metronomic", Paclitaxel and Oral Celecoxib in Patients with Metastatic Melanoma
(2006)
McDermott DF, Cho DC, Merchan JR, Bhatt RS, Seery V, Mosher JL, Farquhar MB, Mier JW, Atkins MB, Sukhatme VP
Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. 24(18S)
Therapy Indications
Testing the Viability of Stored Frozen Serum Samples from the Air Force Health Study Using Human Multi-Analyte Profiles (MAPS)
(2006)
Fox K, Pavuk M
Organohalogen Compounds. 2006 68: 1390-1393
Therapy Indications
Using genetically engineered mouse models of cancer to aid drug development: an industry perspective.
(2006)
Singh M, Johnson L
Clin Cancer Res 12: 5312-5328.
Therapy Indications
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration.
(2006)
Schilling S, Goelz S, Linker R, Luehder F, Gold R
Clin Exp Immunol 145: 101-117.
Therapy Indications
Strain differences influence murine pulmonary responses to Stachybotrys chartarum.
(2006)
Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Brain JD
Am J Respir Cell Mol Biol 35: 415-423.
Therapy Indications
Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy--preliminary results.
(2006)
Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C
Biomed Pharmacother 60: 463-467.
Therapy Indications
TWEAK is a novel arthritogenic mediator.
(2006)
Perper SJ, Browning B, Burkly LC, Weng S, Gao C, Giza K, Su L, Tarilonte L, Crowell T, Rajman L, Runkel L, Scott M, Atkins GJ, Findlay DM, Zheng TS, Hess H
J Immunol 177: 2610-2620.
Therapy Indications
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection.
(2006)
Knorr CW, Allen SD, Torres AR, Smee DF
Antiviral Res 72: 125-133.
Therapy Indications
Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness.
(2006)
Heuer JG, Sharma GR, Zhang T, Ding C, Bailey DL, Stephens EJ, Holmes KC, Grubbs RL, Fynboe KA, Chen YF, Jakubowski JA
J Trauma 60: 865-872.
Therapy Indications
Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells.
(2006)
Guo Y, Graham-Evans B, Broxmeyer HE
Stem Cells 24: 850-856.
Therapy Indications
Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity.
(2006)
Dietsch GN, Dipalma CR, Eyre RJ, Pham TQ, Poole KM, Pefaur NB, Welch WD, Trueblood E, Kerns WD, Kanaly ST
Toxicol Pathol 34: 39-51.
Therapy Indications
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.
(2005)
Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER
J Exp Med 201: 105-115.
Therapy Indications
Prophylactic administration of abatacept prevents disease and bone destruction in a rat model of collagen-induced arthritis.
(2005)
Kliwinski C, Kukral D, Postelnek J, Krishnan B, Killar L, Lewin A, Nadler S, Townsend R
J Autoimmun 25: 165-171.
Therapy Indications
Multiplex proteomic approaches to sepsis research: case studies employing new technologies.
(2005)
Heuer JG, Cummins DJ, Edmonds BT
Expert Rev Proteomics 2: 669-680.
Therapy Indications
Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis.
(2005)
Heuer JG, Zhang T, Zhao J, Ding C, Cramer M, Justen KL, Vonderfecht SL, Na S
J Immunol 174: 7141-7146.
Therapy Indications
Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome.
(2005)
Fath MA, Mullins RF, Searby C, Nishimura DY, Wei J, Rahmouni K, Davis RE, Tayeh MK, Andrews M, Yang B, Sigmund CD, Stone EM, Sheffield VC
Hum Mol Genet 14: 1109-1118.
Therapy Indications
Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment.
(2004)
Motley ST, Morrow BJ, Liu X, Dodge IL, Vitiello A, Ward CK, Shaw KJ
Cell Microbiol 6: 849-865.
Therapy Indications
LXR-dependent gene expression is important for macrophage survival and the innate immune response.
(2004)
Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, Oconnell RM, Cheng G, Saez E, Miller JF, Tontonoz P
Cell 119: 299-309.
Therapy Indications
Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis.
(2004)
Heuer JG, Sharma GR, Gerlitz B, Zhang T, Bailey DL, Ding C, Berg DT, Perkins D, Stephens EJ, Holmes KC, Grubbs RL, Fynboe KA, Chen YF, Grinnell B, Jakubowski JA
Crit Care Med 32: 1570-1578.
Therapy Indications
Validation of a new highly standardised, lab-independent whole-blood leukocyte function assay for clinical trials (ILCS).
(2004)
Schmolz M, Hurst TL, Bailey DM, Powell JR, Forsey RJ, Thompson JM, Williams C, Pawelec G
Exp Gerontol 39: 667-671.
Therapy Indications
Screening for New Biomarkers for Subcortical Vascular Dementia and Alzheimer?s Disease
(2011)
?hrfelt A, Andreasson U, Simon A, Zetterberg H, Edman A, Potter W, Holder D, Devanarayan V, Seeburger J, Smith AD, Blennow K, Wallin A
Dement Geriatr Cogn Disord Extra 1: 31?42.
Therapy Indications
Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy
(2011)
VanGuilder HD, Bixler GV, Kutzler L, Brucklacher RM, Bronson SK, Kimball SR, Freeman WM
PLoS ONE 6: e16271.
Therapy Indications
Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV
(2011)
Casrouge A, Decalf J, Ahloulay M, Lababidi C, Mansour H, Vallet-Pichard A, Mallet V, Mottez E, Mapes J, Fontanet A, Pol S, Albert ML
J Clin Invest. 121: 308-317.
Therapy Indications
Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects
(2010)
van Dijk SJ, Feskens EJM, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LCPGM, Muller M, Afman LA
PLoS ONE 12: e14422.
Therapy Indications
Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys
(2010)
Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG
Alcohol Clin Exp Res. 2010 Nov 30. [Epub ahead of print]
Therapy Indications
Assessment of Biomarkers of Drug-induced Kidney Injury in Cynomolgus Monkeys Treated with a Triple Re-uptake Inhibitor
(2011)
Guha M, Heier A, Price S, Bielenstein M, Caccese RG, Heathcote DI, Simpson TR, Stong DB, Bodes E
Toxicol Sci. 2011 Jan 22. [Epub ahead of print]
Therapy Indications
Novel CSF biomarkers for frontotemporal lobar degenerations
(2010)
Hu WT, Chen-Plotkin A, Grossman M, Arnold SE, Clark CM, Shaw LM, McCluskey L, Elman L, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ
Neurology 75: 2079-86.
Therapy Indications
High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the gamma-secretase inhibitor, RO4929097
(2011)
He W, Luistro L, Carvajal D, Smith M, Nevins T, Yin X, Cai J, Higgins B, Kolinsky K, Rizzo C, Packman K, Heimbrook D, Boylan JF
Molecular Oncology [Epub ahead of print]
Therapy Indications
Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of a-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression
(2011)
Swain A, Turton J, Scudamore CL, Pereira I, Viswanathan N, Smyth R, Munday M, McClure F, Gandhi M, Sondh S, York M
J Appl Toxicol. [Epub ahead of print]
Therapy Indications
Blood Profile of Proteins and Steroid Hormones Predicts Weight Change after Weight Loss with Interactions of Dietary Protein Level and Glycemic Index
(2011)
Wang P, Holst C, Andersen MR, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WKWH, van Baak MA, Larsen TM, Jebb SA, Kafatos A, Pfeiffer AFH, Martinez JA, Handjieva-Darlenska T, Kunesova M, Saris WHM, Mariman ECM
PLoS ONE 6: e16773.
Therapy Indications
Performance evaluation of a multiplex assay for future use in biomarker discovery efforts to predict body composition
(2011)
Bea JW, Wright NC, Thompson P, Hu C, Guerra S, Chen Z
Clin Chem Lab Med. 2011 Mar 2. [Epub ahead of print]
Therapy Indications
Exploratory analysis of multiple omics datasets using the adjusted RV coefficient
(2011)
Mayer CD, Lorent J, Horgan GW
Stat Appl Genet Mol Biol. 2011;10(1):Article 14
Therapy Indications
Sex-specific serum biomarker patterns in adults with Aspergers syndrome
(2010)
Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S
Mol Psychiatry. 2010 Sep 28. [Epub ahead of print]
Therapy Indications
Type I Interferons increase host susceptibility to Trypanosoma cruzi infection
(2011)
Chessler AD, Caradonna KL, Dadara A, Burleigh BA
Infect Immun. 2011 Mar 14. [Epub ahead of print]
Therapy Indications
Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke
(2011)
Xin B, Jones S, Puffenberger EG, Hinze C, Bright A, Tan H, Zhou A, Wu G, Vargus-Adams J, Agamanolis D, Wang H
Proc Natl Acad Sci U S A. 2011 Mar 14. [Epub ahead of print]
Therapy Indications
2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting
(2011)
Bouwman FG, de Roos B, Rubio-Aliaga I, Crosley LK, Duthie SJ, Mayer C, Horgan G, Polley AC, Heim C, Coort SL, Evelo CT, Mulholland F, Johnson IT, Elliott RM, Daniel H, Mariman EC
BMC Med Genomics. Mar 25;4(1):24. [Epub ahead of print]
Therapy Indications
Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain
(2011)
Sharma J, Mares CA, Li Q, Morris EG, Teale JM
Microb Pathog. 2011 Jul-Aug;51(1-2):39-47
Therapy Indications
Depression and Brain-Derived Neurotrophic Factor Levels in Alzheimer?s Disease
(2011)
Hall JR, O?Bryant SE, Johnson L, Barber RC
Neuroscience & Medicine, 2, 43-47
Therapy Indications
Plasma clusterin and the risk of Alzheimer disease
(2011)
Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM
JAMA. 305: 1322-6
Therapy Indications
Modulation of Inflammatory and Lipoprotein Pathways in Skin and Serum from Patients with Psoriasis
(2011)
Faha NNM, Li K, Szapary PO, Krueger J, Brodmerkel C
J Am Coll Cardiol; 57: 576
Therapy Indications
A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma
(2011)
Ghobrial IM, Munshi NC, Harris BN, Shi P, Porter NM, Schlossman RL, Laubach JP, Anderson KC, Desaiah D, Myrand SP, Wooldridge JE, Richardson PG, Abonour R
Am. J. Hematol.
Therapy Indications
Identification of a biological signature for schizophrenia in serum
(2011)
Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S
Mol Psychiatry. 2012 May;17(5):494-502
Therapy Indications
Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
(2011)
Erdely A, Hulderman T, Salmen-Muniz R, Liston A, Zeidler-Erdely PC, Chen BT, Stone S, Frazer DG, Antonini JM, Simeonova PP
Toxicol Lett. 2011 Jul 4;204(1):12-6.
Therapy Indications
Inflammatory profile and response to anti-TNF therapy in patients with chronic pulmonary sarcoidosis
(2011)
Loza MJ, Brodmerkel C, Du Bois RM, Judson MA, Costabel U, Drent M, Kavuru M, Flavin S, Lo KH, Barnathan ES, Baughman RP
Clin Vaccine Immunol. 2011 Apr 20. [Epub ahead of print]
Therapy Indications
Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimers Disease Diagnosis and Prognosis
(2011)
Craig-Schapiro R, Kuhn M, Xiong C, Pickering EH, Liu J, Misko TP, Perrin RJ, Bales KR, Soares H, Fagan AM, Holtzman DM
PLoS One. 2011 Apr 19;6(4):e18850
Therapy Indications
Molecular indicators of non-sentinel node status in breast cancer determined in preoperative biopsies by multiplexed sandwich immunoassays
(2011)
Sauer G, Schneiderhan-Marra N, Muche R, Koretz K, Kazmaier C, Kreienberg R, Joos T, Deissler H
J Cancer Res Clin Oncol. 2011 Apr 24. [Epub ahead of print]
Therapy Indications
Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling
(2011)
Jin YF, Han HC, Berger J, Dai Q, Lindsey ML
BMC Syst Biol. 2011 May 5;5(1):60. [Epub ahead of print]
Therapy Indications
Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD
(2010)
Aaron SD, Vandemheen KL, Ramsay T, Zhang C, Avnur Z, Nikolcheva T, Quinn A
Respir Res. 2010 Apr 22;11:41
Therapy Indications
Molecular Markers for Diagnosis of Periprosthetic Joint Infection
(2011)
Jacovides CL, Parvizi J, Adeli B, Jung KA
J Arthroplasty. 2011 May 12. [Epub ahead of print]
Therapy Indications
Human plasma inflammatory response during 5 days of exercise training in the heat
(2011)
Hailes WS, Slivka D, Cuddy J, Ruby BC
Journal of Thermal Biology
Therapy Indications
Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock
(2011)
Schreiner L, Huber-Lang M, Weiss ME, Hohmann H, Schmolz M, Schneider EM
J Cell Commun Signal. 2011 Jun;5(2):135-44
Therapy Indications
Validation of the Tetracycline Regulatable Gene Expression System for the Study of the Pathogenesis of Infectious Disease
(2011)
Chaturvedi AK, Lazzell AL, Saville SP, Wormley Jr.FL, Monteagudo C, Lopez-Ribot JL
PLoS ONE 6(5): e20449
Therapy Indications
Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status
(2012)
Pellis L, van Erk MJ, van Ommen B, Bakker GCM, Hendriks HFJ, Cnubben NHP, Kleemann R, van Someren EP, Bobeldijk I, Rubingh CM, Wopereis S
Metabolomics
Therapy Indications
Early improvement on antipsychotic treatment as a predictor of subsequent response in schizophrenia: analyses from ziprasidone clinical studies
(2011)
OGorman C, Kapur S, Kolluri S, Kane J
Hum Psychopharmacol. 2011 Jun 2. [Epub ahead of print]
Therapy Indications
Tumor Microenvironment-Derived Proteins Dominate the Plasma Proteome Response During Breast Cancer Induction and Progression
(2011)
Pitteri SJ, Kelly-Spratt KS, Gurley KE, Kennedy J, Busald Buson T, Chin A, Wang H, Zhang Q, Wong CH, Chodosh LA, Nelson PS, Hanash SM, Kemp CJ
Cancer Res. 2011 Jun 8. [Epub ahead of print]
Therapy Indications
Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure
(2011)
Erdely A, Liston A, Salmen-Muniz R, Hulderman T, Shih-Houng Y, Zeidler-Erdely PC, Castranova V, Simeonova PP
Journal of Occupational & Environmental Medicine: June 2011 - Volume 53 - Issue - p S80?S86
Therapy Indications
Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter
(2011)
Erdely A, Salmen-Muniz R, Liston A, Hulderman T, Zeidler-Erdely PC, Antonini JM, Simeonova PP
Toxicology
Therapy Indications
Increased Disease Severity of Parasite-Infected TLR2-/- Mice Is Correlated with Decreased Central Nervous System Inflammation and Reduced Numbers of Cells with Alternatively Activated Macrophage Phenotypes in a Murine Model of Neurocysticercosis
(2011)
Gundra UM, Mishra BB, Wong K, Teale JM
Infect Immun. 2011 Jul;79(7):2586-96
Therapy Indications
Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis
(2011)
Hartgring SA, Willis CR, Dean CE Jr, Broere F, van Eden W, Bijlsma JW, Lafeber FP, van Roon JA
Arthritis Rheum. Jul;63(7):1878-87
Therapy Indications
Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis
(2011)
Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, Biamonte F, Bartalucci N, Gattoni E, Lupo ML, Finazzi G, Pancrazzi A, Antonioli E, Susini MC, Pieri L, Malevolti E, Usala E, Occhini U, Grossi A, Caglio S, Paratore S, Bosi A, Barbui T, Vannucchi AM
Blood. 2011 Jul 1. [Epub ahead of print]
Therapy Indications
Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation
(2011)
Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, De Angelis MH, Hamelmann E, Stoeger T, Schulz H
Respir Res. Jul 15;12(1):94
Therapy Indications
Efficient Colonization and Therapy of Human Hepatocellular Carcinoma (HCC) Using the Oncolytic Vaccinia Virus Strain GLV-1h68
(2011)
Gentschev I, M?ller M, Adelfinger M, Weibel S, Grummt F, Zimmermann M, Bitzer M, Heisig M, Zhang Q, Yu YA, Chen NG, Stritzker J, Lauer UM, Szalay AA
PLoS ONE 6(7): e22069
Therapy Indications
STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
(2011)
Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, Zimmers TA
PLoS ONE 6(7): e22538
Therapy Indications
Mark B. Coventry Award: Synovial C-reactive Protein: A Prospective Evaluation of a Molecular Marker for Periprosthetic Knee Joint Infection
(2011)
Parvizi J, Jacovides C, Adeli B, Jung KA, Hozack WJ
Clin Orthop Relat Res. 2011 Jul 23. [Epub ahead of print]
Therapy Indications
Clinical and Plasma Proteomic Markers Correlating With Chronic Kidney Disease After Liver Transplantation
(2011)
Levitsky J, Salomon DR, Abecassis M, Langfelder P, Horvath S, Friedewald J, Wang E, Kurian SM, Mondala T, Gil S, McDade R, Ballard K, Gallon L
Am J Transplant. 2011 Jul 27.
Therapy Indications
Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression
(2011)
Dreim?ller N, Schlicht KF, Wagner S, Peetz D, Borysenko L, Hiemke C, Lieb K, Tadic A
Neuropharmacology. 2011 Jul 22. [Epub ahead of print]
Therapy Indications
Trefoil Factor 3 Predicts Incident Chronic Kidney Disease: A Case-Control Study Nested within the Atherosclerosis Risk in Communities (ARIC) Study
(2011)
Astor BC, K?ttgen A, Hwang SJ, Bhavsar N, Fox CS, Coresh J
Am J Nephrol. 2011 Aug 9;34(4):291-297.
Therapy Indications
Rapidly Progressive, Fatal, Inhalation Anthraxlike Infection in a Human: Case Report, Pathogen Genome Sequencing, Pathology, and Coordinated Response
(2011)
Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM
Arch Pathol Lab Med. 2011 Aug 9. [Epub ahead of print]
Therapy Indications
Host-derived osteopontin maintains an acute inflammatory response to suppress early progression of extrinsic cancer cells
(2011)
Hsieh YH, Juliana MM, Ho KJ, Kuo HC, van der Heyde H, Elmets C, Chang PL
Int J Cancer. 2011 Aug 8. doi: 10.1002/ijc.26359. [Epub ahead of print]
Therapy Indications
A role for IL-27 in limiting T regulatory cell populations
(2011)
Wojno ED, Hosken N, Stumhofer JS, OHara AC, Mauldin E, Fang Q, Turka LA, Levin SD, Hunter CA
J Immunol. 2011 Jul 1;187(1):266-73
Therapy Indications
Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease
(2011)
Zhang L, Rajan V, Lin E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch WE
FASEB J. 2011 May;25(5):1653-63
Therapy Indications
Modeling of pathological traits in Alzheimers disease based on systemic extracellular signaling proteome
(2011)
Britschgi M, Rufibach K, Bauer Huang SL, Clark CM, Kaye JA, Li G, Peskind ER, Quinn JF, Galasko DR, Wyss-Coray T
Mol Cell Proteomics. 2011 Jul 8. [Epub ahead of print]
Therapy Indications
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis
(2011)
Weinger JG, Brosnan CF, Loudig O, Goldberg MF, Macian F, Arnett HA, Prieto AL, Tsiperson V, Shafit-Zagardo B
J Neuroinflammation. 2011 May 15;8:49
Therapy Indications
Lower urinary connective tissue growth factor levels and incident CKD stage 3 in the general population
(2011)
OSeaghdha CM, Hwang SJ, Bhavsar NA, K?ttgen A, Coresh J, Astor BC, Fox CS
Am J Kidney Dis. 2011 Jun;57(6):841-9
Therapy Indications
Building an integrated neurodegenerative disease database at an academic health center
(2011)
Xie SX, Baek Y, Grossman M, Arnold SE, Karlawish J, Siderowf A, Hurtig H, Elman L, McCluskey L, Van Deerlin V, Lee VM, Trojanowski JQ
Alzheimers Dement. 2011 Jul;7(4):e84-e93
Therapy Indications
TGF-?2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium
(2011)
Singla DK, Singla RD, Lamm S, Glass C
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1442-50
Therapy Indications
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
(2011)
Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G
Nature. 2011 Jul 13;475(7355):226-30
Therapy Indications
Urinary cystatin C as a biomarker for acute kidney injury and its immunohistochemical localization in kidney in the CDDP-treated rats
(2011)
Togashi Y, Sakaguchi Y, Miyamoto M, Miyamoto Y
Exp Toxicol Pathol. 2011 Mar 4. [Epub ahead of print]
Therapy Indications
Serum biomarkers of aging in the Brown Norway rat
(2011)
Gordon CJ, Rowsey PJ, Bishop BL, Ward WO, Macphail RC
Exp Gerontol. 2011 Jul 28. [Epub ahead of print]
Therapy Indications
Multi-analyte profiling reveals matrix metalloproteinase-9 and monocyte chemotactic protein-1 as plasma biomarkers of cardiac aging
(2011)
Chiao YA, Dai Q, Zhang J, Lin J, Lopez EF, Ahuja SS, Chou YM, Lindsey ML, Jin YF
Circ Cardiovasc Genet. 2011 Aug 1;4(4):455-62
Therapy Indications
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
(2011)
Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Despr?s S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T
Nature. 2011 Aug 31;477(7362):90-4
Therapy Indications
Associations between body mass, radiographic joint damage, adipokines and risk factors for bone loss in rheumatoid arthritis
(2011)
Baker JF, George M, Baker DG, Toedter G, Von Feldt JM, Leonard MB
Rheumatology (Oxford). 2011 Sep 2. [Epub ahead of print]
Therapy Indications
Identification of a blood-based biological signature in subjects with psychiatric disorders
(2011)
Schwarz E, Guest PC, Rahmoune H, Martins-de-Souza D, Niebuhr DW, Weber NS, Cowan DN, Yolken RH, Spain M, Barnes A, Bahn S
World J Biol Psychiatry. 2012 Dec;13(8):627-32
Therapy Indications
Discrimination of agonist and antagonist forms of CXCL10 in biologic samples
(2011)
Casrouge A, Bisiaux A, Stephen L, Schmolz M, Mapes J, Pfister C, Pol S, Mallet V, Albert ML
Clin Exp Immunol. 2012 Jan;167(1):137-48
Therapy Indications
Deletion of a Malaria Invasion Gene Reduces Death and Anemia, in Model Hosts
(2011)
G?mez ND, Safeukui I, Adelani AA, Tewari R, Reddy JK, Rao S, Holder A, Buffet P, Mohandas N, Haldar K
PLoS ONE 6(9): e25477
Therapy Indications
Mouse ghrelin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption
(2011)
Kang K, Schmahl J, Lee JM, Garcia K, Patil K, Chen A, Keene M, Murphy A, Sleeman MW
FASEB J. 2011 Sep 29. [Epub ahead of print]
Therapy Indications
Comparison of the course of biomarker changes and kidney injury in a rat model of drug-induced acute kidney injury
(2011)
Sasaki D, Yamada A, Umeno H, Kurihara H, Nakatsuji S, Fujihira S, Tsubota K, Ono M, Moriguchi A, Watanabe K, Seki J
Biomarkers. 2011 Sep 28. [Epub ahead of print]
Therapy Indications
Inflammatory signaling in Alzheimer disease and depression
(2011)
Barber, R
Cleveland Clinic Journal of Medicine vol. 78 Suppl 1 S47-S49
Therapy Indications
Molecular profiling and gene expression analysis in cutaneous sarcoidosis: The role of interleukin-12, interleukin-23, and the T-helper 17 pathway
(2011)
Judson MA, Marchell RM, Mascelli M, Piantone A, Barnathan ES, Petty KJ, Chen D, Fan H, Grund H, Ma K, Baribaud F, Brodmerkel C
J Am Acad Dermatol. 2011 Sep 15. [Epub ahead of print]
Therapy Indications
Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy
(2011)
Stelzhammer V, Rothermundt M, Guest PC, Michael N, Sondermann C, Kluge W, Martins-de-Souza D, Rahmoune H, Bahn S
Proteomics Clin Appl. 2011 Oct 17.
Therapy Indications
Mycobacteria activate gamma delta T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy
(2011)
Fowler DW, Copier J, Wilson N, Dalgleish AG, Bodman-Smith MD
Cancer Immunol Immunother. 2011 Oct 15. [Epub ahead of print]
Therapy Indications
Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
(2011)
Nalabotu SK, Kolli MB, Triest WE, Ma JY, Manne NDPK, Katta A, Addagarla HS, Rice KM, Blough ER
International Journal of Nanomedicine Volume 2011:6 Pages 2327 - 2335
Therapy Indications
Relationship of neurocognitive deficits to diagnosis and symptoms across affective and non-affective psychoses
(2011)
Lewandowski KE, Cohen BM, Keshavan MS, Ong?r D
Schizophr Res. 2011 Oct 11. [Epub ahead of print]
Therapy Indications
Peripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis
(2011)
Richards TJ, Kaminski N, Baribaud F, Flavin S, Brodmerkel C, Horowitz D, Li K, Choi J, Vuga LJ, Lindell KO, Klesen M, Zhang Y, Gibson KF
Am J Respir Crit Care Med. 2011 Oct 20. [Epub ahead of print]
Therapy Indications
Short term inhalation toxicity of a liquid aerosol of CdS/Cd(OH)(2) core shell quantum dots in male Wistar rats
(2011)
Ma-Hock L, Brill S, Wohlleben W, Farias PM, Chaves CR, Ten?rio DP, Fontes A, Santos BS, Landsiedel R, Strauss V, Treumann S, van Ravenzwaay B
Toxicol Lett. 2011 Oct 20. [Epub ahead of print]
Therapy Indications
Measurement of A?1-42 in Cerebrospinal Fluid is Influenced by Matrix Effects
(2011)
Slemmon JR, Meredith J, Guss V, Andreasson U, Andreasen N, Zetterberg H, Blennow K
J Neurochem. 2011 Oct 25.
Therapy Indications
Inhibition of RPE cell sterile inflammatory responses and endotoxin-induced uveitis by a cell-impermeable HSP90 inhibitor
(2011)
Qin S, Ni M, Wang X, Maurier-Mah? F, Shurland DL, Rodrigues GA
Exp Eye Res. 2011 Oct 18. [Epub ahead of print]
Therapy Indications
Serum markers associated with clinical improvement in patients with ankylosing spondylitis treated with golimumab
(2011)
Wagner C, Visvanathan S, Braun J, van der Heijde D, Deodhar A, Hsu B, Mack M, Elashoff M, Inman RD
Ann Rheum Dis. 2011 Oct 28. [Epub ahead of print]
Therapy Indications
Inhibition of experimental Sj?grens syndrome through immunization with HSP60 and its peptide amino acids 437-460
(2008)
Delaleu N, Madureira AC, Immervoll H, Jonsson R
Arthritis Rheum. Aug;58(8):2318-28
Therapy Indications
Algorithm development for diagnostic biomarker assays
(2011)
Izmailov R, Guest PC, Bahn S, Schwarz E
Int Rev Neurobiol. 2011;101:279-98
Therapy Indications
Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging
(2011)
Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z
J Gerontol A Biol Sci Med Sci. 2011 Nov 10. [Epub ahead of print]
Therapy Indications
Effects of DPP-4 Inhibitors on the Heart in a Rat Model of Uremic Cardiomyopathy
(2011)
Chaykovska L, von Websky K, Rahnenf?hrer J, Alter M, Heiden S, Fuchs H, Runge F, Klein T, Hocher B
PLoS ONE 6(11): e27861
Therapy Indications
Bone Marrow Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo
(2011)
Xu S, Menu E, De Becker A, Van Camp B, Vanderkerken K, Van Riet I
Stem Cells. 2011 Nov 18. [Epub ahead of print]
Therapy Indications
Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis
(2011)
Ohashi K, Sato A, Takada T, Arai T, Nei T, Kasahara Y, Motoi N, Hojo M, Urano S, Ishii H, Yokoba M, Eda R, Nakayama H, Nasuhara Y, Tsuchihashi Y, Kaneko C, Kanazawa H, Ebina M, Yamaguchi E, Kirchner J, Inoue Y, Nakata K, Tazawa R
Respir Med. 2011 Nov 22. [Epub ahead of print]
Therapy Indications
G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response
(2011)
Gardner J, Wu S, Ling L, Danao J, Li Y, Yeh WC, Tian H, Baribault H
Biochemical and Biophysical Research Communications
Therapy Indications
A novel detection method of non-small cell lung cancer using multiplexed bead-based serum biomarker profiling
(2011)
Lee HJ, Kim YT, Park PJ, Shin YS, Kang KN, Kim Y, Kim CW
J Thorac Cardiovasc Surg. 2011 Nov 18. [Epub ahead of print]
Therapy Indications
A Longitudinal Analysis of Circulating Stress-Related Proteins and Chronic Ethanol Self-Administration in Cynomolgus Macaques
(2011)
Helms CM, Messaoudi I, Jeng S, Freeman WM, Vrana KE, Grant KA
Alcohol Clin Exp Res. 2011 Dec 5. [Epub ahead of print]
Therapy Indications
A Blood-Based Screening Tool for Alzheimers Disease That Spans Serum and Plasma: Findings from TARC and ADNI
(2011)
OBryant SE, Xiao G, Barber R, Huebinger R, Wilhelmsen K, Edwards M, Graff-Radford N, Doody R, Diaz-Arrastia R; for the Texas Alzheimers Research & Care Consortium; for the Alzheimers Disease Neuroimaging Initiative
PLoS One. 2011;6(12):e28092. Epub 2011 Dec 7.
Therapy Indications
Matrix Metalloproteinase-28 Deletion Amplifies Inflammatory and Extracellular Matrix Responses to Cardiac Aging
(2011)
Ma Y, Chiao YA, Zhang J, Manicone AM, Jin YF, Lindsey ML
Microsc Microanal. 2011 Dec 8:1-10. [Epub ahead of print]
Therapy Indications
Macrophage-Specific Chemokines Induced via Innate Immunity by Amino Acid Copolymers and Their Role in EAE
(2011)
Kovalchin J, Krieger J, Genova M, Kawamoto N, Augustyniak M, Collins K, Bloom T, Masci A, Hittinger T, Dufour I, Strominger JL, Zanelli E
PLoS ONE 6(12): e26274
Therapy Indications
Biomarker analysis of Morquio syndrome: Identification of disease state and drug responsive markers
(2011)
Martell L, Lau K, Mei M, Burnett V, Decker C, Foehr ED
Orphanet Journal of Rare Diseases 2011, 6:84
Therapy Indications
Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus
(2011)
Safronetz D, Zivcec M, LaCasse R, Feldmann F, Rosenke R, Long D, Haddock E, Brining D, Gardner D, Feldmann H, Ebihara H
PLoS Pathog 7(12): e1002426
Therapy Indications
Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients
(2012)
Levitsky J, Mathew JM, Abecassis M, Tambur A, Leventhal J, Chandrasekaran D, Herrera N, Al-Saden P, Gallon L, Abdul-Nabi A, Yang GY, Kurian SM, Salomon DR, Miller J
Hepatology. 2012 Jan 11. doi: 10.1002/hep.25579. [Epub ahead of print]
Therapy Indications
The kinetics of cardiopulmonary bypass: a dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass
(2012)
Umstead TM, Lu CJ, Freeman WM, Myers JL, Clark JB, Thomas NJ, Icitovic N, Chinchilli VM, Undar A, Phelps DS
Artif Organs. 2012 Jan;36(1):E1-E20.
Therapy Indications
Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects
(2012)
Krishnamurthy D, Harris LW, Levin Y, Koutroukides TA, Rahmoune H, Pietsch S, Vanattou-Saifoudine N, Leweke FM, Guest PC, Bahn S
World J Biol Psychiatry. 2012 Jan 17. [Epub ahead of print]
Therapy Indications
Comprehensive serum profiling for the discovery of epithelial ovarian cancer biomarkers
(2011)
Yip P, Chen TH, Seshaiah P, Stephen LL, Michael-Ballard KL, Mapes JP, Mansfield BC, Bertenshaw GP
PLoS One. 2011;6(12):e29533. Epub 2011 Dec 21
Therapy Indications
Biomarkers and Depressive Symptoms in a Sample of Cognitively Intact and Alzheimer?s Disease Elderly Males
(2011)
Hall JR, Vo HT, Johnson LA, Winter S, Barber RC, O?Bryant SE
Neuroscience & Medicine, 2011, 2, 306-312
Therapy Indications
Plasma biomarkers of depressive symptoms in older adults
(2012)
Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VMY, Mackin RS, Trojanowski JQ, Wilson RS, Shaw LM
Translational Psychiatry (2012) 2, e65;
Therapy Indications
Divergence Weighted Independence Graphs for the Exploratory Analysis of Biological Expression Data
(2011)
Xiang Y, Talikka M, Belcastro V, Sperisen P, Peitsch MC, Hoeng J, Whittaker J
J Health Med Informat 2011, S2
Therapy Indications
Bronchial and Bronchiolar Fibrosis in Rats Exposed to 2,3-Pentanedione Vapors: Implications for Bronchiolitis Obliterans in Humans
(2012)
Morgan DL, Jokinen MP, Price HC, Gwinn WM, Palmer SM, Flake GP
Toxicol Pathol. 2012 Jan 3. [Epub ahead of print]
Therapy Indications
Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis
(2012)
Liu WM, Dennis JL, Gravett AM, Chanthirakumar C, Kaminska E, Coulton G, Fowler DW, Bodman-Smith M, Dalgleish AG
Br J Cancer. 2012 Jan 31 [Epub ahead of print]
Therapy Indications
Proteomic approaches to unravel the complexity of schizophrenia
(2012)
Martins-de-Souza D, Guest PC, Rahmoune H, Bahn S
Expert Rev Proteomics. 2012 Feb;9(1):97-108
Therapy Indications
STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma
(2012)
Looyenga BD, Hutchings D, Cherni I, Kingsley C, Weiss GJ, MacKeigan JP
PLoS ONE 7(2): e30820
Therapy Indications
Pharmacokinetics and Pharmacodynamics of Pegylated Interferon Lambda-1 in Cynomolgus Monkeys
(2012)
Byrnes-Blake KA, Pederson S, Klucher KM, Anderson-Haley M, Miller DM, Lopez-Talavera JC, Freeman JA
J Interferon Cytokine Res. 2012 Jan 26. [Epub ahead of print]
Therapy Indications
Association between lead and cadmium and reproductive hormones in peripubertal U.S. girls
(2010)
Lenberg AL, Hediger ML, Lee PA, Himes JH, Louis G
Environ Health Perspect. 2010 Dec;118(12):1782-7
Therapy Indications
Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies
(2008)
Adibhatla RM, Hatcher JF
CNS Neurol Disord Drug Targets. 2008 Jun;7(3):243-53
Therapy Indications
Synthetic Ligands Against TLR2-9 in TruCulture - whole blood assays distinguish clinical stages of SIRS (trauma) and sepsis
(2010)
Bindja J, Weiss ME, Schmolz M, Stein GM, Mapes J, Schneiderhan-Marra N, Joos TO, Schneider EM
TSIS Mar 9-13th
Therapy Indications
Effects of Echinaforce? treatment on ex vivo-stimulated blood cells
(2011)
Ritchie MR, Gertsch J, Klein P, Schoop R
Phytomedicine. 2011 Jul 15;18(10):826-31
Therapy Indications
Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients
(2012)
Schwarz E, Guest PC, Steiner J, Bogerts B, Bahn S
Translational Psychiatry (2012) 2, e82
Therapy Indications
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
(2012)
Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, Catalano JV, Deininger M, Miller C, Silver RT, Talpaz M, Winton EF, Harvey JH Jr, Arcasoy MO, Hexner E, Lyons RM, Paquette R, Raza A, Vaddi K, Erickson-Viitanen S, Koumenis IL, Sun W, Sandor V, Kantarjian HM
N Engl J Med. 2012 Mar;366(9):799-807
Therapy Indications
Preferential Replication of Systemically Delivered Oncolytic Vaccinia Virus in Focally Irradiated Glioma Xenografts
(2012)
Advani SJ, Buckel L, Chen NG, Scanderbeg DJ, Geissinger U, Zhang Q, Yu YA, Aguilar RJ, Mundt A, Szalay AA
Clin Cancer Res. 2012 Feb 29. [Epub ahead of print]
Therapy Indications
Evaluation of multiple variate selection methods from a biological perspective: a nutrigenomics case study
(2012)
Tapp HS, Radonjic M, Kate Kemsley E, Thissen U
Genes Nutr. 2012 Mar 2. [Epub ahead of print]
Therapy Indications
A small animal peripheral challenge model of yellow fever using interferon-receptor deficient mice and the 17D-204 vaccine strain
(2012)
Thibodeaux BA, Garbinoa NC, Lissb NM, Piper J, Blair CD, Roehrig JT
Vaccine
Therapy Indications
RN486, a Selective Brutons Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents
(2012)
Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, Srinivasan D, Woods J, Levin A, OMahony A, Owens TD, Lou Y, Hill RJ, Narula S, Demartino J, Fine JS
J Pharmacol Exp Ther. 2012 Apr;341(1):90-103
Therapy Indications
Inhibin B and luteinizing hormone levels in girls aged 6-11 years from NHANES III, 1988-1994
(2012)
Sims EK, Addo OY, Gollenberg AL, Himes JH, Hediger ML, Lee PA
Clin Endocrinol (Oxf). 2012 Mar 24
Therapy Indications
Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes
(2012)
Willard MD, Lajiness ME, Wulur IH, Feng B, Swearingen ML, Uhlik MT, Kinzler KW, Velculescu VE, Sj?blom T, Markowitz SD, Powell SM, Vogelstein B, Barber TD
Mol Cancer Res. 2012 Apr 19
Therapy Indications
Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
(2012)
Tolcher AW, Messersmith WA, Mikulski SM, Papadopoulos KP, Kwak EL, Gibbon DG, Patnaik A, Falchook GS, Dasari A, Shapiro GI, Boylan JF, Xu ZX, Wang K, Koehler A, Song J, Middleton SA, Deutsch J, Demario M, Kurzrock R, Wheler JJ
J Clin Oncol. 2012 Apr 23
Therapy Indications
Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia
(2012)
Pedroso FE, Spalding PB, Cheung MC, Yang R, Gutierrez JC, Bonetto A, Zhan R, Chan HL, Namias N, Koniaris LG, Zimmers TA
J Cachexia Sarcopenia Muscle. 2012 Mar 29
Therapy Indications
Multivariate Protein Signatures of Pre-Clinical Alzheimers Disease in the Alzheimers Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset
(2012)
Johnstone D, Milward EA, Berretta R, Moscato P
PLoS One. 2012;7(4):e34341
Therapy Indications
Candidate Proteins, Metabolites and Transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) Clinical Study
(2012)
Finkel RS, Crawford TO, Swoboda KJ, Kaufmann P, Juhasz P, Li X, Guo Y, Li RH, Trachtenberg F, Forrest SJ, Kobayashi DT, Chen KS, Joyce CL, Plasterer T
PLoS ONE 7(4): e35462
Therapy Indications
Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) as Predictors of Incident CKD Stage 3: The Atherosclerosis Risk in Communities (ARIC) Study
(2012)
Bhavsar NA, K?ttgen A, Coresh J, Astor BC
Am J Kidney Dis. 2012 Apr 27. [Epub ahead of print]
Therapy Indications
Increased serum ?2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus
(2012)
Hermansen ML, Hummelsh?j L, Lundsgaard D, Hornum L, Keller P, Fleckner J, Fox B, Poulsen LK, Jacobsen S
Lupus. 2012 May 10. [Epub ahead of print]
Therapy Indications
Biomarkers of Basic Activities of Daily Living in Alzheimers Disease
(2012)
Hall JR, Johnson LA, Barber RC, Vo HT, Winter AS, OBryant SE
J Alzheimers Dis. 2012 May 9. [Epub ahead of print]
Therapy Indications
Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses
(2012)
Joubert MK, Hokom M, Eakin C, Zhou L, Deshpande M, Baker MP, Goletz TJ, Kerwin BA, Chirmule N, Narhi LO, Jawa V
J Biol Chem. 2012 Jul 20;287(30):25266-79
Therapy Indications
Identification of cis- regulatory variation influencing protein abundance levels in human plasma
(2012)
Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S; on behalf of the AddNeuroMed Consortium, Dobson R; for the Alzheimer?s Disease Neuroimaging Initiative
Hum Mol Genet. 2012 May 16. [Epub ahead of print]
Therapy Indications
First-Trimester Prediction of Preeclampsia in Nulliparous Women at Low Risk
(2012)
Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, Thorp JM Jr, Mercer BM, Peaceman AM, Ramin SM, Carpenter MW, Iams JD, Sciscione A, Harper M, Tolosa JE, Saade G, Sorokin Y, Anderson GD
Obstet Gynecol. 2012 Jun;119(6):1234-1242
Therapy Indications
Consumption of a High Monounsaturated-Fat Diet Reduces Oxidative Phosphorylation Gene Expression in Peripheral Blood Mononuclear Cells of Abdominally Overweight Men and Women
(2012)
van Dijk SJ, Feskens EJ, Bos MB, de Groot LC, de Vries JH, M?ller M, Afman LA
J Nutr. 2012 May 23. [Epub ahead of print]
Therapy Indications
Analysis of serum and plasma identifies differences in molecular coverage, measurement variability and candidate biomarker selection
(2012)
Alsaif M, Guest PC, Schwarz E, Reif A, Kittel-Schneider S, Spain M, Rahmoune H, Bahn S
Proteomics Clin Appl. 2012 May 29
Therapy Indications
Association of Estimated Glomerular Filtration Rate and Urinary Uromodulin Concentrations with Rare Variants Identified by UMOD Gene Region Sequencing
(2012)
K?ttgen A, Yang Q, Shimmin LC, Tin A, Schaeffer C, Coresh J, Liu X, Rampoldi L, Hwang S, Boerwinkle E, Hixson JE, Linda Kao WH, Fox CS
PLoS ONE 7(5): e38311
Therapy Indications
Biomarkers and Depressive Symptoms in Older Women with and without Cognitive Impairment
(2012)
Hall JR, Johnson LA, Vo HT, Barber RC, Winter AS, O?Bryant SE
Journal of Behavioral and Brain Science, 2012, 2, 276-281
Therapy Indications
Evaluations of Tear Protein Markers in Dry Eye Disease: Repeatability of Measurement and Correlation with Disease
(2012)
Huang JF, Zhang Y, Rittenhouse KD, Pickering EH, McDowell MT
Invest Ophthalmol Vis Sci. 2012 Jun 13. [Epub ahead of print]
Therapy Indications
Interleukin-7 aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation
(2012)
Hartgring SA, Willis CR, Bijlsma JW, Lafeber FP, van Roon JA
Arthritis Res Ther. 2012 Jun 7;14(3):R137
Therapy Indications
Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals
(2012)
Song F, Poljak A, Crawford J, Kochan NA, Wen W, Cameron B, Lux O, Brodaty H, Mather K, Smythe GA, Sachdev PS
PLoS One. 2012;7(6):e34078
Therapy Indications
Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods
(2012)
Jokerst JV, Thangaraj M, Kempen P, Sinclair R, Gambhir SS
ACS Nano. 2012 Jun 10. [Epub ahead of print]
Therapy Indications
Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype
(2012)
Ringman JM, Elashoff D, Geschwind DH, Welsh BT, Gylys KH, Lee C, Cummings JL, Cole GM
Arch Neurol. 2012 Jun 1;69(6):757-64
Therapy Indications
Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity
(2012)
Cockayne DA, Cheng DT, Waschki B, Sridhar S, Ravindran P, Hilton H, Kourteva G, Bitter H, Pillai SG, Visvanathan S, M?ller KC, Holz O, Magnussen H, Watz H, Fine JS
PLoS One. 2012;7(6):e38629
Therapy Indications
The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis
(2011)
Macauley SL, Pekny M, Sands MS
J Neurosci. 2011 Oct 26;31(43):15575-85
Therapy Indications
Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses
(2012)
Racioppi L, Noeldner PK, Lin F, Arvai S, Means AR
J Biol Chem. 2012 Feb 14. [Epub ahead of print]
Therapy Indications
Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity
(2012)
Schuurhof A, Bont L, Hodemaekers HM, de Klerk A, de Groot H, Hofland RW, van de Pol AC, Kimpen JL, Janssen R
Eur Respir J. 2012 Jun;39(6):1475-81
Therapy Indications
Cox-2 expression, PGE2 and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice
(2011)
Gravaghi C, La Perle KM, Ogrodwski P, Kang JX, Quimby F, Lipkin M, Lamprecht SA
J Nutr Biochem. 2011 Apr;22(4):360-5
Therapy Indications
Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis
(2012)
Su?rez-Fari?as M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG
J Invest Dermatol. 2012 Jul 5
Therapy Indications
Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: a controlled phase 2B trial
(2011)
Quoix E, Ramlau R, Westeel V, Papai Z, Madroszyk A, Riviere A, Koralewski P, Breton JL, Stoelben E, Braun D, Debieuvre D, Lena H, Buyse M, Chenard MP, Acres B, Lacoste G, Bastien B, Tavernaro A, Bizouarne N, Bonnefoy JY, Limacher JM
Lancet Oncol. 2011 Nov;12(12):1125-33
Therapy Indications
Identification of blood protein biomarkers that aid in the clinical assessment of patients with malignant glioma
(2012)
Xu BJ, An QA, Srinivasa Gowda S, Yan W, Pierce LA, Abel TW, Rush SZ, Cooper MK, Ye F, Shyr Y, Weaver KD, Thompson RC
Int J Oncol. 2012 Jun;40(6):1995-2003
Therapy Indications
Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB
(2011)
Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L
Brain. 2011 Sep;134(Pt 9):2722-35
Therapy Indications
Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells
(2007)
Farahi N, Cowburn AS, Upton PD, Deighton J, Sobolewski A, Gherardi E, Morrell NW, Chilvers ER
J Immunol. 2007 Jul 15;179(2):1264-73
Therapy Indications
Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease
(2012)
Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, Mondal A, Bedo J, Bush AI, Brown B, De Ruyck K, Ellis KA, Fowler C, Gupta VB, Head R, Macaulay SL, Pertile K, Rowe CC, Rembach A, Rodrigues M, Rumble R, Szoeke C, Taddei K, Taddei T, Trounson B, Ames D, Masters CL, Martins RN; for the Alzheimers Disease Neuroimaging Initiative and Australian Imaging Biomarker and Lifestyle Research Group
Arch Neurol. 2012 Jul 16:1-8
Therapy Indications
Urinary cystatin C as a biomarker for diabetic nephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty (ZDF) rats
(2012)
Togashi Y, Miyamoto Y
Exp Toxicol Pathol. 2012 Jul 11
Therapy Indications
Immunomodulatory Effect of the Topical Ophthalmic Janus Kinase Inhibitor Tofacitinib (CP-690,550) in Patients with Dry Eye Disease
(2012)
Huang JF, Yafawi R, Zhang M, McDowell M, Rittenhouse KD, Sace F, Liew SH, Cooper SR, Pickering EH
Ophthalmology. 2012 Jul;119(7):e43-50
Therapy Indications
Cerebrospinal fluid APOE levels, an endophenotype for genetic studies for Alzheimers disease
(2012)
Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A; the Alzheimer?s Disease Neuroimaging Initiative, Fagan AM, Holtzman DM, Morris JC, Goate AM
Hum Mol Genet. 2012 Jul 20. [Epub ahead of print]
Therapy Indications
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
(2012)
Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M, Brugger W, Dietrich PY, Mendrzyk R, Hilf N, Schoor O, Fritsche J, Mahr A, Maurer D, Vass V, Trautwein C, Lewandrowski P, Flohr C, Pohla H, Stanczak JJ, Bronte V, Mandruzzato S, Biedermann T, Pawelec G, Derhovanessian E, Yamagishi H, Miki T, Hongo F, Takaha N, Hirakawa K, Tanaka H, Stevanovic S, Frisch J, Mayer-Mokler A, Kirner A, Rammensee HG, Reinhardt C, Singh-Jasuja H
Nat Med. 2012 Jul 29. doi: 10.1038/nm.2883. [Epub ahead of print]
Therapy Indications
Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences
(2012)
Eve HE, Carey S, Richardson SJ, Heise CC, Mamidipudi V, Shi T, Radford JA, Auer RL, Bullard SH, Rule SA
Br J Haematol. 2012 Aug 9.
Therapy Indications
A multicenter phase II study of single-agent enzastaurin in previously treated Waldenstrom macroglobulinemia
(2012)
Ghobrial IM, Moreau P, Harris B, Poon T, Jourdan E, Maisonneuve HM, Benhadji KA, Hossain A, Nguyen T, Wooldridge JE, Leblond V
Clin Cancer Res. 2012 Aug 9
Therapy Indications
Altered lung function relates to inflammation in an acute LPS mouse model
(2012)
H?kansson HF, Smailag A, Brunmark C, Miller-Larsson A, Lal H
Pulmonary Pharmacology & Therapeutics
Therapy Indications
Effects of Stimulation of Soluble Guanylate Cyclase on Diabetic Nephropathy in Diabetic eNOS Knockout Mice on Top of Angiotensin II Receptor Blockade
(2012)
Ott IM, Alter ML, von Websky K, Kretschmer A, Tsuprykov O, Sharkovska Y, Krause-Relle K, Raila J, Henze A, Stasch JP, Hocher B
PLoS One. 2012;7(8):e42623. Epub 2012 Aug 10
Therapy Indications
A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation
(2012)
Scalley-Kim ML, Hess BW, Kelly RL, Krostag AR, Lustig KH, Marken JS, Ovendale PJ, Posey AR, Smolak PJ, Taylor JD, Wood CL, Bienvenue DL, Probst P, Salmon RA, Allison DS, Foy TM, Raport CJ
PLoS One. 2012;7(8):e43332
Therapy Indications
Early Urinary and Plasma Biomarkers for Experimental Diabetic Nephropathy
(2012)
Alter ML, Kretschmer A, Von Websky K, Tsuprykov O, Reichetzeder C, Simon A, JP Stasch, Hoche B
Clin. Lab. 2012;58:659-671
Therapy Indications
Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial
(2012)
Chiva-Blanch G, Urpi-Sarda M, Ros E, Valderas-Martinez P, Casas R, Arranz S, Guill?n M, Lamuela-Ravent?s RM, Llorach R, Andres-Lacueva C, Estruch R
Clinical Nutrition (online September 3)
Therapy Indications
Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease
(2012)
Soares HD, Potter WZ, Pickering E, Kuhn M, Immermann FW, Shera DM, Ferm M, Dean RA, Simon AJ, Swenson F, Siuciak JA, Kaplow J, Thambisetty M, Zagouras P, Koroshetz WJ, Wan HI, Trojanowski JQ, Shaw LM; for the Biomarkers Consortium Alzheimers Disease Plasma Proteomics Project
Arch Neurol. 2012 Jul 16:1-8
Therapy Indications
Serum Granulocyte Colony-Stimulating Factor and Alzheimers Disease
(2012)
Barber RC, Edwards MI, Xiao G, Huebinger RM, Diaz-Arrastia R, Wilhelmsen KC, Hall JR, OBryant SE, for the Texas Alzheimers Research and Care Consortium
Dement Geriatr Cogn Disord Extra 2012;2:353-360
Therapy Indications
Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 is Linked to TNF-Alpha Pharmacology
(2012)
Erickson RI, Tarrant J, Cain G, Lewin-Koh SC, Dybdal N, Wong H, Blackwood E, West K, Steigerwalt R, Mamounas M, Flygare JA, Amemiya K, Dambach D, Fairbrother WJ, Diaz D
Toxicol Sci. 2012 Sep 5. [Epub ahead of print]
Therapy Indications
The Relation between Inflammation and Neuropsychological Test Performance
(2012)
Balldin VH, Hall JR, Barber RC, Hynan L, Diaz-Arrastia R, O?Bryant SE
International Journal of Alzheimer?s Disease Volume 2012, Article ID 703871
Therapy Indications
Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice
(2010)
Duval C, Thissen U, Keshtkar S, Accart B, Stienstra R, Boekschoten MV, Roskams T, Kersten S, M?ller M
Diabetes. 2010 Dec;59(12):3181-91
Therapy Indications
Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease
(2012)
Llano DA, Devanarayan V, Simon AJ; The Alzheimer?s Disease Neuroimaging Initiative (ADNI)
Alzheimer Dis Assoc Disord. 2012 Sep 27
Therapy Indications
Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab
(2012)
Wagner CL, Visvanathan S, Elashoff M, McInnes IB, Mease PJ, Krueger GG, Murphy FT, Papp K, Gomez-Reino JJ, Mack M, Beutler A, Gladman D, Kavanaugh A
Ann Rheum Dis. 2012 Sep 12. [Epub ahead of print]
Therapy Indications
Plasma Based Markers of [(11)C] PiB-PET Brain Amyloid Burden
(2012)
Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; for the Alzheimers Disease Neuroimaging Initiative
PLoS One. 2012;7(9):e44260.
Therapy Indications
Preferential Colonization of Metastases by Oncolytic Vaccinia Virus Strain GLV-1h68 in a Human PC-3 Prostate Cancer Model in Nude Mice
(2012)
Donat U, Weibel S, Hess M, Stritzker J, H?rtl B, Sturm JB, Chen NG, Gentschev I, Szalay AA
PLoS ONE 7(9): e45942
Therapy Indications
In-depth analysis of the secretome identifies three major independent secretory pathways in differentiating human myoblasts
(2012)
Le Bihan MC, Bigot A, Jensen SS, Dennis J, Rogowska-Wrzesinska A, Lain? J, Gache V, Furling D, Jensen ON, Voit T, Mouly V, Coulton GR, Butler-Browne G
J Proteomics. 2012 Sep 20. pii: S1874-3919(12)00652-5
Therapy Indications
Neuroinflammatory phenotype in early Alzheimers disease
(2012)
Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM
Neurobiol Aging. 2012 Oct 9. pii: S0197-4580(12)00468-X
Therapy Indications
Proteomic analysis of the maternal protein restriction rat model for schizophrenia: Identification of translational changes in hormonal signalling pathways and glutamate neurotransmission
(2012)
Guest PC, Urday S, Ma D, Stelzhammer V, Harris LW, Amess B, Pietsch S, Oheim C, Ozanne SE, Bahn S
Proteomics. 2012 Oct 16
Therapy Indications
Identification of factors associated with cancer related fatigue syndrome in disease-free breast cancer patients after completing primary treatment
(2012)
Minton O, Alexander S, Stone PC
Breast Cancer Res Treat. 2012 Oct 14. [Epub ahead of print]
Therapy Indications
DPP-4 Inhibition on Top of Angiotensin Receptor Blockade Offers a New Therapeutic Approach for Diabetic Nephropathy
(2012)
Altera ML, Ottb IM, von Webskyb K, Tsuprykovb O, Sharkovska Y, Krause-Relle K, Raila, J, Henze A, Klein T, Hocher B
Kidney Blood Press Res 2012;36:119-130
Therapy Indications
Neural progenitor cells regulate microglia functions and activity
(2012)
Mosher KI, Andres RH, Fukuhara T, Bieri G, Hasegawa-Moriyama M, He Y, Guzman R, Wyss-Coray T
Nat Neurosci. 2012 Nov;15(11):1485-7
Therapy Indications
Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimers disease
(2012)
Verdile G, Laws SM, Henley D, Ames D, Bush AI, Ellis KA, Faux NG, Gupta VB, Li QX, Masters CL, Pike KE, Rowe CC, Szoeke C, Taddei K, Villemagne VL, Martins RN
Mol Psychiatry. 2012 Oct 23
Therapy Indications
Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index
(2012)
Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC
Br J Nutr. 2012 Jan;107(1):106-19
Therapy Indications
Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side application
(2012)
Mueller SC, M?rz R, Schmolz M, Drewelow B
BMC Med Res Methodol. 2012 Aug 1;12(1):112
Therapy Indications
Characterization of AQX-1125, a small molecule SHIP1 activator Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo
(2012)
Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, Macrury T, Szabo C
Br J Pharmacol. 2012 Nov 2
Therapy Indications
Quantitative Proteomic Analysis of Niemann-Pick Disease, Type C1 Cerebellum Identifies Protein Biomarkers and Provides Pathological Insight
(2012)
Cologna SM, Jiang X-S, Backlund PS, Cluzeau CVM, Dail MK, Yanjanin NM, Siebel S, Toth CL, Jun H, Wassif CA, Yergey AL, Porter FD
PLoS ONE 7(10): e47845
Therapy Indications
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of A? amyloidosis
(2012)
Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM
J Exp Med. 2012 Nov 5. [Epub ahead of print]
Therapy Indications
Cardiovascular risk factors, cortisol, and amyloid-? deposition in Alzheimers Disease Neuroimaging Initiative
(2012)
Toledo JB, Toledo E, Weiner MW, Jack CR Jr, Jagust W, Lee VM, Shaw LM, Trojanowski JQ; Alzheimers Disease Neuroimaging Initiative
Alzheimers Dement. 2012 Nov;8(6):483-9
Therapy Indications
Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly
(2012)
Rajagopalan P, Refsum H, Hua X, Toga AW, Jack CR Jr, Weiner MW, Thompson PM; Alzheimers Disease Neuroimaging Initiative
Neurobiol Aging. 2012 Nov 19. pii: S0197-4580(12)00533-7
Therapy Indications
Adipocytokine signaling is altered in flinders sensitive line rats, and adiponectin correlates in humans with some symptoms of depression
(2012)
Wilhelm CJ, Choi D, Huckans M, Manthe L, Loftis JM
Pharmacol Biochem Behav. 2012 Nov 12. pii: S0091-3057(12)00312-7
Therapy Indications
Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients
(2012)
Stelzhammer V, Guest PC, Rothermundt M, Sondermann C, Michael N, Schwarz E, Rahmoune H, Bahn S
Eur Neuropsychopharmacol. 2012 Nov 22. pii: S0924-977X(12)00303-3
Therapy Indications
Aging Exacerbates Obesity-Induced Oxidative Stress and Inflammation in Perivascular Adipose Tissue in Mice: A Paracrine Mechanism Contributing to Vascular Redox Dysregulation and Inflammation
(2012)
Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, Csiszar A, Ungvari Z
J Gerontol A Biol Sci Med Sci. 2012 Dec 3. [Epub ahead of print]
Therapy Indications
Molecular Sex Differences in Human Serum
(2012)
Ramsey JM, Schwarz E, Guest PC, van Beveren NJM, Leweke FM; Rothermundt M, Bogerts B, Steiner J, Ruta L, Baron-Cohen S, Bahn S
PLoS ONE 7(12): e51504
Therapy Indications
Differences in the Association of Peripheral Insulin and Cognitive Function in Non-Diabetic Alzheimers Disease Cases and Normal Controls
(2012)
Pavlik V, Massman P, Barber R, Doody R
J Alzheimers Dis. 2012 Dec 14. [Epub ahead of print]
Therapy Indications
The Link Between C-Reactive Protein and Alzheimers Disease Among Mexican Americans
(2013)
OBryant SE, Johnson L, Edwards M, Soares H, Devous MD, Ross S, Rohlfing G, Hall J
J Alzheimers Dis. 2013;34(3):701-6
Therapy Indications
Comparison of protein concentrations in serum versus plasma from Alzheimer?s patients
(2012)
Huebinger RM, Xiao G, Wilhelmsen KC, Diaz-Arrastia R, Zhang F, O?Bryant SE, Barber RC
Advances in Alzheimer?s Disease Vol.1, No.3, 51-58 (2012)
Therapy Indications
Monitoring biomarkers after pediatric heart surgery: a new paradigm on the horizon
(2013)
Aqirbasli M, Undar A.
Artif Organs. 2013 Jan;37(1):10-5.
Therapy Indications
Biomarkers of Alzheimers Disease Among Mexican Americans
(2013)
OBryant SE, Xiao G, Edwards M, Devous M, Gupta VB, Martins R, Zhang F, Barber R
J Alzheimers Dis. 2013 Jan 11. [Epub ahead of print]
Therapy Indications
Sweet Bing Cherries Lower Circulating Concentrations of Markers for Chronic Inflammatory Diseases in Healthy Humans
(2013)
Kelley DS, Adkins Y, Reddy A, Woodhouse LR, Mackey BE, Erickson KL
J Nutr. 2013 Jan 23. [Epub ahead of print]
Therapy Indications
Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre-eclampsia in a low-risk nulliparous patient population?
(2013)
Myatt L, Clifton R, Roberts J, Spong C, Wapner R, Thorp J Jr, Mercer B, Peaceman A, Ramin S, Carpenter M, Sciscione A, Tolosa J, Saade G, Sorokin Y, Anderson G; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
BJOG. 2013 Jan 18
Therapy Indications
Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function
(2013)
Gordon CJ, Jarema KA, Lehmann JR, Ledbetter AD, Schladweiler MC, Schmid JE, Ward WO, Kodavanti UP, Nyska A, Macphail RC.
Inhal Toxicol. 2013 Feb;25(3):141-59.
Therapy Indications
Assessment of Inhibin B as a Biomarker of Testicular Injury Following Administration of Carbendazim, Cetrorelix, or 1,2-Dibromo-3-Chloropropane in Wistar Han Rats
(2013)
Moffit JS, Her LS, Mineo AM, Knight BL, Phillips JA, Thibodeau MS
Birth Defects Research Part B Developmental and Reproductive Toxicology
Therapy Indications
Biomarkers of Vascular Risk, Systemic Inflammation, and Microvascular Pathology and Neuropsychiatric Symptoms in Alzheimers Disease.
(2013)
Hall JR, Wiechmann AR, Johnson LA, Edwards M, Barber RC, Winter AS, Singh M, OBryant SE.
Journal of Alzheimers Disease
Therapy Indications
Relationship between Plasma Analytes and SPARE-AD Defined Brain Atrophy Patterns in ADNI
(2013)
Toledo JB, Da X, Bhatt P, Wolk DA, Arnold SE, Shaw LM, Trojanowski JQ, Davatzikos C
PLoS One. 2013;8(2):e55531
Therapy Indications
Plasma apolipoprotein A1 as a biomarker for parkinsons disease
(2013)
Qiang JK, Wong YC, Siderowf A, Hurtig HI, Xie SX, Lee VM, Trojanowski JQ, Yearout D, Leverenz J, Montine TJ, Stern M, Mendick S, Jennings D, Zabetian C, Marek K, Chen-Plotkin AS
Ann Neurol. 2013 Feb 27
Therapy Indications
Evaluation of Serum Biomarkers Associated with Radiographic Progression in Methotrexate-naive Rheumatoid Arthritis Patients Treated with Methotrexate or Golimumab
(2013)
Wagner C, Chen D, Fan H, Hsia EC, Mack M, Emery P, Fleischmann RM
J Rheumatol. 2013 Mar 1. [Epub ahead of print]
Therapy Indications
The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
(2013)
Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O
PLoS One. 2013;8(3):e58164
Therapy Indications
Multiplexed protein profiling after bariatric surgery: characterization of improved endothelial dysfunction
(2013)
Bachmayer C, Hammes HP, Hasenberg T, Lammert A, Crowther D, Hess S
Experimental and Clinical Endocrinology & Diabetes
Therapy Indications
Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia
(2013)
Mishra BB, Li Q, Steichen AL, Binstock BJ, Metzger DW, Teale JM, Sharma J
PLoS One. 2013;8(3):e59616
Therapy Indications
The effects of stress on hypothalamic-pituitary-adrenal (HPA) axis function in subjects with schizophrenia
(2013)
Guest FL, Martins-de-Souza D, Rahmoune H, Bahn S, Guest PC
Rev Psiq Cl?n. 2013;40(1):20-7
Therapy Indications
The effects of vitamin A on cells of innate immunity in vitro
(2013)
Wojtal K, Wolfram L, Frey-Wagner I, Lang S, Scharl M, Vavricka SR, Rogler G
Toxicology in Vitro,
Therapy Indications
SMA-MAP: A Plasma Protein Panel for Spinal Muscular Atrophy
(2013)
Kobayashi DT, Shi J, Stephen L, Ballard KL, Dewey R, Mapes J, Chung B, McCarthy K, Swoboda KJ, Crawford TO, Li R, Plasterer T, Joyce C; Biomarkers for Spinal Muscular Atrophy Study Group, Chung WK, Kaufmann P, Darras BT, Finkel RS, Sproule DM, Martens WB, McDermott MP, De Vivo DC; Pediatric Neuromuscular Clinical Research Network, Walker MG, Chen KS
PLoS ONE 8(4): e60113.
Therapy Indications
Newborn screening for autism: in search of candidate biomarkers
(2013)
Mizejewski GJ, Lindau-Shepard B, Pass KA
Biomark Med. 2013 Apr;7(2):247-60
Therapy Indications
Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study
(2013)
Schilte C, Staikovsky F, Couderc T, Madec Y, Carpentier F, Kassab S, Albert ML, Lecuit M, Michault A
PLoS Negl Trop Dis. 2013 Mar;7(3):e2137
Therapy Indications
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
(2012)
Hu WT, Holtzman DM, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M, Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin VM, McCluskey L, Elman L, Karlawish J, Chen-Plotkin A, Hurtig HI, Siderowf A, Swenson F, Lee VM, Morris JC, Trojanowski JQ, Soares H; Alzheimers Disease Neuroimaging Initiative
Neurology. 2012 Aug 28;79(9):897-905
Therapy Indications
Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study
(2013)
Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T
BMC Neurol. 2013 Apr 8;13(1):32
Therapy Indications
Heart-type fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer?s disease
(2013)
Guo L, Alexopoulos P, Perneczky R
European Archives of Psychiatry and Clinical Neuroscience
Therapy Indications
Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4
(2013)
OShannessy DJ, Somers EB, Palmer LM, Thiel RP, Oberoi P, Heath R, Marcucci L
Journal of Ovarian Research 2013, 6:29
Therapy Indications
RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke
(2013)
Tokamia H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, Kiyohara Y, Kamouchi M, Kitazono T
Brain Research, Available online 18 April 2013
Therapy Indications
Application of meta-analysis methods for identifying proteomic expression level differences
(2013)
Amess B, Kluge W, Schwarz E, Haenisch F, Alsaif M, Yolken RH, Leweke FM, Guest PC, Bahn S.
Proteomics. 2013 Apr 14.
Therapy Indications
Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator
(2013)
Patel OV, Wilson WB, Qin Z
BioMetals, April 2013
Therapy Indications
A blood-based predictor for neocortical A? burden in Alzheimer?s disease: results from the AIBL study
(2013)
Burnham SC, Faux NG, Wilson W, Laws SM, Ames D, Bedo J, Bush AI, Doecke JD, Ellis KA, Head R, Jones G, Kiiveri H, Martins RN, Rembach A, Rowe CC, Salvado O, Macaulay SL, Masters CL, Villemagne VL; Alzheimer?s Disease Neuroimaging Initiative; Australian Imaging, Biomarkers and Lifestyle Study Research Group
Mol Psychiatry. 2013 Apr 30
Therapy Indications
Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1
(2013)
Cologna SM, Cluzeau CV, Yanjanin NM, Blank PS, Dail MK, Siebel S, Toth CL, Wassif CA, Lieberman AP, Porter FD.
J Inherit Metab Dis. 2013 May 8.
Therapy Indications
CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients
(2013)
Ragab D, Laird M, Duffy D, Casrouge A, Mamdouh R, Abass A, Shenawy DE, Shebl AM, Elkashef WF, Zalata KR, Kamal M, Esmat G, Bonnard P, Fontanet A, Rafik M, Albert ML
Cytokine. 2013 May 7. pii: S1043-4666(13)00181-6
Therapy Indications
EFFECTS OF CONTRAST MEDIA ON DIFFERENT URINARY BIOMARKERS OF KIDNEY INJURY
(2013)
Steffgen J, Blaschke S, Brun-Schulte-Wissing N, Pagel P, Huber F, Mapes J, Jaehnige A, Pestel S
Nephrol. Dial. Transplant. (2013) 28 (suppl 1): i331-i351.
Therapy Indications
Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin
(2013)
Andrews DA, Hamadeh HK, He YD, Boren BM, Turk JR, Boyce RW, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM
Toxicol Pathol. 2013 May 14. [Epub ahead of print]
Therapy Indications
Dose-related Differences in the Pharmacodynamic and Toxicologic Response to a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin in Sprague-Dawley Rats with Similarly High Hematocrit
(2013)
Andrews DA, Boren BM, Turk JR, Boyce RW, He YD, Hamadeh HK, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM
Toxicol Pathol. 2013 May 14. [Epub ahead of print]
Therapy Indications
CD47 fusion protein targets CD172a+ cells in Crohn?s disease and dampens the production of IL-1? and TNF
(2013)
Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Sch?kel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M
J Exp Med. 2013 May 13. [Epub ahead of print]
Therapy Indications
Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs Without GBA Mutations
(2013)
Chahine LM, Qiang J, Ashbridge E, Minger J, Yearout D, Horn S, Colcher A, Hurtig HI, Lee V M-Y, Van Deerlin VM, Leverenz JB, Siderowf AD, Trojanowski JQ, Zabetian CP, Chen-Plotkin A
JAMA Neurol. 2013;():1-7
Therapy Indications
Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders
(2013)
Ernst A, Sharma AN, Elased KM, Guest PC, Rahmoune H, Bahn S
Transl Psychiatry. 2013 May 28;3:e263
Therapy Indications
Multi-analyte profiling and pathway analysis of plasma for proteins associated with cancer-related fatigue syndrome in disease-free breast cancer patients after primary treatment
(2013)
Minton O, Coulton GR, Stone P
BMJ Support Palliat Care doi:10.1136/bmjspcare-2013-000452
Therapy Indications
Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques
(2013)
Li S,Kievit P, Robertson A-K, Kolumam G. Li X, von Wachenfeldt K, Valfridsson C, Bullens S, Messaoudi I, Bader L, Cowan KJ, Kamath A, van Bruggen N, Bunting S, Frend?us B, Grove KL
Molecular Metabolism, Available online 11 June 2013
Therapy Indications
A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma
(2013)
Nowak AK, Brown C, Millward MJ, Creaney J, Byrne MJ, Hughes B, Kremmidiotis G, Bibby DC, Leske AF, Mitchell PL, Pavlakis N, Boyer M, Stockler MR
Lung Cancer. 2013 Jun 17. pii: S0169-5002(13)00218-3
Therapy Indications
Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats
(2013)
Togashi Y, Imura N, Miyamoto Y
Exp Toxicol Pathol. 2013 Jun 20. pii: S0940-2993(13)00076-6
Therapy Indications
LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
(2013)
Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Meyers SR, Reynolds VL, Smith HW, Wroblewski VJ, Kharitonenkov A
PLoS ONE 8(6): e65763
Therapy Indications
Plasma biomarkers for Alzheimers disease: much needed but tough to find
(2012)
Bazenet C, Lovestone S
Biomark Med. 2012 Aug;6(4):441-54
Therapy Indications
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
(2012)
Erdely A, Antonini JM, Salmen-Muniz R, Liston A, Hulderman T, Simeonova PP, Kashon ML, Li S, Gu JK, Stone S, Chen BT, Frazer DG, Zeidler-Erdely PC
Part Fibre Toxicol. 2012 Jul 9;9:25
Therapy Indications
Biomarkers for drug-induced renal damage and nephrotoxicity-an overview for applied toxicology
(2011)
Fuchs TC, Hewitt P
AAPS J. 2011 Dec;13(4):615-31
Therapy Indications
Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant
(2011)
Ghosn CR, Li Y, Orilla WC, Lin T, Wheeler L, Burke JA, Robinson MR, Whitcup SM
Invest Ophthalmol Vis Sci. 2011 May 2;52(6):2917-23
Therapy Indications
Intracellular Aggregation of Multimodal Silica Nanoparticles for
(2013)
Jokerst JV, Khademi C, Gambhir SS
Sci Transl Med. 2013 Mar 20;5(177):177ra35
Therapy Indications
Increased accumulation of regulatory granulocytic myeloid cells in mannose receptor C type 1-deficient mice correlates with protection in a mouse model of neurocysticercosis
(2013)
Mishra PK, Morris EG, Garcia JA, Cardona AE, Teale JM
Infect Immun. 2013 Apr;81(4):1052-63
Therapy Indications
Efficacy and safety of lanthanoids as X-ray contrast agents
(2011)
Pietsch H, Jost G, Frenzel T, Raschke M, Walter J, Schirmer H, H?tter J, Sieber MA
Eur J Radiol. 2011 Nov;80(2):349-56
Therapy Indications
Plasma methionine sulfoxide in persons with familial Alzheimers disease mutations
(2012)
Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G
Dement Geriatr Cogn Disord. 2012;33(4):219-25
Therapy Indications
Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis
(2012)
Wong H, Budha NR, West K, Blackwood E, Ware JA, Yu R, Darbonne WC, Gould SE, Steigerwalt R, Erickson R, Hop CE, LoRusso P, Eckhardt SG, Wagner A, Chan IT, Mamounas M, Flygare JA, Fairbrother WJ
Toxicol Sci. 2012 Nov;130(1):205-13
Therapy Indications
The role of LOX and LOXL2 in scar formation after glaucoma surgery
(2013)
Van Bergen T, Marshall D, Van de Veire S, Vandewalle E, Moons L, Herman J, Smith V, Stalmans I
Invest Ophthalmol Vis Sci. 2013 Jul 2. pii: iovs.13-11696v1
Therapy Indications
Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-a Receptor 1
(2013)
Holland MC, Wurthner JU, Morley PJ, Birchler MA, Lambert J, Albayaty M, Serone AP, Wilson R, Chen Y, Forrest RM, Cordy JC, Lipson DA, Bayliffe AI
Journal of Clinical Immunology, July 2013
Therapy Indications
Influence of Genetic Variation on Plasma Protein Levels in Older Adults Using a Multi-Analyte Panel
(2013)
Kim S, Swaminathan S, Inlow M, Risacher SL, Nho K, Shen L, Foroud TM, Petersen RC, Aisen PS, Soares H, Toledo JB, Shaw LM, Trojanowski JQ, Weiner MW, McDonald BC, Farlow MR, Ghetti B, Saykin AJ; Alzheimer?s Disease Neuroimaging Initiative (ADNI)
PLoS One. 2013 Jul 23;8(7):e70269
Therapy Indications
Impact of Sunitinib on Human Thyroid Cancer Cells
(2013)
Grosse J, Warnke E, Pohl F, Magnusson NE, Wehland M, Infanger M, Eilles C, Grimm D
Cell Physiol Biochem. 2013 Jul 12;32(1):154-170
Therapy Indications
Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin
(2013)
Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R
Ann Rheum Dis. 2013 Jul 19
Therapy Indications
Elevated Carbon Monoxide in the Exhaled Breath of Mice during a Systemic Bacterial Infection
(2013)
Barbour AG, Hirsch CM, Ghalyanchi Langeroudi A, Meinardi S, Lewis ER, Estabragh AS, Blake DR
PLoS One. 2013 Jul 31;8(7):e69802
Therapy Indications
Quantitative assessment of biological impact using transcriptomic data and mechanistic network models
(2013)
Thomson TM, Sewer A, Martin F, Belcastro V, Frushour B, Gebel S, Park J, Schlage WK, Talikka M, Vasilyev D, Westra JW, Hoeng J, Peitsch MC
Toxicol Appl Pharmacol. 2013 Aug 7. pii: S0041-008X(13)00310-4
Therapy Indications
Case study: the role of mechanistic network models in systems toxicology
(2013)
Hoeng J, Talikka M, Martin F, Sewer A, Yang X, Iskandar A, Schlage WK, Peitsch MC
Drug Discovery Today, Available online 9 August 2013
Therapy Indications
Systemic sRAGE is a Biomarker of Emphysema and Associated with AGER Genetic Variants in COPD Patients
(2013)
Cheng DT, Kim DK, Cockayne DA, Belousov A, Bitter H, Cho, MH, Duvoix A, Edwards LD, Lomas DA, Miller BE, Reynaert N, Tal-Singer R, Wouters E, Agusti A, Fabbri LM, Rames A, Visvanathan S, Rennard SI, Jones P, Parmar H, MacNee W, Wolff G, Silverman EK, Mayer RJ, Pillai SG, and on Behalf of the TESRA and ECLIPSE Investigators
American Journal of Respiratory And Critical Care Medicine ja (2013)
Therapy Indications
IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
(2013)
Wang J, Platt A, Upmanyu R, Germer S, Lei G, Rabe C, Benayed R, Kenwright A, Hemmings A, Martin M, Harari O
BMJ Open. 2013 Aug 19;3(8):e003199
Therapy Indications
CSF protein biomarkers predicting longitudinal reduction of CSF ?-amyloid42 in cognitively healthy elders
(2013)
Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M
Transl Psychiatry. 2013 Aug 20;3:e293
Therapy Indications
Modulation of cardiometabolic pathways in skin and serum from patients with psoriasis
(2013)
Mehta NN, Li K, Szapary P, Krueger J, Brodmerkel C
J Transl Med. 2013 Aug 22;11(1):194.
Therapy Indications
Investigation of molecular serum profiles associated with predisposition to antipsychotic-induced weight gain
(2013)
Schwarz E, Steiner J, Guest PC, Bogerts B, Bahn S
World J Biol Psychiatry. 2013 Sep 3. [Epub ahead of print]
Therapy Indications
Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases
(2013)
Van Rompaey L, Galien R, van der Aar EM, Clement-Lacroix P, Nelles L, Smets B, Lepescheux L, Christophe T, Conrath K, Vandeghinste N, Vayssiere B, De Vos S, Fletcher S, Brys R, van t Klooster G, Feyen JH, Menet C
J Immunol. 2013 Sep 4. [Epub ahead of print]
Therapy Indications
Interleukin 17F Level and Interferon Beta Response in Patients With Multiple Sclerosis
(2013)
Hartung HP, Steinman L, Goodin DS, Comi G, Cook S, Filippi M, OConnor P, Jeffery DR, Kappos L, Axtell R, Knappertz V, Bogumil T, Schwenke S, Croze E, Sandbrink R, Pohl C
JAMA Neurol. 2013 Aug 1;70(8):1017-21
Therapy Indications
Does ethnicity moderate dementias biomarkers
(2013)
Royall DR, Palmer RF; Texas Alzheimers Research and Care Consortium
Neurobiol Aging. 2013 Sep 18. pii: S0197-4580(13)00340-0
Therapy Indications
Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults
(2013)
Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack Jr. CR, Tosun D, Weiner M, Alzheimers Disease Neuroimaging Initiative
Neurobiology of Aging, Available online 1 October 2013
Therapy Indications
Cigarette smoke induces molecular responses in respiratory tissues of ApoE-/- mice that are progressively deactivated upon cessation
(2013)
Bou? S, De Le?n H, Schlage WK, Peck MJ, Weiler H, Berges A, Vuillaume G, Martin F, Friedrichs B, Lebrun S, Meurrens K, Schracke N, Moehring M, Steffen Y, Schueller J, Vanscheeuwijck P, Peitsch MC, Hoeng J
Toxicology, Available online 1 October 2013
Therapy Indications
Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism
(2013)
DeLeon-Pennell KY,de Castro Br?s LE, Lindsey ML
Physiological Reports Volume 1, Issue 5, October 2013
Therapy Indications
Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia
(2013)
Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI
J Neurosci. 2013 Oct 2;33(40):16016-16032
Therapy Indications
The Innate Immune Response May Be Important For Surviving Plague In Wild Gunnisons Prairie Dogs
(2013)
Busch JD, Van Andel R, Stone NE, Cobble KR, Nottingham R, Lee J, VerSteeg M, Corcoran J, Cordova J, Van Pelt W, Shuey MM, Foster JT, Schupp JM, Beckstrom-Sternberg S, Beckstrom-Sternberg J, Keim P, Smith S, Rodriguez-Ramos J, Williamson JL, Rocke TE, Wagner DM
Journal of Wildlife Diseases 2013 49:4, 920-931
Therapy Indications
Allogeneic mesenchymal stem cell infusion for the stabilization of focal segmental glomerulosclerosis
(2013)
Belingheri M, Lazzari L, Parazzi V, Groppali E, Biagi E, Gaipa G, Giordano R, Rastaldi MP, Croci D, Biondi A, Rebulla P, Edefonti A, Ghio L
Biologicals. 2013 Oct 14. pii: S1045-1056(13)00111-5. doi: 10.1016/j.biologicals.2013.09.004
Therapy Indications
Integrative Omics Approach Identifies Interleukin-16 as a Biomarker of Emphysema
(2013)
Bowler RP, Bahr TM, Hughes G, Lutz S, Kim YI, Coldren CD, Reisdorph N, Kechris KJ
OMICS. 2013 Oct 19. [Epub ahead of print]
Therapy Indications
Prognostic/predictive value of 207 serum factors in colorectal cancer treated with cediranib and/or chemotherapy
(2013)
Spencer SK, Pommier AJ, Morgan SR, Barry ST, Robertson JD, Hoff PM, J?rgensmeier JM
Br J Cancer. 2013 Oct 22
Therapy Indications
The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis
(2013)
Duffy D, Saleh R, Laird M, Soneson C, Fouler LL, El-Daly M, Casrouge A, Decalf J, Abbas A, Eldin NS, Fontes M, Hamid MA, Mohamed MK, Rafik M, Fontanet, Albert, M. L.
Hepatology
Therapy Indications
Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology
(2013)
Erdely A, Dahm M, Chen BT, Zeidler-Erdely PC, Fernback JE, Birch ME, Evans DE, Kashon ML, Deddens JA, Hulderman T, Bilgesu SA, Battelli L, Schwegler-Berry D, Leonard HD, McKinney W, Frazer DG, Antonini JM, Porter DW, Castranova V, Schubauer-Berigan MK
Part Fibre Toxicol. 2013 Oct 21;10(1):53
Therapy Indications
Identification of a molecular profile associated with immune status in first onset schizophrenia patients
(2013)
Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S
Clin Schizophr Relat Psychoses
Therapy Indications
Impaired glycemia increases disease progression in mild cognitive impairment
(2013)
Morris JK, Vidoni ED, Honea RA, Burns JM
Neurobiology of Aging, Available online 23 October 2013
Therapy Indications
C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production
(2014)
Chand D, Colacci M, Dixon K, Kollara A, Brown TJ, Lovejoy DA
Histochem Cell Biol. 2014 Feb;141(2):191-211
Therapy Indications
A Multicenter Phase II Study of Single-agent Enzastaurin in Previously Treated Multiple Myeloma
(2013)
Jourdan E, Leblond V, Maisonneuve H, Benhadji KA, Hossain AM, Nguyen TS, Wooldridge JE, Moreau P
Leuk Lymphoma. 2013 Nov 3. [Epub ahead of print]
Therapy Indications
Biomarker identification in serum samples from patients with recurrent cervical cancer treated with ADXS11-001 immunotherapy
(2013)
Molli P, Malinina I, Wallecha A
Journal for ImmunoTherapy of Cancer 2013, 1(Suppl 1):P61
Therapy Indications
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space
(2013)
Ma X, Pietsch J, Wehland M, Schulz H, Saar K, H?bner N, Bauer J, Braun M, Schwarzw?lder A, Segerer J, Birlem M, Horn A, Hemmersbach R, Wa?er K, Grosse J, Infanger M, Grimm D
FASEB J. 2013 Nov 6. [Epub ahead of print]
Therapy Indications
Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever
(2010)
Gowen BB, Julander JG, London NR, Wong MH, Larson D, Morrey JD, Li DY, Bray M
Virol J. 2010 Sep 16;7:240
Therapy Indications
Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole blood
(2012)
Schmohl M, Schneiderhan-Marra N, Baur N, Hefner K, Blum M, Stein GM, Joos TO, Schmolz M
Int Immunopharmacol. 2012 Dec;14(4):722-8
Therapy Indications
The Proton-Activated Receptor GPR4 Modulates Glucose Homeostasis by Increasing Insulin Sensitivity
(2013)
Giudici L, Velic A, Daryadel A, Bettoni C, Mohebbi N, Suply T, Seuwen K, Ludwig MG, Wagner CA
Cell Physiol Biochem. 2013 Nov 28;32(5):1403-1416
Therapy Indications
Development of a small animal peripheral challenge model of Japanese encephalitis virus using interferon deficient AG129 mice and the SA14-14-2 vaccine virus strain
(2013)
Calvert AE, Dixon KL, Delorey MJ, Blair CD, Roehrig JT
Vaccine. 2013 Nov 17. pii: S0264-410X(13)01533-8
Therapy Indications
Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory
(2013)
Liu B, Zupan B, Laird E, Klein S, Gleason G, Bozinoski M, Gal Toth J, Toth M
Nat Neurosci. 2013 Dec 1
Therapy Indications
Transient inflammatory-like state and microbial dysbiosis are pivotal in establishment of mucosal homeostasis during colonisation of germ-free mice
(2013)
Aidy SE, Derrien M, Aardema R, Hooiveld G, Richards SE, Dane A, Dekker J, Vreeken R, Levenez F, Dor? J, Zoetendal EG, van Baarlen P, Kleerebezem M
Benef Microbes. 2013 Dec 9:1-11.
Therapy Indications
Cytokine Profile Changes In 309 Myelofibrosis Patients: Comparison Of JAK1/JAK2 Inhibitor Therapy Vs. Placebo ? Correlative Analysis From The Comfort-I Trial
(2013)
Dueck AC, Cleeland CS, Dantzer R, Sloan J, Verstovsek S, Emanuel RM, Geyer HL, Mesa RA
Blood October 21, 2013 vol. 122 no. 21 4074
Therapy Indications
Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model
(2013)
Kobayashi SD, Olsen RJ, Lacasse RA, Safronetz D, Ashraf M, Porter AR, Braughton KR, Feldmann F, Clifton DR, Kash JC, Bailey JR, Gardner DJ, Otto M, Brining DL, Kreiswirth BN, Taubenberger JK, Parnell MJ, Feldmann H, Musser JM, Deleo FR
Virulence. 2013 Oct 8;4(8). [Epub ahead of print]
Therapy Indications
First-in-Human Phase I Study of PRS-050 (Angiocal), an Anticalin Targeting and Antagonizing VEGF-A, in Patients with Advanced Solid Tumors
(2013)
Mross K, Richly H, Fischer R, Scharr D, B?chert M, Stern A, Gille H, Audoly LP, Scheulen ME
PLoS One. 2013 Dec 13;8(12):e83232
Therapy Indications
Short sleep duration is associated with decreased serum leptin, increased energy intake, and decreased diet quality in postmenopausal women
(2013)
Stern JH, Grant AS, Thomson CA, Tinker L, Hale L, Brennan KM, Woods NF, Chen Z
Obesity (Silver Spring). 2013 Dec 17
Therapy Indications
Protective role of Mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation
(2013)
Sharma A, Steichen AL, Jondle CN, Mishra BB, Sharma J
J Infect Dis. 2013 Dec 17. [Epub ahead of print]
Therapy Indications
Suppression of soluble T cell-associated proteins by an anti-interferon-a monoclonal antibody in adult patients with dermatomyositis or polymyositis
(2013)
Guo X, Higgs BW, Rebelatto M, Zhu W, Greth W, Yao Y, Roskos LK, White WI
Rheumatology (Oxford). 2013 Dec 19
Therapy Indications
REG3-gamma-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum
(2013)
Loonen LM, Stolte EH, Jaklofsky MT, Meijerink M, Dekker J, van Baarlen P, Wells JM
Mucosal Immunol. 2013 Dec 18
Therapy Indications
The Senescence-Associated Secretory Phenotype In Multiple Myeloma
(2013)
Wildes TM, Paasch J, Fiala MA, Chen L, Vij R, Stockerl-Goldstein KE, Stewart S, Colditz GA,Tomasson M
Blood October 21, 2013 vol. 122 no. 21 5357
Therapy Indications
A Canonical Transforming Growth Factor Beta-Dependent Signaling Pathway is Present in Peripheral Blood Cells of Cancer Patients with Skeletal Metastasis
(2013)
Kadam S, Cleverly AL, Farmen M, Grondin J, Cox YI, Lahn M
J Mol Biomark Diagn 2013, 4:3
Therapy Indications
Multi-analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection
(2013)
Huckans M, Fuller BE, Olavarria H, Sasaki AW, Chang M, Flora KD, Kolessar M, Kriz D, Anderson JR, Vandenbark AA, Loftis JM
Brain and Behavior
Therapy Indications
Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3? signaling in bipolar patients
(2013)
Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S
Journal of Affective Disorders
Therapy Indications
Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation
(2013)
Sauer UG, Vogel S, Aumann A, Hess A, Kolle SN, Ma-Hock L, Wohlleben W, Dammann M, Strauss V, Treumann S, Gr?ters S, Wiench K, van Ravenzwaay B, Landsiedel R
Toxicol Appl Pharmacol. 2013 Dec 29. pii: S0041-008X(13)00570-X
Therapy Indications
Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study
(2014)
ONeal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R, Woodruff PG, Couper DJ, Davis SM
J Transl Med. 2014 Jan 8;12(1):9
Therapy Indications
Distinct Roles For Hepcidin and Interleukin 6 In The Recovery From Anemia Following Administration Of Heat-Killed Brucella Abortus
(2013)
Gardenghi S, Renaud TM, Meloni A, Casu C, Crielaard BJ, Bystrom LM, Greenberg-Kushnir N, Sasu BJ, Cooke KS, Rivella S
Blood. 2013 Dec 19. [Epub ahead of print]
Therapy Indications
CSF Apo-E levels associate with cognitive decline and MRI changes
(2014)
Toledo JB, Da X, Weiner MW, Wolk DA, Xie SX, Arnold SE, Davatzikos C, Shaw LM, Trojanowski JQ; For the Alzheimer?s Disease Neuroimaging Initiative
Acta Neuropathol. 2014 Jan 3. [Epub ahead of print]
Therapy Indications
The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins
(2014)
Yassine HN, Jackson AM, Borges CR, Billheimer D, Koh H, Smith D, Reaven P, Lau SS, Borchers CH
Lipids Health Dis. 2014 Jan 8;13(1):8
Therapy Indications
Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation
(2014)
Blonder JP, Mutka SC, Sun X, Qiu J, Green LH, Mehra NK, Boyanapalli R, Suniga M, Look K, Delany C, Richards JP, Looker D, Scoggin C, Rosenthal GJ
BMC Pulm Med. 2014 Jan 10;14(1):3
Therapy Indications
Implementing lessons learned from previous bronchial biopsy trials in a new randomized controlled COPD biopsy trial with roflumilast
(2014)
Barnes NC, Saetta M, Rabe KF
BMC Pulm Med. 2014 Jan 31;14(1):9
Therapy Indications
Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome
(2014)
Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S
Mol Autism. 2014 Jan 27;5(1):4
Immunomodulatory Activities of a Concentrated Fruit and Vegetable Juice Tested in a Randomized, Placebo-Controlled, Double-Blind Clinical Trial in Healthy Volunteers
(2014)
Schmolz M, M?rz RW, Schaudt M, Schaudt C, Lauster C
Food and Nutrition Sciences, Vol. 5 No. 4, 2014, pp. 341-350
Therapy Indications
Altered Macrophage-Phenotype Transition Impairs Skeletal Muscle Regeneration
(2014)
Wang H, Melton D, Porter L, Sarwar ZU, McManus LM, Shireman PK
Am J Pathol. 2014 Feb 10. pii: S0002-9440(14)00025-X
Therapy Indications
Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men with and without Alzheimers Disease
(2014)
Cunningham RL1, Singh M1, OBryant SE2, Hall JR3, Barber RC
J Alzheimers Dis. 2014 Feb 4. [Epub ahead of print]
Therapy Indications
Phosphorylated tau-A?42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimers Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid.
(2014)
Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM; Alzheimer?s Disease Neuroimaging Initiative
Biol Psychiatry. 2014 Jan 19. pii: S0006-3223(14)00018-3
Therapy Indications
Role of protein C in renal dysfunction after polymicrobial sepsis
(2007)
Gupta A, Berg DT, Gerlitz B, Sharma GR, Syed S, Richardson MA, Sandusky G, Heuer JG, Galbreath EJ, Grinnell BW
J Am Soc Nephrol. 2007 Mar;18(3):860-7
Therapy Indications
Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface car
(2013)
Ma-Hock L, Strauss V, Treumann S, K?ttler K, Wohlleben W, Hofmann T, Gr?ters S, Wiench K, van Ravenzwaay B, Landsiedel R
Part Fibre Toxicol. 2013 Jun 17;10(1):23
Therapy Indications
alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung
(2008)
Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I.
Am J Respir Cell Mol Biol. 2008 Jun;38(6):689-98
Therapy Indications
Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment
(2014)
de Witte L, Tomasik J, Schwarz E, Guest PC, Rahmoune H, Kahn RS, Bahn S
Schizophr Res. 2014 Feb 26. pii: S0920-9964(14)00071-1
Therapy Indications
A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors
(2014)
Weekes CD, Beeram M, Tolcher AW, Papadopoulos KP, Gore L, Hegde P, Xin Y, Yu R, Shih LM, Xiang H, Brachmann RK, Patnaik A
Invest New Drugs. 2014 Mar 7. [Epub ahead of print]
Therapy Indications
Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke
(2014)
Wakisakaa Y, Agoa T, Kamouchib M, Kurodaa J, Matsuoa R, Hataa J, Gotoha S, Isomurad T, Awanod H, Suzukid, K, Fukudaa K, Okadaf Y, Kiyoharac Y, Ooboshig H, Kitazonoa T, on behalf of the REBIOS Investigators
Journal of the Neurological Sciences 04 Mar 2014
Therapy Indications
Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS?)
(2014)
Xiang Y, Kogel U, Gebel S, Peck MJ, Peitsch MC, Akmaev VR, Hoeng J
Gene Regul Syst Bio. 2014 Feb 19;8:45-61
Therapy Indications
Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product
(2014)
Ruff KJ, DeVore DP
Modern Research in Inflammation, 3, 19-25
Therapy Indications
The Impact of APOE Status on Relationship of Biomarkers of Vascular Risk and Systemic Inflammation to Neuropsychiatric Symptoms in Alzheimers Disease
(2014)
Hall JR, Wiechmann AR, Johnson LA, Edwards M, Barber RC, Cunningham R, Singh M, OBryant SE
J Alzheimers Dis. 2014 Feb 20. [Epub ahead of print]
Therapy Indications
MRI signal and texture features for the prediction of MCI to Alzheimers disease progression
(2014)
Mart?nez -Torteya A, Rodr?guez-Rojas J, Celaya-Padilla JM, Galv?n-Tejada JI, Trevi?o V, Tamez-Pe?a JG
Proc. SPIE 9035
Therapy Indications
Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential
(2013)
Johnston J, Hu W, Fardo D, Greco S, Perry G, Montine T, Trojanowski J, Shaw L, Ashford J, Tezapsidis N, For The Alzheimers Disease Neuroimaging Initiative
Curr Alzheimer Res. 2013 Dec 11. [Epub ahead of print]
Therapy Indications
Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli
(2014)
Duffy D, Rouilly V, Libri V, Hasan M, Beitz B, David M, Urrutia A, Bisiaux A, LaBrie ST, Dubois A, Boneca IG, Delval C, Thomas S, Rogge L, Schmolz M, Quintana-Murci L, Albert ML
Immunity Volume 40, Issue 3, 20 March 2014, Pages 436?450
Therapy Indications
Normal Ranges and Variability of Novel Urinary Renal Biomarkers in Sprague-Dawley Rats
(2014)
Gautier JC, Gury T, Guffroy M, Khan-Malek R, Hoffman D, Pettit S, Harpur E
Toxicol Pathol. 2014 Apr 7. [Epub ahead of print]
Therapy Indications
Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection
(2014)
Riva A, Laird M, Casrouge A, Ambrozaitis A, Williams R, Naoumov NV, Albert ML, Chokshi S
Hepatology. 2014 Mar 26
Therapy Indications
Rapid Onset Clinical and Mechanistic Effects of anti-C5aR Treatment in the Mouse Collagen Induced Arthritis Model
(2014)
Andersson C, Wenander CS, Usher PA, Hebsgaard JB, Sondergaard BC, R?n? B, Mackay C, Friedrichsen B, Chang C, Tang R, Hornum L
Clin Exp Immunol. 2014 Mar 25
Therapy Indications
The Human Salivary Proteome is Radiation Responsive
(2014)
Moore HD, Ivey RG, Voytovich UJ, Lin C, Stirewalt DL, Pogosova-Agadjanyan EL, Paulovich AG
Radiat Res. 2014 Apr 10. [Epub ahead of print]
Therapy Indications
Comparison between Male and Female Sprague-Dawley Rats in the Response of Urinary Biomarkers to Injury Induced by Gentamicin
(2014)
Gautier JC, Gury T, Guffroy M, Masson R, Khan-Malek R, Hoffman D, Pettit S, Harpur E
Toxicol Pathol. 2014 Apr 9. [Epub ahead of print]
Therapy Indications
Evaluation of antidepressant properties of the p38 MAP kinase inhibitor losmapimod (GW856553) in Major Depressive Disorder: Results from two randomised, placebo-controlled, double-blind, multicentre studies using a Bayesian approach
(2014)
Inamdar A, Merlo-Pich E, Gee M, Makumi C, Mistry P, Robertson J, Steinberg E, Zamuner S, Learned S, Alexander R, Ratti E
J Psychopharmacol. 2014 Apr 2. [Epub ahead of print]
Therapy Indications
Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease
(2014)
Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C
PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2786
Therapy Indications
Inflammatory Molecular Signature Associated With Infectious Agents in Psychosis
(2014)
Hayes LN, Severance EG, Leek JT, Gressitt KL, Rohleder C, Coughlin JM, Leweke FM, Yolken RH, Sawa A
Schizophr Bull. 2014 Apr 17. [Epub ahead of print]
Therapy Indications
Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns
(2014)
Mikerov AN, Phelps DS, Gan X, Umstead TM, Haque R, Wang G, Floros J
Toxicol Lett. 2014 Apr 21. pii: S0378-4274(14)00167-2
Therapy Indications
Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects
(2014)
Ramirez TA, Iyer RP, Ghasemi O, Lopez EF, Levin DB, Zhang J, Zamilpa R, Chou YM, Jin YF, Lindsey ML
J Mol Cell Cardiol. 2014 Apr 22. pii: S0022-2828(14)00118-7
Therapy Indications
Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS)
(2014)
Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T
BMC Neurol. 2013 Apr 8;13:32
Therapy Indications
Therapeutic Potential of Cerium Oxide Nanoparticles for the Treatment of Peritonitis Induced by Polymicrobial Insult in Sprague-Dawley Rats.
(2015)
Manne ND, Arvapalli R, Nepal N, Thulluri S, Selvaraj V, Shokuhfar T, He K, Rice KM, Asano S, Maheshwari M, Blough ER
Crit Care Med.
Therapy Indications
A Phase 1 Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma
(2015)
Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA
Mol Cancer Ther.
Therapy Indications
Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice
(2015)
Mardare C, Kr?ger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC
J Diabetes Res
Therapy Indications
Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia
(2015)
Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB
Schizophr Bull
Therapy Indications
Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining
(2015)
Yoshimura K, Okanoue T, Ebise H, Iwasaki T, Mizuno M, Shima T, Ichihara J, Yamazaki K
Hepatology.
Therapy Indications
Lipoprotein-associated phospholipase A2, homocysteine, and Alzheimer?s disease
(2015)
Doody RS, Demirovic J, Ballantyne CM, Chan W, Barber R, Powell S, Pavlik V
Alzheimers Dement (Amst)
Therapy Indications
New biomarkers for primary mitral regurgitation
(2015)
Deroyer C, Magne J, Moonen M, Le Goff C, Dupont L, Hulin A, Radermecker M, Colige A, Cavalier E, Kolh P, Pierard L, Lancellotti P, Merville MP, Fillet M
Clin Proteomics
Therapy Indications
Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data
(2015)
Parkitny L, Middleton S, Baker K, Younger J
BMC Immunology
Therapy Indications
Neuropilin 1 (NRP1) may be prognostic and identify a subgroup of Patients with Metastatic Colorectal Cancer (mCRC) who Benefit from Tivozanib + mFOLFOX6 compared to Bevacizumab + mFOLFOX6
(2015)
Benson A, Krivoshik A, Van Sant C, Needle M
Annals of Oncology
Therapy Indications
Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use
(2015)
Srivastava AK, Jaganathan S, Stephen L, Hollingshead MG, Govindharajulu JP, Layhee A, Damour E, Donohue J, Esposito D, Mapes JP, Kinders R, Takebe N, Tomaszewski JE, Kummar S, Doroshow JH, Parchment RE
Clinical Cancer Research
Therapy Indications
A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression
(2015)
Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ
J Immunol.
Therapy Indications
Responses to Bacteria, Virus and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia
(2015)
Valim C, Ahmad R, Lanaspa M, Tan Y, Ac?cio S, Gillette MA, Almendinger KD, Milner DA Jr, Madrid L, Pell? K, Harezlak J, Silterra J, Alonso PL, Carr SA, Mesirov JP, Wirth DF, Wiegand RC, Bassat Q
Am J Respir Crit Care Med.
Therapy Indications
Cerium oxide nanoparticles attenuate acute kidney injury induced by intra-abdominal infection in Sprague?Dawley rats
(2015)
Manne ND, Arvapalli R, Nepal N, Shokuhfar T, Rice KM, Asano S, Blough ER
J Nanobiotechnology
Therapy Indications
Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients
(2015)
Tomasik J, Schwarz E, Lago SG, Rothermundt M, Leweke FM, van Beveren NJ, Guest PC, Rahmoune H, Steiner J, Bahn S.
Brain Behav Immun.
Therapy Indications
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages
(2015)
Rosati A, Basile A, DAuria R, dAvenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC.
Nat Commun.
Therapy Indications
MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis
(2015)
Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ.
J Clin Invest
Markers of inflammation are associated with clinical outcomes in patients with metastatic renal cell carcinoma treated with nivolumab
(2015)
Sznol M, Fishman M, Escudier B, McDermott DF, Kluger H, Stadler WM, Perez-Gracia J, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Drake CG, Young TC, Chasalow SD, Ross-MacDonald P, Simon JS, Walker D, Choueiri TK
J Immunother Cancer
Therapy Indications
Identification of circulatory biomarkers from clinical trial samples
(2015)
Brunet LR, Bodman-Smith K, Bodman-Smith M, Kassam Z, Dalgleish A, LaBrie S and Hagemann T
J Immunother Cancer
Therapy Indications
Plasma Biomarkers for Neuronal Ceroid Lipofuscinosis.
(2015)
Hersrud SL, Geraets RD, Weber KL, Chan CH, Pearce DA
FEBS J.
Therapy Indications
Serum biomarkers predictive of depressive episodes in panic disorder
(2015)
Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BWJH, Bahn S
Journal of Psychiatric Research
Therapy Indications
Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders
(2015)
Ramsey JM, Guest PC, Broek JA, Glennon JC, Rommelse N, Franke B, Rahmoune H, Buitelaar JK, Bahn S.
Mol Autism
Therapy Indications
A Phase 1 Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX 2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
(2014)
Northfelt DW, Ramanathan RK, Cohen PA, Von Hoff DD, Weiss GJ, Dietsch GN, Manjarrez KL, Randall TD, Hershberg RM
Clin Cancer Res. 2014 May 7
Therapy Indications
Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross sectional study
(2014)
Andersen, M., Boesen, M., Ellegaard, K., Christensen, R., S?derstr?m, K., S?e, N., & Bliddal, H
Arthritis Research & Therapy, 16(3), R107
Therapy Indications
Spheroid formation of human thyroid cancer cells
(2014)
Warnke E, Pietsch J, Wehland M, Bauer J, Infanger M, G?r?g M, Hemmersbach R, Braun M, Ma X, Sahana J, Grimm D
Cell Communication and Signaling 2014, 12:32
Therapy Indications
Nonclinical Safety Profile of BMS-986001, a Nucleoside Transcriptase Inhibitor for Combination Retroviral Therapy
(2014)
Mausumee G, Frank S, Shawn C, Dara H, Zhao Y, Soleil PM, Sanderson TP, Michael G, Marc D
Int J Toxicol. 2014 May 20;33(3):204-218
Therapy Indications
A prospective assessment of the effect of aminophylline therapy on urine output and inflammation in critically ill children
(2014)
Tamburro RF, Thomas NJ, Ceneviva GD, Dettorre MD, Brummel GL, Lucking SE
Front. Pediatr. 2:59
Therapy Indications
A Phase 2, Randomized, Double-blind, Multicenter Study Comparing Siltuximab Plus Best Supportive Care With Placebo Plus Best Supportive Care in Anemic Patients With International Prognostic Scoring System Low- or Intermediate-1?Risk Myelodysplastic Syndrome
(2014)
Garcia-Manero G, Gartenberg G, Steensma DP, Schipperus MR, Breems DA, de Paz R, Valc?rcel D, Kranenburg B, Reddy M, Komrokji RS
Am J Hematol. 2014 May 31
Therapy Indications
Altered microglial response to A? plaques in APPPS1-21 mice heterozygous for TREM2
(2014)
Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, Jiang H, Stewart FR, Piccio L, Colonna M, Holtzman DM
Mol Neurodegener. 2014 Jun 3;9(1):20
Therapy Indications
Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT
(2014)
Pilat C, Frech T, Wagner A, Kr?ger K, Hillebrecht A, Pons-K?hnemann J, Scheibelhut C, B?deker RH, Mooren FC
Scand J Med Sci Sports. 2014 Jun 12
Therapy Indications
Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study
(2014)
Brana I, Calles A, LoRusso PM, Yee LK, Puchalski TA, Seetharam S, Zhong B, de Boer CJ, Tabernero J, Calvo E
Target Oncol. 2014 Jun 15
Therapy Indications
Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment
(2014)
Toledo JB, Korff A, Shaw LM, Trojanowski JQ, Zhang J
Alzheimers Research & Therapy 2014, 6:36
Therapy Indications
CD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model
(2014)
Lin Y, Manning PT, Jia J, Gaut JP, Xiao Z, Capoccia BJ, Chen CC, Hiebsch RR, Upadhya G, Mohanakumar T, Frazier WA, Chapman WC
Transplantation. 2014 Jun 30. [Epub ahead of print]
Therapy Indications
Total Cholesterol and Neuropsychiatric Symptoms in Alzheimers Disease: The Impact of Total Cholesterol Level and Gender
(2014)
Hall JR, Wiechmann AR, Johnson LA, Edwards M, Barber RC, Cunningham R, Singh M, OBryant SE
Dementia and Geriatric Cognitive Disorders Vol. 38, No. 5-6, 2014
Therapy Indications
Combination treatment with oncolytic Vaccinia virus and cyclophosphamide results in synergistic antitumor effects in human lung adenocarcinoma bearing mice
(2014)
Hofmann E, Weibel S, Szalay AA
Journal of Translational Medicine 2014 Jul 17;12:197. doi: 10.1186/1479-5876-12-197
Therapy Indications
Vitamin D Binding Protein as a Serum Biomarker of Alzheimers Disease.
(2014)
Bishnoi RJ, Palmer RF, Royall DR.
Journal of Alzheimers Disease 2014 Jul 30. [Epub ahead of print]
Therapy Indications
Plasma protein biomarkers enhance the clinical prediction of kidney injury recovery in patients undergoing liver transplantation.
(2014)
Levitsky J, Baker TB, Jie C, Ahya S, Levin M, Friedewald J, Al-Saden P, Salomon DR, Abecassis MM.
Hepatology 2014 Jul 31. doi: 10.1002/hep.27346. [Epub ahead of print]
Therapy Indications
Ethnicity Moderates Dementias Biomarkers.
(2014)
Royall DR, Palmer RF
Journal of Alzheimers Disease 2014 Jul 30. [Epub ahead of print]
Therapy Indications
Neutrophils release extracellular DNA traps in response to exercise.
(2014)
Beiter T, Fragasso A, Hudemann J, Schild M, Steinacker J, Mooren FC, Niess AM.
Journal of Applied Physiology 2014 Aug 1;117(3):325-33. doi: 10.1152/japplphysiol.00173.2014
Therapy Indications
Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: a randomized feeding trial
(2014)
Chiva-Blancha G, Magraner E, Condines X, Valderas-Mart?nez P, Roth I, Arranz S, Casa R, Navarro M, Hervas A, Sis? A, Mart?nez-Hu?lamo M, Vallverd?-Queralt A, Quifer-Rada P, Lamuela-Raventos R-M, Estruch R
Elsevier - Nutrition, Metabolism and Cardiovascular Diseases 2014 Aug 2; doi: 10.1016/j.numecd.2014.07.008
Therapy Indications
Are Blood-Based Protein Biomarkers for Alzheimers Disease also Involved in Other Brain Disorders? A Systematic Review
(2014)
Chiam JTW, Dobson RJB, Kiddle SJ, Sattlecker M
Journal of Alzheimers Disease 2014 Aug 5; 1875-8908 doi:10.3233/JAD-140816
Therapy Indications
An integrated omics analysis: impact of microgravity on host response to lipopolysaccharide in vitro
(2014)
Chakraborty N, Gautam A, Muhie S, Miller SA, Jett M, Hammamieh R.
BMC Genomics 2014 Aug 7;15(1):659. [Epub ahead of print]
Therapy Indications
Disrupted TH17/Treg Balance in Patients with Chronic Low Back Pain.
(2014)
Luchting B, Rachinger-Adam B, Zeitler J, Egenberger L, M?hnle P, Kreth S, Azad SC
PLoS ONE 2014 Aug 14;9(8):e104883. doi: 10.1371/journal.pone.0104883
Therapy Indications
Serum protein profiling reveals baseline and pharmacodynamic biomarker signatures associated with clinical outcome in mCRC patients treated with chemotherapy ? cediranib.
(2014)
Pommier AJ, Shaw R, Spencer SK, Morgan SR, Hoff PM, Robertson JD, Barry ST, J?rgensmeier JM.
British Journal of Cancer 2014 Aug 14. doi: 10.1038/bjc.2014.436. [Epub ahead of print]
Therapy Indications
Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats.
(2014)
Zeidler-Erdely PC, Meighan TG, Erdely A, Fedan JS, Thompson JA, Bilgesu S, Waugh S, Anderson S, Marshall NB, Afshari A, McKinney W, Frazer DG, Antonini JM.
Inhalation Toxicology 2014 Aug 20:1-11. [Epub ahead of print]
Therapy Indications
Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia.
(2014)
van Beveren NJ, Schwarz E, Noll R, Guest PC, Meijer C, de Haan L, Bahn S.
Translational Psychiatry 2014 Aug 26;4:e430. doi: 10.1038/tp.2014.52.
Therapy Indications
Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the neural cardiac therapy for heart failure (NECTAR-HF) randomized controlled trial.
(2014)
Zannad F, De Ferrari GM, Tuinenburg AE, Wright D, Brugada J, Butter C, Klein H, Stolen C, Meyer S, Stein KM, Ramuzat A, Schubert B, Daum D, Neuzil P, Botman C, Caste MA, DOnofrio A, Solomon SD1, Wold N, Ruble SB.
European Heart Journal 2014 Aug 31. pii: ehu345. [Epub ahead of print]
Therapy Indications
Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults
(2014)
Chiu S, Williams PT, Dawson T, Bergman RN, Stefanovski D, Watkins SM, Krauss RM
Journal of Nutrition September 3, 2014, doi: 10.3945/?jn.114.197624
Therapy Indications
Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome.
(2014)
Cheng JM, Oemrawsingh RM, Akkerhuis KM, Garcia-Garcia HM, de Boer SP, Battes LC, Buljubasic N, Lenzen MJ, de Jaegere PP, van Geuns RJ, Serruys PW, Kardys I, Boersma E.
Informa Healthcare Biomarkers 2014 Sep 8:1-9. [Epub ahead of print]
Therapy Indications
Fat Quality and Incident Cardiovascular Disease, All-Cause Mortality and Cancer Mortality
(2014)
Rosenquist KJ, Massaro JM, Pedley A, Long MT, Kreger BE, Vasan RS, Murabito JM, Hoffmann U, Fox CS.
Journal of Clinical Endocrinology & Metabolism 2014 Sep 16:jc20134296. [Epub ahead of print]
Therapy Indications
Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension
(2014)
Kolli MB, Manne ND, Para R, Nalabotu SK, Nandyala G, Shokuhfar T, He K, Hamlekhan A, Ma JY, Wehner PS, Dornon L, Arvapalli R, Rice KM, Blough ER.
Biomaterials. 2014 Sep 12. pii: S0142-9612(14)00962-4. doi: 10.1016/j.biomaterials.2014.08.037. [Epub ahead of print]
Therapy Indications
Multiplex Screen of Serum Biomarkers in
(2014)
Statlanda J, Donlin-Smithb CM, Tapscottc SJ, van der Maarel S, Tawil, R
Journal of Neuromuscular Diseases DOI 0.3233/JND-140034
Therapy Indications
A phase I dose-escalation study to a predefined dose of a transforming growth factor-?1 monoclonal antibody (T?M1) in patients with metastatic cancer
(2014)
Cohn A, Lahn MM, Williams KE, Cleverly AL, Pitou C, Kadam SK, Farmen MW, Desaiah D, Raju R, Conkling P, Richards D
International Journal of Oncology 10.3892/ijo.2014.2679
Therapy Indications
An Anti-Neuroinflammatory That Targets Dysregulated Glia Enhances the Efficacy of CNS-Directed Gene Therapy in Murine Infantile Neuronal Ceroid Lipofuscinosis.
(2014)
Macauley SL, Wong AMS, Shyng C, Augner DP, Dearborn JT, Pearse Y, Roberts MS, Fowler SC, Cooper JD, Watterson DM, Sands MS
Journal of Neuroscience 2014 Sep 24;34(39):13077-82. doi: 10.1523/JNEUROSCI.2518-14.2014.
Therapy Indications
Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (XL765), an orally administered PI3K/mTOR inhibitor: a phase 1 expansion cohort in patients with relapsed or refractory lymphoma.
(2014)
Papadopoulos KP, Egile C, Ruiz-Soto R, Jiang J, Shi W, Bentzien F, Rasco D, Abrisqueta P, Vose JM, Tabernero J.
Informa Healthcare Leuk Lymphoma. 2014 Oct 10:1-32. [Epub ahead of print]
Therapy Indications
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes
(2014)
Carolan BJ, Hughes G, Morrow J, Hersh CP, ONeal WK, Rennard S, Pillai SG, Belloni P, Cockayne DA, Comellas AP, Han M, Zemans RL, Kechris K, Bowler RP.
Respiratory Research 2014 Oct 12;15(1):127. doi: 10.1186/s12931-014-0127-9.
Therapy Indications
Predicting therapeutic efficacy of intravenous immunoglobulin (IVIG) in individual patients with relapsing remitting multiple sclerosis (RRMS) by functional genomics
(2014)
Berger T, Jacob C, Haas J, Ransmayr G, Guger M, Zettl UK, Di Pauli F, Taumberger B, Wietek S, Meuer S, Reindl M, Giese T
Journal of Neuroimmunology DOI: 10.1016/j.jneuroim.2014.10.001
Therapy Indications
Genome-Wide Association Study of CSF Levels of 59 Alzheimers Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation
(2014)
Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S; Alzheimers Disease Neuroimaging Initiative, Fagan AM, Holtzman DM, Morris JC, Goate AM
PLoS Genet
Therapy Indications
Bone marrow from blotchy mice is nonessential to regulate blood copper and aortic pathologies in LDLR deficient mice during chronic angiotensin II infusion
(2014)
Harris D, Liang Y, Chen C, Li S, Patel O, Qin Z
Annals of Vascular Surgery
Therapy Indications
TRAMP Prostate Tumor Growth Is Slowed by Walnut Diets Through Altered IGF-1 Levels, Energy Pathways, and Cholesterol Metabolism
(2014)
Kim H, Yokoyama W, Davis PA.
J Med Food. 2014 Oct 29. [Epub ahead of print]
Therapy Indications
Plasma leptin levels are not predictive of dementia in patients with mild cognitive impairment.
(2014)
Oania R, McEvoy LK.
Age Ageing. 2014 Oct 27. pii: afu160. [Epub ahead of print]
Therapy Indications
Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease.
(2014)
Suzuki M, Makita H, Ostling J, Thomsen LH, Konno S, Nagai K, Shimizu K, Pedersen JH, Ashraf H, Bruijnzeel PL, Maciewicz RA, Nishimura M; for the Hokkaido COPD cohort study and DLCST investigators.
Ann Am Thorac Soc. 2014 Nov 5. [Epub ahead of print]
Therapy Indications
Circulating acute phase proteins in relation to extent and composition of coronary atherosclerosis and cardiovascular outcome: results from the ATHEROREMO-IVUS study
(2014)
Battes LC, Akkerhuis KM, Cheng JM, Garcia-Garcia HM, Oemrawsingh RM, de Boer SPM, Reger E, van Geuns R-J, Serruys PW, Boersma E, Kardys I
International Journal of Cardiology
Therapy Indications
A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases/phosphatases in rat brain.
(2014)
Wesseling H, Rahmoune H, Tricklebank M, Guest PC, Bahn S.
J Proteome Res. 2014 Nov 2. [Epub ahead of print]
Therapy Indications
Multiplexed protein profiling after aneurysmal subarachnoid hemorrhage: Characterization of differential expression patterns in cerebral vasospasm.
(2014)
Walcott BP, Patel AP, Stapleton CJ, Trivedi RA, Young AM, Ogilvy CS.
J Clin Neurosci. 2014 Jul 28. pii: S0967-5868(14)00318-X. doi: 10.1016/j.jocn.2014.06.004. [Epub ahead of print]
Therapy Indications
FASTKD2 is associated with memory and hippocampal structure in older adults.
(2014)
Ramanan VK, Nho K, Shen L, Risacher SL, Kim S, McDonald BC, Farlow MR, Foroud TM, Gao S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, De Jager PL, Yu L, Bennett DA, Saykin AJ.
Mol Psychiatry. 2014 Nov 11. doi: 10.1038/mp.2014.142. [Epub ahead of print]
Therapy Indications
First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors.
(2014)
Schultheis B, Strumberg D, Santel A, Vank C, Gebhardt F, Keil O, Lange C, Giese K, Kaufmann J, Khan M, Drevs J.
J Clin Oncol. 2014 Nov 17. pii: JCO.2013.55.0376. [Epub ahead of print]
Therapy Indications
Multi-analyte profiling of inflammatory mediators in COPD sputum ? The effects of processing
(2014)
Pedersen F, Holz O, Lauer G, Quintini G, Kiwull-Schone H, Kirsten A-M, Magnussen H, Rabe KF, Goldmann T, Watz H
Cytokine. 2014 Nov 15. doi:10.1016/j.cyto.2014.10.008
Therapy Indications
Deferasirox effect on renal haemodynamic parameters in patients with transfusion-dependent ? thalassaemia.
(2014)
Piga A, Fracchia S, Lai ME, Cappellini MD, Hirschberg R, Habr D, Wegener A, Bouillaud E, Forni GL.
Br J Haematol. 2014 Nov 17. doi: 10.1111/bjh.13217. [Epub ahead of print]
Therapy Indications
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.
(2014)
Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, Bellmunt J, Burris HA, Petrylak DP, Teng SL, Shen X, Boyd Z, Hegde PS, Chen DS, Vogelzang NJ.
Nature. 2014 Nov 26;515(7528):558-62. doi: 10.1038/nature13904.
Therapy Indications
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
(2014)
Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS.
Nature. 2014 Nov 26;515(7528):563-7. doi: 10.1038/nature14011.
Therapy Indications
Cardiac mMCP-4+ mast cell expansion and elevation of IL-6, and CCR1/3 and CXCR2 signaling chemokines in an adjuvant-free mouse model of tree nut allergy.
(2014)
Gonipeta B, Para R, He Y, Srkalovic I, Ortiz T, Kim E, Parvataneni S, Gangur V.
Immunobiology. 2014 Dec 2. pii: S0171-2985(14)00237-X. doi: 10.1016/j.imbio.2014.11.012. [Epub ahead of print]
Therapy Indications
Biomarkers of Central Nervous System Inflammation in Infantile and Juvenile Gangliosidoses.
(2014)
Utz JR, Crutcher T, Schneider J, Sorgen P, Whitley CB.
Mol Genet Metab. 2014 Dec 6. pii: S1096-7192(14)00376-X. doi: 10.1016/j.ymgme.2014.11.015. [Epub ahead of print]
Therapy Indications
Assessment of serum biomarkers in rats after exposure to pesticides of different chemical classes.
(2014)
Moser VC, Stewart N, Freeborn DL, Crooks J, MacMillan DK, Hedge JM, Wood CE, McMahen RL, Strynar MJ, Herr DW.
Toxicol Appl Pharmacol. 2014 Dec 9;282(2):161-174. doi: 10.1016/j.taap.2014.11.016. [Epub ahead of print]
Therapy Indications
Obesity superimposed on aging magnifies inflammation and delays the resolving response following myocardial infarction.
(2014)
Lopez EF, Kabarowski J, Ingle KA, Kain V, Barnes S, Crossman DK, Lindsey ML, Halade GV.
Am J Physiol Heart Circ Physiol. 2014 Dec 5:ajpheart.00604.2014. doi: 10.1152/ajpheart.00604.2014. [Epub ahead of print]
Therapy Indications
Citrus limonin glucoside supplementation decreased biomarkers of liver disease and inflammation in overweight human adults.
(2014)
Kelley DS, Adkins YC, Zunino SJ, Woodhouse LR, Bonnel EL, Breksa III AP, Manners GD, Mackey BE
Journal of Functional Foods
Therapy Indications
Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.
(2014)
B?r C, de Jesus BB, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert KC, Bosch F, Blasco MA.
Nat Commun. 2014 Dec 18;5:5863. doi: 10.1038/ncomms6863.
Therapy Indications
Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-? receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer.
(2014)
Rod?n J, Carducci M, Sepulveda-S?nchez JM, Azaro A, Calvo E, Seoane J, Bra?a I, Sicart E, Gueorguieva I, Cleverly A, Pillay NS, Desaiah D, Estrem ST, Paz-Ares L, Holdhoff M, Blakeley J, Lahn MM, Baselga J.
Invest New Drugs. 2014 Dec 23. [Epub ahead of print]
Therapy Indications
High fidelity between saliva proteomics and the salivary glands biological state defines biomarker-signatures for primary Sj?grens syndrome.
(2014)
Delaleu N, Mydel P, Kwee I, Brun JG, Jonsson MV, Jonsson R.
Arthritis Rheumatol. 2014 Dec 29. doi: 10.1002/art.39015. [Epub ahead of print]
Therapy Indications
CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.
(2014)
Siddiqi FS, Chen L, Advani SL, Thai K, Batchu SN, Alghamdi TA, White KE, Sood MM, Gibson IW, Connelly KA, Marsden PA, Advani A.
Endocrinology. 2014 Dec 30:en20141650. [Epub ahead of print]
Therapy Indications
Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation
(2014)
Adage T, Konya V, Weber C, Strutzmann E, Fuchs T, Zankl C, Gerlza T, Jeremic D, Heinemann A, Kungl AJ.
Eur J Pharmacol. 2014 Dec 29. pii: S0014-2999(14)00889-9. doi: 10.1016/j.ejphar.2014.12.019. [Epub ahead of print]
Therapy Indications
Basal inflammation and innate immune response in chronic multisite musculoskeletal pain.
(2014)
Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, Dekker J, Penninx BW.
Pain. 2014 Aug;155(8):1605-12. doi: 10.1016/j.pain.2014.05.007. Epub 2014 May 9.
Therapy Indications
The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis.
(2014)
Peterson JL, Phelps ED, Doll MA, Schaal S, Ceresa BP.
Invest Ophthalmol Vis Sci. 2014 May 1;55(5):2870-80. doi: 10.1167/iovs.13-12943.
Therapy Indications
Proteomic changes in serum of first onset, antidepressant drug-na?ve major depression patients.
(2014)
Stelzhammer V, Haenisch F, Chan MK, Cooper JD, Steiner J, Steeb H, Martins-de-Souza D, Rahmoune H, Guest PC, Bahn S.
Int J Neuropsychopharmacol. 2014 Oct;17(10):1599-608. doi: 10.1017/S1461145714000819. Epub 2014 Jun 5.
Therapy Indications
Effects of Ruxolitinib Treatment on Metabolic and Nutritional Parameters in Patients With Myelofibrosis From COMFORT-I.
(2014)
Mesa RA, Verstovsek S, Gupta V, Mascarenhas J, Atallah E, Burn T, Sun W, Sandor V, Gotlib J.
Clin Lymphoma Myeloma Leuk [Epub ahead of print]
Therapy Indications
Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction.
(2014)
Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF.
Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1398-407. doi: 10.1152/ajpheart.00090.2014. Epub 2014 Mar 21.
Therapy Indications
Towards a Psychosis Risk Blood Diagnostic for Persons Experiencing High-Risk Symptoms: Preliminary Results From the NAPLS Project.
(2014)
Perkins DO, Jeffries CD, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Heinssen R.
Schizophr Bull. 2014 Aug 6. pii: sbu099. [Epub ahead of print]
Therapy Indications
Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression.
(2014)
Diniz BS, Sibille E, Ding Y, Tseng G, Aizenstein HJ, Lotrich F, Becker JT, Lopez OL, Lotze MT, Klunk WE, Reynolds CF, Butters MA.
Mol Psychiatry. 2014 Aug 5. doi: 10.1038/mp.2014.76. [Epub ahead of print]
Therapy Indications
Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats.
(2014)
Erdely A, Antonini JM, Young SH, Kashon ML, Gu JK, Hulderman T, Salmen R, Meighan T, Roberts JR, Zeidler-Erdely PC.
Part Fibre Toxicol. 2014 Aug 15;11:34. doi: 10.1186/s12989-014-0034-8.
Therapy Indications
The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results From a Phase 3, Randomized, Placebo-Controlled Trial (PALACE 1).
(2015)
Schafer P, Chen P, Fang L, Wang A, Chopra R.
J Immunol Res 2015 Jan 10 [Epub ahead of print]
Therapy Indications
Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods.
(2015)
Morrow JD, Qiu W, Chhabra D, Rennard SI, Belloni P, Belousov A, Pillai SG, Hersh CP.
BMC Med Genomics. 2015 Jan 13;8(1):1. [Epub ahead of print]
Therapy Indications
Anti-inflammatory T-cell shift in neuropathic pain.
(2015)
Luchting B, Rachinger-Adam B, Heyn J, Hinske L, Kreth S, Azad S.
J Neuroinflammation. 2015 Jan 21;12(1):12. [Epub ahead of print]
Therapy Indications
Acute and chronic plasma metabolomic and liver transcriptomic stress effects in a mouse model with features of post-traumatic stress disorder.
(2015)
Gautam A, DArpa P, Donohue DE, Muhie S, Chakraborty N, Luke BT, Grapov D, Carroll EE, Meyerhoff JL, Hammamieh R, Jett M.
PLoS One. 2015 Jan 28;10(1):e0117092. doi: 10.1371/journal.pone.0117092. eCollection 2015.
Therapy Indications
Evaluation of thymosin alpha 1 (Ta1) in nonclinical models of the immune-suppressing indications melanoma and sepsis.
(2015)
King RS, Tuthill C.
Expert Opin Biol Ther. 2015 Feb 2:1-9. [Epub ahead of print]
Therapy Indications
Phase II Evaluation of IPI-926, an Oral Hedgehog Inhibitor, in Patients with Myelofibrosis.
(2015)
Sasaki K, Gotlib JR, Mesa RA, Newberry KJ, Ravandi F, Cortes JE, Kelly P, Kutok JL, Kantarjian HM, Verstovsek S.
Leuk Lymphoma. 2015 Feb 2:1-20. [Epub ahead of print]
Therapy Indications
Nox4 supports proper capillary growth in exercise and retina neo-vascularization.
(2015)
Vogel J, Kruse C, Zhang M, Schr?der K.
J Physiol. 2015 Feb 4. doi: 10.1113/jphysiol.2014.284901. [Epub ahead of print]
Therapy Indications
Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes.
(2015)
Looker HC, Colombo M, Agakov F, Zeller T, Groop L, Thorand B, Palmer CN, Hamsten A, de Faire U, Nogoceke E, Livingstone SJ, Salomaa V, Leander K, Barbarini N, Bellazzi R, van Zuydam N, McKeigue PM, Colhoun HM; on behalf of the SUMMIT Investigators.
Diabetologia. 2015 Mar 5. [Epub ahead of print]
Therapy Indications
The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses.
(2015)
Christiansson L, Soderlund S, Mangsbo SM, Hjorth-Hansen H, H?glund M, Markevarn B, Richter J, Stenke L, Mustjoki S, Loskog A, Olsson-Stromberg U.
Mol Cancer Ther. 2015 Mar 11. pii: molcanther.0849.2014. [Epub ahead of print]
Therapy Indications
Study of cardiovascular disease biomarkers among tobacco consumers, part 2: biomarkers of biological effect.
(2015)
Nordskog BK, Brown BG, Marano KM, Campell LR, Jones BA, Borgerding MF.
Inhal Toxicol. 2015 Mar 19:1-10. [Epub ahead of print]
Therapy Indications
Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory.
(2015)
Kim A, Fagan AM, Goate AM, Benzinger TL, Morris JC, Head D; Alzheimer?s Disease Neuroimaging Initiative.
Cogn Affect Behav Neurosci. 2015 Mar 18. [Epub ahead of print]
Therapy Indications
Detection of Rheumatoid Arthritis-Interstitial Lung Disease is Enhanced by Serum Biomarkers.
(2015)
Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO.
Am J Respir Crit Care Med. 2015 Mar 30. [Epub ahead of print]
Therapy Indications
The long-acting ?2-agonist olodaterol attenuates pulmonary inflammation.
(2015)
Wex E, Kollak I, Duechs MJ, Naline E, Wollin L, Devillier P.
Br J Pharmacol. 2015 Mar 30. doi: 10.1111/bph.13143. [Epub ahead of print]
Therapy Indications
Novel first-dose adverse drug reactions during a phase I trial of olipudase alfa (recombinant human acid sphingomyelinase) in adults with Niemann-Pick disease type B (acid sphingomyelinase deficiency).
(2015)
McGovern MM, Wasserstein MP, Kirmse B, Duvall WL, Schiano T, Thurberg BL, Richards S, Cox GF.
Genet Med. 2015 Apr 2. doi: 10.1038/gim.2015.24. [Epub ahead of print]
Therapy Indications
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.
(2015)
Phillips B, Veljkovic E, Peck MJ, Buettner A, Elamin A, Guedj E, Vuillaume G, Ivanov NV, Martin F, Bou?b S, Schlage WK, Schneider T, Titz B, Talikka M, Vanscheeuwijck P, Hoeng J, Peitsch MC.
Food Chem Toxicol. 2015 Apr 2. pii: S0278-6915(15)00088-5. doi: 10.1016/j.fct.2015.03.009. [Epub ahead of print]
Therapy Indications
Temporal phenotypic features distinguish polarized macrophages in vitro.
(2015)
Melton DW, McManus LM, Gelfond JA, Shireman PK.
Autoimmunity. 2015 Mar 31:1-16. [Epub ahead of print]
Therapy Indications
Serum IGF-BP2 Strongly Moderates Age?s Effect on Cognition: A MIMIC Analysis.
(2015)
Royall DR, Bishnoi RJ, Palmer RF
Neurobiol. Aging. 14 April 2015. [Epub ahead of print]
Therapy Indications
Mechanism-based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy.
(2015)
Hawkins-Salsbury JA, Shea L, Jiang X, Hunter DA, Guzman AM, Reddy AS, Qin EY, Li Y, Gray SJ, Ory DS, Sands MS.
J Neurosci. 2015 Apr 22;35(16):6495-505. doi: 10.1523/JNEUROSCI.4199-14.2015.
Therapy Indications
Alarmin function of galectin-9 in murine respiratory tularemia.
(2015)
Steichen AL, Simonson TJ, Salmon SL, Metzger DW, Mishra BB, Sharma J.
PLoS One. 2015 Apr 21;10(4):e0123573. doi: 10.1371/journal.pone.0123573. eCollection 2015.
Therapy Indications
Plasma BDNF levels associate with Pittsburgh Compound B binding in the brain.
(2015)
Hwang KS, Lazaris AS, Eastman JA, Teng E, Thompson PM, Gylys KH, Cole GM, Apostolova LG, for the
Alzheimers Dement (Amst) 2015 Apr 22. [Epub ahead of print]
Therapy Indications
Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study.
(2015)
Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, de Geus EJ, Penninx BW, Dekker J.
Ann Rheum Dis. 2015 Apr 22. pii: annrheumdis-2014-206741. doi: 10.1136/annrheumdis-2014-206741. [Epub ahead of print]
Therapy Indications
CHOP Links Endoplasmic Reticulum Stress to NF-kB Activation in the Pathogenesis of Nonalcoholic Steatohepatitis.
(2015)
Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC.
Mol Biol Cell. 2015 Apr 22. pii: mbc.E15-01-0036. [Epub ahead of print]
Therapy Indications
Discovery of serum biomarkers predicting development of a subsequent depressive episode in social anxiety disorder.
(2015)
Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BW, Bahn S.
Brain Behav Immun. 2015 Apr 28. pii: S0889-1591(15)00118-X. doi: 10.1016/j.bbi.2015.04.011. [Epub ahead of print]
Therapy Indications
Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model.
(2015)
Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L.
Autoimmunity. 2015 Apr 27:1-11. [Epub ahead of print]
Therapy Indications
Total testosterone and neuropsychiatric symptoms in elderly men with Alzheimer?s disease.
(2015)
Hall JR, Wiechmann AR, Cunningham RL, Johnson LA, Edwards M, Barber RC, Singh M, Winter S, O?Bryant SE, and for the Texas Alzheimer?s Research and Care Consortium.
Alzheimers Res Ther. 2015; 7(1): 24. Published online 2015 May 1. doi: 10.1186/s13195-015-0107-4
Therapy Indications
Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study.
(2015)
Hoeven TA, Kavousi M, Ikram AM, van Meurs JB, Bindels PJ, Hofman A, Franco OH, Bierma-Zeinstra SM.
Rheumatology (Oxford). 2015 May 6. pii: kev106. [Epub ahead of print]
Effect of cerium oxide nanoparticles on sepsis induced mortality and NF-?B signaling in cultured macrophages.
(2015)
Selvaraj V, Manne ND, Arvapalli R, Rice KM, Nandyala G, Fankenhanel E, Blough ER.
Nanomedicine (Lond). 2015 Apr;10(8):1275-88. doi: 10.2217/nnm.14.205.
Therapy Indications
Blood Protein Markers of Neocortical Amyloid-? Burden: A Candidate Study Using SOMAscan Technology.
(2015)
Voyle N, Baker D2, Burnham SC, Covin A, Zhang Z, Sangurdekar DP, Tan Hehir CA, Bazenet C, Lovestone S, Kiddle S, Dobson RJ.
J Alzheimers Dis. 2015 Apr 16. [Epub ahead of print]
Therapy Indications
Development, manufacturing and characterization of a highly purified, liquid immunoglobulin g preparation from human plasma.
(2014)
Laursen IA, Blou L, Sullivan JS, Bang P, Balstrup F, Houen G.
Transfus Med Hemother. 2014 Jun;41(3):205-12. doi: 10.1159/000357982. Epub 2014 Apr 14.
Therapy Indications
Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles.
(2015)
Selvaraj V, Nepal N1, Rogers S, Manne ND, Arvapalli R, Rice KM, Asano S, Fankhanel E, Ma JJ, Shokuhfar T, Maheshwari M, Blough ER.
Biomaterials. 2015 May 8;59:160-171. doi: 10.1016/j.biomaterials.2015.04.025. [Epub ahead of print]
Therapy Indications
Ferritin levels in the cerebrospinal fluid predict Alzheimers disease outcomes and are regulated by APOE.
(2015)
Ayton S, Faux NG, Bush AI; Alzheimers Disease Neuroimaging Initiative.
Nat Commun. 2015 May 19;6:6760. doi: 10.1038/ncomms7760.
Therapy Indications
Hippocampal proteomic and metabonomic abnormalities in neurotransmission, oxidative stress and apoptotic pathways in a chronic phencyclidine rat model.
(2015)
Wesseling H, Want EJ, Guest PC, Rahmoune H, Holmes E, Bahn S.
J Proteome Res. 2015 Jun 4. [Epub ahead of print]
Therapy Indications
Immune cell profiling to guide therapeutic decisions in rheumatic diseases.
(2015)
Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S.
Nat Rev Rheumatol. 2015 Jun 2. doi: 10.1038/nrrheum.2015.71. [Epub ahead of print]
Therapy Indications
Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial.
(2015)
Tomasik J, Yolken RH, Bahn S, Dickerson FB.
Biomark Insights. 2015 Jun 1;10:47-54. doi: 10.4137/BMI.S22007. eCollection 2015.
Therapy Indications
Multiplex immunoassay analysis of plasma shows differences in biomarkers related to manic or mixed mood states in bipolar disorder patients.
(2015)
Haenisch F, Alsaif M, Guest PC, Rahmoune H, Yolken R, Dickerson F, Bahn S.
Journal of Affective Disorders. 2015 Jun 24. doi:10.1016/j.jad.2015.05.065. [Epub ahead of print]
Therapy Indications
Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in Adult Patients with Systemic Sclerosis.
(2015)
Guo X, Higgs BW, Bay-Jensen AC, Karsdal MA, Yao Y, Roskos LK, White WI.
J Invest Dermatol. 2015 May 20. doi: 10.1038/jid.2015.188. [Epub ahead of print]
Therapy Indications
Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of TNF-a receptor 1
(2015)
Cordy JC, Morley PJ, Wright TJ, Birchler MA, Lewis AP, Emmins R, Chen YZ, Powley WM, Bareille PJ, Wilson R, Tonkyn J, Bayliffe AI, Lazaar AL.
Clin Exp Immunol.
Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans
(2015)
Saykin A, Shen L, Xiohui Y, Kim S, Kwangsik N, Risacher SL, Ramanan VK, Foroud T, Faber KM, Sarwar N, Minsie L, Xiaolan H, Soares HD, Potkin S, Thompson PM, Kauwe JSK, Kaddurah-Daouk R, Green RC, Toga AW, Weiner MW
Alzheimers & Dementia
Therapy Indications
Perspective: The Alzheimers Disease Neuroimaging Initiative and the role and contributions of the Private Partner Scientific Board (PPSB)
(2015)
Liu E, Luthman J, Cedarbaum JM, Scmidt ME, Cole PE, Hendrix J, Carillo MC, Jones-Davis D, Tarver E, Novak G, De Santi S, Soares HD, Potter QZ, Siemers E, Schwarz AJ
Alzheimers & Dementia
Therapy Indications
Biomarkers of rapid chronic kidney disease progression in type 2 diabetes
(2015)
Looker HC, Colombo M, Hess S, Brosnan MJ, Farran B, Dalton RN, Wong MC, Turner C, Palmer CNA, Nogceke E, Groop L, Salomaa V, Dunger DB, Agakov F, McKeigue PM, Colhoun HM
Kidney International
Therapy Indications
Identifying amyloid pathology?related cerebrospinal fluid biomarkers for Alzheimers disease in a multicohort study
(2015)
Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, Soares HD, Kling MA, Mailman M, Arnold SE, Narayan VA, Lee VMY, Shaw LM, Baker D, Wittenberg GM, Trojanowski JQ, Wang LS
Alzheimers & Dementia
Therapy Indications
Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia
(2015)
Shaikh H, Boudes E, Khoja Z, Shevell M, Wintermark P
PLOS One
Therapy Indications
Late Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337)
(2015)
Dietsch GN, Randall TD, Gottardo R, Northfelt DW, Ramanathan RK, Cohen PA, Manjarrez KL, Newkirk M, Bryan JK, Hershberg RM
Clinical Cancer Research
Therapy Indications
A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis
(2015)
Pardanani A, Tefferi A, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, Xu C, Cao H and Talpaz M
Blood Cancer Journal
Therapy Indications
THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab
(2015)
Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B
Ann Rheum Dis
Therapy Indications
Identification of plasma biomarker concentration changes resulting from the administration of the Vascular Disrupting Agent BNC105 across 3 clinical trials in mesothelioma, ovarian and renal cancer
(2015)
Kremmidiotis G, Leske A, Simpson J, Doolin E, Iglesias J
AACR 2015
Therapy Indications
Biomarker results from a clinical trial of nivolumab in patients (pts) with metastatic renal cell carcinoma (mRCC) (CA209-009): Gene expression, serum profiling for immune markers, and multiplex tissue immunohistochemistry (IHC)
(2015)
Choueiri TK, Fishman MN, Escudier B, Stadler WM, Chasalow S, Ross-Macdonald P, Jure-Kunkel M, Sznol M, and Simon JS
Cancer Res
Therapy Indications
Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease
(2015)
Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC
Pediatr Res.
Therapy Indications
Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat
(2015)
Svejgaard B, Wehland M, Ma X, Kopp S, Sahana J, Warnke E, Aleshcheva G, Hemmersbach R, Hauslage J, Grosse J, Bauer J, Corydon TJ, Islam T, Infanger M, Grimm D
PLoS One
Therapy Indications
Central and peripheral changes underlying susceptibility and resistance to social defeat stress ? a proteomic profiling study
(2015)
Stelzhammer V, Ozcan S, Gottschalk MG, Steeb H, Hodes GE, Guest PC, Rahmoune H, Wong EHF, Russo SJ, Bahn S
Diagnostics in Neuropsychiatry
Therapy Indications
A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimers Disease.
(2015)
Khan W, Aguilar C, Kiddle SJ, Doyle O, Thambisetty M, Muehlboeck S, Sattlecker M, Newhouse S, Lovestone S, Dobson R, Giampietro V, Westman E, Simmons A
PLoS One
Therapy Indications
Multianalyte markers of schizophrenia and bipolar disorder: A preliminary study.
(2015)
Dickerson F, Schroeder J, Stallings C, Origoni A, Bahn S, Yolken R
Schizophr Res.
Therapy Indications
PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation.
(2015)
Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ
Cytokine
Therapy Indications
Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague?Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology
(2015)
Phillips B, Esposito M, Verbeeck J, Bou? S, Iskandar A, Vuillaume G, Leroy P, Krishnan S, Kogel U, Utan A, Schlage WK, Bera M, Veljkovic E, Hoeng J, Peitsch MC, Vanscheeuwijck P
Inhal Toxicol.
Therapy Indications
Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders.
(2015)
Wesseling H, Guest PC, Lee CM, Wong EH, Rahmoune H, Bahn S
Mol Autism.
Therapy Indications
Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion.
(2015)
Poussin C, Laurent A, Peitsch MC, Hoeng J, De Leon H
Toxicol Sci.
Therapy Indications
MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Sle1-Human CD19 Transgenic Mice.
(2015)
Gallagher S, Yusuf I, McCaughtry TM, Turman S, Sun H, Kolbeck R, Herbst R, Wang Y
Arthritis Rheumatol.
Therapy Indications
Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer
(2015)
Pommier AJC, Farren M, Patel B, Wappett M, Michopoulos F, Smith NR, Kendrew J, Frith J, Huby R, Eberlein C, Campbell H, Womack C, Smith PD, Robertson J, Morgan S, Critchlow SE, Barry ST
Cell Metabolism
Therapy Indications
Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells
(2015)
Poussin C, Laurent A, Peitsch MC, Hoeng J, and De Leon H
Toxicology
Therapy Indications
Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders
(2015)
Frye MA, Nassan M, Jenkins GD, Kung S, Veldic M, Palmer BA, Feeder SE, Tye SJ, Choi DS and Biernacka HM
Translational Psychiatry
Therapy Indications
Prognostic and predictive biomarkers of AAA growth rate.
(2015)
Deeg MA, Meijer CA, Chan LS, Shen L, Lindeman JH.
Curr Med Res Opin
Therapy Indications
Self-reactive IgE exacerbates interferon responses associated with autoimmunity
(2015)
Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA
Nat Immunol.
Therapy Indications
Comparing biological markers of Alzheimers disease across blood fraction and platforms: Comparing apples to oranges
(2015)
OBryant SE, Listac S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, King M, Baker L, Hampel H
Alzheimers Dement (2015) 1-8
Therapy Indications
Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant
(2016)
Felsky D, De Jager PL, Schneider JA, Arfanakis K, Fleischman DA, Arvanitakis Z, Honer WG, Pouget JG, Mizrahi R, Pollock BG, Kennedy JL, Bennett DA, Voineskos AN
J Cereb Blood Flow Metab
Therapy Indications
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
(2016)
Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, Alzheimer?s Disease Neuroimaging Initiative (ADNI), Holtzman D, Morris JC, Bales K, Pickering EH, Lee J, Heitsch L, Kauwe J, Goate A, Piccio L, Cruchaga C
Scientific Reports
Therapy Indications
Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination
(2016)
Fourati S, Cristescu R, Loboda A, Talla A, Filali A, Railkar R, Schaeffer AK, Favre D, Gagnon D, Peretz Y, Wang IM, Beals CR, Casimiro DR, Carayannopoulos LN, S?kaly RP
Nat Commun. 2016 Jan 8;7:10369
Therapy Indications
A Randomized Trial Evaluating Various Administration Routes of Natalizumab in Multiple Sclerosis
(2016)
Plavina T, Fox EJ, Lucas N, Muralidharan KK, Mikol D
J Clin Pharmacol
Therapy Indications
Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study
(2016)
Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AH, Bartlett A, Kissel JT
Ann Clin Transl Neurol
Therapy Indications
Serum apolipoprotein E is associated with long-term risk of Alzheimers disease: the Rotterdam Study
(2016)
Wolters FJ, Koudstaal PJ, Hofman A, Duijn CM, Ikram MA.
Neurosci Lett
Therapy Indications
Predicting Progression from Mild Cognitive Impairment to Alzheimers Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification
(2016)
Korolev IO, Symonds LL, Bozoki AC; Alzheimers Disease Neuroimaging Initiative
PLoS One
Therapy Indications
Dynamic Macrophage Polarization-Specific miRNA Patterns Reveal Increased Soluble VEGF Receptor 1 by miR-125a-5p Inhibition.
(2016)
Melton DW, Lei XF, Gelfond JAL, Shireman PK
Physiological Genomics
Therapy Indications
Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
(2016)
Bateman ED, Goehring UM, Richard F, Watz H
Journal of Allergy and Clinical Immunology
Therapy Indications
Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity
(2016)
Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM
PLoS ONE
Therapy Indications
2. Plasma insulin-like growth factor I levels are higher in depressive and anxiety disorders, but lower in antidepressant medication users
(2016)
Bot M, Milaneschi Y, Penninx BWJH, Drent ML
Psychoneuroendocrinology
Therapy Indications
1. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia
(2016)
Jondle CN, Sharma A, Simonson TJ, Larson B, Mishra BB, Sharma J
Journal of Immunology
Therapy Indications
Thrombopoietin is associated with ds intercept, and only in Non-Hispanic Whites
(2016)
Royall DR, Palmer RF
Alzheimers & Dementia: Diagnosis, Assessment & Disease Monitoring
Therapy Indications
The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy
(2016)
Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenf?hrer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S, Hocher B
Kidney International
Therapy Indications
Immune Monitoring Technology Primer: Immunoprofiling of Antigen-Stimulated Blood
(2016)
Brunet LR, LaBrie S, Hagemann T
Journal for Immunotherapy of Cancer
Therapy Indications
System-Based Proteomic and Metabonomic Analysis of the Df(16)a+/- Mouse Identifies Potential Mir-185 Targets and Molecular Pathway Alterations
(2016)
Wesseling H, Xu B, Want EJ, Holmes E, Guest PC, Karayiorgou M, Gogos JA, Bahn S
Molecular Psychiatry
Therapy Indications
A Sputum Proteomic Signature That Associates with Increased Il-1? Levels and Bacterial Exacerbations of COPD
(2016)
Damera G, Pham T-H, Zhang J, Ward CK, Newbold P, Ranade K, Sethi S
Lung
Therapy Indications
Evaluation of Novel Biomarkers of Nephrotoxicity in Cynomolgus Monkeys Treated with Gentamicin
(2016)
Gautier J-C, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, L?onard J-F, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BHJ, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li B
Toxicology and Applied Pharmacology
Therapy Indications
Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial
(2016)
Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG
Neuromodulation: Technology at the Neural Interface
Therapy Indications
Plasma Egf and Cognitive Decline in Parkinsons Disease and Alzheimers Disease
(2016)
Lim NS, Swanson CR, Cherng H-R, Unger TL, Xie SX, Weintraub D, Marek K, Stern MB, Siderowf A, Pars Investigators, Alzheimers Disease Neuroimaging Initiative, Trojanowski JQ, Chen-Plotkin AS
Annals of Clinical and Translational Neurology
Therapy Indications
Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on Bmd among Young Childhood Cancer Survivors: A Randomized Clinical Trial
(2016)
Mogil RJ, Kaste SC, Ferry Jr RJ, Hudson MM, Mulrooney DA, Howell CR, Partin RE, Srivastava DK, Robison LL, Ness KK
JAMA Oncology
Therapy Indications
A Novel Approach for Emerging and Antibiotic Resistant Infections: Innate Defense Regulators as an Agnostic Therapy
(2016)
North JR, Takenaka S, Rozek A, Kielczewska A, Opal S, Morici LA, Finlay BB, Schaber CJ, Straube R, Donini O
Journal of Biotechnology
Therapy Indications
Apolipoprotein a-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis
(2016)
Walsh KB, Hart K, Roll S, Sperling M, Unruh D, Davidson WS, Lindsell CJ, Adeoye O
Journal of Stroke and Cerebrovascular Diseases
Therapy Indications
High false-positive rate of a putative biomarker test to aid in the diagnosis of schizophrenia
(2016)
Wehler CA, Preskorn, SH
Journal of Clinical Psychiatry
Therapy Indications
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis
(2016)
Rovin B, van Vollenhoven R, Aranow C, Wagner C, Gordon R, Zhuang Y, Belkowski S, Hsu B
Arthritis & Rheumatology
Therapy Indications
Characterization of Renal Biomarkers for Use in Clinical Trials: Effect of Preanalytical Processing and Qualification Using Samples from Subjects with Diabetes
(2015)
Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N
Drug Design, Development and Therapy
Therapy Indications
Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time
(2016)
Schild M, Eichner G, Beiter T, Zuegel M, Niess AM, Steinacker JM, Mooren FC
Mediators of Inflammation
Therapy Indications
Altered Cerebrospinal Fluid Proteins in Smith?Lemli?
(2016)
Cologna SM, Shieh C, Toth CL, Cougnoux A, Burkert KR, Bianconi SE, Wassif CA, Porter FD
American Journal of Medical Genetics Part A
Therapy Indications
Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology
(2016)
Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB
American Journal of Nephrology
Therapy Indications
Predictors of Asthma Following Severe Respiratory Syncytial Virus (Rsv) Bronchiolitis in Early Childhood
(2016)
Lu S, Hartert TV, Everard ML, Giezek H, Nelsen L, Mehta A, Patel H, Knorr B, Reiss TF
Pediatric Pulmonology
Therapy Indications
Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2-O-Methoxyethyl Modified Antisense Oligonucleotide
(2016)
Shen L, Engelhardt JA, Hung G, Yee J, Kikkawa R, Matson J, Tayefeh B, Machemer T, Giclas PC, Henry SP
Nucleic Acid Therapeutics
Therapy Indications
Type I Ifns Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-Versus-Host Disease
(2016)
Delaney TA, Morehouse C, Brohawn PZ, Groves C, Colonna M, Yao, Y, Sanjuan M, Coyle AJ
The Journal of Immunology
Therapy Indications
-Europe Workshop Report: Opportunities and Challenges in Developing Clinical Trials for Spinal Muscular Atrophy in Europe
(2013)
Kayadjanian N, Burghes A, Finkel RS, Mercuri E, Rouault F, Schwersenz I, Talbot Ka
Orphanet Journal of Rare Diseases
Therapy Indications
Inflammatory Profile in Lrrk2-Associated Prodromal and Clinical Pd
(2016)
Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos TO, Gasser T, Sch?le B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W
Journal of Neuroinflammation
Therapy Indications
Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma
(2016)
Choueiri TK, Fishman M, Escudier B, McDermott DF, Drake CG, Kluger HM, Stadler WM, Perez-Gracia JL, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Albiges L, Cohen LJ, Young TC, Chasalow SD, Ross-MacDonald P, Srivastava S, Jure-Kunkel M, Kurland JF, Simon JS, Sznol M
Clinical Cancer Research
Therapy Indications
Amyloid Proteotoxicity Initiates an Inflammatory Response Blocked by Cannabinoids
(2016)
Currais A, Quehenberger O, Armando AM, Daugherty D, Maher P, Schubert D
NPJ Aging and Mechanisms of Disease
Therapy Indications
Tenascin-C drives persistence of organ fibrosis
(2016)
Bhattacharyya S, Wang W, Morales-Nebreda L, Feng G, Wu M, Zhou X, Lafyatis R, Lee J, Hinchcliff M, Feghali-Bostwick C, Lakota K, Budinger GRS, Raparia K, Tamaki Z, Varga J
Nature Communications
Therapy Indications
C-Type Lectin Receptor Clec4d Plays a Protective Role in Resolution of Gram-Negative Pneumonia
(2013)
Steichen AL, Binstock BJ, Mishra BB, Sharma J
Journal of Leukocyte Biology
Therapy Indications
Update on the Safety and Efficacy of the Pan Class I Pi3k Inhibitor Sar245408 (Xl147) in Chronic Lymphocytic Leukemia and Non-Hodgkin?s Lymphoma Patients
(2013)
Davids MS, Rodon J, Abrisqueta P, Egile C, Ruiz-Soto R, Awan F
Blood
Therapy Indications
Low Plasma Apoe Levels Are Associated with Smaller Hippocampal Size in the Alzheimers Disease Neuroimaging Initiative Cohort
(2015)
Teng E, Chow N, Hwang KS, Thompson PM, Gylys KH, Cole GM, Jack Jr CR, Shaw LM, Trojanowski JQ, Soares HD, Weiner MW, Apostolova LG
Dementia and Geriatric Cognitive Disorders
Therapy Indications
Identifying Novel Biomarkers for Cardiovascular Events or Death in People with Dysglycemia
(2015)
Gerstein HC, Par? G, Mcqueen MJ, Haenel H, Lee SF, Pogue J, Maggioni AP, Yusuf S, Hess S
Circulation
Therapy Indications
Candidate Blood Proteome Markers of Alzheimers Disease Onset and Progression: A Systematic Review and Replication Study
(2014)
Kiddle SJ, Sattlecker M, Proitsi P, Simmons A, Westman E, Bazenet C, Nelson SK, Williams S, Hodges A, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Newhouse S, Lovestone S, Dobson RJ
Journal of Alzheimers Disease
Therapy Indications
Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways
(2013)
Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S
Schizophrenia Bulletin
Therapy Indications
The Application of Multiple Reaction Monitoring to Assess Apoa-I Methionine Oxidations in Diabetes and Cardiovascular Disease
(2014)
Yassine HN, Jackson AM, Reaven PD, Nedelkov D, Nelson RW, Lau SS, Borchers CH
Translational Proteomics
Therapy Indications
Mesenteric Ischemia-Reperfusion Injury up-Regulates Certain Cc, Cxc, and Xc Chemokines and Results in Multi-Organ Injury in a Time-Dependent Manner
(2013)
Jawa RS, Quist E, Boyer CW, Shostrom VK, Mercer DW
European Cytokine Network
Therapy Indications
Reduced Bdnf Attenuates Inflammation and Angiogenesis to Improve Survival and Cardiac Function Following Myocardial Infarction in Mice
(2013)
Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O, Jin Y-F, Lindsey ML
American Journal of Physiology - Heart and Circulatory Physiology
Therapy Indications
Rg7212 Anti-Tweak Mab Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response
(2013)
Yin X, Luistro L, Zhong H, Smith M, Nevins T, Schostack K, Hilton H, Lin T-A, Truitt T, Biondi D, Wang X, Packman K, Rosinski J, Berkofsky-Fessler W, Tang J-P, Pant S, Geho D, Vega-Harring S, Demario M, Levitsky H, Simcox M
American Association for Cancer Research
Therapy Indications
Plasma Lipid Profiling across Species for the Identification of Optimal Animal Models of Human Dyslipidemia
(2012)
Yin W, Carballo-Jane E, Mclaren DG, Mendoza VH, Gagen K, Geoghagen NS, Mcnamara LA, Gorski JN, Eiermann GJ, Petrov A, Wolff M, Tong X, Wilsie LC, Akiyama TE, Chen J, Thankappan A, Xue J, Ping X, Andrews G, Wickham LA, Gai CL, Trinh T, Kulick AA, Donnelly MJ, Voronin GO, Rosa R, Cumiskey A-M, Bekkari K, Mitnaul LJ, Puig O, Chen F, Raubertas R, Wong PH, Hansen BC, Koblan KS, Roddy TP, Hubbard BK, Strack AM
Journal of Lipid Research
Therapy Indications
Serum Proteomic Profiling of Major Depressive Disorder
(2015)
Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH
Translational Psychiatry
Therapy Indications
An Adaptive Genetic Algorithm for Selection of Blood-Based Biomarkers for Prediction of Alzheimers Disease Progression
(2015)
Vandewater L, Brusic V, Wilson W, Macaulay L, Zhang P
BMC Bioinformatics
Therapy Indications
Distinctive Colonic Mucosal Cytokine Signature in New-Onset, Untreated Pediatric Crohn Disease
(2014)
Sylvester FA, Draghi A, Menoret A, Fernandez ML, Wang Z, Vella AT
Journal of Pediatric Gastroenterology and Nutrition
Therapy Indications
Phase I Trial of the Pan-Pi3k Inhibitor Pilaralisib (Sar245408/Xl147) in Patients with Chronic Lymphocytic Leukemia (Cll) or Relapsed/Refractory Lymphoma
(2015)
Brown JR, Davids MS, Rodon J, Abrisqueta P, Kasar SN, Lager J, Jiang J, Egile C, Awan FT
American Association for Cancer Research
Therapy Indications
Circulating Cytokines in Relation to the Extent and Composition of Coronary Atherosclerosis: Results from the Atheroremo-Ivus Study
(2014)
Battes LC, Cheng JM, Oemrawsingh RM, Boersma E, Garcia-Garcia HM, De Boer SPM, Buljubasic N, Mieghem NaV, Regar E, Geuns R-JV, Serruys PW, Akkerhuis KM, Kardys I
Atherosclerosis
Therapy Indications
Sj?gren?s Syndrome Patients with Ectopic Germinal Centers Present with a Distinct Salivary Proteome
(2016)
Delaleu N, Mydel P, Brun JG, Jonsson MV, Alimonti A, Jonsson R
Rheumatology
Therapy Indications
Inflammatory Mediator Profiling Reveals Immune Properties of Chemotactic Gradients and Macrophage Mediator Production Inhibition During Thioglycollate Elicited Peritoneal Inflammation
(2013)
Lam D, Harris D, Qin Z
Mediators of Inflammation
Therapy Indications
Elevated Carbon Monoxide to Carbon Dioxide Ratio in the Exhaled Breath of Mice Treated with a Single Dose of Lipopolysaccharide
(2014)
Langeroudi AG, Hirsch CM, Estabragh AS, Meinardi S, Blake DR, Barbour AG
Open Forum Infectious Diseases
Therapy Indications
Dipeptidyl Peptidase-4 Inhibition Improves Left Ventricular Function in Chronic Kidney Disease
(2014)
Connelly KA, Bowskill BB, Advani SL, Thai K, Chen L-H, Kabir MG, Gilbert RE, Advani A
Clinical & Investigative Medicine
Therapy Indications
Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma
(2016)
Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ
British Journal of Cancer
Therapy Indications
Cytokine Production Capacity in Depression and Anxiety
(2016)
Vogelzangs N, De Jonge P, Smit JH, Bahn S, Penninx BW
Translational Psychiatry
Therapy Indications
The Effect Trial: Evaluating Exacerbations, Biomarkers, and Safety Outcomes with Two Dose Levels of Fluticasone Propionate/Formoterol in Copd
(2015)
Papi A, Jones PW, Dalvi PS, Mcaulay K, Mciver T, Dissanayake S
International Journal of COPD
Therapy Indications
Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk
(2015)
Cannon TD, Chung Y, He G, Sun D, Jacobson A, Van Erp TGM, Mcewen S, Addington J, Bearden CE, Cadenhead K, Cornblatt B, Mathalon DH, Mcglashan T, Perkins D, Jeffries C, Seidman LJ, Tsuang M, Walker E, Woods SW, Heinssen R
Biological Psychiatry
Therapy Indications
Development of a Blood-Based Molecular Biomarker Test for Identification of Schizophrenia before Disease Onset
(2015)
Chan MK, Krebs MO, Cox D, Guest PC, Yolken RH, Rahmoune H, Rothermundt M, Steiner J, Leweke FM, Van Beveren NJM, Niebuhr DW, Weber NS, Cowan DN, Suarez-Pinilla P, Crespo-Facorro B, Mam-Lam-Fook C, Bourgin J, Wenstrup RJ, Kaldate RR, Cooper JD, Bahn S
Translational Psychiatry
Therapy Indications
Apolipoprotein H Expression Is Associated with Il28b Genotype and Viral Clearance in Hepatitis C Virus Infection
(2014)
Laird ME, Mohsen A, Duffy D, Mamdouh R, Lefouler L, Casrouge A, El-Daly M, Rafik M, Abdel-Hamid M, Soulier A, Pawlotsky J-M, H?zode C, Rosa I, Renard P, Mohamed MK, Bonnard P, Izopet J, Mallet V, Pol S, Albert ML, Fontanet A
Journal of Hepatology
Therapy Indications
Towards a Blood-Based Diagnostic Panel for Bipolar Disorder
(2016)
Haenisch F, Cooper JD, Reif A, Kittel-Schneider S, Steiner J, Leweke FM, Rothermundt M, Van Beveren NJM, Crespo-Facorro B, Niebuhr DW, Cowan DN, Weber NS, Yolken RH, Penninx BWJH, Bahn S
Brain, Behavior, and Immunity
Therapy Indications
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests
(2016)
Ramsey JM, Cooper JD, Penninx BWJH, Bahn S
Scientific Reports
Therapy Indications
Behavioural Traits Propagate across Generations Via Segregated Iterative-Somatic and Gametic Epigenetic Mechanisms
(2016)
Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, Van Den Brink M, Toth M
Nature Communications
Therapy Indications
Intratumoral Inf-g Triggers an Antiviral State in Gl261 Tumor Cells: A Major Hurdle to Overcome for Oncolytic Vaccinia Virus Therapy of Cancer
(2015)
Kober C, Weibel S, Rohn S, Kirscher L, Szalay AA*2015*Intratumoral Inf-G Triggers an Antiviral State in Gl261 Tumor Cells: A Major Hurdle to Overcome for Oncolytic Vaccinia Virus Therapy of Cancer
Molecular Therapy ? Oncolytics
Therapy Indications
Sublytic Concentrations of Staphylococcus Aureus Panton-Valentine Leukocidin Alter Human Pmn Gene Expression and Enhance Bactericidal Capacity
(2012)
Graves SF, Kobayashi SD, Braughton KR, Whitney AR, Sturdevant DE, Rasmussen DL, Kirpotina LN, Quinn MT, Deleo FR
Journal of Leukocyte Biology
Therapy Indications
Defining Map3 Kinases Required for Mda-Mb-231 Cell Tumor Growth and Metastasis
(2012)
Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL
Oncogene
Therapy Indications
Significance of Plasma Adiponectin for Diagnosis, Neurological Severity and Functional Outcome in Ischemic Stroke ? Research for Biomarkers in Ischemic Stroke (Rebios)
(2014)
Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T
Metabolism
Therapy Indications
Distinct Molecular Phenotypes in Male and Female Schizophrenia Patients
(2013)
Ramsey JM, Schwarz E, Guest PC, Van Beveren NJM, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S
PLoS ONE
Therapy Indications
An Antiinflammatory Dietary Mix Modulates Inflammation and Oxidative and Metabolic Stress in Overweight Men: A Nutrigenomics Approach
(2010)
Bakker GC, Van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, Van Ommen B, Hendriks HF
The American Journal of Clinical Nutrition
Therapy Indications
A Potential Endophenotype for Alzheimers Disease: Cerebrospinal Fluid Clusterin
(2016)
Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C
Neurobiology of Aging
Therapy Indications
Metronomic Gemcitabine Suppresses Tumour Growth, Improves Perfusion, and Reduces Hypoxia in Human Pancreatic Ductal Adenocarcinoma
(2010)
Cham KKY, Baker JHE, Takhar KS, Flexman JA, Wong MQ, Owen DA, Yung A, Kozlowski P, Reinsberg SA, Chu EM, Chang CWA, Buczkowski AK, Chung SW, Scudamore CH, Minchinton AI, Yapp DTT, Ng SSW
British Journal of Cancer
Therapy Indications
Clinical and Preclinical Characterization of the Histamine H4 Receptor Antagonist Jnj-39758979
(2014)
Thurmond RL, Chen B, Dunford PJ, Greenspan AJ, Karlsson L, La D, Ward P, Xu XL
Journal of Pharmacology and Experimental Therapeutics
Therapy Indications
Targeting Tnf-? to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy
(2012)
Calcinotto A, Grioni M, Jachetti E, Curnis F, Mondino A, Parmiani G, Corti A, Bellone M
Journal of Immunology
Therapy Indications
Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and Cognitive Problems in Adults with and without Methamphetamine Dependence: An Exploratory Protein Array Study
(2015)
Huckans M, Fuller BE, Chalker ALN, Adams M, Loftis JM
Frontiers in Psychiatry
Therapy Indications
Altered Levels of Circulating Insulin and Other Neuroendocrine Hormones Associated with the Onset of Schizophrenia
(2011)
Guest PC, Schwarz E, Krishnamurthy D, Harris LW, Leweke FM, Rothermundt M, Van Beveren N, Spain M, Barnes A, Steiner J, Rahmoune H, Bahn S
Psychoneuroendocrinology
Therapy Indications
Leucine-Rich Repeat Kinase 2 (Lrrk2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis
(2013)
Ness D, Ren Z, Gardai S, Sharpnack D, Johnson VJ, Brennan RJ, Brigham EF, Olaharski AJ
PLoS ONE
Therapy Indications
Brown Norway Chromosome 1 Congenic Reduces Symptoms of Renal Disease in Fatty Zucker Rats
(2014)
Warden CH, Slupsky C, Griffey SM, Bettaieb A, Min E, Le A, Fisler JS, Hansen S, Haj F, Stern JS
PLoS ONE
Therapy Indications
Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury
(2015)
Schley G, K?berle C, Manuilova E, Rutz S, Forster C, Weyand M, Formentini I, Kientsch-Engel R, Eckardt K-U, Willam C
PLoS ONE
Therapy Indications
Ascending Dose-Controlled Trial of Beloranib, a Novel Obesity Treatment for Safety, Tolerability, and Weight Loss in Obese Women
(2013)
Hughes TE, Kim DD, Marjason J, Proietto J, Whitehead JP, Vath JE
Obesity
Therapy Indications
Moderate Alcohol Consumption Alters Both Leucocyte Gene Expression Profiles and Circulating Proteins Related to Immune Response and Lipid Metabolism in Men
(2012)
Joosten MM, Van Erk MJ, Pellis L, Witkamp RF, Hendriks HFJ
British Journal of Nutrition
Therapy Indications
Dysregulation of Serum Gamma Interferon Levels in Vascular Chronic Q Fever Patients Provides Insights into Disease Pathogenesis
(2015)
Pennings JLA, Kremers MNT, Hodemaekers HM, Hagenaars JCJP, Koning OHJ, Renders NHM, Hermans MHA, De Klerk A, Notermans DW, Wever PC, Janssen R
Clinical and Vaccine Immunology
Therapy Indications
Analysis of a Urinary Biomarker Panel for Incident Kidney Disease and Clinical Outcomes
(2013)
O?Seaghdha CM, Hwang S-J, Larson MG, Meigs JB, Vasan RS, Fox CS
Journal of the American Society of Nephrology
Therapy Indications
Sequencing of Lrp2 Reveals Multiple Rare Variants Associated with Urinary Trefoil Factor-3
(2014)
Mcmahon GM, Olden M, Garnaas M, Yang Q, Liu X, Hwang S-J, Larson MG, Consortium C, Goessling W, Fox CS
Journal of the American Society of Nephrology
Therapy Indications
Cd4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate Copd Phenotypes
(2015)
Roberts MEPH, Brandon W.; Brohawn, Philip; Pilataxi, Fernanda; Guo, Xiang; Kuziora, Michael; Bowler, Russell P.; White, Wendy I.
Chronic Obstructive Pulmonary Diseases
Therapy Indications
A Semi-Mechanism Approach Based on Mri and Proteomics for Prediction of Conversion from Mild Cognitive Impairment to Alzheimer?s Disease
(2016)
Liu H, Zhou X, Jiang H, He H, Liu X
Scientific Reports
Therapy Indications
Early Role of Vascular Dysregulation on Late-Onset Alzheimers Disease Based on Multifactorial Data-Driven Analysis
(2016)
Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Perez JM, Evans AC, The Alzheimers Disease Neuroimaging Initiative
Nature Communications
Therapy Indications
Loss of Immune Tolerance Is Controlled by Icos in Sle1 Mice
(2016)
Mittereder N, Kuta E, Bhat G, Dacosta K, Cheng LI, Herbst R, Carlesso G
Journal of Immunology
Therapy Indications
Contribution of Staphylococcus Aureus Coagulases and Clumping Factor a to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection
(2016)
Malachowa N, Kobayashi SD, Porter AR, Braughton KR, Scott DP, Gardner DJ, Missiakas DM, Schneewind O, Deleo FR
PLoS ONE
Therapy Indications
Molecular Neuropsychology: Creation of Test-Specific Blood Biomarker Algorithms
(2014)
OBryant SE, Xiao G, Barber R, Cullum CM, Weiner M, Hall J, Edwards M, Grammas P, Wilhelmsen K, Doody R, Diaz-Arrastia R
Dementia and Geriatric Cognitive Disorders
Therapy Indications
Bone Marrow from Blotchy Mice Is Dispensable to Regulate Blood Copper and Aortic Pathologies but Required for Inflammatory Mediator Production in Ldlr-Deficient Mice During Chronic Angiotensin Ii Infusion
(2015)
Harris D, Liang Y, Chen C, Li S, Patel O, Qin Z
Annals of Vascular Surgery
Therapy Indications
Molecular Validation of the Acute Phencyclidine Rat Model for Schizophrenia: Identification of Translational Changes in Energy Metabolism and Neurotransmission*Journal of Proteome Research
(2012)
Ernst A, Ma D, Garcia-Perez I, Tsang TM, Kluge W, Schwarz E, Guest PC, Holmes E, Sarnyai Z, Bahn S
Journal of Proteome Research
Therapy Indications
The Different Effects of Strength and Endurance Exercise Training on Cox-2 and Mpges-Expression in Mouse Brain Are Independent of Peripheral Inflammation
(2016)
Kr?ger K, Bredeh?ft J, Mooren FC, Rummel C
Journal of Applied Physiology
Therapy Indications
Placebo-Controlled Randomized Clinical Trial on the Immunomodulating Activities of Low- and High-Dose Bromelain after Oral Administration ? New Evidence on the Antiinflammatory Mode of Action of Bromelain
(2013)
M?ller S, M?rz R, Schmolz M, Drewelow B, Eschmann K, Meiser P
Phytotherapy Research
Therapy Indications
Proteolytic Activity in Wound Fluids and Tissues Derived from Chronic Venous Leg Ulcers
(2009)
Moor AN, Vachon DJ, Gould LJ
Wound Repair and Regeneration
Therapy Indications
The Association of 83 Plasma Proteins with Chd Mortality, Bmi, Hdl-, and Total-Cholesterol in Men: Applying Multivariate Statistics to Identify Proteins with Prognostic Value and Biological Relevance
(2009)
Heidema AG, Thissen U, Boer JMA, Bouwman FG, Feskens EJM, Mariman ECM
Journal of Proteome Research
Therapy Indications
Pilot Study of Younger and Older Hiv-Infected Adults Using Traditional and Novel Functional Assessments
(2013)
Sandkovsky U, Robertson KR, Meza JL, High RR, Bonasera SJ, Fisher CM, Marsh AJ, Sheehy MK, Fox HS, Swindells S
HIV Clinical Trials
Therapy Indications
Regional Neurovascular Inflammation and Apoptosis Are Detected after Electrical Contact Injury
(2014)
Prindeze NJ, Jo DY, Paul DW, Ortiz RT, Carney BC, Bullock RM, Moffatt LT, Shupp JW
Journal of Burn Care & Research
Therapy Indications
Plasma Protein Profiling of Mild Cognitive Impairment and Alzheimers Disease across Two Independent Cohorts
(2015)
Muenchhoff JP, Anne; Song, Fei; Raftery, Mark; Brodaty, Henry; Duncan, Mark; Mcevoy, Mark; Attia, John; Schofield, Peter W.; Sachdev, Perminder S.
Journal of Alzheimers Disease
Therapy Indications
Endometriosis Leads to an Increased Trefoil Factor 3 Concentration in the Peritoneal Cavity but Does Not Alter Systemic Levels
(2016)
Henze D, Doecke W-D, Hornung D, Agueusop I, Von Ahsen O, Machens K, Schmitz AA, Gashaw I
Reproductive Sciences
Therapy Indications
BAFF (B Cell Activating Factor) Transcript Level in Peripheral Blood of Patients with SLE Is Associated with Same-Day Disease Activity as Well as Global Activity over the Next Year
(2015)
Zollars E, Bienkowska J, Czerkowicz J, Allaire N, Ranger AM, Magder L, Petri M
Lupus Science
Therapy Indications
Comprehensive Systems Biology Analysis of a 7-Month Cigarette Smoke Inhalation Study in C57bl/6
(2016)
Ansari S, Baumer K, Bou? S, Dijon S, Dulize R, Ekroos K, Elamin A, Foong C, Guedj E, Hoeng J, Ivanov NV, Krishnan S, Leroy P, Martin F, Merg C, Peck MJ, Peitsch MC, Phillips B, Schlage WK, Schneider T, Talikka M, Titz B, Vanscheeuwijck P, Veljkovic E, Vihervaara T, Vuillaume G, Woon CQ
Scientific Data
Therapy Indications
The Use of Multiplex Platforms for Absolute and Relative Protein Quantification of Clinical Material
(2014)
Christiansson L, Mustjoki S, Simonsson B, Olsson-Str?mberg U, Loskog ASI, Mangsbo SM
EuPA Open Proteomics
Therapy Indications
Effects of an Anti-Tslp Antibody on Allergen-Induced Asthmatic Responses
(2014)
Gauvreau GM, Obyrne PM, Boulet L-P, Wang Y, Cockcroft D, Bigler J, Fitzgerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR
New England Journal of Medicine
Therapy Indications
Mechanisms of Three-Dimensional Growth of Thyroid Cells During Long-Term Simulated Microgravity*Scientific Reports
(2015)
Kopp S, Warnke E, Wehland M, Aleshcheva G, Magnusson NE, Hemmersbach R, Corydon TJ, Bauer J, Infanger M, Grimm D
Scientific Reports
Therapy Indications
A Phase I/Ii Trial of Bnc105p with Everolimus in Metastatic Renal Cell Carcinoma
(2015)
Pal S, Azad A, Bhatia S, Drabkin H, Costello B, Sarantopoulos J, Kanesvaran R, Lauer R, Starodub A, Hauke R, Sweeney CJ, Hahn NM, Sonpavde G, Richey S, Breen T, Kremmidiotis G, Leske A, Doolin E, Bibby DC, Simpson J, Iglesias J, Hutson T
Clinical Cancer Research
Therapy Indications
The Milieu Int?rieur Study ? an Integrative Approach for Study of Human Immunological Variance
(2015)
Thomas S, Rouilly V, Patin E, Alanio C, Dubois A, Delval C, Marquier L-G, Fauchoux N, Sayegrih S, Vray M, Duffy D, Quintana-Murci L, Albert ML, Abel L, Alcover A, Bousso P, Bruhns P, Cumano A, Da?ron M, Delval C, Demangel C, Deriano L, Di Santo J, Dromer F, Eberl G, Enninga J, Freitas A, Gelpi O, Gomperts-Boneca I, Hercberg S, Lantz O, Leclerc C, Mouquet H, Pellegrini S, Pol S, Rogge L, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Soumelis V, Tangy F, Tartour E, Toubert A, Ungeheuer M-N, Quintana-Murci L, Albert ML
Clinical Immunology
Therapy Indications
Time Course of Cigarette Smoke-Induced Changes of Systemic Inflammation and Muscle Structure
(2015)
Kr?ger K, Dischereit G, Seimetz M, Wilhelm J, Weissmann N, Mooren FC
American Journal of Physiology - Lung Cellular and Molecular Physiology
Therapy Indications
Plasma Angiopoietin-2 Outperforms Other Markers of Endothelial Injury in Prognosticating Pediatric ARDS Mortality
(2015)
Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A
American Journal of Physiology - Lung Cellular and Molecular Physiology
Therapy Indications
The Relationship between Complement Factor C3, Apoe ?4, Amyloid and Tau in Alzheimer?s Disease
(2016)
Bonham LW, Desikan RS, Yokoyama JS
Acta Neuropathologica Communications
Therapy Indications
Variants in Ccl16 Are Associated with Blood Plasma and Cerebrospinal Fluid Ccl16 Protein Levels
(2016)
Ebbert MTW, Staley LA, Parker J, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JSK
BMC Genomics
Therapy Indications
Blood Biomarkers of Chronic Inflammation in Gulf War Illness
(2016)
Johnson GJ, Slater BCS, Leis LA, Rector TS, Bach RR
PLoS ONE
Therapy Indications
Identification of Plexin A4 as a Novel Clusterin Receptor Links Two Alzheimers Disease Risk Genes
(2016)
Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD
Human Molecular Genetics
Therapy Indications
Vagus Nerve Stimulation Inhibits Cytokine Production and Attenuates Disease Severity in Rheumatoid Arthritis
(2016)
Koopman FA, Chavan SS, Miljko S, Grazio S, Sokolovic S, Schuurman PR, Mehta AD, Levine YA, Faltys M, Zitnik R, Tracey KJ, Tak PP
PNAS
Therapy Indications
Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT
(2016)
Muders K, Pilat C, Deuster V, Frech T, Kruger K, Pons-Kuhnemann J, Mooren F-C
Mediators of Inflammation
Therapy Indications
Characterizing the Inflammatory Response in Esophageal Mucosal Biopsies in Children with Eosinophilic Esophagitis
(2016)
Sayej WN, Menoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT
Clinical & Translational Immunology
Therapy Indications
Genome-Wide Association Study of Prolactin Levels in Blood Plasma and Cerebrospinal Fluid
(2016)
Staley LA, Ebbert MTW, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JSK
BMC Genomics
Therapy Indications
Serum Proteomic Profiles of Depressive Subtypes
(2016)
Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BWJH
Translational Psychiatry
Therapy Indications
Peripheral Blood Cell Gene Expression Diagnostic for Identigying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures
(2016)
Kurian SM, Novais M, Whisenant T, Gelbart T, Buxbaum JN, Kelly JW, Coelho T, Salomon DR
Theranostics
Therapy Indications
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children
(2016)
Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, Von Mutius E, Vercelli D, Ober C, Sperling AI
New England Journal of Medicine
Therapy Indications
Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD
(2016)
Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen T-H, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O?neal WK, Bowler RP, Group SR, Investigators CO
PLOS Genetics
Therapy Indications
Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (Am0010) in Patients with Advanced Solid Tumors
(2016)
Naing A, Papadopoulos KP, Autio KA, Ott PA, Patel MR, Wong DJ, Falchook GS, Pant S, Whiteside M, Rasco DR, Mumm JB, Chan IH, Bendell JC, Bauer TM, Colen RR, Hong DS, Van Vlasselaer P, Tannir NM, Oft M, Infante JR
Journal of Clinical Oncology
Therapy Indications
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses
(2016)
Urrutia A, Duffy D, Rouilly V, Posseme C, Djebali R, Illanes G, Libri V, Albaud B, Gentien D, Piasecka B, Hasan M, Fontes M, Quintana-Murci L, Albert Matthew l, Abel L, Alcover A, Astrom K, Bousso P, Bruhns P, Cumano A, Demangel C, Deriano L, Di santo J, Dromer F, Eberl G, Enninga J, Fellay J, Freitas A, Gelpi O, Gomperts-Boneca I, Hercberg S, Lantz O, Leclerc C, Mouquet H, Pellegrini S, Pol S, Rogge L, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Soumelis V, Tangy F, Tartour E, Toubert A, Ungeheuer M-N, Quintana-Murci L, Albert Matthew
Cell Reports
Therapy Indications
Blood-based immune-endocrine biomarkers of treatment response in depression
(2016)
Chan MK, Cooper JD, Bot M, Birkenhanger TK, Bergink V, Drexhage HA, Steiner J, Rothermundt M, Penninx BWJH, Bahn S
Journal of Psychiatric Research
Therapy Indications
Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer
(2016)
Saif MW, Knost JA, Chiorean EG, Kambhampati SR, Yu D, Pytowski B, Qin A, Kauh JS, ONeil BH
Cancer Chemother Pharmacol
Therapy Indications
Plasma cystatin C and neutrophil gelatinase-associated lipocalin in relation to coronary atherosclerosis on intravascular ultrasound and cardiovascular outcome: Impact of kidney function (ATHEROREMO-IVUS study).
(2016)
Brankovic M, Akkerhuis KM, Buljubasic N, Cheng JM, Oemrawsingh RM, Garcia-Garcia HM, Regar E, Serruys PW, van Geuns RJ, Boersma E, Kardys I.
Atherosclerosis
Therapy Indications
Enhanced Molecular Aging in Late-Life Depression: the Senescent Associated Secretory Phenotype
(2016)
Diniz BS, Reynolds III CF, Sibille E, Lin C, Tseng G, Lotrich F, Aizenstein HJ, Butters MA
The American Journal of Geriatric Psychiatry
Therapy Indications
Pathogen and Host Response Dynamics in a Mouse Model of Borrelia hermsii Relapsing Fever
(2016)
Crowder CD, Langeroudi AG, Estabragh AS, Lewis ERG, Marcsisin RA, Barbour AG
Veterinary Sciences
Therapy Indications
Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.
(2016)
Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine Iii R, Martinez FJ, Bowler RP, ONeal WK; for COPDGene and SPIROMICS Investigators.
Am J Respir Crit Care Med.
Therapy Indications
A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
(2016)
Jimeno A, Posner MR, Wirth LJ, Saba NF, Cohen RB, Popa EC, Argiris A, Grossmann KF, Sukari A, Wilson D, Zhang X, Sun J, Glasser C, Attie KM, Sherman ML, Pandya SS, Weiss J.
Cancer
Therapy Indications
Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli.
(2016)
S?derlund S, Christiansson L, Persson I, Hjorth-Hansen H, Richter J, Simonsson B, Mustjoki S, Olsson-Str?mberg U, Loskog A.
Leuk Res
Therapy Indications
Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis.
(2016)
Amalakuhan B, Habib SA, Mangat M, Reyes LF, Rodriguez AH, Hinojosa CA, Soni NJ, Gilley RP, Bustamante CA, Anzueto A, Levine SM, Peters JI, Aliberti S, Sibila O, Chalmers JD, Torres A, Waterer GW, Martin-Loeches I, Bordon J, Blanquer J, Sanz F, Marcos PJ, Rello J, Ramirez J, Sol?-Viol?n J, Luna CM, Feldman C, Witzenrath M, Wunderink RG, Stolz D, Wiemken TL, Shindo Y, Dela Cruz CS, Orihuela CJ, Restrepo MI.
Cytokine
Therapy Indications
Do Single or Sequential Measurements of Leptin and Adiponectin in Plasma Have Prognostic Value in Pulmonary Arterial Hypertension?
(2016)
Tonelli AR, Fares WH, Dakkak W, Rao Y, Dweik RA
Pulmonary Circulation
Therapy Indications
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke
(2016)
Wong ET, Kogel U, Veljkovic E, Martin F, Xiang Y, Boue S, Vuillaume G, Leroy P, Guedj E, Rodrigo G, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P.
Regul Toxicol Pharmacol.
Therapy Indications
Primary Analysis Of A Phase II Open-Label Trial Of INCB039110, A Selective JAK1 Inhibitor, In Patients With Myelofibrosis
(2016)
Mascarenhas JO, Talpaz M, Gupta V, Foltz LM, Savona MR, Paquette R, Turner AR, Coughlin P, Winton E, Burn TC, ONeill P, Clark J, Hunter D10, Assad A, Hoffman R, Verstovsek S
Haematologica
Therapy Indications
Biological stress systems, adverse life events and the improvement of chronic multi-site musculoskeletal pain across a 6-year follow-up.
(2016)
Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, de Geus EJ, Dekker J, Penninx BW.
J Pain
Therapy Indications
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke
(2016)
Oviedo A, Lebrun S, Kogel U, Ho J, Tan WT, Titz B, Leroy P, Vuillaume G, Bera M, Martin F, Rodrigo G, Esposito M, Dempsey R, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P.
Regul Toxicol Pharmacol.
Therapy Indications
Insulin-like growth factor binding protein-2 interactions with Alzheimers disease biomarkers.
(2016)
Lane EM, Hohman TJ, Jefferson AL; Alzheimer?s Disease Neuroimaging Initiative.
Brain Imaging Behav
Therapy Indications
Selective p38a MAP kinase/MAPK14 inhibition in enzymatically-modified LDL-stimulated human monocytes: implications for atherosclerosis.
(2016)
Cheng F, Twardowski L, Fehr S, Aner C, Schaeffeler E, Joos T, Knorpp T, Dorweiler B, Laufer S, Schwab M, Torzewski M.
FASEB J
Therapy Indications
Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application.
(2016)
Vasquez MM, Hu C, Roe DJ, Chen Z, Halonen M, Guerra S
BMC Med Res Methodol
Therapy Indications
Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor
(2016)
Gill M, Horn K, Hennan J, White R, Bounous D, Clark S, Megill JR, Janovitz E, Davies M, Sanderson T, Graziano M.
Toxicol Sci
Therapy Indications
Social status alters immune regulation and response to infection in macaques
(2016)
Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J
Science
Therapy Indications
Exercise-induced cytokine changes in antigen stimulated whole-blood cultures compared to serum
(2016)
Pilat C, Kr?ger K, Frech T, Mooren FC
J Immunol Methods.
Therapy Indications
Oxidative stress in drug-na?ve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders
(2016)
Jordan W, Dobrowolny H, Bahn S, Bernstein HG, Brigadski T
Eur Arch Psychiatry Clin Neurosci
Therapy Indications
Serum protein mediators of dementia and aging proper
(2016)
Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF
Aging
Therapy Indications
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease
(2016)
Nakagawa N, Barron L, Gomez IG, Johnson BG, Roach AM, Kameoka S, Jack RM, Lupher ML, Gharib SA, Duffield JS
JCI Insight
Therapy Indications
Growth Differentiation Factor 15 as a Novel Biomarker for Metformin
(2016)
Gerstein HC, Pare G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee S, Haenel H, Steinberg GR; ORIGIN Investigators.
Diabetes Care
Therapy Indications
Mindfulness-Based Cognitive Therapy Associated with Decreases in C-Reactive Protein in Major Depressive Disorder: A Pilot Study
(2016)
Eisendrath SJ, Gillung E, Hartzler A, James-Myers M, Wolkowitz O, Sipe W, Ramanatham D, Delucchi K
J. Altern. Complement. Med.
Therapy Indications
Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study
(2016)
Inman RD, Baraliakos X, Hermann KA, Braun J, Deodhar A, Heijde D, Xu S, and Hsu B
Arthritis Res Ther.
Therapy Indications
Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study
(2016)
Brahimaj A, Ligthart S, Ikram MA, Hofman A, Franco OH, Sijbrands EJ, Kavousi M, Dehghan A
Diabetes Care
Therapy Indications
Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinsons disease
(2017)
Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W.
Eur J Neurol
Therapy Indications
Protein Biomarker Druggability Profiling
(2017)
Mani S, Cannon D, Ohls R, Oprea T, Mathias S, Ballard K, Ursu O, Bologa C
J Biomed Inform
Therapy Indications
Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CR-8 ISS space mission - The SPHEROIDS project.
(2017)
Pietsch J, Gass S2, Nebuloni S, Echegoyen D, Riwaldt S, Baake C, Bauer J, Corydon TJ, Egli M, Infanger M, Grimm D
Biomaterials
Therapy Indications
CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.
(2017)
Fardo DW, Katsumata Y, Kauwe JS, Deming Y, Harari O, Cruchaga C; Alzheimers Disease Neuroimaging Initiative, Nelson PT
Exp Gerontol
Therapy Indications
The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility.
(2017)
van den Broek TJ, Kremer BH, Marcondes Rezende M, Hoevenaars FP, Weber P, Hoeller U, van Ommen B, Wopereis S
Genes Nutr
Therapy Indications
Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients.
(2017)
Luchting B, Hinske LC, Rachinger-Adam B, Celi LA, Kreth S, Azad SC
Biomark Med
Therapy Indications
Effects of Traumeel (Tr14) on recovery and inflammatory immune response after repeated bouts of exercise: a double-blind RCT.
(2017)
Muders K, Pilat C, Deuster V, Frech T, Kr?ger K, Pons-Kuhnemann J, Mooren FC
Eur J Appl Physiol.
Therapy Indications
Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular
(2017)
Thimraj TA, Birru RL, Mitra A, Schulz H, Leikauf GD, Ganguly K
Lung
Therapy Indications
PH20 is not expressed in murine CNS and oligodendrocyte precursor cells
(2017)
Marella M, Ouyang J, Zombeck J, Zhao C, Huang L, Connor RJ, Phan KB, Jorge MC, Printz MA, Paladini RD, Gelb AB, Huang Z, Frost GI, Sugarman BJ, Steinman L, Wei G, Shepard HM, Maneval DC, Lapinskas PJ
Ann Clin Transl Neurol
Therapy Indications
Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study
(2017)
Brahimaj A, Ligthart S, Ghanbari M, Ikram MA, Hofman A, Franco OH, Kavousi M, Dehghan A
Eur. J. Epidemiol.
Therapy Indications
Few serum proteins mediate APOE?s association with dementia.
(2017)
Royall DR, Al-Rubaye S, Bishnoi R, Raymond PF
PLOS ONE
Therapy Indications
Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Ployunsaturated Fatty Acids in a Dose Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial.
(2017)
Lefort N, LeBlanc R, Surette M
Nutrients
Therapy Indications
Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.
(2017)
Steele NZ, Carr JS, Bonham LS, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS
PloS Med.
Therapy Indications
Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study.
(2017)
Stringa N, Brahimaj A, Zaciragic A, Dehghan A, Ikram MA, Hofman A, Muka T, Kiefte-de Jong JC, Franco OH
Metab.
Therapy Indications
Impact of Maternal antibodies and infant gut microbiota on the immunogenicity of rotacirus vaccines in African, Indian, and European infants: protocol for a prospective cohort study.
(2017)
Sindhu KN, Cunliffe N, Peak M, Turner M, Darby A, Grassly N, Gordon M, Dube Q, Babji S, Praharaj I, Verghese V, Iturriza-Gomara M, Kang G
BMJ
Therapy Indications
Immunodepression after CPB: Cytokine dynamics and clinics after pediatric cardiac surgery ? A prospective trial
(2017)
Justus G, Walker C, Rosenthal LM, Berger F, Miera O, Schmitt KR
Cytokine
Therapy Indications
Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Undergoing Diagnostic Coronary Angiography (From the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study)
(2017)
McCarthy CP, Van Kimmenade R, Gaggin HK, Simon ML, Ibrahim NE, Gandhi P, Kelly N, Motiwala SR, Belcher AM, Harisiades J, Magaret CA, Rhyne RF, Januzzi Jr. JL
Am J Cardiol
Therapy Indications
Serum proteins mediate depression?s association with dementia
(2017)
Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF
Plos One
Therapy Indications
Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy
(2017)
Gnjatic S, Bronte V, Brunet LR, Butler MO, Disis ML, Galon J, Hakansson LG, Hanks BA, Karanikas V, Khleif SN, Kirkwood JM, Miller LD, Schendel DJ, Tanneau I, Wigginton JM and Butterfield LH
J Immunother Cancer
Therapy Indications
The REAnimation Low Immune Status Markers (REALISM) project: a protocol for broad characterisation and follow-up of injury-induced immunosuppression in intensive care unit (ICU) critically ill patients
(2017)
Rol ML, Venet F, Rimmele T, Moucadel V, Cortez P, Quemeneur L, Gardiner D, Griffiths A, Pachot A, Textoris J, Monneret G, On behalf of the REALISM study group
BMJ Open
Therapy Indications
The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden. CETP mice
(2017)
Landlinger C, Pouwer MG, Juno C, van der Hoorn J, Pieterman EJ, Jukema JW, Staffler G, Princen H, and Galabova, G
Eur. Heart J.
Therapy Indications
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.
(2017)
Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T
Nature
Therapy Indications
Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder
(2017)
Singh S, Yazdani U, Gadad B, Zaman S, Hynan LS, Roatch N, Schutte C, Marti CN, Hewitson L and German DC
J. Neuroinflammation
Therapy Indications
Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension.
(2017)
Nishida K, Brune KA, Putcha N, Mandke P, ONeal WK, Shade D, Srivastava V, Wang M, Lam H, An SS, Drummond MB, Hansel NN, Robinson DN, Sidhaye VK.
Am J Physiol Lung Cell Mol Physiol
Therapy Indications
Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?
(2017)
Tonelli AR, Fares WH, Dakkak W, Rao Y, Zhou X, Dweik RA
Pulm Circ
Therapy Indications
Vitamin D-deficiency and sex-specific dysregulation of placental inflammation
(2017)
Liu NQ, Larner DP, Yao Q, Chun RF, Ouyang Y, Zhou R, Tamblyn JA, Wagner CL, Hewison M
J Steroid Biochem Mol Biol.
Therapy Indications
Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach
(2017)
Nassan M, Jia Y, Jenkins G, Colby C, Feeder S, Choi D, Veldic M, McElroy SL, Bond DJ, Weinshilboum R, Biernacka JM, Frye MA
J Psychiatr Res
Therapy Indications
Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimers disease spectrum.
(2017)
Swanson A, Willette AA; Alzheimer?s Disease Neuroimaging Initiative.
Brain Behav Immun.
Therapy Indications
Proteomics to predict the response to tumour necrosis factor-a inhibitors in rheumatoid arthritis using a supervised cluster-analysis based protein score
(2017)
Cuppen BVJ, Fritsch-Stork RDE, Eekhout, W de Jager I, Marijnissen AC, Bijlsma JWJ, Custers M, Van Laar JM, Lafeber FPJG, Welsing PMJ & on behalf of all Society for Rheumatology Research Utrecht (SRU) investigators
Scand J Rheumatol
Therapy Indications
Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension.
(2017)
Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W
Pulm Circ.
Therapy Indications
Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats.
(2017)
Manne NDPK, Arvapalli R, Graffeo VA, Bandarupalli VVK, Shokuhfar T, Patel S, Rice KM, Ginjupalli GK, Blough ER
Cell Physiol Biochem
Therapy Indications
Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks
(2017)
Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, Trivedi MH
J Affect Disord
Therapy Indications
Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood.
(2017)
Schuchardt JP, Ostermann AI, Stork L, Fritzsch S, Kohrs H, Greupner T, Hahn A, Schebb NH
Prostaglandins Leukot Essent Fatty Acids
Therapy Indications
A multivariate predictive modeling approach reveals a novel CSF peptide signature for both Alzheimer ?s Disease state classification and for predicting future disease progression
(2017)
Llano DA, Bundela S, Mudar RA, Devanarayan V
Plos One
Therapy Indications
A randomised, placebo-controlled trial of anti-interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease.
(2017)
Calverley PMA, Sethi S, Dawson M, Ward CK, Finch DK, Penney M, Newbold P, van der Merwe R
Respir Res.
Therapy Indications
Nintedanib macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis
(2017)
Huang J, Maier C, Zhang Y, Soare A, Dees C, Beyer C, Harre U, Chen CW, Distler O, Schett G, Wollin L, Distler JHW
Ann Rheum Dis.
Therapy Indications
Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine.
(2017)
Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, Kr?ger M, Hemmersbach R, Infanger M, L?tzenberg R, Grimm D
Cell Physiol Biochem.
Therapy Indications
IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD.
(2017)
Briend E, Ferguson GJ, Mori M, Damera G, Stephenson K, Karp NA, Sethi S, Ward CK, Sleeman MA, Erjef?lt JS, Finch DK
Respir Res.
Therapy Indications
Assessment of Proteomic Measures Across Serious Psychiatric Illness.
(2017)
Schulz SC, Overgaard S, Bond DJ, Kaldate R.
Clin Schizophr Relat Psychoses
Therapy Indications
Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.
(2017)
Phillips B, Titz B, Kogel U, Sharma D, Leroy P, Xiang Y, Vuillaume G, Lebrun S, Sciuscio D2, Ho J, Nury C2, Guedj E, Elamin A, Esposito M, Krishnan S, Schlage WK, Veljkovic E, Ivanov NV, Martin F, Peitsch MC, Hoeng J, Vanscheeuwijck P
Food Chem Toxicol.
Therapy Indications
In Vivo Toxicity Assessment of Occupational Components of the Carbon Nanotube Life Cycle To Provide Context to Potential Health Effects.
(2017)
Bishop L, Cena L, Orandle M, Yanamala N, Dahm MM, Birch ME, Evans DE, Kodali VK, Eye T1, Battelli L, Zeidler-Erdely PC, Casuccio G, Bunker K, Lupoi JS, Lersch TL, Stefaniak AB, Sager T, Afshari A, Schwegler-Berry D, Friend S, Kang J, Siegrist KJ, Mitchell CA, Lowry DT, Kashon ML, Mercer RR, Geraci CL, Schubauer-Berigan MK, Sargent LM, Erdely A.
ACS Nano.
Therapy Indications
Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study
(2017)
Duffy D, Rouilly V, Braudeau C, Corbi?re V, Djebali R, Ungeheuer MN, Josien R, LaBrie ST, Lantz O, Louis D, Martinez-Caceres E, Mascart F, Ruiz de Morales JG, Ottone C, Redjah L, Guen N, Savenay A, Schmolz M, Toubert A, Albert ML
Clin Immunol
Therapy Indications
Changes in IL-17A, macrophage-derived chemokine and adiponectin following treatment of psoriasis with calcipotriol plus betamethasone dipropionate aerosol foam: results from the PSO-ABLE study.
(2017)
R?pke M, Bulai Livideanu C, Kaldate R, Snel A, Paul C
Br J Dermatol.
Therapy Indications
Altered Immune Activation and IL-23 Signaling in Response to Candida albicans in Autoimmune Polyendocrine Syndrome Type 1
(2017)
Bruserud O, Bratland E, Hellesen A, Delaleu N, Reikvam H, Oftedal BE, and Wolff A
Front Immunol.
Therapy Indications
Inflammatory proteins in nasal lavage of workers exposed to occupational agents.
(2017)
Castano R, Yucesoy B, Johnson VJ, Castellanos L, Cartier A
Clin Exp Allergy
Therapy Indications
Intrathecal 2-hydroxypropyl-?-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial.
(2017)
Ory DS, Ottinger EA, Farhat NY, King KA, Jiang X, Weissfeld L, Berry-Kravis E, Davidson CD, Bianconi S, Keener LA, Rao R, Soldatos A, Sidhu R, Walters KA, Xu X, Thurm A, Solomon B, Pavan WJ, Machielse BN, Kao M, Silber SA, McKew JC, Brewer CC, Vite CH, Walkley SU, Austin CP, Porter FD
Lancet
Therapy Indications
Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons.
(2017)
Parviainen L, Dihanich S, Anderson GW, Wong AM, Brooks HR, Abeti R, Rezaie P, Lalli G, Pope S, Heales SJ, Mitchison HM, Williams BP, Cooper JD
Acta Neuropathol Commun.
Therapy Indications
Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer.
(2017)
Yeh CY, Adusumilli R, Kullolli M, Mallick P, John EM, Pitteri SJ
Biomark Res.
Therapy Indications
Perspectives on using a multiplex human kidney safety biomarker panel to detect cisplatin-induced tubular toxicity in male and female Cynomolgus monkeys.
(2017)
Chen Y, Dale Thurman J, Kinter LB, Bialecki R, Eric McDuffie J
Toxicol Appl Pharmacol.
Therapy Indications
Biomarker-guided stratification of autoimmune patients for biologic therapy.
(2017)
Ivison S, Des Rosiers C, Lesage S, Rioux JD, Levings MK.
Curr Opin Immunol.
Therapy Indications
Exercise training reverses inflammation and muscle wasting after tobacco smoke exposure.
(2017)
Kr?ger K, Seimetz M, Ringseis R, Wilhelm J, Pichl A, Couturier A, Eder K, Weissmann N, Mooren FC
Am J Physiol Regul Integr Comp Physiol.
Therapy Indications
Randomized clinical study of safety, pharmacokinetics, andpharmacodynamics of RIPK1 inhibitor GSK2982772 in healthyvolunteers
(2017)
Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JE, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang M
Pharmacol Res Perspect.
Therapy Indications
Differential expression of P2X7 receptor and IL-1? in nociceptive and neuropathic pain.
(2016)
Luchting B, Heyn J, Woehrle T, Rachinger-Adam B, Kreth S, Hinske LC, Azad SC
J Neuroinflammation
Therapy Indications
Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats.
(2017)
Chen G, Xu Y
Mater Sci Eng C Mater Biol Appl.
Therapy Indications
The role of anxious distress in immune dysregulation in patients with major depressive disorder.
(2017)
Gaspersz R, Lamers F, Wittenberg G, Beekman ATF, van Hemert AM, Schoevers RA, Penninx BWJH
Transl Psychiatry
Therapy Indications
Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers.
(2017)
Sgambato JA, Jones BA, Caraway JW, Prasad GL
Cytokine
Therapy Indications
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment.
(2017)
Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI
J Immunother Cancer
Therapy Indications
The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia.
(2017)
Quiros-Roldan E, Castelli F, Lanza P, Pezzoli C, Vezzoli M; Inflammation in HIV Study Group, Biasiotto G, Zanella I
J Transl Med.
Therapy Indications
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
(2017)
Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L, Milieu Int?rieur Consortium
Proc Natl Acad Sci U S A
Therapy Indications
Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study
(2018)
Wolters F, Boender J, de Vries P, Sonneveld M, Koudstaal P, de Maat M, Franco O, Ikram M, Leebeek F, Ikram MA
Scientific Reports 2018 Apr
Therapy Indications
A Multi-site In-depth Evaluation of the Qunaterix Simoa from a Users Perspective
(2018)
Chunyk A, Joyce A, Fischer S, Dysinger M, Mikulskis A, Jeromin A, Lawrence-Henderson R, Baker D, Yeung D
The AAPS Journal 2018
Therapy Indications
Comparison of a microsphere-based platform with a multiplex flow cytometric assay for determination of circulating cytokines in the mouse
(2018)
Stricker-Krongrad A, Shoemake C, Zhong M, Liu J, Bouchard G
BMC Clinical Pathology Jan 2018
Therapy Indications
A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle
(2018)
Stein MM, Thempson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Morin A, Washinton C, Nicolae D, Bonnelykke K, Ober C
J Allergy Clin Immunol 2018
Therapy Indications
Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease
(2018)
Gu JM, Yuam S, Sim D, Abe K, Liu P, Rosenbruch M, Bringmann P, Kauser K
Experimental Hematology 2018
Therapy Indications
Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury
(2018)
Proudfood A, Bayliffe A, OKane C, Wright T, Serone A, Bareille P, Brown V, Hamid U, Chen Y, Wilson R, Cordy J, Morley P, de Wildt Ruud, Elborn S, Hind M, Chilvres E, Griffiths M, Summers C, McAuley D
Thorax
Therapy Indications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment
(2018)
van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A
PLoS One
Therapy Indications
Allostatic load is associated with psychotic symptoms and decreases withantipsychotic treatment in patients with schizophrenia and ?rst-episodepsychosis
(2018)
Berger M, Juster RP, Westphal S, Amminger P, Bogerts B, Schiltz K, Bahn S, Steiner J, Sarnyai Z
Psychoneuroendocrinology
Therapy Indications
Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in
(2018)
Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, OConnell A, Chan G, Cortes JE
Clinical Cancer Research
Therapy Indications
Embelin and its derivatives unravel the signaling, proin?ammatoryand antiatherogenic properties of GPR84 receptor
(2018)
Gaidarov I, Anthony T, Gatlin J, Chen X, Mills D, Solomon M, Han S, Semple G, Unett DJ
Pharmacological Research
Therapy Indications
Therapy Indications
Effects of canagliflozin versus glimepiride on adipokines and in inflammatory biomarkers in type 2 diabetes
(2018)
Garvey WT, Van Gaal L, Leiter LA, Vijapurkar U, List J, Cuddihy R, Ren J, Davies M
Metabolism Clinical and Experimenta
Therapy Indications
The Orally Available Selective Axl Inhibitor BGB324 Induces Diversification of the Immune Repertoire and Specific Changes in Plasma Biomarker Profiles
(2017)
Loges S, Gjertsen BT, Heuser M, Chromik J, Ben-Batalla I, Akyuz N, Micklem D, Brown A, Lorens J, Yule M, Kebenko M, Janning M, Binder M, Fiedler W, Cortes J
Blood
Therapy Indications
S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome
(2018)
Wang L, Rose CD, Foley KP, Anton J, Bader-Meunier B, Brissaud P, Chedeville G, Cimaz R, Fernandez-Martin J, Guly C, Hachulla E, Harjacek M, Mackensen F, Merino R, Modesto C, Hernandez A, Pajot C, Ramanan A, Thatayatikom A, Thomee C, Vastert S, Votta B, Bertin J, Wouters CH
Rheumatology
Therapy Indications
An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study
(2017)
Maher TM, Oballa E, Simpson JK, Porte J, Habgood A, Fahy WA, Flynn A, Monlyneaux PL, Braybrooke R, Divyateja H, Parfrey H, Rassl D, Russell AM, Saini G, Renzoni EA, Duggan AM, Hubbard R, Wells AU, Lukey PT, Marshall RP, Jenkins RG
Lancet Respir Med
Therapy Indications
Toxoplasma gondii inactivates human plasmacytoid dendritic cells by functional mimicry of IL-10
(2018)
Piotr L, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P
The Journal of Immunology
Therapy Indications
Pharmacokinetics of Telavancin at Fixed Doses in Normal-Body-Weight and Obese (Classes I, II and III) Adult Subjexts
(2018)
Bunnell KL, Pai MP, Sikka M, Bleasdale S, Wenzler E, Danziger LH, Rodvold KA
Antimicrobial Agents and Chemotherapy
Therapy Indications
Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS
(2018)
Putcha N, Paul GG, Azar A, Wise RA, ONeal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R 3rd, Han MK, Martinez FJ, Bowler RP, Barr RG, Hansel NN, SPIROMICS investigators
PLoS One
Therapy Indications
Carbon nanotube and nanofiber exposure and sputum and blood biomarkers of early effect among U.S. workers
(2018)
Beard JD, Erdely A, Dahm MM, de Perio MA, Birch ME, Evans DE, Fernback JE, Eye T, Kodali V, Mercer RR, Bertke SJ, Schubauer-Berigan MK
Environmental Internation 116 (2018)
Therapy Indications
CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype
(2018)
Candido J, Morton JP, Bailey P, Barry ST, Balkwill FR, Sansom OJ
Cell Reports
Therapy Indications
Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease
(2018)
Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E
Journal of Inherited Metabolic Disease
Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study
(2018)
Andersen M, Boesen M, Ellegaard K, Soderstrom K, Soe NH, Spee P, Morch UGW, Torp-Pedersen S, Bartels EM, Danneskiold-Samsoe B, Karlsson L, Bliddal H
Plos One
Therapy Indications
NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort
(2018)
Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine III R, Ortega VE, Peters SP, Krishnan JA, Bowler RP
Respiratory Medicine
Therapy Indications
IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses
(2018)
van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICP, de Jong HM, Fluri IA, Latuhihin TE, van Kuijk AWR, Rogge L, Yeremenko NG, Baeten DLP
Arthritis Rheumatol
Therapy Indications
A clinical and proteomics approach to predict the presense of obstructive peripheral arterial disease (From CASABLANCA)
(2018)
McCarthy CP, Ibrahim NE, van Kimmenade RRJ, Gaggin HK, Simon ML, Gandhi P, Kelly N, Motiwala SR, Mukai R, Magaret CA, Barnes G, Rhyne RF, Garasic JM, Januzzi JL Jr
Clin Cardiol
Therapy Indications
Networks of blood proteins in the neuroimmunology of schizophrenia
(2018)
Jeffries CD, Perkins DO, Fournier M, Do KQ, Cuenod M, Khadimallah I, Domenici E, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang M, Walker EF, Woods SW
Transl Psychiatry
Therapy Indications
Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis
(2018)
Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG
Journal of Allergy and Clinical Immunology
Therapy Indications
Cellular toxicity of silicon carbide nanomaterials as a function of morphology
(2018)
Chen F, Li G, Zhao ER, Li J, Hableel G, Lemaster JE, Bai Y, Sen GL, Jokerst JV
Biomaterials
Therapy Indications
Cereblon modulator iberdomide induces degradation of the transcription factor Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus
(2018)
Schafer PH, Ye Y, Wu L, Kosek J, Ringheim G, Yang Z, Liu L, Thomas M, Palmisano M, Chopra R
Ann Rheum Dis
Therapy Indications
IL-23 secreted by myeloid cells drives castration-resistant prostate cancer
(2018)
Calcinottoa A, Spataro C, Zagato E, Di Mitri D, Gil V, Crespo M, De Bernardis G, Losa M, Mirenda M, Pasquini E, Rinaldi A, Sumanasuriya S, Lambros MB, Neeb A, Luciano R, Bravi CA, Nava-Rodriques D, Dolling D, Prayer-Galetti T, Ferreira A, Briganti A, Esposito A, Barry S, Yuan W, Sharp A, de Bono J, Alimonti A
Nature
Therapy Indications
Standardized Immunomonitoring: Separating the Signals from the Noise
(2018)
Duffy D
Trends in Biotechnology
Therapy Indications
Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome
(2018)
Lal C, Hardiman G, Kumbhare S, Strange C
Sleep and Breathing
Therapy Indications
Effects of an FcyRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies
(2018)
Stein MM, Hrusch CL, Sperling AI, Ober C
Genes and Immunity
Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease
(2018)
Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, Hess S, Pare G
Journal of the American College of Cardiology
Therapy Indications
Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project
(2018)
Vonaesch P, Randremanana R, Gody JC, Collard JM, Giles-Vernick T, Doria M, Vigan-Womas I, Rubbo PA, Etienne A, Andriatahirintsoa EJ, Kapel N, Brown E, Huus KE, Duffy D, Finlay BB, Hasan M, Hunald FA, Robinson A, Manirakiza A, Wegener-Parfrey L, Vray M, Sansonetti PJ
BMC Pediatrics
Therapy Indications
Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension
(2018)
Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A
Pulmonary Circulation
Therapy Indications
Testing a multivariate proteomic panel for TBI biomarker discovery: A track-TBI pilot study
(2018)
Huie JR, Diaz-Arrastia R, Yue JK, Sorani M, Puccio A, Okonkwo DO, Manley GT, Ferguson AR
Journal of Neurotrauma
Therapy Indications
Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrom
(2018)
Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A
American Journal of Respiratory and Critical Care Medicine
Therapy Indications
Circulating biomarkers from the phase I trial of sirolimus and autophagy inhibition for patients with lymphangioleiomyomatosis (SAIL).
(2018)
Lamattina AM, Taveira-Dasilva A, Goldberg HJ, Bagwe S, Cui Y, Rosas IO, Moss J, Henske EP, El-Chemaly S
Chest Journal
Therapy Indications
Altered regulation of the T-cell system in patients with CRPS
(2018)
Heyn J, Azad SC, Luchting B
Inflammation Research
Therapy Indications
A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis
(2018)
Palmer SM, Snyder L, Todd JL, Soule B, Christian R, Anstrom K, Luo Y, Gagnon R, Rosen G
Chest Journal
Therapy Indications
The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and -negative subjects. A post-hoc analysis of the ORIGIN-trial
(2018)
Birkeland KI, Grill V, Wium C, McQueen MJ, Lopez-Jaramillo P, Lee SF, Gerstein HC
Diabetes, Obesity and Metabolism
Therapy Indications
Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions
(2018)
Mozaffari SV, Stein MM, Magnaye KM, Nicolae DL, Ober C
PLoS One
Therapy Indications
Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy)
(2018)
Anroedh SS, Akkerhuis KM, Oemrawsingh RM, Garcia-Garcia HM, Brankovic M, Regar E, van Geuns RJ, Serruys PW, Daemen J, Van Mieghem NM, Boersma E, Kardys I
Current Atherosclerosis Reports
Therapy Indications
Adiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome
(2018)
Marino BCA, Buljubasic N, Akkerhuis M, Cheng JM, Garcia-Garcia HM, Regar E, van Guens RJ, Serruys PW, Boersma E, Kardys I
Sociedade Brasileira De Cardiologia
Therapy Indications
Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction
(2018)
Lindsey ML, Ma Y, Flynn ER, Winniford MD, Hall ME, DeLeon-Pennell KY
BBA - Molecular Basis of Disease
Therapy Indications
Dose escalation results from a first-in-human, phase I study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors
(2018)
Tran B, Carvajal RD, Marabelle A, Patel SP, LoRusso PM, Rasmussen E, Juan G, Upreti VV, Beers C, Ngarmchamnanrith G, Schoffski P
Journal for ImmunoTherapy of Cancer
Therapy Indications
Amygdalar activity predicts future incident diabetes independently of adiposity
(2019)
Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A
Psychoneuroendocrinology
Therapy Indications
Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants
(2018)
Timmers M, Ravenstijn P, Xi L, Triana-Baltzer G, Furey M, Van Hemelryck S, Biewenga J, Ceusters M, Bhattacharya A, van den Boer M, van Nueten L, de Boer P
Journal of Psychopharmacology
Therapy Indications
Peripheral immune system in aging and Alzheimers disease.
(2018)
Cao W, Zheng H
Molecular Neurodegeneartion
Therapy Indications
Serum kidney injury molecule 1 and B2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes
(2018)
Colombo M, Looker HC, Farran B, Hess S, Groop L, Palmer CNA, Brosnan MJ, Dalton RN, Wong M, Turner C, Ahlqvist E, Dunger D, Agakov F, Durrington P, Livingstone S, Betteridge J, McKeigue PM, Colhoun HM
Diabetologia
Therapy Indications
Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines
(2018)
Dandekar MP, Saxena A, Scaini G, Shin JH, Migut A, Giridharan VV, Zhou Y, Barichello T, Soares JC, Quevedo J, Fenoy AJ
Molecular Neurobiology
Therapy Indications
Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103)
(2018)
Lindemann K, Beale PJ, Rossi E, Goh JC, Vaughan MM, Tenney ME, Martyn JK, Sommeijer D, Iglesias JL, Kremmidiotis G, Simpson J, Doolin E, Lavranos TC, Veillard AS, Espinoza D, Stockler MR, Rischin D
Cancer Chemotherapy and Pharmacology
Therapy Indications
Multiple biomarker panel to screen for severe aortic stenosis: results from the CASABLANCA study
(2018)
Elmariah S, McCarthy C, Ibrahim N, Furman D, Mukai R, Magaret C, Rhyne R, Barnes G, van Kimmenade RRJ, Januzzi Jr JL
Open Heart
Therapy Indications
Phase I/II trial of combination of anti-CD3/CD7 immunotoxins for steroid-refractory acute graft-versus-host disease
(2018)
Groth C, van Groningen LFJ, Matos TR, Bremmers ME, Preijers FWMB, Dolstra H, Reicherts C, Schaap NPM, van Hooren EHG, IntHout J, Masereeuw R, Netea MG, Levine JE, Morales G, Ferrara JL, Blijlevens NMA, van Oosterhout YVJM, Stelljes M, van der Velden WJFM
Biology of Blood and Marrow Transplantation
Therapy Indications
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients
(2018)
Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Autio KA, Wong DJ, Patel MR, Ott PA, Falchook GS, Pant S, Hung A, Pekarek KL, Wu V, Adamow M, McCauley S, Mumm JB, Wong P, Van Vlasselaer P, Levegue J, Tannir NM, Oft M
Cancer Cell
Therapy Indications
Elevated circulating MMP-9 is linked to increased COPD exacerbation in SPIROMICS and COPDGene
(2018)
Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, ONeal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A
JCI Insight
Therapy Indications
Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE
(2018)
Casey KA, Guo X, Smith MA, Wang S, Sinibaldi D, Sanjuan MA, Wang L, Illei GG, White WI
Lupus Science and Medicine
Therapy Indications
Association of baseline inflammatory markers and the development of negative symptoms in individuals at clinical high risk for psychosis
(2018)
Goldsmith DR, Haroon E, Miller AH, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Mathalon D, McGlashan T, Seidman L, Tsunag M, Woods SW, Walker EF, Perkins DO
Brain, Behavior, and Immunity
Therapy Indications
Pegbelfermin (BMS-986036), PEGlyated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study
(2018)
Charles ED, Neuschwander-Tetri BA, Pablo Frias J, Kundu S, Luo Y, Tirucherai GS, Christrian R
Obesity (Silver Spring)
Therapy Indications
Serum IP-10 levels and increased DPPIV activity are linked to circulating CXCR3+ T cells in cholestatic HCV patients
(2018)
Rau M, Schmitt J, Berg T, Kremer AE, Stieger B, Spanaus K, Bengsch B, Romero MR, Marin JJ, Keitel V, Klinker H, Tony HP, Mullhaupt B, Geier A
PLoS One
Therapy Indications
Idiopathic Pulmonary Fibrosis: Prospective, Case-Controlled Study of Natural History and Circulating Biomarkers
(2018)
Raghu G, Richeldi L, Jagerschmidt A, Martin V, Subramaniam A, Ozoux ML, Esperet CA, Soubrane C
Chest
Therapy Indications
Dominace rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons
(2018)
Lea AJ, Akinyi MY, Nyakundi R, Mareri P, Kariuki T, Alberts SC, Archie EA, Tung J
PNAS
Therapy Indications
Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort
(2018)
Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT, SPIROMICS investigators
Respiratory Research
Therapy Indications
Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial
(2018)
Wang A, Arver S, Boman K, Gerstein HC, Fu Lee S, Hess S, Ryden L, Mellbin LG
Preventive Cardiology
Therapy Indications
RNA-antimicrobial peptide complexes fuel a TLR- and NETosis-mediated inflammatory cycle of neutrophil activation in psoriasis
(2018)
Herster F, Bittner Z, Dickhoefer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Loeffler MW, Hartl D, Freund L, Schaekel K, Heiser M, Ghoreschi K, Weber ANR
bioRxiv
Therapy Indications
Serum Apolipoprotein E and Other Inflammatory Markers Can Identify Non-Responding Patients to a Dendritic Cell Vaccine
(2018)
Leeman H, Kaminska E, Green D, Bodman-Smith M, Gravett A, Bodman-Smith K, Copier J, Coulton G, Fusi A, Dalgleish AG
Translational Oncology
Therapy Indications
Drug-induced Obstructive and Retrograde Nephropathy Associated with a2u-globulin in Male Rats
(2018)
Jacobsen B, Freichel C, Eichinger-Chapelon A, Brink A, Hoflack JC, Albassam M, Lenz B
Toxocologic Pathology
Therapy Indications
PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study
(2018)
Charnigo RJ, Beidler D, Rybin D, Pittman DD, Tan B, Howard J, Michelson AD, Frelinger AL II, Clark N
Clinical and Translational Science
Therapy Indications
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis
(2019)
Gautam A, Muhie S, Cakraborty N, Hoke A, Donohue D, Miller SA, Hammamieh R, Jett M
Metabolomics
Therapy Indications
Cortisol associated with hypometabolism across the Alzheimers disease
(2019)
Wirth M, Huijbers W, Lange C
bioRxiv
Therapy Indications
Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases
(2019)
Sridhar S, Liu H, Damera G, Newbold P
Respiratory Research
Therapy Indications
The Role of Clusterin in Amyloid-B-Associated Neurodegeneration
(2014)
Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM
JAMA Neurology
Therapy Indications
SOMAscan-based proteomic measurements of plasma brain natriuretic peptide are decreased in mild cognitive impairment and in Alzheimers dementia patients
(2019)
Begic E, Hadzidedic S, Kulaglic A, Ramic-Brkic B, Begic Z, Causevic M
PLoS One
Therapy Indications
VaccHemInf Project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients
(2019)
Conrad A, Boccard M, Valour F, Alcazer V, Tovar Sanchez AT, Chidiac C, Laurent F, Vanhems P, Salles G, Brengel-Pesce K, Meunier B, Trouillet-Assant S, Ader F, Lyyon HEMINF Study Group
BMJ Journals
Therapy Indications
Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques
(2019)
Sanz J, Maurizio PL, Snyder-Mackler N, Simons ND, Voyles T, Kohn J, Michopoulos V, Wilson M, Tung J, Barreiro LB
bioRxiv
Therapy Indications
Inflammatory parameters associated with systemic reactogenicity following vaccinatino with adjuvanted hepatitis B vaccines in humans
(2019)
Burny W, Marchant A, Herve C, Callegaro A, Caubet M, Fissette L, Gheyle L, Legrand C, Ndour C, Tavares Da Silva F, van der Most R, Willems F, Didierlaurent AM, Yarzabal J, ECR-008 study group
Vaccine
Therapy Indications
Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak
(2019)
Gramaglia I, Velez J, Chang YS, Caparros-Wanderley W, Combes V, Grau G, Stins MF, van der Heyde HC
PLoS One
Therapy Indications
Early changes in immune, coagulation, and organ function after clinical and experimental polytrauma
(2019)
Halbgbauer
Repositorium der Universit?t Ulm
Therapy Indications
TGFb receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer
(2019)
Melisi D, Garcia-Carbonero R, Macarulla T, Pezet D, Deplangue G, Fuchs M, Trojan J, Kozloff M, Simionato F, Cleverly A, Smith C, Wang S, Man M, Driscoll KE, Estrem ST, Lahn MMF, Benhadji KA, Tabernero J
Cancer Chemotherapy and Pharmacology
Therapy Indications
A blood-based signature of cerebrospinal fluid A?1-42 status
(2019)
Goudey B, Fung BJ, Schieber C, Faux NG, Alzheimers Disease Metabolomics Consortium, Alzheimers Disease Neuroimaging Initiative
Scientific Reports
Therapy Indications
Exploring and redefining Autoimmune polyendocrine syndrome type 1
(2019)
Bruserud
Skipnes Kommunikasjon, University of Bergen
Therapy Indications
A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity
(2019)
Williams PT, Bergeron N, Chiu S, Krauss RM
Lipids in Health and Disease
Therapy Indications
External Validation of a Pre-Transplant Biomarker Model (REVERSE) Predictive of Renal Recovery after Liver Transplantation
(2019)
Levitsky J, Asrani SK, Abecassis M, Ruiz R, Jennings LW, Klintmalm G
Hepatology
Therapy Indications
Biomarkers of Community-Acquired Pneumonia: A Key to Disease Diagnosis and Management
(2019)
Savvateeva EN, Rubina AY, Gryadunov DA
BioMed Research International
Therapy Indications
Maternal deprivation increases microglial activiation and neuroinflammatory markers in the prefrontal cortex and hippocampus of infant rats
(2019)
Giridharan VV, Gislaine ZR, Selvaraj S, Scaini G, Barichello T, Quevedo J
Journal of Psychiatric Research
Therapy Indications
Performance of a clinical/proteomic panel to predict obstructive peripheral artery disease in patients with and without diabetes
(2019)
McCarthy CP, Shrestha S, Ibrahim N, van Kimmenade RRJ, Gaggin HK, Mukai R, Magaret C, Barnes G, Rhyne R, Garasic JM, Januzzi JL
Open Heart
Therapy Indications
VEGF-A from Granuloma Macrophages Regulates Granulomatous Inflammation by a Non-angiogenic Pathway during Mycobacterial Infection
(2019)
Harding JS, Herbath M, Chen Y, Rayasam A, Ritter A, Csoka B, Hasko G, Michael IP, Faby Z, Nagy A, Sandor M
Cell Reports
Therapy Indications
Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation.
(2019)
Haraden CA, Huebner JL, Hsueh MF, Li YJ, Kraus VB
Arthritis Research & Therapy
Therapy Indications
Applying modern Omic technologies to the Neuronal Ceroid Lipofuscinoses.
(2019)
Kline RA, Wishart TM, Mills K, Heywood WE
BBA - Molecular Basis of Disease
Therapy Indications
Increased serum levels of leptin and insulin in both schizophrenia and major depressive disorder: A cross-disorder proteomics analysis
(2019)
Cakici N, Bot M, Lamers F, Janssen T, van der Haan L, Bahn S, Penninx BWJH, van Beveren NJM
European Neuropsychopharmacology
Therapy Indications
Biomarker panels associated with progression of renal disease in type 1 diabetes.
(2019)
Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM
Diabetologia
Therapy Indications
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome.
(2019)
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Pare G
Circulation
Therapy Indications
Identification of Novel Causal Blood Biomarkers Linking Metabolically Favorable Adiposity With Type 2 Diabetes Risk
(2019)
Pigeyre M, Sjaarda J, Mao S, Chong M, Hess S, Yusuf S, Gerstein H, Pare G
Diabetes Care
Therapy Indications
Immune function as predictor of infectious complications and clinical outcome in patients undergoing solid organ transplantation (the ImmuneMo:SOT study): a prospective non-interventional observational trial.
(2019)
Drabe CH, Sorensen SS, Rasmussen A, Perch M, Gustafsson F, Rezahosseini O, Lundgren JD, Osrowski SR, Nielson SD
BMC Infectious Diseases
Therapy Indications
Key inflammatory pathway activations in the MCI stage of Alzheimers disease
(2019)
Pillai JA, Maxwell S, Bena J, Bekris LM, Rao SM, Chance M, Lamb BT, Leverenz JB
Annals of Clinical and Translational Neurology
Therapy Indications
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
(2019)
Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO , Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC
The Journal of Clinical Investigation
Therapy Indications
Plasma cortisol is associated with cerebral hypometabolism across the Alzheimer?s disease spectrum
(2019)
Wirth M, Lange C, Huijbers W, for the Alzheimers Disease Neuroimaging Initiative
Neurobiology of Aging
Therapy Indications
Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology
(2019)
Meyer PF, Savard M, Poirier J, Morgan D, Breitner J, for the Alzheimers Disease Neuroimaging Initiative
Alzheimers & Dementia
Therapy Indications
T cell phenotypes are associated with serum IgE levels in Amish and Hutterite children
(2019)
Hrusch CL, Stein MM, Gozdz J, Holbreich M, Von Mutius E, Vercelli D, Ober C, Sperling AI
Journal of Allergy and Clinical Immunology
Therapy Indications
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.
(2019)
Fajgenbaum DC, Langan RA, Sada Japp A, Patridge HL, Pierson SK, Singh A, Arenas DJ, Ruth JR, Nabel CS, Stone K, Okumura M, Schwarer A, Jose FF, Hamerschlak N, Wertheim GB, Jordan MB, Cohen AD, Krymskaya V, Rubenstein A, Betts MR, Kambayashi T, van Rhee F, Uldrick TS
The Journal of Clinical Investigation
Therapy Indications
Impaired kidney structure and function in spinal muscular atrophy
(2019)
Nery FC, Siranosian JJ, Rosales I, Deguise MO, Sharma A, Muhtaseb AW, Nwe P, Johnstone AJ, Zhang R, Fatouraei M, Huemer N, Alves CRR, Kothary R, Swoboda KJ
Neurology Genetics
Therapy Indications
The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation.
(2019)
Leiter O, Bernas SN, Seidemann S, Overall RW, Horenburg C, Kowal S, Kempermann G, Walker TL
Scientific Reports
Therapy Indications
Morphological and Molecular Changes in Juvenile Normal Human Fibroblasts Exposed to Simulated Microgravity.
(2019)
Buken C, Sahana J, Corydon TJ, Melnik D, Bauer J, Wehland M, Kruger M, Balk S, Abuagela N, Infanger M, Grimm D
Scientific Reports
Therapy Indications
Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults.
(2019)
Diniz BS, Reynolds Iii CF, Sibille E, Bot M, Penninx BWJH
Translational Psychiatry
Therapy Indications
Type I Interferon Predicts an Alternate Immune System Phenotype in Systemic Lupus Erythematosus
(2019)
Thanarajasingam U, Muppirala AN, Jensen MA, Ghodke-Puranik Y, Dorschner JM, Vsetecka DM, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold TB
ACR Open Rheumatology
Therapy Indications
Innate Immune Cells and C-Reactive Protein in Acute First-Episode Psychosis and Schizophrenia: Relationship to Psychopathology and Treatment
(2019)
Steiner J, Frodl T, Schiltz K, Dobrowolny H, Jacobs R, Fernandes BS, Guest PC, Meyer-Lotz G, Borucki K, Bahn S, Bogerts B, Falkai P, Bernstein HG
Schizophrenia Bulletin
Therapy Indications
Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome.
(2019)
Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A
PLoS One
Therapy Indications
Therapy with 2O methly phosphorothioate antisense oligonucleotides causes reversible proteinuria by inhibiting renal protien reabsorption
(2019)
Janssen MJ, Nieskens TTG, Steevels TAM, Caetano-Pinto P, den Braanker D, Mulder M, Ponstein Y, Jones S, Masereeuw R, den Besten C, Wilmber MJ
Molecular Therapy Nucleic Acids
Therapy Indications
Apremilast Mechanism of Efficacy in Systemic-Naive Patients With Moderate Plaque Psoriasis: Pharmacodynamic Results From the UNVEIL Study
(2019)
Strober B, Alikhan A, Lockshin B, Shi R, Cirulli J, Schafer P
Journal of Dermatological Science
Therapy Indications
Discovery and validation of a biomarker model (preserve) predictive of renal outcomes after liver transplantation
(2019)
Levitsky J, Asrani SK, Klintmalm G, Schiano T, Moss A, Chavin K, Miller C, Guo K, Zhao L, Jennings LW, Brown M, Armstrong B, Abecassis M
Hepatology
Therapy Indications
Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.
(2019)
Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Alberson T, Bartz RR, Brakenridge SC, Delano MJ, Park PK, Donnino MW, Tidswell M, Mayr FB, Angus DC, Coopersmith CM, Moldawer LL, Catlett IM, Girgis IG, Ye J, Grasela DM
Intensive Care Med
Therapy Indications
SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus
(2019)
Smith MA, Henault J, Karnell JL, Parker ML, Riggs JM, Sinibaldi D, Taylor DK, Ettinger R, Grant EP, Sanjuan MA, Kolbeck R, Petri MA, Casey KA
Scientific Reports
Therapy Indications
Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation
(2019)
Bornstein SR, Voit-Bak K, Rosenthal P, Tselmin S, Julius U, Schatz U, Boehm BO, Thuret S, Kempermann G, Reichmann H, Chrousos GP, Licinio J, Wong ML, Schally AV, Straube R
Molecular Psychiatry
Therapy Indications
Functional immune monitoring in severely injured patients - a pilot study.
(2019)
Halbgebauer R, Kllermann S, Schafer F, Weckbach S, Weiss M, Barth E, Bracht H, Kalbitz M, Gebhard F, Huber-Lang MS, Perl M
Scandinavian Journal of Immunology
Therapy Indications
Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects
(2019)
Medvedeva IV, Stokes ME, Eisinger D, LaBrie ST, Ai J, Trotter MWB, Schafer P, Yang R
Scientific Reports
Therapy Indications
A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough.
(2019)
Ahmad R, Xie L, Pyle M, Suarez MF, Broger T, Steinberg D, Ame SM, Lucero MG, Szucs MJ, MacMullan M, Berven FS, Dutta A, Sanvictores DM, Tallo VL, Bencher R, Eisinger DP, Dhingra U, Deb S, Ali SM, Mehta S, Fawzi WW, Riley ID, Sazawal S, Premji Z, Black R, Murray CJL, Rodriguez B, Carr SA, Walt DR, Gillette MA
Science Translational Medicine
Therapy Indications
Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab.
(2019)
Molinero L, Li Y, Chang CW, Maund S, Berg M, Harrison J, Fasso M, OHear C, Hedge P, Emens LA
Journal for ImmunoTherapy of Cancer
Therapy Indications
Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors
(2019)
Piha-Paul SA, Hann CL, French CA, Cousin S, Brana I, Cassier PA, Moreno V, de Bono JS, Duckworth Harward S, Ferron-Brady G, Barbash O, Wyce A, Wu Y, Horner T, Annan M, Parr NJ, Prinjha RK, Carpenter CL, Hilton J, Hong DS, Hass NB, Markowski MC, Dhar A, ODwyer PJ, Shapiro GI
JNCI Cancer Spectrum
Therapy Indications
Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study.
(2019)
Schafer PH, Kivitz AJ, Ma J, Korish S, Sutherland D, Li L, Azaryan A, Kosek J, Adams M, Capone L, Hur EM, Hough DR, Ringheim GE
Rheumatology and Therapy
Therapy Indications
Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats.
(2019)
Komninou D, Malloy VL, Zimmerman JA, Sinha R, Richie JP Jr
GeroScience
Therapy Indications
A Machine-Learning Approach to Identify a Prognostic Cytokine Signature That Is Associated With Nivolumab Clearance in Patients With Advanced Melanoma.
(2019)
Wang R, Shao X, Zheng J, Saci A, Qian X, Pak I, Roy A, Bello A, Rizzo JI, Hosein F, Moss RA, Wind-Rotolo M, Feng Y
Clinical Pharmacology and Therapeutics
Therapy Indications
A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer.
(2019)
Rammensee HG, Wiesmuller KH, Chandran PA, Zelba H, Rusch E, Gouttefangeas C, Kowalewski DJ, Di Marco M, Haen SP, Walz JS, Gloria YC, Bodder J, Schertel JM, Tunger A, Muller L, Kiebler M, Wehner R, Schmitz M, Jakobi M, Schneiderhan-Marra N, Klein R, Laske K, Artzner K, Backert L, Schuster H, Schwenck J, Weber ANR, Pichler BJ, Kneilling M, la Fougere C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanovic S, Loffler MW
Journal for ImmunoTherapy of Cancer
Therapy Indications
Novel Biomarkers for Change in Renal Function in People With Dysglycemia.
(2019)
Gerstein HC, Pare G, McQueen MJ, Lee SF, Bangdiwala SI, Kannt A, Hess A, ORIGIN Trial Investigators
Diabetes Care
Therapy Indications
Neuroinflammation trajectories precede cognitive impairment after experimental meningitis-evidence from an in vivo PET study.
(2020)
Giridharan VV, Collodel A, Generoso JS, Scaini G, Wassather R, Selvaraj S, Hasbun R, Dal-Pizzol F, Petronilho F, Barichello T
Journal of Neuroinflammation
Therapy Indications
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.
(2020)
Herster F, Bittner Z, Archer NK, Dickhofer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Loffler MW, Kalbacher H, Vierbuchen T, Heine H, Miller LS, Hartl D, Freund L, Schakel K, Heister M, Ghoreschi K, Weber ANR
Nature Communications
Therapy Indications
Blood-based protein mediators of senility with replications across biofluids
(2019)
Royall DR, Palmer RF, The Alzheimers Disease Neuroimaging Initiative
Brain Communications
Therapy Indications
Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma.
(2019)
Wang R, Zheng J, Shao X, Ishii Y, Roy A, Bello A, Lee R, Zhang J, Wind-Rotolo M, Feny Y
Journal for ImmunoTherapy of Cancer
Therapy Indications
Serum Alpha-1 Antitrypsin Levels and the Clinical Course of Chronic Obstructive Pulmonary Disease
(2019)
Takei N, Suzuki M, Makita H, Konno S, Shimizu K, Kumura H, Kumura H, Nishimura M
International Journal of Chronic Obstructive Pulmonary Disease
Therapy Indications
Vaccine Protection against Multidrug-Resistant Klebsiella pneumoniae in a Nonhuman Primate Model of Severe Lower Respiratory Tract Infection
(2019)
Malachowa N, Kobayashi SD, Porter AR, Freedman B, Hanley PW, Lovaglio J, Saturday GA, Gardner DJ, Scott DP, Griffin A, Cordova K, Long D, Rosenke R, Sturdevant DE, Bruno D, Martens C, Kreiswirth BN, DeLeo FR
mBio
Therapy Indications
Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant
(2019)
Herlin T, Jorgensen SE, Host C, Mitchell PS, Christensen MH, Lausten M, Larsen DA, Schmidt FI, Christiansen M, Mogensen TH
Rheumatology
Therapy Indications
Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimers disease
(2019)
Wu W, Su BJ, Shen XN, Bi YL, Tan CC, Li JQ, Dong Q, Tan L, Alzheimers Disease Neuroimaging Initiative, Yu JT
Cognitive Neuroscience
Therapy Indications
Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes.
(2020)
Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM, Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators
Diabetologia
Therapy Indications
Nasal Microbiota Modifies the Effects of Particulate Air Pollution on Plasma Extracellular Vesicles.
(2020)
Mariana J, Favero C, Carungno M, Pergoli L, Ferrari L, Bonzini M, Cattaneo A, Pesatori AC, Bollati V
International Journal of Environmental Research and Public Health
Therapy Indications
Dynamic Aspects of Associations in Coronary Artery Disease: From Intracoronary Imaging to Blood Biomarkers
(2020)
Buljubasic, N.
Erasmus University Rotterdam
Therapy Indications
Cerebrospinal fluid ceruloplasmin levels predict cognitive decline and brain atrophy in people with underlying ?-amyloid pathology
(2020)
Diouf I, Bush AI, Ayton S
Neurobiology of Disease
Therapy Indications
Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma.
(2020)
Wick A, Desjardins A, Suarez C, Forsyth P, Gueorguieva I, Burkholder T, Cleverly AL, Estrem ST, Wang S, Lahn MM, Guba SC, Capper D, Rodon J
Investigational New Drugs
Therapy Indications
Degree of Genetic Liability for Alzheimer?s Disease Associated with Specific Proteomic Profiles in Cerebrospinal Fluid
(2020)
Reus LM, Stringer S, Posthuma D, Teunissen CE, Scheltens P, Pijnenburg YAL, Visser PJ, Tijms BM, for the Alzheimers Disease Neuroimaging
Neurology of Aging
Therapy Indications
Association of occupational exposures with ex vivo functional immune response in workers handling carbon nanotubes and nanofibers
(2020)
Schubauer-Berigan MK, Dahm MM, Toennis CA, Sammons DL, Eye T, Kodali V, Zeidler-Erdely PC, Erdely A
Nanotoxicology
Therapy Indications
ACE and Type 2 Diabetes Risk: A Mendelian Randomization Study.
(2020)
Pigeyre M, Sjaarda J, Chong M, Hess S, Bosch J, Yusuf S, Gerstein H, Pare G
Diabetes Care
Therapy Indications
Application of the TruCulture? whole blood stimulation system for immune response profiling in cattle
(2020)
OBrien MB, McLoughlin RM, Meade KG
Veterinary Immunology and Immunopathology
Therapy Indications
Influence of Genetic Ancestry on Human Serum Proteome
(2020)
Sjaarda J, Gerstein HC, Kutalik Z, Mohammadi-Shemirani P, Pigeyre M, Hess S, Pare G
The American Journal of Human Genetics
Therapy Indications
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia
(2020)
Narayanan P, Curtis BR, Shen L, Schneider E, Tami JA, Paz S, Burel SA, Tai LJ, Machemer T, Kwoh TJ, Xia S, Shattil SJ, Witztum JL, Engelhardt JA, Henry SP, Monia BP, Hughes SG
Nucleic Acid Therapeutics
Therapy Indications
Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma
(2020)
Timmerman J, Herbaux C, Ribrag V, Zelenetz AD, Houot R, Neelapu SS, Logan T, Lossos IS, Urba W, Salles G, Ramchandren R, Jacobson C, Godwin J, Carpio C, Lathers D, Liu Y, Neely J, Suryawanshi S, Koguchi Y, Levy R
American Journal of Hematology
Therapy Indications
Molecular Epidemiology of Inflammation Link with Type 2 Diabetes and Coronary Heart Disease
(2020)
Ligthart S
Erasmus University Rotterdam
Therapy Indications
Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-?RI inhibitor galunisertib.
(2020)
Giannelli G, Santoro A, Kelley RK, Gane E, Paradis V, Cleverly A, Smith C, Estrem ST, Man M, Wang S, Lahn MM, Raymond E, Benhadji KA, Faivre S
PLoS One
Therapy Indications
Measurement of a Surrogate Biomarker for Arginine Vasopressin Secretion in Association with Physiometric and Molecular Biomarkers of Aging.
(2020)
Guest PC, Bernstein HB, Dobrowolny H, Borucki K, Westphal S, Steiner J
Methods in Molecular Biology
Therapy Indications
Quantitative Assays of Plasma Apolipoproteins.
(2020)
Poljak A, Duncan MW, Jayasena T, Sachdev PS
Methods of Molecular Biology
Therapy Indications
Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.
(2020)
Recourt K, van der Aart J, Jacobs G, de Kam M, Drevets W, van Nueten L, Kanhal K, Siebenga P, Zuiker R, Ravenstijn P, Timmers M, van Gerven J, de Boer P
Journal of Psychopharmacology
Therapy Indications
Fenebrutinib versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial (ANDES Study).
(2020)
Cohen S, Tuckwell K, Katsumoto TR, Zhao R, Galanter J, Lee C,, Rae J, Toth B, Ramamoorthi N, Hackney JA, Berman A, Damjanov N, Fedkov D, Jeka S, Chinn W, Townsend MJ, Morimoto AM, Genovese MC
Arthritis& Rheumatology
Therapy Indications
Proteomics as a reliable approach for discovery of blood-based Alzheimers disease biomarkers: a systematic review and meta-analysis.
(2020)
Rehiman SH, Lim SM, Neoh CF, Majeed ABA, Chin AV, Tan MP, Kamaruzzaman SB, Ramasamy K
Ageing Reserch Reviews
Therapy Indications
High cytomegalovirus serology and subsequent COPD-related mortality: a longitudinal study
(2020)
Nenna R, Zhai J, Packard SE, Spangenberg A, Sherrill DL, Martinez FD, Halonen M, Guerra S
ERJ Open Research
Therapy Indications
Systematic investigation of polyurethane biomaterial surface roughness on human immune responses in vitro
(2020)
Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H
BioMed Research International
Therapy Indications
Elevated serum interlukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors
(2020)
Schalper KA, Carleton M, Zhou M, Chen T, Feng Y, Huang SP, Walsh AM, Baxi V, Pandya D, Baradet T, Locke D, Wu Q, Reilly TP, Phillips P, Nagineni V, Gianino N, Gu J, Zhao H, Perez-Gracia JL, Snmamed MF, Melero I
Nature Medicine
Therapy Indications
APOE e4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer?s disease
(2020)
Konijnenberg E, Tijms BM, Gobom J, Dobricic V, Bos I, Vos S, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleo A, Frolich L, Lovestone S, Streffer J, Bertram L, Blennow K, Teunissen CE, Veerhuis R, Smit AB, Scheltens P, Zetterberg H, Visser PJ
Alzheimers Research & Therapy
Therapy Indications
A comprehensive systematic review of CSF proteins and peptides that define Alzheimer?s disease
(2020)
Pedrero-Prieto CM, Garcia-Carpintero S, Frontinan-Rubio J,Llanos-Gonzalez E, Aguilera Garcia C, Alcain FJ, Lindberg I, Duran-Prado M, Peinado J, Rabanal-Ruiz Y
Clinical Proteomics
Therapy Indications
Innate Immune Stimulation of Whole Blood Reveals IFN-1 Hyper-Responsiveness in Type 1 Diabetes
(2020)
Rodrigues KB, Dufort MJ, Llibre A, Speake C, Jubayer Rahman M, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbell KV
Diabetologia
Therapy Indications
Serum biomarkers that predict lean mass loss over bed rest in older adults: An exploratory study
(2020)
Gawel SH, Davis GJ, Luo M, Deutz NEP, Wolfe RR, Pereira SL
Clinica Chimica Acta
Therapy Indications
Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation
(2020)
Jorgensen SE, Christiansen M, Host C, Glerup M, Mahler B, Lausten MM, Gad HH, Hartmann R, Herlin T, Mogensen TH
Rheumatology
Therapy Indications
Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotaxemia versus ex vivo stimulation
(2020)
Tawfik DM, Lankelma JM, Vachot L, Cerrato E, Pachot A, Wiersinga WJ, Textoris J
Scientific Reports
Therapy Indications
Inhibition of cytokine signaling by ruxolitinib and implactions for COVID-19 treatment
(2020)
Yeleswaram S, Smith P, Burn T, Covington M, Juvekar A, Li Y, Squier P, Langmuir P
Clinical Immunology
Therapy Indications
Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition
(2020)
Laino AS, Woods D, Vassallo M, Qian X, Tang H, Wind-Rotolo M, Weber J
Journal for ImmunoTherapy of Cancer
Therapy Indications
Proteomic profiling as a diagnotic biomarker for discriminating between bipolar and unipolar depression
(2020)
Kittel-Schneider S, Hahn T, Haenisch F,McNeill R, Reif A, Bahn S
Frontiers in Psychiatry
Therapy Indications
Elevated plasma cortisol associated with larger ventricles and smaller hippocampal volumes - a study in 2 independent elderly cohorts
(2020)
Rajagopalan P, Nho K, Risacher SL, Jahanshad N, Boyle CP, Saykin AJ, Thompson PM
bioRxiv
Therapy Indications
The effects of rare SERPINA1 variants on lung function and emphysema in SPIROMICS
(2020)
Ortega VE, Li X, ONeal WK, Lackey L, Ampleford E, Hawkins GA, Grayeski P, Laederach A, Barjaktarevic I, Barr RG, Cooper C, Douper D, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Paine R III, Peters SP, Pirozzi C, Rennard SI, Woodruff PG, Hoffman EA, Meyers DA, Bleecker ER
American Journal of Respiratory and Critical Care Medicine
Therapy Indications
Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties
(2020)
Barrera LN, Evans A, Lane B, Brumskill S, Oldfield FE, Campbell F, Andrews T, Lu Z, Perez-Mancera PA, Liloglou T, Ashworth M, Jalali M, Dawson R, Nunes Q, Phillips PA, Timms JF, Halloran C, Greenhalf W, Neoptolemos JP, Costello E
Cancer Research
Therapy Indications
Predicting and elucidating the etiology of fatty liver disease: a machine learning modeling and validation study in the IMI DIRECT cohorts
(2020)
Atabaki-Pasdar N, Ohlsson M, Vinuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chaanova E, Dale M, De Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong MG, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Haussler RS, Sharma S, Thomsen HS, Vangipurapu J, Vestergaard H, t Hart LM, Adamski J, Musholt P, Brage S, Brunak S, Dermitzakis E, Frost G, Hansen T, Laakso M, pedersen O, Ridderstrale M, Ruetten H, Hattersley AT, Walker M, Beulens JWJ, Mari A, Schwenk JM, Gupta R, McCarthy MI, Pearson ER, Bell JD, Pavo I, Franks PW
PLoS Medicine
Therapy Indications
A phase I study of ASTX660, an antagonist of inhibitors of apoptosis proteins, in adults with advanced cancers or lymphoma
(2020)
Mita MM, LoRusso PM, Papadopoulos KP, Gordon MS, Mita AC, Ferraldeschi R, Keer H, Oganesian A, Su XY, Jueliger S, Tolcher AW
Clinical Cancer Research
Therapy Indications
Towards standardization of immune functional assays
(2020)
Mouton W, Albert-Vega C, Boccard M, Bartolo F, Oriol G, Lopez J, Pachot A, Textoris J, Mallet F, Brengel-Pesce K, Trouillet-Assant S
Clinical Immunology
Therapy Indications
Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium bacillus calmette guerin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy
(2020)
Rentsch CA, Bosshard P, Mayor G, Rieken M, Puschel H, Wirth G, Cathomas R, Parzmair GP, Grode L, Eisele B, Sharma H, Gupta M, Gairola S, Shaligram U, Goldenberger D, Spertini F, Audran R, Enoui M, Beradi S, Hayoz S, Wicki A
Oncoimmunology
Therapy Indications
An integrative study of five biological clocks in somatic and mental health
(2020)
Jansen R, Verhoeven J, Han LKM, Aberg KA, van den Oord ECGJ, Milaneschi Y, Penninx BWJH
bioRxiv
Therapy Indications
Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus
(2020)
Smith MA, Chiang CC, Zerrouki K, Rahman S, White W, Streicher K, Rees WA, Schiffenbauer A, Rider LG, Miller FW, Manna Z, Hasni S, Kaplan M, Siegel R, Sinibaldi D, Sanjuan MA, Casey KA
Scientific Reports
Therapy Indications
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitnes in old age
(2020)
Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbaren N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A
Nature Metabolism
Therapy Indications
Impact of carbohydrate-reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial
(2020)
Rahmel T, Hubner M, Koos B, Wolf A, Willemsen KM, Straub G, Effinger D, Adamzik M, Kreth S
BMJ Open
Therapy Indications
Preoperative TruCulture whole blood cytokine response predicts postoperative inflammation in pancreaticoduodenectomy patients - a pilot cohort study
(2020)
Aasvang EK, Pitter S, Hansen CP, Storkholm JH, Krohn PS, Burgdorf SK, Von Stemann JH, Lundgren JD, Nielsen SD, Kehlet H, Ostrowski SR
Scandinavian Journal of Immunology
Therapy Indications
Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression
(2020)
van Eeden WA, van Hemert AM, Carlier IVE, Penninx BWJH, Fried EI, Schoevers R, Giltay EJ
Translational Psychiatry
Therapy Indications
Immune transriptome of cells infected with enterovirus strains obtained from cases of type 1 diabetes
(2020)
Poma AM, Genoni A, Broccolo F, Denaro M, Pugliese A, Basolo F, Toniolo A
Microorganisms
Therapy Indications
Inexpensive, non-invasive biomarkers predict Alzheimer transition using machine learning analysis of the Alzheimers Disease Neuroimaging (ADNI) database
(2020)
Beltran JF, Wahba BM, Hose N, Shasha D, Kline RP, ADNI
PLoS One
Therapy Indications
Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study
(2020)
Genovese MC, Gaylis NB, Sikes D, Kivitz A, Horowitz DL, Peterfy C, Glass EV, Levine YA, Chernoff D
The Lancet Rheumatology
Therapy Indications
Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration
(2020)
Lashkari K, Teague GC, Beattie U, Betts J,Kumar S, McLaughlin MM, Lopez FJ
PLOS One
Therapy Indications
Model informed dosing regimen and phase I results of the anti-PD-1 antibody budigalimab (ABBV-181)
(2020)
Powderly J, Spira A, Kondo S, Doi T, Luke JL, Rasco D, Gao B, Tanner M, Cassier PA, Gazzah A, Italiano A, Tosi D, Afar DE, Parikh A, Engelhardt B, Englert S, Lambert SL, Kasichayanula S, Mensing S, Menon R, Vosganian G, Tolcher A
Clinical and Translational Science
Therapy Indications
Reduced chronic toxicity and carcinogenicity in A/J mice in response to life-time exposure to aerosol from a heated tobacco product compared with cigarette smoke
(2020)
Wong ET, Luettch K, Krishan S, Wong SK, Lim WT, Yeo D, Buttner A, Leroy P, Vuillaume G, Boue S, Hoeng J, Vansheeuwijck P, Peitsch M
Toxicological Sciences
Therapy Indications
Investigating data-driven biological subtypes of sychiatric disorders using specification-curve analysis
(2020)
Beijers L, van Loo HM, Romeijn JW, Lamers F, Schoevers RA, Wardenaar KJ
Psychological Medicine
Therapy Indications
Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes
(2020)
Adams SF, Grimm AJ, Chiang CLL, Mookerjee A, Flies D, Jean S, McCann GA, Michaux J, Pak H, Huber F, Neal C, Dangaj D, Bassani-Sternberg M, Rusakiewicz S, Facciabene A, Coukos G, Gimotty PA, Kandalaft LE
Journal for ImmunoTherapy of Cancer
Therapy Indications
Molecular biomarkers of anti-TNF response in patients with rheumatoid arthritis
(2020)
Yoosuf N, Maciejewski M, Ziemek D, Jelinsky S, Folkersen, Muller M, Sahlstrom P, Vivar N, Catrina A, Berg L, Klareskog L, Padyukov L, Brynedal B
Arthritis Research & Therapy
Therapy Indications
Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,30dioxygenase 2, in patients with advanced solid tumors
(2020)
Naing A, Eder JP, Piha-Paul SA, Gimmi C, Hussey E, Zhang S, Hildebrand V, Hosagrahara V, Habermehl C, Moisan J, Papadopoulos KP
Journal for ImmunoTherapy of Cancer
Therapy Indications
Genetics meets proteomics: perspectives for large population-based studies
(2020)
Suhre K, McCarthy MI, Schwenk JM
Nature Reviews Genetics
Therapy Indications
Modulation of cardiometabolic disease markers by type I interferon inhibition in systemic lupus erythematosus
(2020)
Casey KA, Smith MA, Sinibaldi D, Seto NL, Playford MP, Wang X, Carlucci PM, Wang L, Illei G, Yu B, Wang S, Remaley AT, Mehta NH, Kaplan MJ, White WI
Arthritis Rheumatology
Therapy Indications
Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimers disease
(2020)
Pillai JA, Bena J, Bebek Gurkan, Bekris LM, Bonner-Jackson A, Kou L, Pai A, Sorensen L, Neilsen M, Rao SM, Chance M, Lamb BT, Leverenz JB, Alzheimers Disease Neuroimaging Initiative
Annals of Clinical and Translational Neurology
Therapy Indications
HepatoScore-14: Measures of biological heterogeneity significantly improve prediction of hepatocellular carcinoma risk
(2020)
Morris JS, Hassan MM, Zohner YE, Wang Z, Xiao L, Rashid A, Haque A, Abdel-Wahab R, Mohamed YA, Ballard KL, Wolff RA, George B, Li L, Allen G, Weylandt M, Li D, Wang W, Raghav K, Yao J, Amin HM, Kaseb AO
Heptology
Therapy Indications
Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab - a study protocol
(2020)
Takeshi N, Kenji I, Daisuke O, Satoshi N, Risa TM, Koji M, Susumu I, Hidehisa S, Yudai K, Riichiro A, Mamitaro O, Koji K, Tatsuro O, Tomomitsu M, Yozo I, Akihiko a, Hiroshi K, Keiji T, Hiroshi M, Tatsuyoshi K, Takuya T, Masashi A, Emi N, Akimchi M, Kyoko t, Yukinobu N, Koji S, Chicharu T, YOko K, Rai F, Sakae K, Eishin M, Akio T, Mchihiro H, Natsuko A, Shigetoshi S, Haruna M, Yutaka H, Motoi T, Hiroyuki M, Norito K, Masutaka F
Medicine
Therapy Indications
First-in-human, single- and multiple-ascending dose studies in healthy subjects to assess pharmacokinetics, pharmacodynamics, and safety/tolerability of iberdomide, a novel cereblon E3 ligase modulator
(2020)
Ye Y, Gaudy A, Schafer P, Thomas M, Weiss D, Chen N, Liu L, Xue Y, Carayannopoulos L, Palmisano M
Clinical Pharmacology in Drug Development
Therapy Indications
Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study
(2020)
Albert Vega C, Oriol G, Bartolo F, Lopez J, Pachot A, Rimmele T, Venet F, Leray V, Monneret G, Delwarde B, Brengel-Pesce K, Textoris J, Mallet F, Trouillet-Assant S
Scientific Reports
Therapy Indications
Immune profiling enables stratification of patients with active TB disease or M. tuberculosis infection
(2020)
Duffy D, Nemes E, Llibre A, Rouilly V, Musvosvi M, Smith N, Filander E, Africa H, Mabwe S, Jaxa L, Charbit B, Mulenga H, the Milieu Interieur Consortium, Tameris M, Walzl G, Malherbe S, Thomas S, Hatherill M, Bilek N, Scriba TJ, Albert ML
Clinical Infectious Diseases
Therapy Indications
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
(2020)
Fokersen L, Gustafsson S, Qang Q, Hansen DH, Hedman AK, Schork A, Page K, Zhernakova DV, Wu Y, Peteres J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Entroth S, Kalnapenkis A, Gadin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Smith GD, de Masi F, Elmstahl S, Engstrom G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson A, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Magi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Palsson E, Qi T, Sjogren M, Sundstrom J, Surendran P, Vosa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Arnlov J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Homes MV, Ingelsson E, Malarstig A
Nature Metabolism
Therapy Indications
Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial
(2020)
Aranow C, Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos TP, Datta-Chaundhuri T, Bouton C, Tracey KJ, Diamond B
Annals of the rheumatic diseases
Therapy Indications
Methamphetamine increases the proportion of SIV-infected microglia/macrophases, alters metabolic pathways, and elevates cell death pathways: a single-cell analysis
(2020)
Niu M, Morsey B, Lamberty BG, Emanuel K, Yu F, Leon-Rivera R, Berman JW, Gaskill PJ, Matt SM, Ciborowski PS, Fox HS
Viruses
Therapy Indications
Efficacy and safety of abatacept in active primary Sj?grens syndrome: results of a phase III, randomised, placebo-controlled trial
(2020)
Baer AN, Gottenberg JE, St Clair EW, Sumida T, Takeuchi T, Seror R, Foulks G, Nys M, Mukherjee S, Wong R, Ray N, Boothsma H
Annals of the Rheumatic Disease
Therapy Indications
Basal forebrain degeneration and cortisol as biomarkers mediating Alzheimers disease pathology: a machine learning approach
(2020)
Nakirikanti AS
Research Thesis
Therapy Indications
The utility of novel urinary biomarkers in mice for drug development studies
(2020)
Adedeji AO, Gu YZ, Pourmohamad T, Kanerva J, Chen Y, Atabakhsh E, Tackett MR, Chen F, Bhatt B, Gury T, Dorchies O, Sonee M, Morgan M, Burkey J, Gautier JC, McDuffie JE
International Journal of Toxicology
Therapy Indications
Left and right atrial biomarker analysis in atrial fibrillation
(2020)
Goldberger JJ, Green D, Ringwala S, Andrei AC, Xu Y, Passman R
JACC Clinical Electrophysiology
Therapy Indications
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo
(2020)
Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermuller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot G, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S, Milieu interieur Consortium, Sellam J, Berenbaum F, Miceli C, Dougados M, Bianchi E, Rogge L
Ann Rheum Dis
Therapy Indications
Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort
(2020)
Bauer Y, de Bernard S, Hickey P, Ballard K, Cruz J, Cornelisse P, Chadha-Boreham H, Distler O, Rosenberg D, Doelberg M, Roux S, Nayler O, Lawrie A
European Respiratory Journal
Therapy Indications
Soluble receptor for advanced glycation end products (sRAGE) as a biomarker for COPD
(2020)
Pratte KA, Curtis JL, Kechris K, Couper D, Cho MH, Silverman EK, DeMeo DL, Sciurba FC, Zhang Y, Ortega VE, ONeal W, Gillenwater LA, Lynch DA, Newell Jr JD, Comellas AP, Castaldi PJ, Miller B, Pouwels SD, ten Hacken NHT, Bischoff R, Klont F, Woodruff P, Paine R, Barr RG, Hoidal J, Doerschuk CM, Charbonnier JP, Sung R, Locantore N, Yonchuk J, Tal-Singer R, Jacobson S, Merrill D, Bowler RP
Research Square
Therapy Indications
Characterization of LY2775240, a selective phosphodiesterase-4 inhibitor, in nonclinical models and in healthy subjects
(2020)
Patel DR, Urva S, Ho S, Buckman CJ, Ma Y, Lim J, Sissons SE, Zuniga MS, Philips D, Cox K, Dairaghi D
Clinical and Translational Science
Therapy Indications
Therapy Indications
Assessment of advanced glycation end products and receptors and the risk of dementia
(2021)
Chen J, Mooldijk SS, Licher S, Waqas K, Ikram MK, Uitterlinden AG, Zillikens MC, Ikram MA
JAMA Network Open
Therapy Indications
Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes
(2021)
Stein MM, Conery M, Magnaye KM, Clay SM, Billstrand C, Nicolae R, Naughton K, Ober C, Thompson EE
Scientific Reports
Therapy Indications
A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy
(2021)
Choueiri TK, Atkins MB, Rose TL, Alter RS, Yawen J, Niland K, Wang Y, Arbeit R, Parasuraman S, Gan L, McDermott DF
Investigational New Drugs
Therapy Indications
First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects
(2021)
Yang J, Lickliter JD, Hilson JL, Means GD, Sanderson RJ, Carley K, Tercero A, Manjarrez KL, Wiley JR, Peng SL
Clinical and Translational Science
Therapy Indications
LY3022855, an anti-colony stimulating factor-1 receptor (CSF-1R) monoclonal antibody, in patients with advanced solid tumors refractory to standard therapy: phase 1 dose-escalation trial
(2021)
Dowlati A, Jarvey RD, Carvajal RD, Hamid O, Klempner SJ, Wook Kauh JS, Peterson DA, Yu D, CHapman SC, Szpurka AM, Carlsen M, Quinlan T, Wesolowski R
Investigational New Drugs
Therapy Indications
Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers
(2021)
Mezghiche I, Yahia-Cherbal H, Rogge L, Bianchi E
Expert Review of Clinical Immunology
Therapy Indications
Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response
(2021)
Aevermann B, Shannon CP, Novotny M, Ben-Othman R, Cai B, Zhang Y, Ye JC, Kobor MS, Gladish N, Lee A, Blimke TM, Hancock RE, Llibre A, Duffy D, Koff WC, Sadarangani M, Tebbutt SJ, Kollmann TR, Scheuermann RH
medRxiv
Therapy Indications
Novel signatures associated with systemic lupus erythematosus clinical response to IFN-a/-? inhibition
(2021)
Seridi L, Cesaroni M, Orillion A, Schreiter J, Chevrier M, Marciniak S, Migone TS, Stohl W, Chatham WW, Furie RA, Benson J, Jordan J
Lupus
Therapy Indications
TNFRSF1B gene variants and related soluble TNFR2 levels impact reilience in Alzheimers disease
(2021)
Pillai JA, Bebek G, Khrestian M, Bena J, Bergmann CC, Bush WS, Leverenz JB, Bekris LM
Frontiers in Aging Neuroscience
Therapy Indications
Influence of cell quality on inflammatory biomarkers in COPD sputum supernatant
(2021)
Pedersen F, Trinkmann F, Abdo M, Kirsten AM, Rabe KF, Watz H, Baraldo S, Saetta M, Hohlfeld JM, Holz O
International Journal of Chronic Obstructive Pulmonary Disease
Therapy Indications
Molecular correlates of response to nivolumab at baseline and on treatment in patients with RCC
(2021)
Ross-Macdonald P, Walsh AM, Chasalow SD, Ammar R, Papillon-Cavanagh S, Szabo pm, Choueiri TK, Sznol M, Wind-Rotolo M
Journal for Immunotherapy for Cancer
Therapy Indications
Identifying associations among genomic, proteomic and imaging biomarkers via adaptive sparse multi-view canonical correlation analysis
(2021)
Du L, Zhang J, Liu F, Wang H, Guo L, Han J, the Alzheimers Disease Neuroimaging Initiative
Medical Image Analysis
Therapy Indications
Primary human dendritic cells and whole-blood based assays to evaluate immuno-modulatory properties of heat-killed commensal bacteria
(2021)
Norton JE Jr., Kommineni S, Akrivoulis P, Gutierrez DA, Hazuda DJ, Swaminathan G
Vaccines
Therapy Indications
Correlative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma
(2021)
Lee CH, Motzer RJ, Glen H, Michaelson MD, Larkin J, Minoshima Y, Kanekiyo M, Ikezawa H, Sachdev P, Dutcus CE, Funashashi Y, Voss MH
British Journal of Cancer
Therapy Indications
Muscle damage in systemic sclerosis and CXCL10: The potential therapeutic role of PDE5 inhibition
(2021)
Corinalesi C, Ross RL, Abignano G, Antinozzi C, Marampon F, di Luigi L, Buch MH, Riccieri V, Lenzi A, Crescioli C, Del Galdo F
International Journal of Molecular Sciences
Therapy Indications
Differential response induced by LPS and MPLA in immunocompetent and septic individuals
(2021)
Vega CA, Karakike E, Bartolo F, Mouton W, Cerrato E, Brengel-Pesce K, Giamarellos-Bourboulis EJ, Mallet F, Trouillet-Assant S
Clinical Immunology
Therapy Indications
Characterization of the pathophysiological determinants of diarrheagenic Escherichia coli infection using a challenge model in healthy adults
(2021)
van Hoffen E, Mercenier A, Vidal K, Benyacoub J, Schloesser J, Kardinaal A, Lucas-van de Bos E, van Alen I, Rogero I, Duintjer K, Berendts A, Albers R, Kleerebezem M, Bruggencate ST
Scientific Reports
Therapy Indications
Development of an affordable, sustainable and efficacious plant-based immunomodulatory food ingredient based on bell pepper or carrot RG-I pectic polysaccharides
(2021)
McKay S, Oranje P, Helin J, Koek JH, Kreijveld E, van den Abbeele P, Phol u, Bothe G, Tzoumaki M, Aparicio-Vergara M
Nutrients
Therapy Indications
Nonclinical development of SRK-181: An anti-latent TGFb1 monoclonal antibody for the treatment of locally advanced or metastatic solid tumors
(2021)
Welsh BT, Faucette R, Bilic S, Martin CJ, Schurpf T, Chen D, Nicholls S, Lansita J, Kalra A
International Journal of Toxicology
Therapy Indications
Functional immune reconstitution early after allogeneic hematopoietic cell transplantation: A comparison of pre- and post-transplantation cytokine responses in stimulated whole-blood
(2021)
Gjaerde LK, Brooks PT, Andersen NS, Friss LS, Kornblit B, Petersen SL, Schjodt I, Nielsen SD, Ostrowski SR, Sengelov H
Scandinavaian Journal of Immunology
Therapy Indications
Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results
(2021)
Advani R, Moskowitz AJ, Bartlett NL, Vose J, Ramchandren R, Feldman T, LaCasce AS, Christian B, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood
Therapy Indications
NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia ? A brief report from the ORIGIN trial
(2021)
Wijkman MO, Claggett BL, Pfeffer MA, Pare G, McQueen M, Hess S, Fu Lee S, Gerstein HC
Journal of Diabetes and its Complications
Therapy Indications
Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study
(2021)
Goepfert PA, Fu B, Chabanon AL, Bonaparte MI, Davis MG, Essink BJ, Frank I, Haney O, Janosczyk H, Keefer MC, koutsoukos M, Kimmel MA, Masotti R, Savarino SJ, Schuerman L, Schwarts H, Sher LD, Smith J, Tavares-Da-Silva F, Gurunathan S, DiazGranados CA, de Bruyn G
The Lancet, Infectious Disease
Therapy Indications
The Effect of a natural oral nutritional supplement on the level of intra-articular inflammatory mediators in patients with osteoarthritis of the knee
(2021)
Sharkey P, Shah Z, Gross M, Meade T, Davidoff S, Shohat N, Parvizi J
Journal of Orthopaedic Experience and Innovation
Therapy Indications
Regional relationships between CSF VEGF levels and Alzheimers disease brain biomarkers and cognition
(2021)
Tubi MA, Kothapalli D, Hapenney M, Feingold FW, Mack WJ, King KS, Thompson PM, Braskie MN
Neurobiology of Aging
Therapy Indications
Pretreatment with ibrutinib reduces cytokine secretion and limits the risk of obinutuzumab-induced infusion-related reactions in patients with CLL: analysis from the iLLUMINATE study
(2021)
Greil R, Tedeschi A, Moreno C, Anz B, Larratt L, Simkovic M, Gill D, Gribben JG, Flinn IW, Wang Z, Cheung LWK, Nguyen AN, Zhou C, Styles L, Demirkan F
Annals of Hematology
Therapy Indications
Safety, pharmacokinetics, and efficacy of budigalimab with rovalpituzumab teserine in patients with small cell lung cancer
(2021)
Calvo E, Spira A, de Miguel M, Kondo S, Gazzah A, Millward M, Prenen H, Rottey S, Warburon L, Alanko T, Cassier PA, Yoh K, Italiano A, Moreno V, Peltola K, Seto T, Toyozawa R, Afar DE, Englert S, Komarnitsky P, Lambert S, Parikh A, Vosganian G, Gao B
Cancer Treatment and Research Communities
Therapy Indications
Preclinical and clinical characterization of the ROR?t inhibitor JNJ-61803534
(2021)
Xue X, De Leon-Tabaldo A, Luna-Roman R, Castro G, Albers M, Shoetens F, DePrimo S, Devineni D, Wilde T, Goldberg S, Hoffmann T, Fourie AM, Thurmond RL
Scientific Reports
Therapy Indications
Ligand conjugate structure activity relationships and enhanced endosomal escape with a targeted polymer micelle in non-human primates
(2021)
Holland RJ, Lam K, Ye X, Martin AD, Wood MC, Palmer L, Fraser D, McClintock K, Majeski S, Jarosz A, Lee ACH, Thi EP, Judge A, Heyes J
Molecular Therapy
Therapy Indications
Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons
(2021)
Anderson JA, Lea AJ, Voyles TN, Akinyi MY, Nyakundi R, Ochola L, Omondi M, Nyundo F, Zhang Y, Campos FA, Alberts SC, Archie EA, Tung J
bioRxiv preprint
Therapy Indications
The migration of human follicular dendritic cell-like cell is facilitated by matrix metalloproteinase 3 expression that is mediated through TNFa-ERK1/2-AP1 signaling
(2021)
Pak HK, Kim YW, Nam B, Lee AN, Roh J, Gil M, Liu C, Chung YS, Park CS
Journal of Immunology Research
Therapy Indications
Anti-interleukin-6 antibody clazakizumab in late antibody-mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism
(2021)
Muhlbacher J, Schorgenhofer C, Doberer K, Durr M, Budde K, Eskandary F, Mayer KA, Schranza S, Ely S, Reiter B, Chong E, Adler SH, Jilma B, Bohmig GA
Transplant Internatinoal
Therapy Indications
Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming
(2021)
Hirschberger S, Straub G, Effinger D, Marstaller X, Ferstl A, Muller MB, Wu T, Hubner M, Rahmel T, Mascolo H, Exner N, Heb J, Kreth FW, Unger K, Kreth S
EMBO Molecular Medicine
Therapy Indications
First-in-human phase 1 study of budigalimab, an anti-PD-1 inhibitor, in patients with non-small cell lung cancer and head and neck squamous cell carcinoma
(2021)
Italiano A, Cassier PA, Lin CC, Alanko T, Peltola KJ, Gazzah A, Shiah HS, Calvo E, Cervantes A, Roda D, Tosi D, Gao B, Millward M, Warburton L, Tanner M, Englert S, Lambert S, Parikh A, Afar DE, Vosganian G, Moreno V
Cancer Immunology, Immunotherapy
Therapy Indications
Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid 1-42
(2021)
Ekblad LL, Visser PJ, Tijims BM, for the Alzheimers Disease Neuroimaging Initiative
Neurobiology of Aging
Therapy Indications
Improving the power to detect indirect effects in mediation analysis
(2021)
Kidd J, Lin DY
Conrell University
Therapy Indications
CSF proteomic Alzheimers disease-predictive subtypes in cognitively intact amyloid negative individuals
(2021)
Tijms BM, Gobom J, Teunissen C, Dobricic V, Tsolaki M, Verhey F, Popp J, Martinex-Lage P, Vandenberghe R, Lleo A, Luis-Molineuvo J, Engelborghs S, Freund-Levi Y, Foelich L, Bertram L, Lovestone S, Streffer J, Vos S, ADNI, Blennow K, Scheltens P, Zetterberg H, Jelle Visser P
Proteomes
Therapy Indications
Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice
(2021)
Yun JH, Lee CH, Liu S, Kim EY, Xu S, Curtis JL, Pinello L, Bowler RP, Silverman EK, Hersh CP, Zhou X
JCI Insight
Therapy Indications
NBAS variants are associated with quantitative and qualitative NK and B cell deficiency
(2021)
Lenz, D, Pahl J, Hauck F, Alameer S, Balasubramanian M, Baric I, Boy N, Church JA, Crushell E, Dick A, Distelmaier F, Gujar J, Indolfi G, Lurz E, Peters B, Schwerd T, Serranti D, Kolker S, Klein C, Hoffmann GF, Prokisch H, Greil J, Cerwenka A, Giese T Staufner C
Journal of Clinical Immunology
Therapy Indications
Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8
(2021)
Port A, Shaw JV, Klopp-Schulze L, Bytyqi A, Vetter C, Husey E, Mammasse N, Ona V, Bachmann A, Strugala D, Reh C, Goteti K
Pharmacology Researh and Perspective
Therapy Indications
Antitumor necrosis factor-like ligand 1A therapy targets tissue inflammation and fibrosis pathways and reduces gut pathobionts in ulcerative colitis
(2021)
Hassan-Zahraee M, Ye Z, Baniecki ML, Li X, Hyde CL, Zhang J, Raha N, Karlsson F, Quan J, Ziemek D, Neelakantan S, Lepsy C, Allegretti JR, Romatowski J, Scherl EJ, Klopocka M, Danese S, Chandra DE, Schoenbeck U, Vincent MS, Longman R,Hung KE
Inflammatory Bowl Diseases
Therapy Indications
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease
(2021)
Pierson SK, Shenoy S, Oromendia AB, Gorzewski AM, Pai RA, Nabel CS, Ruth JR, parente SAT, Arenas DJ, Guilfoyle M, Reddy MP, Weinblatt M, Shadick N, Bower M, Pria AD, Masaki Y, Katz L, Mezey J, Beineke P, Lee D, Tendler C, Kambayashi T, Fossa A, van Rhee F, Fajgenbaum DC
Blood Advances
Therapy Indications
Association of systemic inflammation with depressive symptoms in individuals with COPD
(2021)
Strollo HC, Nouraie SM, Hoth KF, Riley CM, Karoleski C, Zhang Y, Hanania NA, Bowler RP, Bon J, Sciurba FC
International Journal of Chronic Obstructive Pulmonary Disease
Therapy Indications
A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis
(2021)
Alexander Jr LC, McHorse G, Huebner JL, Bay-Jensen AC, Karsdal MA, Kraus VB
Arthritis Research & Therapy
Therapy Indications
Distinct patterns of blood cytokines beyond a cytokine storm predict mortality in COVID-19
(2021)
Herr C, Mang S, Mozafari B, Guenther K, Speer T, seibert M, Srikakulam SK, Beisswenger C, Ritzmann F, Keller A, Mueller R, smola S, Eisinger D, Zemlin M, Danziger G, Volk T, Hoersch S, Krawczyk M, Lammert F, Adams T, Wagenpfeil G, Kindermann M, Marcu C, Ataya ZWD, Mittag M, Schwarzkopf K, Custodis F, Grandt D, Schaefer H, Eltges K, Lepper PM, Bals R
Journal of Inflammation Research
Therapy Indications
Associations of the cerebrospinal fluid hepatocyte growth factor with Alzheimers disease pathology and cognitive function
(2021)
Zhao LJ, Wang ZT, Ma YH, Zhang W, Dong Q, Yu JT, Tan L, ADNI
BMC Neurology
Therapy Indications
High insulin in early childhood is associated with subsequent asthma risk independent of body mass index
(2021)
Carr TF, Granell R, Stern DA, Guerra S, Wright A, Halonen M, Henderson J, Martinex FD
The Journal of Allergy and Clinical Immunology: In Practice
Therapy Indications
Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial
(2021)
Pigeyre M, Hess S, Gomez MF, Asplund O, Groop L, Pare G, Gerstein H
Diabetologia
Therapy Indications
Serum peptidome: diagnostic window into pathogenic processes following occupational exposure to carbon nanomaterials
(2021)
Mostovenko E, Dahm MM, Schubauer-Berigan MK, Eye T, Erdely A, Young TL, Campen MJ, Ottens AK
Particle and Fibre Toxicology
Therapy Indications
Interferon genes are influenced by 17?-estradiol in SLE
(2021)
Singh RP, Hahn BH, Bischoff DS
Frontiers in Immunology
Therapy Indications
Soluble amyloid-beta isoforms predict downstream Alzheimers disease pathology
(2021)
Povala G, Bellaver B, De Bastiani MA, Brum WS, Ferreira PCL, Bieger A, Pascoal TA, Benedet AL, Souza DO, Araujo RM, Zatt B, Rosa-Neto P, Zmmer ER
Research Square
Therapy Indications
Systems biology methods applied to blood and tissue for comprehensive analysis of immune response to hepatitis B vaccine in adults
(2020)
Ben-Othman R, Cai B, Liu AC, Varankovich N, He D, Blimkie TM, Lee AH, Gill EE, Novotny M, Aevermann B, Drissler s, Shannon CP, McCann S, Marty K, Bjornson G, Edgar RD, Lin DTS, Gladish N, MacIsaac J, Amenyogbe N, Chan Q, Libre A, Collin J, Landais, E, Le K, Reiss SM, Koff WC, Havenar-Daughton C, Heran M, Sangha B, Walt D, Krajden M, Crotty S, Sok D, Briney B, Burton DR, Duffy D, Foster LJ, Mohn WW, Kobor MS, Tebbutt SJ, Brinkman RR, Scheuermann RH, Hancock REW, Kollmann TR, Sadarangani M
Frontiers in Immunology
Therapy Indications
Biomarker signature in cancer patients with and without venous thromboembolism events: a substudy of CASSINI
(2021)
Khorana A, Barnard J, Wun T, Vijapurkar U, Damaraju CV, Moore K, Wildgoose P, McCrae K
Blood Advances
Therapy Indications
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome
(2021)
Perlin DS, Neil GA, Anderson C, Zafir-Lavie I, Raines S, Ware CF, Wilkins HJ
Journal of Clinical Investigation
Therapy Indications
Combination of atezolizumab and obinutuzumab in patients with relapsed/refractory follicular lymphoma and diffuse large B-cell lymphome: Results from a phase 1b study
(2021)
Palomba ML, Till BG, Park SI, Morschhauser F, Cartron G, Marks R, Shivhare M, Hong WJ, Raval A, Change AC, Penuel E, Popplewell LL
Clinical Lymphoma Myeloma and Leukemia
Therapy Indications
3Repetitive xenon treatment improves post-stroke sensorimotor and neuropsychiatric dysfunction
(2022)
Dandekar MP, Yin X, Peng T, Devaraj S, Moarles R, McPherson DD, Huang S
Journal of Affective Disorders
Therapy Indications
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
(2022)
Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong M, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, tHart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D
Cell Reports Medicine
Therapy Indications
Whole-blood cytokine secretion assay as a high-throughput alternative for assessing the cell-mediated immunity profile after two doses of an adjuvanted SARS-CoV-2 recombinant protein vaccine candidate
(2022)
De Rosa SC, Cohen KW, Bonaparte M, Fu B, Garg S, Gerard C, Goepfert PA, Huang Y, Larocque D, McElrath MJ, Morris d, Van der Most R, de Bruyn G, Anke Pagnon
Clinical & Translational Immunology
Therapy Indications
Cellular and humoral immunity to SARS-CoV-2 infection in multiple sclerosis patients on ocrelizumab and other disease-modifying therapies: a multi-ethnic observational study
(2022)
Kister I, Patskovsky Y, Curtin R, Pei J, Perdomo K, Rimler Z, Voloshyna I, Samanovic MI, Cornelius AR, Velmurugu Y, Nyovanie S, Kim J, Tardio E, Bacon TE, Zhovtis L, Ryerson LZ, Raut P, Pedotti R, Hawker K, Raposo C, Priest J, Cabatingan M, Winger RC, Mulligan MJ, Krogsgaard M, Silverman GJ
medRxiv
Therapy Indications
Dissection of depression heterogeneity using proteomic clusters
(2022)
van Haeringen M, Milaneschi Y, Lamers F, Penninx BWJH, Jansen R
Psychological Medicine
Therapy Indications
T cell apoptosis characterizes severe Covid-19 disease
(2022)
Andre S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butauz A, Soundaramourty C, Santa Cruz A, Mendes-Frias A, Gotti C, Leclercq M, Nicolas A, Tauzin A, Carvalho A, Capela c, Pedrosa J, Castro AG, Kundura L, Loubet P, Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Racine G, zghidi-Abouzid O, Nioche P, Silvestre R, Droit A, Mammano F, Corbeau P, Estaquier J
CDD Press
Therapy Indications
Antibody profiles in COVID-19 convalescent plasma prepared with amotosalen/UVA pathogen reduction treatment
(2022)
Bagri A, de Assis RR, Tsai CT, Simmons G, Mei ZW, Von Goetz M, Gatmaitan M, Stone M, Di Germanio C, Martinelli R, Darst O, Rioveros J, Robinson PV, Ward D, Ziman A, Settel D, Khan S, Busch MP, Felgner PL, Corash LM
Transfusion
Therapy Indications
Platelet-derived growth factor-BB and white matter hyperintensity
burden in APOE4 carriers
(2022)
Arunima Kapoor, Daniel A Nation
Cerebral Circulation - Cognition and Behavior
Therapy Indications
Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin
(2022)
Christina B. Joseph, Marta Mariniello, Ayumi Yoshifuji, Guglielmo Schiano, Jennifer Lake, Jonathan Marten, Anne Richmond, Jennifer E. Huffman, Archie Campbell, Sarah E. Harris, Stephan Troyanov, Massimiliano Cocca, Antonietta Robino, S?bastien Th?riault, Kai-Uwe Eckardt, Matthias Wuttke, Yurong Cheng, Tanguy Corre, Ivana Kolcic, Corrinda Black, Vanessa Bruat, Maria Pina Concas, Cinzia Sala, Stefanie Aeschbacher, Franz Schaefer, Sven Bergmann, Harry Campbell, Matthias Olden, Ozren Polasek, David J. Porteous, Ian J. Deary, Francois Madore, Philip Awadalla, Giorgia Girotto, Sheila Ulivi, David Conen, Elke Wuehl, Eric Olinger, James F. Wilson, Murielle Bochud, Anna K?ttgen, Caroline Hayward and Olivier Devuyst
Journal of the American Society of Nephrology
Therapy Indications
Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
(2022)
Marion Cremoni, S?bastien Cuozzo, Emanuela Martinuzzi, Susana Barbosa, Nadia Ben Hassen, Filippo Massa, Elisa Demonchy, Matthieu Durand, Olivier Thaunat, Vincent Esnault, Moglie Le Quintrec, Sophie Caillard, Nicolas Glaichenhaus, and Antoine Sicard
Viruses
Therapy Indications
Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia
(2022)
Suzette L. Pereira , Marni E. Shoemaker, Susan Gawel, Gerard J. Davis Menghua Luo, Vikkie A. Mustad and Joel T. Cramer
Nutrients
Therapy Indications
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
(2022)
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, L?lia Delamarre & Ira Mellman
Nature Immunology
Therapy Indications
Utility of urinary cytokine levels as predictors of the immunogenicity and reactogenicity of AS01-adjuvanted hepatitis B vaccine in healthy adults
(2022)
Wivine Burny, Caroline Herve, Magalie Caubet, Juan Pablo Yazabal, Arnaud M Didierlaurent
Vaccine
Therapy Indications
Peripheral lymphocyte signaling pathway deficiencies predict treatment response in first-onset drug-na?ve schizophrenia
(2022)
Santiago G. Lago, Jakub Tomasik, Geertje F. Rees, Nitin Rustogi, Javier Vazquez-Bourgon, Sergi Papiol, Paula Suarez-Pinilla, Benedicto Crespo-Facorro, Sabine Bahn
Brain Behavior and Immunity
Therapy Indications
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women
(2022)
Nardhy Gomez-Lopez, Roberto Romero, Li Tao, Meyer Gershater, Yaozhu Leng, Chengrui Zou, Marcelo Farias-Jofre, Jose Galaz, Derek Miller, Adi L. Tarca, Marcia Arenas-Hernandez, Gaurav Bhatti, Valeria Garcia-Flores, Zhenjie Liu, Robert Para, Tomi Kanninen, Ola Hadaya, Carmen Paredes and Yi Xu
Journal of Immunology
Therapy Indications
Relationship between cerebrospinal fluid neurodegeneration
biomarkers and temporal brain atrophy in cognitively healthy older
adults
(2022)
DidacVidal-Pi?eiro, ?ysteinS?rensen, KajBlennow, Elettra Capogna, Nathalie Bodd Halaas, Ane-VictoriaId, Athanasia Monica Mowinckel, Joana Braga Pereira, Leiv Otto Watne, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell
Neurobiology of Aging
Therapy Indications
Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation
(2022)
Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Li Tao, Catherine Demery-Poulos, Marcia Arenas-Hernandez, Gaurav Bhatti, Zhenjie Liu, Naoki Kawahara, Tomi Kanninen, Zachary Shaffer, Tinnakorn Chaiworapongsa, Kevin R. Theis, Adi L. Tarca & Nardhy Gomez-Lopez
Inflammation Research
Therapy Indications
Defective type I interferon immunity is associated with increasing COVID-19 severity
(2022)
Nika?a Smith, C?line Poss?m?, Vincent Bondet, Jamie Sugrue, Liam Townsend, Bruno Charbit, Vincent Rouilly, Violaine Saint-Andr?, Tom Dott, Andre Rodriguez Pozo, Nader Yatim, Olivier Schwartz, Minerva Cervantes-Gonzales, Jade Ghosn, Paul Bastard, Jean Laurent Casanova, Tali-Anne Szwebel, Benjamin Terrier, Niall Conlonm, Cliona O?Farrelly, Cl?ona N? Cheallaigh, Nollaig M Bourke, Darragh Duffy
Research Square
Therapy Indications
An Exploratory Analysis of Biomarkers of Perihematomal Edema in the CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial
(2022)
Jay B Lusk, Jesse Troy, Nathaniel Nowacki, Peter G Kranz, Maureen Maughan, Daniel T Laskowitz, Michael L James
Journal of Stroke and Cerebrovascular Diseases
Therapy Indications
Pre- and post-operative psychological interventions to prevent pain and fatigue after breast cancer surgery (PREVENT): Protocol for a randomized controlled trial
(2022)
Silje Endresen Reme, Alice Munk, Marianne Therese Smogeli Holter, Ragnhild S. Falk, Henrik B?rsting Jacobsen
Plos One
Therapy Indications
Childhood trauma and LPS-stimulated inflammation in adulthood: Results from the Netherlands Study of Depression and Anxiety
(2022)
Ricki M.de Koning, Erika Kuzminskaite, Christiaan H.Vinkers, Erik J. Giltay, Brenda W.J.H.Penninx
Brain, Behavior, and Immunity
Therapy Indications
Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Renal Allograft Rejection: Accumulation of Antibody-neutralized Interleukin-6 Without Signs of Proinflammatory Rebound Phenomena
(2022)
Anita Borski, Farsad Eskandary, Susanne Haindl, Konstantin Doberer, Jakob M?hlbacher, Katharina A Mayer, Klemens Budde, Philip F Halloran, Edward Chong, Bernd Jilma, Georg A B?hmig, Markus Wahrmann
Transplantation
Therapy Indications
CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-infammatory cytokine production
(2022)
Rajula Gaur, Kofi A Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik 1, Jamie Connarn 1, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ram?rez-Valle
Arthritis Research and Therapy
Therapy Indications
A Phase Ib Dose-finding Study of Panobinostat and Ruxolitinib in Myelofibrosis
(2022)
Claire Harrison Florian H. Heidel, Alessandro M. Vannucchi, Jean-Jacques Kiladjian, Amjad Hayat, Francesco Passamonti, Eibhlin Conneally, Thomas Kindler, Bruno Martino,9 Daniel B. Lipka, Tommaso Stefanelli, Pantelia Roussou,Davide Germano,Jacqueline Ewan, and Vincent Ribrag
Hemasphere
Therapy Indications
Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study
(2022)
Lars Krogvold, Angelo Genoni, Anna Puggioni, Daniela Campani, Sarah J. Richardson, Christine S. Flaxman, Bj?rn Edwin, Trond Buanes, Knut Dahl-J?rgensen & Antonio Toniolo
Diabetologia
Therapy Indications
Early stimulated immune responses predict clinical disease severity in hospitalized COVID-19 patients
(2022)
Rebecka Svanberg, Cameron MacPherson, Adrian Zucco, Rudi Agius, Tereza Faitova, Michael Asger Andersen, Caspar da Cunha-Bang, Lars Klingen Gj?rde, Maria Elizabeth Engel M?ller, Patrick Terrence Brooks, Birgitte Lindegaard, Adin Sejdic, Anne Ortved Gang, Ditte Stampe Hersby, Christian Brieghel, Susanne Dam Nielsen, Daria Podlekareva, Annemette Hald, Jakob Thaning Bay, Hanne Marquart, Jens Lundgren, Anne-Mette Lebech, Marie Helleberg, Carsten Utoft Niemann & Sisse Rye Ostrowski
Communications Medicine
Therapy Indications
Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction
(2022)
Upendra Chalise, Mediha Becirovic-Agic, Jocelyn R. Rodriguez-Paar, Shelby R. Konfrst, Sharon D. B. de Morais, Catherine S. Johnson, Elizabeth R. Flynn, Michael E. Hall, Daniel R. Anderson, Leah M. Cook, Kristine Y. DeLeon-Pennell & Merry L. Lindsey
Journal of Cardiovascular Translational Research
Therapy Indications
Exploration of the induced cytokine responses in European Lyme neuroborreliosis: A longitudinal cohort study
(2022)
Rosa Maja M?hring Gynthersen, Mathilde Orbaek, Helene Mens, Christian Stenor, Lothar Wiese, Sisse Rye Ostrowski, Susanne Dam Nielsen, Anne-Mette Lebech
Ticks and Tick-borne Diseases
Therapy Indications
Sex differences in Alzheimer?s disease: plasma MMP-9 and markers of disease severity
(2022)
Amaryllis A. Tsiknia, Erin E. Sundermann, Emilie T. Reas, Steven D. Edland, James B. Brewer, Douglas Galasko & Sarah J. Banks
Alzheimers Research & Therapy
Therapy Indications
Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology
(2022)
Keun You Kim, Junghee Ha, Minae Kim, So Yeon Cho, Hyunjeong Kim & Eosu Kim
Alzheimers Research & Therapy
Therapy Indications
Distinct Immune Reconstitution Profiles Captured by Immune Functional Assays at 6 Months Post Allogeneic Hematopoietic Stem Cell Transplantation
(2022)
William Mouton, Anne Conrad, Vincent Alcazer, Mathilde Boccard, Maxime Bodinier, Guy Oriol, Fabien Subtil, Helene Labussiere-Wallet, Sophie Ducastelle-Lepretre, Fiorenza Barraco, Marie Balsat, Gaelle Fossard, Karen Brengel-Pesce, Florence Adler, Sophie Trouillet-Assant
Transplantation and Cellular Therapy
Therapy Indications
First-in-human study of deucravacitinib: A selective, potent, allosteric small-molecule inhibitor of tyrosine kinase 2
(2022)
Ian M Catlett, Urvi Aras, Lars Hansen, Yali Liu, Di Bei, Ihab G Girgis, Bindu Murthy
Clinical Translational Science
Therapy Indications
Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs
(2022)
Nickolas Chelyapov, Toai T Nguyen, Rafael Gonzalez
Biochemistry and Biophysics Reports
Therapy Indications
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
(2022)
Nika?a Smith, C?line Poss?m?, Vincent Bondet, Jamie Sugrue, Liam Townsend, Bruno Charbit, Vincent Rouilly, Violaine Saint-Andr?, Tom Dott, Andre Rodriguez Pozo, Nader Yatim, Olivier Schwartz, Minerva Cervantes-Gonzalez, Jade Ghosn, Paul Bastard, Jean Laurent Casanova, Tali-Anne Szwebel, Benjamin Terrier, Niall Conlon, Cliona OFarrelly, Cl?ona N? Cheallaigh, Nollaig M Bourke, Darragh Duffy
Nature Communciations
Therapy Indications
Efficacy and exploratory biomarker analysis of entinostat plus exemestane in advanced of recurrent breast cancer: phase II randomized controlled trial
(2022)
Hiroji Iwata, Rikiya Nakamura, Norikazu Masuda, Toshinari Yamashita, Yutaka Yamamoto, Kokoro Kobayashi, Junji Tsurutani, Tsutomu Iwasa, Kan Yonemori, Kenji Tamura, Tomoyuki Aruga, Eriko Tokunaga, Koji Kaneko, Min-Jung Lee, Akira Yuno, Azusa Kawabata, Toshihiro Seike, Ayumi Kaneda, Yozo Nishimura, Jane B Trepel, Shigehira Saji
Japanese Journal of Clinical Oncology
Therapy Indications
Are U-shaped relationships between risk factors and outcomes artifactual?
(2022)
Reema Shah, Lehana Thabane, Hertzel C. Gerstein
Journal of Diabetes
Therapy Indications
Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response
(2022)
Adam J. Walker, Mohammadreza Mohebbi, Michael Maes, Michael Berk, Ken Walder, Chiara C. Bortolasci, Zoe SJ. Liu, Chee H. Ng, Melanie M. Ashton, Lesley Berk, Ajeet B. Singh, Gin S. Malhi Olivia M. Dean
Brain, Behavior, & Immunity - Health
Therapy Indications
Innate immune function during antineoplastic treatment is associated with 12-months survival in non small cell lung cancer
(2022)
Heidi Ryssel, Kristian Egebjerg, Susanne Dam Nielsen, Jens Lundgren5,6, Mette P?hl, Seppo W. Langer2, Andreas Kjaer, Sisse Rye Ostrowski and Barbara Malene Fischer
Frontiers in Immunology
Therapy Indications
Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-? and tau pathology in Alzheimer?s disease
(2022)
Zhi-Bo Wang, Ya-Hui Ma1, Yan Sun1, Lan Tan1, Hui-Fu Wang, Jin-Tai Yu and for the Alzheimer?s Disease Neuroimaging Initiative
Journal of Neuroinflammation
Therapy Indications
Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial
(2023)
Elizabeth A. Brown, Anne Minnich, Arun J. Sanyal, Rohit Loomba, Shuyan Du, John Schwarz, Richard L. Ehman, Morten Karsdal, Diana J. Leeming, Giovanni Cizza, Edgar D. Charles
JHEP Reports
Therapy Indications
Elevated Levels of the Cytokine LIGHT in Pediatric Crohns Disease
(2023)
Christopher J Cardinale, Debra J Abrams, Frank D Mentch, John A Cardinale, Xiang Wang, Charlly Ka, Patrick M A Sleiman, Hakon Hakonarson
Journal of Immunology
Therapy Indications
Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis
(2023)
Ahmad Akhgar, Dominic Sinibaldi, Lingmin Zeng, Alton B Farris III, Jason Cobb, Monica Battle, David Chain, Jennifer A Cann, Gabor G Illei, S Sam Lim , Wendy I White
Lupis Science and Medicine
Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD
(2023)
Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, , Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas O. Joos, Thomas Knorpp, Nicole Schneiderhan-Marra and Kathrin Brockmann
Nature
Therapy Indications
Hybrid and vaccine-induced immunity against SARS-CoV-2 in MS patients on different disease-modifying therapies
(2022)
Ilya Kister , Ryan Curtin, Jinglan Pei, Katherine Perdomo, Tamar E. Bacon, Iryna Voloshyna,
Annals of Clinical and Translational Neurology
Therapy Indications
Early and recent exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study
(2023)
Susan K Lutgendorf, Sharaf Zia, Yi Luo, Michael ODonnell, Adrie van Bokhoven, Catherine S Bradley, Robert Gallup, Jennifer Pierce, Bayley J Taple, Bruce D Naliboff, J Quentin Clemens, Karl J Kreder, Andrew Schrepf
Brain, Behavior, and Immunity
Therapy Indications
Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF
(2023)
Elizabeth S Hickford, James O?Connell , Alison Maloney, Peter Florian, Geoffrey I
Bioanalysis
Therapy Indications
Regorafenib plus nivolumab in patients with mismatch repair-proficient/microsatellite stable metastatic colorectal cancer: a single-arm, open-label, multicentre phase 2 study
(2023)
Marwan Fakih, Kanwal Pratap Singh Raghav, David Z. Chang, Tim Larson, Allen L. Cohn, Timothy K. Huyck, David Cosgrove, Joseph A. Fiorillo, Rachel Tam, David D?Adamo, Neelesh Sharma, Barbara J. Brennan, Ying A. Wang,k Sabine Coppieters, Hong Zebger-Gong, Anke Weispfenning,m Henrik Seidel, Bart A. Ploeger,m Udo Mueller, Carolina Soares Viana de Oliveira, and Andrew Scott Paulsono
eClinicalMedicine
Therapy Indications
Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans
(2023)
Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan
Brain Stimulation
Therapy Indications
First-in-human study of E7130 (a tumor microenvironment-ameliorating microtubule inhibitor) in patients with advanced solid tumors: Primary results of the dose-escalation part
(2023)
Toshihiko Doi MD, PhD, Nobuaki Matsubara MD, Yoichi Naito MD, Yasutoshi Kuboki MD, Kenichi Harano MD, Makiko Ono MD, PhD, Tetsuya Urasaki MD, PhD, Akihiro Ohmoto MD, PhD, Tsubasa Kawanai MSc, Takashi Hisai MSc, Hiroki Ikezawa MSc, Sari Shiba MSc, Ken Ito PhD, Taro Semba MSc, Osamu Asano PhD, Shunji Takahashi MD, PhD
Cancer
Therapy Indications
Evaluation of BMS-986142, a reversible Brutons tyrosine kinase inhibitor, for the treatment of rheumatoid arthritis: a phase 2, randomised, double-blind, dose-ranging -ranging, placebo controlled, adaptive design study
(2023)
Philip G Conaghan, Miroslawa Nowak, Shuyan Du, Yi Luo, Jessica Landis, Chahin Pachai, Aberra Fura, Ian M Catlett, Dennis M Grasela, Mikkel ?stergaard
Rheumatoloty
Therapy Indications
Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline
(2023)
Neel H. Mehta, Liangdong Zhou, Yi Li, Laura Beth McIntire, Anna Nordvig, Tracy Butler, Mony de Leon & Gloria C. Chiang
Nature
Therapy Indications
Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas
(2023)
Andrew L Coveler, David C Smith, Tycel Phillips, Brendan D Curti, Sanjay Goel, Amitkumar N Mehta, Timothy M Kuzel, Svetomir N Markovic, Olivier Rixe, David L Bajor, Thomas F Gajewski, Martin Gutierrez, Hun Ju Lee, Ajay K Gopal, Paolo Caimi, Elisabeth I Heath, John A Thompson, Sahar Ansari, Celine Jacquemont, Ariel Topletz-Erickson, Peigen Zhou, Michael W Schmitt, Juneko E Grilley-Olson
Journal for ImmunoTherapy of Cancer
Therapy Indications
Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers?In cognitively unimpaired older adults
(2023)
Elettra Capogna, Leiv Otto Watne, ?ystein S?rensen, Carlijn Jamila Guichelaar, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Pi?eiro
Brain Behavior Immunology
Therapy Indications
Phase 1 trial of bemcentinib (BGB324), a first-in-class, selective AXL inhibitor, with docetaxel in patients with previously treated advanced non-small cell lung cancer
(2023)
Sheena Bhalla, FarjanaJ. Fattah, Chul Ahn, Jessica Williams, Alyssa Macchiaroli, Jonathan Padro, Mereth Pogue, Jonathan E. Dowell, William C. Putnam, Nigel McCracken, David Micklem, Rolf, A. Brekken, David E. Gerber
Lung Cancer
Therapy Indications
Long-term in vivo vitamin D3 supplementation modulates bovine IL-1 and chemokine responses
(2023)
Cian Reid , Susana Flores-Villalva, Aude Remot, Emer Kennedy, Cliona O?Farrelly
Nature
Therapy Indications
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
(2023)
Kasper Recourt, Peter de Boer, Peter van der Ark, Heike Benes, Joop M A van Gerven, Marc Ceusters, Luc van Nueten, Wayne C Drevets, Anindya Bhatacharya, Michael Browning, Gabriel E Jacobs
Translational Psychiatry
Therapy Indications
Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk: A 2-Sample Mendelian Randomization Study
(2023)
Tushar Sood, Nicolas Perrot, Michael Chong, Pedrum Mohammadi-Shemirani, Maha Mushtaha, Darryl Leong, Sumathy Rangarajan, Sibylle Hess, Salim Yusuf, Hertzel C Gerstein, Guillaume Par?, Marie Pigeyre
JAMA Network
Therapy Indications
A phase Ib/II study of galunisertib in combination with nivolumab in solid tumors and non-small cell lung cancer
(2023)
Ernest Nadal, Mansoor Saleh , Santiago Ponce Aix , Maria Ochoa de Olza, Sandip Pravin Patel , Scott Antonia, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Shawn T. Estrem, Jiangang Liu, Emin Avsar, Wen Hong Lin, Karim A. Benhadji, Leena Gandhi, Susan C. Guba and Inmaculada Ales Diaz
BMC Cancer
Therapy Indications
Quantifying the spatial clustering characteristics of radiographic emphysema explains variability in pulmonary function
(2023)
Brian E. Vestal, Debashis Ghosh, Ra?l San Jos? Est?par, Katerina Kechris,
Nature
Therapy Indications
Tezepelumab Efficacy in Patients with Severe, Uncontrolled Asthma with Comorbid Nasal Polyps in NAVIGATOR
(2023)
Tanya M Laidlaw, Andrew Menzies-Gow, Scott Caveney, Joseph K Han, Nicole
Journal of Asthma and Allergy
Therapy Indications
Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1
(2023)
Jennifer Leohr and Maria C. Kjellsson
CPT: Pharmacometrics & Systems Pharmacology
Therapy Indications
Clinical and Prognostic Biomarker Value of Blood-Circulating Inflammatory Cytokines in Hepatocellular Carcinoma
(2023)
Shadi Chamseddine, Yehia I. Mohamed, Sunyoung S. Lee, James C. Yao,
Clinical Translational Research
Therapy Indications
Levels of iron and iron-related proteins in Alzheimers disease: a systematic review and meta-analysis
(2023)
Lin Gong, Jiahui Sun, Shuyan Cong
Journal of Trace Elements in Medicine and Biology
Therapy Indications
Tyrosine kinase signaling-independent MET-targeting with CAR-T cells
(2023)
Anna Qin1, Yuan Qin1, Joseph Lee2, Anna Anna Qin, Yuan Qin1, Joseph Lee, Anna Musket, Mingyao Ying, Giedre Krenciute, Francesco M. Marincola5,
Journal of Translational Medicine
Therapy Indications
Identification of molecular subphenotypes in two cohorts of paediatric ARDS
(2023)
Nadir Yehya , Matt S Zinter , Jill M Thompson, Michelle J Lim, Mark R Hanudel, Mustafa F Alkhouli, Hector Wong, Matthew N Alder,Daniel J McKeone, E Scott Halstead, Pratik Sinha, Anil Sapru5
Thorax
Therapy Indications
Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase 1b Trial
(2023)
Steffan T. Nawrocki, Julian Olea, Claudia Villa Celi, Homa Dadrastoussi,Kaijin Wu, Denice Tsao-Wei, Anthony Colombo, Matt Coffey, Eduardo Fernandez Hernandez, Xuelian Chen, Gerard J. Nuovo, Jennifer S. Carew, Ann F. Mohrbacher, Paul Fields, Peter Kuhn, Imran Siddiqi, Akil Merchant, and Kevin R. Kelly
Clinical Cancer Research
Therapy Indications
Identification of an APOE e4?specific blood-based molecular pathway for Alzheimers disease risk
(2023)
Qiushan TaoMD, Chao Zhang PhD, Gustavo MercierMD, PhD, Kathryn Lunetta, Ting Fang Alvin AngMD, Samia Akhter-Khan MS Zhengrong Zhang PhD, Andrew Taylor PhD, Ronald J. Killiany PhD,
Alzheimer?s & Dementia: Diagnosis, Assessment & DiseaseMonitoring
Therapy Indications
Effect of anterior quadratus lumborum block with ropivacaine on the immune response after laparoscopic surgery in colon cancer: a substudy of a randomized clinical
(2023)
Lukas Balsevicius, Paulo C M Urbano, Rune Petring Hasselager, Ahmed Abdirahman Mohamud, Maria Olausson, Melina Svraka, Kirsten L Wahlstr?m, Carolin Oppermann, Dilara Seyma G?genur, Emma Rosenkrantz H?lmich, Britt Cappelen, Susanne Gj?rup S?kmose, Katrine Tanggaard, Thomas Litman, Jens B?rglum, Susanne Brix, Ismail G?genur
Reg Anesth Pain Med
Therapy Indications
Sex hormone-binding globulin and heart failure hospitalizations in patients with dysglycemia Experiences from the Outcome Reduction with an Initial Glargine
(2023)
Anne Wang, Sibylle Hess, Shun Fu Lee, Hertzel C. Gerstein
Diabetes Res Clin Pract
Therapy Indications
IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial
(2023)
Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard Schwartz, Brian J. Feinstein, Phillip La Stella, Afsaneh Alavi, Ashwin Gollerkeri, Jeffrey Davis, Veronica Campbell, Alice McDonald, Sagar Agarwal, Rahul Karnik, Kelvin Shi, Aimee Mishkin, Jennifer Culbertson, Christine Klaus, Bradley Enerson, Virginia Massa, Eric Kuhn, Kirti Sharma, Erin Keaney, Randy Barnes, Dapeng Chen, Xiaozhang Zheng, Haojing Rong, Vijay Sabesan, Chris Ho Nello Mainolfi, Anthony Slavin & Jared A. Gollob
Nature Medicine
Therapy Indications
A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients
(2023)
Barbara Klughammer, Luca Piali, Alexandra Nica, Sandra Nagel, Lorna Bailey, Christoph Jochum, Stanislav Ignatenko, Angela Bl?uer,Sabrina Danilin, Pratiksha Gulati, Joanne Hayward, Petar Scepanovic, Jitao David Zhang, Satish Bhosale, Chui Fung Chong, Andreas Christ
Clinical and Translational Medicine
Therapy Indications
Enabling the evaluation of COVID-19 vaccines with correlates of protection
(2023)
Arnaud Marchant, Pierre Van Damme, Stanley Plotkin, Pieter Neels, Maria Cristina Cassetti, Jakob Cramer, Marion F. Gruber, David Goldblatt, Deborah King, Wendy Hartig-Merkel, Joris Vandeputte
Biologicals
Therapy Indications
Smoking changes adaptive immunity with persistent effects
(2024)
Violaine Saint-Andr?, Bruno Charbit3, Anne Biton, Vincent Rouilly, C?line Poss?m?, Anthony Bertrand, Maxime Rotival, Jacob Bergstedt, Etienne Patin, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy
Nature
Therapy Indications
Interferon-Gamma-Release assay and absolute CD8 lymphocyte count for acquired immunosuppression monitoring in critically ill patients
(2024)
Muzhda Haem Rahimi, Fabienne Venet, Anne-Claire Lukaszewicz, Estelle Peronnet, Elisabeth Cerrato, Thomas Rimmel?, Guillaume Monneret
Cytokine
Therapy Indications
Seladelpar treatment reduces interleukin-31 and pruritus in patients with primary biliary cholangitis
(2023)
Andreas E. Kremer, Marlyn J. Mayo, Gideon M. Hirschfield, Cynthia Levy, Christopher L. Bowlus, David E. Jones, Jeff D. Johnson, Charles A. McWherter, Yun-Jung Choi
Hepatology
Therapy Indications
A clinical, proteomics, and artificial intelligence-driven model to predict acute kidney injury in patients undergoing coronary angiography
(2019)
Nasrien E. Ibrahim, Cian P. McCarthy, Shreya Shrestha, Hanna K. Gaggin, Renata Mukai, Craig A. Magaret, Rhonda F. Rhyne and James L. Januzzi, Jr
Clinical Cardiology
Therapy Indications
A Human Whole Blood Culture System Reveals Detailed Cytokine Release Profiles of Implant Materials
(2024)
Sascha Niclas Klimosch, Marbod Weber, Jordi Caball?-Serrano, Thomas Knorpp, Antonio Munar-Frau, Birgit Margareta Schaefer, Manfred Schmolz
Medical Devices: Evidence and Research
Therapy Indications
Whole blood stimulation provides preliminary evidence of altered immune function following SRC
(2024)
Alex P. Di Battista, Shawn G. Rhind, Maria Shiu and Michael G. Hutchison
BMC Immunology
Therapy Indications
An Exploratory Study of Early Immune Response Markers for Pembrolizumab in Urothelial Tract Cancer
(2024)
Dag Rune Stormoen ,Lise H?j Omland,Kent William Mouw,Zoltan Szallasi,Sisse Rye Ostrowski, Susanne Dam Nielsen and Helle Pappot
Uro
Therapy Indications
Cedirogant Population Pharmacokinetics and Pharmacodynamic Analyses of Interleukin-17A Inhibition in Two Phase I Studies in Healthy Participants and Participants with Moderate to Severe Psoriasis
(2024)
Corinna S Maier, Doerthe Eckert, F Stephen Laroux, Kinjal M Hew, Ahmed A Suleiman, Wei Liu, Mohamed-Eslam F Mohamed
Clin Pharmacol Drug Dev
Therapy Indications
Betaine and L-Carnitine Synergistically Influence the Metabolome and Immune Response in Dogs
(2024)
Dennis E. Jewell, Selena K. Tavener, Renea Creech and Kiran S. Panickar
Animals
Therapy Indications
Proteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study
(2024)
Jonah F. Byrne, Colm Healy, Melanie F?cking, Subash Raj Susai, David Mongan, Kieran Wynne, Eleftheria Kodosaki, Meike Heurich, Lieuwe de Haan, Ian B. Hickie, Stefan Smesny, Andrew Thompson, Connie Markulev, Alison Ruth Young, Miriam R. Sch?fer, Anita Riecher-R?ssler, Nilufar Mossaheb, Gregor Berger, Monika Schl?gelhofer, Merete Nordentoft, Eric Y.H. Chen, Swapna Verma, Dorien H. Nieman, Scott W. Woods, Barbara A. Cornblatt, William S. Stone, Daniel H. Mathalon, Carrie E. Bearden, Kristin S. Cadenhead, Jean Addington, Elaine F. Walker, Tyrone D. Cannon, Mary Cannon, Pat McGorry, Paul Amminger, Gerard Cagney, Barnaby Nelson, Clark Jeffries, Diana Perkins, and David R. Cotter
Schizophrenia Bulletin
Therapy Indications
Plant stanol consumption increases anti-COVID-19 antibody responses, independent of changes in serum cholesterol concentrations: a randomized controlled trial
(2024)
Lieve van Brakel, Ronald P Mensink, Dieter L?tjohann, Jogchum Plat
The Americal Journal of Clinical Nutrition
Therapy Indications
A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome
(2024)
Terese C. Hammond, Marco A. Purbhoo, Sapana Kadel, Jerome Ritz, Sarah Nikiforow4, Heather Daley, Kit Shaw, Koen van Besien, Alexandra Gomez-Arteaga, Don Stevens, WaldoOrtuzar, Xavier Michelet, Rachel Smith, Darrian Moskowitz, Reed Masakayan, Burcu Yigit, Shannon Boi, Kah Teong Soh, John Chamberland, Xin Song, Yu Qin, Ilya Mishchenko, Maurice Kirby, Valeriia Nasonenko, Alexa Buffa, Jennifer S. Buell, Dhan Chand, Marc van Dijk, Justin Stebbing & Mark A. Exley
Nature Communications
Therapy Indications
Whole-blood culture-derived cytokine combinations for the diagnosis of tuberculosis
(2024)
Anne Ahrens ?stergaard, S?ren Feddersen, Mike B. Barnkob, Rasmus Bank Lynggaard, Amanda Cecilie Annie Karstoft, Maria Borup, Ingrid Louise Titlestad, Torben Tranborg Jensen, Ole Hilberg, Christian Wejse, Stephanie Bjerrum, Morten Blaabjerg, Kristian Assing, Isik Somuncu Johansen
Frontiers in Immunology
Therapy Indications
Immune cell populations and induced immune responses at admission in patients hospitalized with vaccine breakthrough SARS-CoV-2 infections
(2024)
Adin Sejdic, Hans Jakob Hartling, Jon Gitz Holler, Lars Klingen Gj?rde 4, Birgitte Lindegaard, Arnold Matovu Dungu, Filip Gnesin, Maria Elizabeth Engel M?ller, Rebecca Svanberg Teglgaard, Carsten Utoft Niemann, Patrick Terrence Brooks, Charlotte Sv?rke J?rgensen, Kristina Tr?holt Franck, Thea K Fischer, Hanne Vibeke Marquart, Zitta Barrella Harboe, Sisse Rye Ostrowski
Frontiers in Immunology
Therapy Indications
Low testosterone levels relate to poorer cognitive function in women in an APOE-e4-dependant manner
(2024)
Melanie A Dratva, Sarah J Banks, Matthew S Panizzon, Douglas Galasko, Erin E Sundermann
Biology of Sex Differences
Therapy Indications
Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial
(2024)
Thomas Seufferlein, Ludwig Lausser, Alexander Stein, Dirk Arnold, Gerald Prager, Stefan Kasper-Virchow, Michael Niedermeier, Lothar M?ller, Stefan Kubicka, Alexander K?nig, Petra B?chner-Steudel, Kai Wille, Andreas W Berger, Angelika M R Kestler, Johann M Kraus, Silke D Werle, Lukas Perkhofer, Thomas J Ettrich, Hans A Kestler
Plos One
Therapy Indications
Deep immune cell phenotyping and induced immune cell responses at admission stratified by BMI in patients hospitalized with COVID-19: An observational multicenter cohort pilot study
(2024)
Adin Sejdic. Hans Jakob Hartling, Jon Gitz Holler, Lars Klingen Gj?rde, Arnold Matovu Dungu, Maria Elizabeth Engel Moller, Rebecca Svanberg Teglgaard, Carsten Utoft Utoft Niemann, Patrick Terrence Brooks, Trine H. Mogensen, Nina Weis, Daria Podlekareva, Marie Louise Baum Jorgensen, Anne Ortved Gang, Ditte Stampe Hersby, Annemette Hald, Susanne Dam Nielsen, Anne-Mette Lebech, Marie Helleberg, Jens Lundgren, Kristina Tr?holt Franck, Thea K. Fischer, Zitta Barrella Harboe, Hanne Vibeke Marquart, Sisse Rye Ostrowski,
Clinical Immunology
Therapy Indications
Cytokine Autoantibodies Alter Gene Expression Profiles of Healthy Donors
(2024)
Jakob Hjorth von Stemann, Florian Dubois, Violaine Saint-Andr?, Vincent Bondet, Celine Posseme, Bruno Charbit, Lluis Quintana-Murci, Morten Bagge Hansen, Sisse Rye Ostrowski, Darragh Duffy
European Journal of Immunology
Therapy Indications
Oral pathologic conditions and impaired cytokine response in patients with previous cerebral abscess or cervical necrotizing soft tissue infection
(2025)
Frederik Viktor Bang Jespersen, Signe Undall-Behrend Sisse Rye Ostrowski, Claus Henrik Nielsen, Claus Henrik Nielsen, Lars Haukali OmlandLars Haukali Omland, Simon Storg?rd Jensen, Merete Markvart
Frontiers
Therapy Indications
Pharmacokinetics and Pharmacodynamics of KT-474, a Novel Selective Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults
(2025)
Sagar Agarwal, Alice A McDonald, Veronica Campbell, Dapeng Chen, Jeff Davis, Haojing Rong, Aimee Mishkin, Anthony Slavin, Ashwin Gollerkeri, Jared A Gollob
Clinical Translationasl Science
Therapy Indications
Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes
(2025)
Megan E Smithmyer, Alex Hu, Matthew J Dufort, Anne M Hocking, Alice E Wiedeman, Kayla J Fasano, Troy R Torgerson, Peter J Skene, Julian Reading, Xiaojun Li, Qiuyu Gong, S Alice Long, Adam Lacy-Hulbert, Claire E Gustafson, Jane H Buckner, Cate Speake
Science Translational Medicine
Therapy Indications
Functional immune reconstitution after allogeneic hematopoietic stem cell transplantation in myeloablative and non-myeloablative conditioned patients
(2025)
Patrick Terrence Brooks, Lia Minculescu, Rebecca Svanberg Teglgaard, Hans Jakob Hartling, Jose Antonio Salado-Jimena, Lone Smidstrup Friis, Brian Kornblit, Ida Schj?dt, S?ren Lykke Petersen, Niels Smedegaard Andersen, Susanne Dam Nielsen, Jens Lundgren, Hanne Vibeke Marquart, Lars Klingen Gjaerde, Henrik Sengel?v, Sisse Rye Ostrowski
Nature Research
Therapy Indications
The Pivotal Role of Immune Functional Assays in Deciphering Immune Function Alterations
(2025)
Marion Debombourg, Guy Oriol 1, Caroline Dupre, Chlo? Albert-Vega, Fabienne Venet, Thomas Rimmel?, Realism Study Group, Anne Conrad, Florence Ader, Vincent Alcazer, VaccHemInf Study Group, Karen Brengel-Pesce, Aurore Fleurie, Sophie Trouillet-Assant, William Mouton
Clinical and Experimental Immunology
Therapy Indications
Adverse Events and Immune Response in Psoriasis Patients Receiving Interleukin-17 Inhibitors
(2025)
Christopher Willy Schwarz, Charlotte N?slund-Koch, Claus Zachariae, Jakob Benedict Seidelin, Susanne Dam Nielsen, Sisse Rye Ostrowski, Karen Marie Thyssen Astvad, Inger Brock, Lars Iversen, Mads Kirchheiner Rasmussen, Nikolai Loft, Lone Skov
Acta Dermato-Venereologica
Therapy Indications
Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E-selectin
(2025)
Tianai Lou, Jamie A Sugrue, Etienne Patin; Milieu Int?rieur Consortium; Lluis Quintana-Murci, Darragh Duffy, Cliona OFarrelly
Transfusion
Therapy Indications
Intravenous immunoglobulin and prednisolone to women with unexplained recurrent pregnancy loss after assisted reproductive technology treatment: a protocol for a randomised, double- blind, placebo- controlled trial
(2022)
K Nielsen, R Steffensen, MM J?rgensen, US Kesmodel
BJM Open
Therapy Indications
