Antibody discovery campaigns

At Specifica our goal is to generate as many different target-specific antibodies as possible that meet your unique requirements. We have generated more than 100 naïve individual libraries using different scaffolds, formats, variable gene sources and diversity sets.

Using three powerful coordinating technologies

 

We first carry out selections from our Generation 3 phage display libraries to obtain an initial pool of antibody leads with maximum diversity.

 

Then, we use yeast display to narrow this down to a diverse, high affinity fully binding population, reflecting requirements for cross-reactivity, ligand antagonism or additional specificity needs.

 

Finally, we evaluate selection outputs with next generation sequencing and AbXtract, Specifica’s next-generation sequencing (NGS) analysis software.

Antibody clustering